◀ Back to EPHB2

CXCL12 — EPHB2

Text-mined interactions from Literome

Montes et al., Eur Cytokine Netw 2000 : SDF-1 induced activation of ERK enhances HIV-1 expression ... In HeLa cells, ERK-2 only is activated by SDF-1 or by a SDF derived peptide
Bajetto et al., J Neurochem 2001 : Moreover, both astrocyte proliferation and ERK1/2 phosphorylation, induced by SDF-1alpha , were inhibited by pertussis toxin ( PTX ) and wortmannin treatment indicating the involvement of a PTX sensitive G-protein and of phosphatidyl inositol-3 kinase in the signalling of SDF-1alpha
Weber et al., Mol Biol Cell 2001 : Stimulation of Jurkat T cells with the CXC chemokine stromal cell derived factor-1alpha ( SDF-1alpha ) resulted in a rapid increase in the phosphorylation, i.e., activation of extracellular signal receptor activated kinase ( ERK ) but not c-Jun NH ( 2 ) -terminal kinase or p38 kinase, and phosphorylation of Akt, reflecting phosphatidylinositol 3-kinase (PI3-K) activation
Wang et al., Biochemistry 2002 : Moreover, CXCL1 activation of PAK1 is independent of ERK1/2 activation, a conclusion based on the observations that the inhibition of MEK-ERK activation by expression of dominant negative ERK or by the MEK inhibitor, PD98059, has no effect on CXCL1 induced PAK1 activation or CXCL1 induced chemotaxis
Lee et al., Blood 2002 (MAP Kinase Signaling System) : SDF-1 alpha induced transient activation of extracellular stress regulated kinase ( ERK1/2 ), ribosomal S6 kinase ( p90RSK ) and Akt, molecules implicated in cell survival
Barbero et al., Ann N Y Acad Sci 2002 (Brain Neoplasms...) : Moreover, we studied by western blot the intracellular pathway involved in cell proliferation, demonstrating that SDF1alpha induces the ERK1/2 phosphorylation that is reduced by the PD98059 compound, an MEK inhibitor
Wang et al., Biochemistry 2003 : Moreover, CXCL10 can inhibit CXCL1 induced PAK1 and ERK activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate
Curnock et al., J Immunol 2003 : Our results show that expression of either kinase-dead PI3Kgamma ( KD-PI3Kgamma ) or Deltap85 ( a construct unable to bind class I ( A ) p110alpha, -beta, or -delta ) leads to a partial inhibition of SDF-1 stimulated protein kinase B phosphorylation, but had no effect on SDF-1 induced phosphorylation of the mitogen activated protein kinase ERK1/2
Laakko et al., J Biol Chem 2003 : Adhesion regulation of stromal cell derived factor-1 activation of ERK in lymphocytes by phosphatases ... Activation of ERK by the chemokine SDF-1 can be regulated by adhesion to beta 1-integrin substrates in the T-cell lines MOLT-3, Jurkat, and H9 and in the Daudi B-cell line ... In Jurkat T-cells, adhesion to the immobilized alpha 4 beta 1-integrin ligand VCAM-1 or to the alpha 5 beta 1-integrin ligand fibronectin regulated stromal-cell derived factor-1 (SDF-1) activation of ERK ... Therefore, these data suggest that adhesion influences SDF-1 activation of ERK by regulating the activity of ERK phosphatases
Kremer et al., J Immunol 2003 : Because TCR activates ERK via SLP-76 mediated activation of the linker of activated T cells (LAT) scaffold protein, we examined the role of LAT in SDF-1alpha mediated ERK activation ... Together, our results describe the distinct mechanism by which SDF-1alpha stimulates prolonged ERK activation in T cells and indicate that this pathway is specific for cells expressing both ZAP-70 and SLP-76
Uchida et al., Exp Cell Res 2003 (Carcinoma, Squamous Cell...) : SDF-1alpha also activated Src family kinases (SFKs), and its inhibitor PP1 diminished the SDF-1alpha induced chemotaxis and activation of both ERK1/2 and Akt/PKB
Jaleel et al., Mol Hum Reprod 2004 : Immunocytochemistry confirmed SDF-1 induced nuclear translocation of phosphorylated ERK1/2
Ottaiano et al., Cancer Immunol Immunother 2005 (Carcinoma...) : Further, CXCL12 activated ERK1/2 in SW480 cells ... Further, CXCL12 activated ERK1/2 in SW480 cells
