Kumar et al., Blood 2004
(Leukemia) :
Gene expression profiling revealed that expression of Mll-AF9 led to overexpression of Hoxa5 , Hoxa6, Hoxa7, Hoxa9, and Hoxa10
Ansari et al., Br J Cancer 2012
:
The MLL4 regulates expression of various critical cell-cycle regulatory genes such as cyclin D, cyclin E, p27, HOXA5 and HOXB7 via histone H3K4 trimethylation and recruitment of RNA polymerase II