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CTNNB1 — KRAS

Text-mined interactions from Literome

Li et al., Gastroenterology 2005 (Cell Transformation, Neoplastic...) : The effects of K-ras ( Val12 ) on VEGF and T-cell factor 4 (TCF-4) promoter activity, nuclear levels of beta-catenin and beta-catenin/TCF-4 complexes, glycogen synthase kinase 3beta ( GSK-3beta ) phosphorylation, and GSK-3beta kinase activity were measured ... K-ras ( Val12 ) increased the stability of beta-catenin, the levels of nuclear beta-catenin , and the formation of nuclear beta-catenin/TCF-4 complexes, and these effects were also blocked by LY294002
Janssen et al., Gastroenterology 2006 (Colorectal Neoplasms) : This KRAS induced increase in Wnt/beta-catenin signaling may enhance the plasticity and self-renewal capacity of the tumor, thus resulting in the drastically augmented tumor multiplicity and malignant behavior in compound mutant animals
Phelps et al., Cell 2009 (Adenoma...) : APC mutation induced intestinal differentiation defects instead depend on the transcriptional corepressor C-terminal binding protein-1 (CtBP1), whereas proliferation defects and nuclear accumulation of beta-catenin require the additional activation of KRAS