Sela et al., J Immunol 2005 (Disease Models, Animal...) : This was accompanied by diminished SDF1-alpha induced T cell adhesion and ERK phosphorylation
Chen et al., Immunology 2005 (HIV Infections) : TGF-beta1 up-regulated CXCR4 and enhanced SDF-1alpha stimulated ERK1,2 phosphorylation in these cells
Luo et al., J Neurochem 2005 : Stimulation of the more differentiated progenitors ( E14.5 ) with SDF1alpha resulted in rapid activation of the extracellular signal regulated kinase ( ERK ) 1/2 ... This SDF1alpha induced ERK activity was dose dependent and could be inhibited by pre-treatment of the cells with either pertussis toxin, an inactivator of G-protein coupled receptors, or PD98059, a MEK1 inhibitor
Peng et al., Mol Cancer Res 2005 : The SDF-1alpha induced Akt and ERK1/2 activations are CXCR4 dependent as confirmed by their total inhibition by T134, a CXCR4-specific peptide antagonist ... Cell signaling analysis with pathway-specific inhibitors reveals that SDF-1alpha induced Akt activation is not required for ERK1/2 activation and vice versa, indicating that activations of Akt and ERK1/2 occur independently
Su et al., Zhonghua Yi Xue Za Zhi 2005 (Lung Neoplasms...) : Moreover, SDF-1a induced the phosphorylation of ERK1/2 in human lung cancer cells
Wain et al., Cell Signal 2005 : However, co-ligation of the B cell antigen receptor and FcgammaRIIB inhibits the PI3K dependent phosphorylation of PKB and ERK1/2 in response to CXCL12
Zhao et al., Mol Pharmacol 2006 : The Src inhibitor 4-amino-5-methylphenyl-7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ) and the Rho-kinase ( ROCK ) inhibitor N- ( 4-pyridyl ) -4- ( 1-aminoethyl ) cyclohexanecarboxamide dihydrochloride ( Y27632 ) also attenuated SDF-1 induced ERK1/2 phosphorylation ... A large portion of the SDF-1 mediated ERK phosphorylation was detected in the nucleus, as shown by Western blotting and confocal microscopy, and resulted in the phosphorylation of the transcription factor Elk
Florio et al., Mol Pharmacol 2006 (Adenoma...) : To identify a possible cross-talk and a molecular ordering among these pathways, we tested these antagonists on SDF1alpha dependent activation of ERK1/2 , Pyk2, and BK ( Ca ) channels ... From these experiments, we observed that the inhibition of [ Ca ( 2+ ) ] ( i ) increase or BK ( Ca ) channel activity did not affect ERK1/2 activation by SDF1alpha ; Pyk2 activation was purely Ca ( 2+ ) -dependent, not involving ERK1/2 or BK ( Ca ) channels ; and BK ( Ca ) channel activity was antagonized by Pyk2 but not by ERK1/2 inhibitors
Granata et al., Eur J Immunol 2006 : sPLA ( 2 ) induced the phosphorylation of the MAPK p38 and ERK1/2 , and inhibition of these kinases by SB203580 and PD98059, respectively, reduced TNF-alpha and CXCL8 release
Salvucci et al., Blood 2006 : We further demonstrate that EphB2 and EphB4 activation enhance SDF-1 induced signaling and chemotaxis that are also required for extracellular matrix dependent endothelial cell clustering
Redondo-Muñoz et al., Blood 2006 (Leukemia, B-Cell...) : Accordingly, alpha4beta1 engagement activated the PI3-K/Akt/NF-kappaB pathway, while CXCL12/CXCR4 interaction activated ERK1/2/c-Fos signaling
Zhao et al., Gynecol Oncol 2006 (Endometrial Neoplasms) : ERK1/2 was significantly activated for more than 2 h by SDF-1alpha at 20 ng/ml in HEC-1A cells, but not in Ishikawa cells
Sai et al., J Biol Chem 2006 : Although both mutant and wild-type receptors could mediate Akt and Erk activation in response to CXCL8 , the level of activation of these two kinases was much lower in the cell line expressing the mutant receptors
Lee et al., Int J Biochem Cell Biol 2007 (MAP Kinase Signaling System) : The OSM stimulated expression of SDF-1 in hATSCs was completely abrogated by pretreatment of the cells with U0126, an MEK-specific inhibitor, but not with AG490, a JAK2 inhibitor, or WHI-P131, a JAK3 inhibitor, suggesting that ERK , but not JAK2 and JAK3, is involved in the OSM induced expression of SDF-1
