Shimizu et al., Liver Int 2003
(Carcinoma, Hepatocellular...) :
Our studies showed that E2 suppressed hepatic fibrosis in hepatic fibrosis models, inhibited the activation of activator protein 1 and nuclear factor-kappa B in cultured hepatocytes undergoing oxidative stress, and attenuated HSC activation in primary culture
Li et al., Zhonghua Yi Xue Za Zhi 2005
:
Stimulation of HSC by Ang II and Aldo results in activation of AP-1 via ERK1/2 pathway leading to up-regulation of AP-1 target gene alpha1 ( I ) procollagen mRNA expression
Li et al., Zhonghua Gan Zang Bing Za Zhi 2005
:
EMSA showed that stimulation of HSC by Aldo markedly increased AP-1 DNA binding activity