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CBL — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CBL → SRC (directlyIncreases, CBL Activity)
  Evidence: 12522270;12604776;10829062
• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: EGF R/SRC/EGF complex (EGFR-SRC-EGF) → CBL (protein ubiquitination, collaborate)
• Reactome Reaction: CBL → SRC (reaction) Rao et al., J Leukoc Biol 2002*, Wollberg et al., Biochem J 2003, Masson et al., Biochem J 2006*, Sun et al., Exp Cell Res 2007
• Reactome Reaction: CBL → SRC (indirect_complex) Rao et al., J Leukoc Biol 2002*, Wollberg et al., Biochem J 2003, Masson et al., Biochem J 2006*, Sun et al., Exp Cell Res 2007

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: SRC — CBL (coimmunoprecipitation) Szymkiewicz et al., FEBS Lett 2004*
• IRef Bind_translation Interaction: SRC — CBL (affinity chromatography technology) Szymkiewicz et al., FEBS Lett 2004*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Rellahan et al., Exp Cell Res 2003
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Hashimoto et al., Proc Natl Acad Sci U S A 2006
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Kassenbrock et al., J Biol Chem 2002*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Rafiq et al., J Biol Chem 2012*
• IRef Biogrid Interaction: SRC — CBL (direct interaction, enzymatic study) Vantler et al., FEBS Lett 2006*
• IRef Biogrid Interaction: SRC — CBL (direct interaction, pull down) Shishido et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Shishido et al., Proc Natl Acad Sci U S A 2000*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Song et al., Cell Signal 2010*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Sanjay et al., FEBS J 2006*
• IRef Biogrid Interaction: SRC — CBL (direct interaction, pull down) Tanaka et al., J Biol Chem 1995*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Tanaka et al., J Biol Chem 1995*
• IRef Biogrid Interaction: SRC — CBL (physical association, affinity chromatography technology) Szymkiewicz et al., FEBS Lett 2004*
• MIPS CORUM SH3P2/OSTF1-CBL-SRC complex: SH3P2/OSTF1-CBL-SRC complex complex (CBL-OSTF1-SRC) Szymkiewicz et al., FEBS Lett 2004*
• IRef Corum Interaction: Complex of CBL-SRC-SRC-OSTF1-CBL-OSTF1 (association, coimmunoprecipitation) Szymkiewicz et al., FEBS Lett 2004*
• IRef Hprd Interaction: SRC — CBL (in vivo) Vantler et al., FEBS Lett 2006*, Ng et al., EMBO J 2008, Odai et al., Jpn J Cancer Res 1995*
• IRef Hprd Interaction: SRC — CBL (in vitro) Vantler et al., FEBS Lett 2006*, Ng et al., EMBO J 2008, Odai et al., Jpn J Cancer Res 1995*
• IRef Intact Interaction: SRC — CBL (physical association, pull down) Hashimoto et al., Proc Natl Acad Sci U S A 2006
• IRef Intact Interaction: SRC — CBL (physical association, competition binding) Sanjay et al., FEBS J 2006*
• IRef Intact Interaction: SRC — CBL (physical association, pull down) Sanjay et al., FEBS J 2006*
• IRef Intact Interaction: SRC — CBL (physical association, anti tag coimmunoprecipitation) Sanjay et al., FEBS J 2006*
• IRef Intact Interaction: SRC — CBL (physical association, anti bait coimmunoprecipitation) Sanjay et al., FEBS J 2006*
• IRef Intact Interaction: SRC — CBL (phosphorylation reaction, protein kinase assay) Vantler et al., FEBS Lett 2006*
• IRef Intact Interaction: SRC — CBL (direct interaction, isothermal titration calorimetry) Ng et al., EMBO J 2008
• IRef Ophid Interaction: SRC — CBL (aggregation, confirmational text mining) Odai et al., Jpn J Cancer Res 1995*
• IRef Ophid Interaction: SRC — CBL (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Suzuki et al., J Immunol 2000 : Tyrosine phosphorylation of Vav and c-Cbl was restored in common by a-Lyn, a-Hck, and a-Src , but Fc gamma RIIB tyrosine phosphorylation, which is implicated in negative signaling, was reconstituted solely by a-Lyn and a-Hck
Hakak et al., Oncogene 2000 : Activation of PI3-kinase by v-Src may be mediated by the association of the adapter protein Cbl with the p85 subunit
Sanjay et al., J Cell Biol 2001 : The activation of integrin alpha(v)beta ( 3 ) induces the [ Ca ( 2+ ) ] ( i ) -dependent phosphorylation of Pyk2 Y402, its association with Src SH2, Src activation , and the Src SH3 dependent recruitment and phosphorylation of c-Cbl
Magnifico et al., J Biol Chem 2003 : Cbl-b also targets active Src for degradation in cells, and Nedd4 similarly reverses Cbl mediated Src degradation
Kim et al., Oncogene 2004 (Cell Transformation, Neoplastic) : The level of v-Src protein was reduced by Cbl-c , possibly through a lysosome dependent pathway
Valverde et al., J Bone Miner Res 2005 (Bone Resorption) : c-Src dependent c-Cbl phosphorylation was 8-fold higher in RAW264.7 cells treated with BSP and RANKL than in those treated with RANKL alone
Sanjay et al., FEBS J 2006 : We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl ... Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src induced phosphorylation of Cbl , and the inhibition of Src kinase activity by Cbl ... In contrast, disabling the tyrosine kinase binding domain of full-length Cbl by mutating glycine 306 to glutamic acid, and thereby preventing the previously described binding of the tyrosine kinase binding domain to the Src phosphotyrosine 416, had no effect on Cbl phosphorylation, the inhibition of Src activity by full-length Cbl, or bone resorption
Dragone et al., Proc Natl Acad Sci U S A 2006 : Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl dependent manner
Eisinger et al., J Biol Chem 2009 (MAP Kinase Signaling System) : The failure of morphine to desensitize ERK1/2 signaling is mediated by persistent activation of c-Src , which induces degradation of c-Cbl
Song et al., Cell Signal 2010 : Data from gene knockdown experiments with an RNA interference ( RNAi ) technique show that c-Cbl is involved in the interaction between Src and PI3K p85 during TRAIL treatment, playing an important role in TRAIL induced Akt phosphorylation
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Lee et al., J Biol Chem 2012 : Src inhibition blocked metformin mediated Cbl phosphorylation, suggesting that metformin stimulates AMPK-Src-Cbl axis pathway
Ryan et al., PloS one 2012 : Binding of Hic-5 to Cbl-c leads to an increase in the ubiquitin ligase activity of Cbl-c once Cbl-c has been activated by Src phosphorylation or through an activating phosphomimetic mutation
Deckert et al., J Biol Chem 1998 : These findings implicate Fyn as an adaptor protein that facilitates the interaction between Syk and Cbl, and suggest that Src and Syk family PTKs coordinately regulate the tyrosine phosphorylation of Cbl