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CSF1 — TGFB1
Text-mined interactions from Literome
Yano et al., J Am Coll Cardiol 2006
(Myocardial Infarction...) :
Five days after MI,
M-CSF increased the number of ED-1 positive cells, mRNA levels of
transforming growth factor-beta-1 , collagen I and III, and collagen fibers within the infarct
Rosenfeld et al., Stem Cells 1994
:
TGF-beta 1 ( 0.1 ng/ml ) significantly ( p < 0.05 )
augmented M-CSF induced macrophage colony forming units ( CFU-M ) by twofold to fourfold in 8/8 donors ... These studies indicate that
TGF-beta 1 directly
enhances M-CSF activity by a mechanism other than upregulation of M-CSF receptors
Hong et al., J Immunol 1997
:
Here we show that
TGF-beta1 induces the expression of
macrophage-CSF (M-CSF) in vascular endothelial cells via a signaling pathway ( s ) involving hydrogen peroxide ( H2O2 ) ... Furthermore, the
TGF-beta1 induced
M-CSF mRNA expression was inhibited by catalase, but not by superoxide dismutase, suggesting that H2O2 rather than superoxide anion ( O2.- ) is the primary mediator of the effects of TGF-beta1 ... These results indicate that the generation of H2O2 and activation of NF-kappaB by
TGF-beta1 are
required for the induction of
M-CSF gene transcription