Mijatovic et al., Nitric Oxide 2008
(Melanoma) :
GIT-27NO significantly inhibited the expression of the transcription repressor and apoptotic resistant factor YY1 and, in parallel, augmented the presence of total p53 Mijatovic et al., Free Radic Biol Med 2010
(Mammary Neoplasms, Experimental...) :
In parallel, GIT-27NO rapidly but transiently prevented the loss of p53 through phosphorylation on Ser 20 and provided the necessary signals for the execution of downstream processes without p53 de novo synthesis