Massa et al., Ann N Y Acad Sci 2006 (Adenoma...) : SDF-1 increased cytosolic [ Ca2+ ] and activated Pyk2, ERK1/2 , and BKCa channels ... To identify a possible crosstalk and a molecular ordering among these pathways, we tested these antagonists on SDF-1 dependent activation of ERK1/2 , Pyk2, and BKCa channels ... We report that the inhibition of [ Ca2+ ] i increase or the blockade of BKCa channel activity did not affect ERK1/2 activation by SDF-1 ; Pyk2 activation was purely Ca2+ dependent, not involving ERK1/2 or BKCa channels ; and BKCa channel activity was antagonized by Pyk2 but not by ERK1/2 inhibitors
Schutyser et al., Eur Cytokine Netw 2007 (Anoxia...) : Furthermore, hypoxia and serum starvation were required for cell surface display of CXCR4 and CXCL12 induction of ERK activation in HMEC-1 cells
Pattarozzi et al., Mol Pharmacol 2008 (Breast Neoplasms) : Gefitinib treatment inhibited not only the EGF dependent proliferation and ERK1/2 activation but also the effects of SDF-1 and E2, suggesting that these activities were mediated by EGFR transactivation
Petrai et al., Int J Biochem Cell Biol 2008 : In cells expressing CXCR3-A, CXCL10 ( IP-10 ) at nanomolar concentrations induced activation of ERK , Akt, and Src, as previously described in human vascular pericytes
Zagzag et al., Am J Pathol 2008 (Brain Neoplasms...) : Similarly, inhibition of CXCR4 decreased levels of SDF-1alpha induced phosphorylation of FAK, AKT, and ERK1/2 , suggesting CXCR4 involvement in glioma invasion signaling
Lee et al., J Endocrinol 2008 : CXCL12 dependent phosphorylation of ERK1/2 was also confirmed by western blot analysis, supporting the evidence that MAPK is an intracellular mediator of CXCL12/CXCR4 interaction in GH3 cell proliferation
Ryser et al., Mol Immunol 2008 : S1P(1) overexpression resulted in reduced CXCR4 surface expression levels and strong inhibition of SDF-1 dependent ERK1/2 phosphorylation and Ca ( 2+ ) flux
Gilbert et al., J Pathol 2009 (Neoplasm Invasiveness...) : We show that CXCL12 stimulates the invasive migration of a TGCT cell line in vitro in a CXCR4 dependent fashion and activates ERK
Ierano et al., Cell cycle (Georgetown, Tex.) 2009 (Neoplasms) : CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12
Gao et al., Stem Cells 2009 : Impaired MSC migration correlated with decreased levels of phosphorylated STAT3 and ERK1/2, suggesting that SDF-1 stimulation activates Jak2/STAT3 as well as MEK/ERK1/2 signaling, which in turn promotes migration of MSCs toward tumor cells
Acharya et al., Leukemia 2009 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : SDF-1 and PDGF enhance alphavbeta5 mediated ERK activation and adhesion independent growth of human pre-B cell lines
Kim et al., Cancer research and treatment : official journal of Korean Cancer Association 2008 : SDF-1 induced the phosphorylation of AKT and ERK1/2 in the PLC/PRF5 cells and the phosphorylation of Stat3, AKT and ERK1/2 in the Hep3B cells
Sun et al., Molecular cancer 2010 (Chondrosarcoma...) : CXCR4/SDF1 mediate hypoxia induced chondrosarcoma cell invasion through ERK signaling and increased MMP1 expression
Oh et al., Biochem Biophys Res Commun 2010 (Myocardial Ischemia) : ECFCs with high CXCR4 expression showed enhanced ERK and Akt activation in response to SDF-1alpha ... In addition, SDF-1alpha induced migration and ERK1/2 , Akt, and eNOS activation were reduced by AMD3100, a CXCR4-specific peptide antagonist, or by siRNA-CXCR4
Singh et al., Br J Cancer 2010 (Pancreatic Neoplasms) : CXCL12 induced the activation of FAK, ERK , and Akt signalling pathways, enhanced transcriptional activities of ß-catenin and NF-?B, and expression of survival proteins
