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ANGPT2 — MMP1
Text-mined interactions from Literome
Etoh et al., Cancer Res 2001
(Neovascularization, Pathologic...) :
MMP-1,
MMP-9 , and urokinase-type plasminogen activator in ECs were strongly
up-regulated by
Ang-2 in the presence of VEGF in vitro ...
MMP-1 , MMP-9, and urokinase-type plasminogen activator in ECs were strongly
up-regulated by
Ang-2 in the presence of VEGF in vitro
Chen et al., Circ Res 2004
(MAP Kinase Signaling System) :
The functional role of endoglin in modulating
Ang II effects on
matrix metalloproteinase-1 (MMP-1) and type I collagen expression was also analyzed
Battle et al., Cancer Res 2006
:
IFN-gamma blocks the biological activity of VEGF through inhibition of genes necessary for the VEGF response, including
angiopoietin-2 , urokinase plasminogen activator, tissue
inhibitor of
matrix metalloproteinase-1 , cyclooxygenase-2, and VEGF receptor 2
Nazari et al., J Med Invest 2007
(MAP Kinase Signaling System) :
We next tested the
effect of broad-spectrum
matrix metalloproteinase ( MMP ) inhibitor ( GM6001 ) on
Ang II-inhibition of insulin signaling pathway
Zack et al., Atherosclerosis 2011
(Aortic Aneurysm, Abdominal...) :
Ang II induction of cyclooxygenase-2, interleukin-6,
matrix metalloproteinase (MMP)-2 , MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Martinez-Lemus et al., Am J Physiol Heart Circ Physiol 2011
(Disease Models, Animal...) :
Inhibition of
MMP activation ( with GM-6001 ) or ROS production ( with apocynin or tempol )
prevented the NE +
ANG II-induced inward remodeling