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MAPK3 — UTS2
Text-mined interactions from Literome
Chen et al., Zhonghua Yi Xue Za Zhi 2000
:
The effect of
Urotensin II-stimulated airway smooth muscle cells DNA synthesis is
mediated by Ca2+, PKC,
MAPK and CaN signal transduction pathway
Watanabe et al., Circulation 2001
:
The synergistic interaction between
UII and moxLDL was partially inhibited by anti-Gq/11alpha antibody, the epidermal growth factor receptor tyrosine kinase inhibitor erbstatin A ( 10 micromol/L ), and the intracellular free radical scavenger N-acetylcysteine ( 400 micromol/L ) and was completely
inhibited by the c-Src tyrosine kinase inhibitor radicicol ( 10 micromol/L ), the protein kinase C ( PKC ) inhibitor Ro31-8220 ( 0.1 micromol/L ), and the mitogen activated protein kinase (
MAPK ) kinase inhibitor PD098059 ( 10 micromol/L )
Chen et al., Chin Med J (Engl) 2004
:
In primary cultures of rat ASMCs, activities of protein kinase C ( PKC ),
mitogen activated protein kinase ( MAPK ) and calcineurin ( CaN )
induced by
UII were measured ...
UII 10 ( -7 ) mol/L
stimulated ASMC PKC and
MAPK activities by 44 % and 24 % ( P < 0.01 ), respectively, after incubating for 20 minutes ...
UII increases cytosolic free calcium concentration and
activates PKC,
MAPK and CaN
Onan et al., Mol Endocrinol 2004
(Cardiomegaly) :
Urotensin II potently
activated the MAPKs,
ERK1/2 and p38, and blocking these kinases with PD098059 and SB230580, respectively, significantly inhibited urotensin II-mediated hypertrophy
Dai et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006
:
[
Effect of
urotensin II on proliferative potential and phosphorylation of
extracellular signal regulated kinase 1/2 of adventitial fibroblasts from spontaneously hypertensive rat ]