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EPHB2 — IL12B
Text-mined interactions from Literome
Feng et al., J Immunol 1999
:
In contrast, while p38 promotes induction of IL-12 ( p40 ) mRNA,
ERK activation
suppresses LPS mediated
IL-12 transcription
Gollob et al., J Immunol 2000
(Immunologic Deficiency Syndromes...) :
An examination of cytokine signaling revealed that STAT4 and
extracellular regulated kinase 1 (ERK1) activation by
IL-12 was intact, whereas the activation of STAT1, -3, and -5 by IL-12 was lost
Yanagawa et al., J Leukoc Biol 2002
:
These findings suggest that TNF-alpha induced
ERK activation negatively
controls maturation and
IL-12 production in murine DC
Xia et al., Scand J Immunol 2003
:
In addition, inhibition of
ERK by PD98059 significantly suppressed IL-10 and
increased the
IL-12 production ... The above findings suggest a unidirectional negative autocrine regulation of IL-12 by IL-10 in activated DCs and that activation of
ERK involves the differential production of IL-10 and
IL-12 by activated DCs
Kikuchi et al., Immunol Lett 2003
:
It seems that
roles of
ERK and p38 MAPK for
IL-12 production are developmentally changed in murine DC
Chino et al., Int Immunopharmacol 2005
(MAP Kinase Signaling System) :
Treatment with chemical inhibitors of NF-kappa B and p38 mitogen activated protein kinases ( MAPKs ) in vitro inhibited LPS induced IL-12 production, whereas JNK and
ERK inhibitors
increased IL-12 production
Correa et al., Br J Pharmacol 2005
:
3 The inhibitory effect of JWH-133 ( 100 nM ) on IL-12p40 production may involve extracellular regulated kinase ( ERK1/2 ) signaling : ( i ) JWH-133 induced a greater and sustained activation of ERK1/2 kinase in comparison with the level of activation observed following LPS ; ( ii ) the inhibition of
ERK1/2 by the specific inhibitor PD98059
increased LPS induced
IL-12p40 production in the presence or absence of JWH-133 suggesting a negative regulation of ERK pathway on IL-12p40 biosynthesis
Kondadasula et al., Blood 2008
:
Retroviral transfection of
ERK1 into primary human NK cells substantially increased IFN-gamma production in
response to immobilized IgG and
IL-12 , while transfection of human NK cells with a dominant negative ERK1 abrogated IFN-gamma production
Cheung et al., J Immunol 2008
(Inflammation) :
Further investigations showed that IL-17A, IL-17F, and
IL-23 differentially
activated the
ERK , p38 MAPK, and NF-kappaB pathways
Zhang et al., Hum Immunol 2008
:
Also,
IL-12 augmented the expression of cytotoxic effector molecules, TRAIL and perforin, and the phosphorylation of STAT1, STAT4, and
ERK1/2 , which may also contribute to lysis by NK cells
Canda-Sánchez et al., Immunobiology 2009
:
IL-12 dependent activation of
ERK1/2 in human T lymphoblasts
Kang et al., Cytokine 2009
:
Induction of
IL-12 by LMM in peritoneal macrophages
involved NF-kappaB, p38 and JNK, but not
ERK1/2
Saraiva et al., Immunity 2009
:
We showed that development of IL-10 producing Th1 cells required high T cell receptor ( TCR ) ligation, sustained
ERK1 and ERK2 MAP kinases phosphorylation, and
IL-12 induced STAT4 transcription factor
activation
Ju et al., Eur J Immunol 2009
(Melanoma, Experimental) :
Activation of p38 MAP kinase, but not
ERK or JNK, by either TCR-stimuli or
IL-12 and IL-18 is diminished in Gadd45b ( -/- ) CD8 ( + ) T cells, resulting in reduced production of IFN-gamma
Cuong et al., Life Sci 2009
(Inflammation...) :
Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6, and
IL-12 p40, and the
activation of
ERK1/2 and p38
Boucher et al., Viral Immunol 2010
(HIV Infections...) :
In THP-1 cells, p38,
ERK , and JNK inhibition
increased NF-kappaB and Sp1 binding to the
IL-12p40 promoter, while inhibiting AP-1 binding
Xuan et al., Cell Physiol Biochem 2010
:
Both LPS and GA stimulated the production of IL-6, IL-10,
IL12p70 and TNFalpha in a p38- and/or
ERK dependent manner
Rastogi et al., Am J Respir Crit Care Med 2011
(Sarcoidosis, Pulmonary) :
Inhibition of p38, but not
ERK ,
attenuated production of both
IL12/IL23p40 and TNF-a ... Inhibition of p38, but not
ERK ,
attenuated production of both
IL12/IL23p40 and TNF-a
Zhang et al., Cell Mol Immunol 2012
:
Interestingly, although p38 was required for HKBA phagocytosis and phagosome maturation,
ERK1/2 did not affect these processes but negatively
regulated IL-12 production ... Furthermore, Ras-guanine nucleotide releasing protein 1 ( RasGRP1 ) mediated the TLR2 induced
ERK1/2 activation and
inhibition of
IL-12p40 production
Hedl et al., Gastroenterology 2012
:
In mouse macrophages, which do not produce IL-1 in response to PRR stimulation alone, addition of exogenous IL-1 reversed the
ERK mediated inhibition of
IL-12p40