Messmer et al., Blood 2011 (Leukemia, Lymphocytic, Chronic, B-Cell) : The CXCL12 induced phosphorylation of ERK and MEK in ZAP-70 ( + ) CLL cells was blocked by sorafenib, a small molecule inhibitor of RAF
Badr et al., PloS one 2011 (Multiple Myeloma) : Activation of CXCR4 by CXCL12 resulted in the association of CXCR4 with CD45 and activation of PLCß3, AKT, RhoA, I?Ba and ERK1/2
Nasser et al., PloS one 2011 (Breast Neoplasms) : Elucidation of the molecular mechanisms using various biochemical techniques and confocal microscopy revealed that JWH-015 treatment inhibited CXCL12 induced P44/P42 ERK activation , cytoskeletal focal adhesion and stress fiber formation, which play a critical role in breast cancer invasion and metastasis
Drury et al., Proc Natl Acad Sci U S A 2011 (Colorectal Neoplasms...) : Dimeric CXCL12 activated G-protein dependent calcium flux, adenylyl cyclase inhibition, and the rapid activation of ERK1/2 , but only weakly, if at all, recruited arrestin, stimulated actin polymerization, or promoted chemotaxis
Sambandam et al., Oncogene 2013 (Carcinoma, Squamous Cell...) : Also, CXCL13 significantly increased p-ERK1/2 in SAKA-T and MC3T3-E1 cells
Heinrich et al., Journal of translational medicine 2012 (Pancreatic Neoplasms) : Conversely, KRAS knockdown greatly reduced CXCL12 mediated increases in ERK1/2 phosphorylation
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Rigo et al., PloS one 2012 : In contrast, the structural variant [ N33A ] CXCL12 triggered no ß-arrestin dependent phosphorylation of ERK1/2 , and signaled via G protein dependent pathways alone ... In contrast, the structural variant [ N33A ] CXCL12 triggered no ß-arrestin dependent phosphorylation of ERK1/2 , and signaled via G protein dependent pathways alone ... We conclude that both recombinant CXCL12 and its structural variant [ N33A ] CXCL12 may transinhibit HER1 via G-proteins/calmodulin/calcineurin, but [ N33A ] CXCL12 does not activate ß-arrestin dependent ERK1/2 phosphorylation and retains a stronger inhibitory effect
Li et al., Am J Transplant 2012 (Arteriosclerosis) : Conditioned media from Ltv-p53 transferred SMCs activated PI3K/Akt/mTOR and MAPK/Erk signaling in a SDF-1a dependent manner and thereby promoted mesenchymal stem cell (MSC) migration and proliferation
Lipfert et al., Cell Mol Neurobiol 2013 : We demonstrate that Grk2 mediates signalling of SDF-1/CXCL12 bound CXCR7 as suggested by the finding that SDF-1/CXCL12 induced activation of Erk1/2 and Akt is abrogated following RNAi mediated inhibition of Grk2, but not of Grk3, Grk5, or Grk6
Huang et al., J Cell Physiol 2013 (Colorectal Neoplasms...) : Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of ERK and p38 mitogen activated protein kinase ( MAPK ) pathways are critical for visfatin induced SDF-1 expression
McCaig et al., PloS one 2012 : Dasatinib pre-treatment inhibited Akt and ERK phosphorylation in CLL cells upon stimulation with CXCL12
Badr et al., PloS one 2012 (Multiple Myeloma) : We found that WEV and WEV+NP clearly decreased the CXCL12/CXCR4 mediated activation of AKT, ERK , NF?B and Rho-A using western blot analysis ; abrogated the CXCL12 mediated proliferation of MM cells using the CFSE assay ; and induced apoptosis in MM cell as determined by PI/annexin V double staining followed by flow cytometry analysis
Heckmann et al., Translational oncology 2013 : SDF-1a increased proliferation, invasion, and ERK signaling of endogenously and lentivirally CXCR4 expressing cells
Kremer et al., J Biol Chem 2013 (Leukemia, Myeloid, Acute...) : We show that SDF-1 , the sole ligand for CXCR4, induces the expected migration and ERK activation in the KG1a AML cell line transiently overexpressing CXCR4, but ERK activation did not lead to survival
Esencay et al., BMC cancer 2013 (Glioma...) : In addition, knockdown of CXCR7 expression in LN229 and LN308 glioma cells decreased levels of SDF-1a induced phosphorylation of ERK1/2 and Akt