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IL12B — IL13

Text-mined interactions from Literome

Delespesse et al., Int Arch Allergy Immunol 1999 : The production of IL-4 and IL-13 by naive T cells is differentially regulated by TGF-beta and IL-12
Hoshino et al., J Immunol 1999 : In contrast, IL-12 did not enhance the IL-13 production induced by IL-2 alone
Bullens et al., Scand J Immunol 2001 : The increased IL-12 production in the presence of IL-4 and IL-13 is however, not the indirect result of a reduction in IL-10 production, but is most likely owing to a direct effect of IL-4 and IL-13
Chakir et al., Cell Immunol 2001 : DX5+ splenocytes showed a rapid ( 6 h ) and sustained ( 6-72 h ) accumulation of IFN-gamma transcripts followed by a delayed ( 12-24 h ) up-regulation of IL-10 or IL-13 expression in response to IL-2 + IL-12 or IL-2 + IL-18, respectively
Pfaff et al., Parasite Immunol 2003 (Entamoebiasis...) : This study disclosed that IL-18 will significantly down-regulate parasite-specific IL-10 production, whereas IL-12 induced IFN-gamma and inhibited IL-13 production by PBMC from humans exposed to O. volvulus and E. histolytica
Agrawal et al., Int Immunol 2005 : MUC1 expression on activated T cells was increased in the presence of IL-12 but was not affected by IFN-gamma, IL-2, IL-4, IL-5, IL-10, IL-13 or TNF-alpha
Rodriguez-Galán et al., J Immunol 2005 : The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but independent of Stat6, T-bet, or NFAT
Finkelman et al., J Immunol 2005 (Bronchial Hyperreactivity) : Although IL-4, but not IL-13 , induces IL-12 and IFN-gamma, which suppress many effects of IL-4, IL-12 suppresses only the Ca2T6 gene, and IL-4 induced IFN-gamma production does not suppress the Ca2T6 or SPRR genes
Fichtner-Feigl et al., J Immunol 2007 (Colitis...) : In vitro stimulation studies suggest that this IL-13 production is dependent on IL-23 and IL-25, but not on IL-12p70 ... In vitro stimulation studies suggest that this IL-13 production is dependent on IL-23 and IL-25, but not on IL-12p70
Shao et al., J Leukoc Biol 2008 (Fibrosis) : IL-4, IL-13 , and IFN-gamma act directly on monocytes to regulate fibrocyte differentiation, and IL-12 acts indirectly, possibly through CD16 positive NK cells
Yang et al., Cell Physiol Biochem 2010 : IL-12 not only by itself, but also synergistically enhanced LPS induced IL-13 release from P815 cells ... It appears that IL-12 induced IL-13 release and TLR4 expression is through activation of MAPK and PI3K/Akt signaling pathways, whereas IL-12 induced upregulation of TLR2 is via activation of PI3K/Akt signaling pathway, but not MAPK pathway
Mentink-Kane et al., Gastroenterology 2011 (Disease Models, Animal...) : IL-10, IL-12p40 , and IL-13Ra2 reduced the production and activity of the profibrotic cytokine IL-13
Lewkowich et al., Mucosal Immunol 2013 : In our model, IL-12 did not diminish T helper type 2 responses but rather directly antagonized IL-13-inducible gene expression, highlighting a novel role for IL-12 in regulation of IL-13 signaling
Hegde et al., Cell Immunol 1995 (Neoplasms, Experimental) : AK-5 tumor induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression
Jung et al., Eur J Immunol 1996 : Under these conditions, however, IL-12 inhibited IL-13 production by CD45RA+ T cells and to a lesser extent by CD45RO+ T cells in a dose dependent fashion
Flesch et al., Int Immunol 1997 (Granuloma...) : Although direct activation of host macrophages by IL-13 is possible, we consider it more likely that IL-13 acted indirectly through stimulation of IL-12 production and inhibition of IL-4 release early after infection
Minty et al., Eur Cytokine Netw 1997 : Indeed, IL-13 actually increases SAC induced IL-12 production ... The priming effect of IL-13 on IL-12 production is additive with that of IFN-gamma, and is partly independent of IFN-gamma
Yssel et al., Clin Exp Allergy 1998 (Asthma...) : Both IL-4 and IL-13 are inducing IgE synthesis whereas IFN-gamma and IL-12 are blocking IgE synthesis