Gene interactions and pathways from curated databases and text-mining

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CRH — UCN2

Text-mined interactions from Literome

Nijsen et al., Neurogastroenterol Motil 2005 (Pain) : Selective activation of the CRF2 receptor by stresscopin related peptide ( SRP ; i.p. 25 microg kg-1 ) reduced the distension induced visceromotor and behavioural response
Nemoto et al., J Endocrinol 2007 : In the anterior pituitary cells, corticotropin releasing factor (CRF) increased mRNA expression levels and secretion of Ucn 2 , although arginine vasopressin (AVP) did not induce any significant change in Ucn 2 expression or secretion ... In the intermediate pituitary, CRF increased both the mRNA expression levels and secretion of Ucn 2 ... These results suggest that the mRNA expression and secretion of Ucn 2 in POMC cells of the pituitary are positively regulated by CRF and negatively regulated by glucocorticoids
Nemoto et al., J Endocrinol 2009 : We previously demonstrated that Ucn 2 is expressed in the corticotrophs of rat pituitary, and the mRNA expression and secretion of Ucn 2 in corticotrophs of rat anterior pituitary are regulated by CRF and glucocorticoids
Kageyama et al., Frontiers in endocrinology 2013 : In corticotrophs, stress induced increases in CRF stimulate Ucn2 production, which leads to the inhibition of gonadotropin secretion via the CRF ( 2 ) receptor in the pituitary