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Mo et al., Exp Eye Res 1999 (Uveitis) : The levels of LPS induced aqueous IL-8 and MCP-1 at 12 hr were inhibited by anti-TNFalpha mAb but not by an IL-1 receptor antagonist (IL-1Ra), while concentrations of the two chemokines at 24 hr were inhibited by both anti-TNFalpha mAb and IL-1Ra
Steube et al., Leuk Res 1999 (Inflammation...) : Stimulation of HL-60 and MONO-MAC-6 with lipopolysaccharide (LPS) , and stimulation of ML-2 and MUTZ-3 with 12-tetradecanoyl phorbol 13-acetate ( TPA ) dramatically increased the MCP-1 level in the culture medium
Jiang et al., J Periodontol 1999 (Dental Plaque) : In mononuclear cells, LPS induced high levels of MIP-1alpha and RANTES and moderate levels of MCP-1 ; in osteoblasts LPS only induced MCP-1
Olszyna et al., J Infect Dis 2000 (Endotoxemia) : Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1 ... Pretreatment with IL-10 inhibited LPS induced release of MIP-1alpha, MIP-1beta, and MCP-1
Bukara et al., Alcohol 2000 (Acute Disease...) : Splenectomy significantly suppressed LPS induced RANTES release, but not MIP-1alpha and MCP-1
van Aken et al., Blood Coagul Fibrinolysis 2000 : Furthermore, lipopolysaccharide (LPS) stimulation of MM6, cultured with elevated HCY ( 200 micromol/l ) levels, resulted in a 3.5-fold increased response after 18 h, whereas no effect on LPS induced IL-8 and MCP-1 response was observed
Wang et al., Kidney Int 2000 : These studies prove that NF-kappaB is critical for LPS induced MCP-1 transcription, and AP-1 and Sp1 are essential for basal expression of MCP-1 in rat tubule cells
Lakics et al., J Immunol 2000 : Overexpression of Bcl-xL in this macrophage cell line was also associated with a marked inhibition of LPS induced TNF-alpha, JE/monocyte chemoattractant protein 1 , and macrophage inflammatory protein 2 secretion
Szczepanik et al., J Neuroimmunol 2001 (Alzheimer Disease...) : IL-10 was found to suppress all A beta and LPS induced inflammatory proteins measured ( IL-1 alpha, IL-1 beta, IL-6, TNF-alpha and MCP-1 ) in both cell types with the exception of LPS induced MCP-1 in THP-1 cells where no change was observed
Aung et al., J Acquir Immune Defic Syndr 2001 (Disease Progression...) : In contrast to the findings with MIP-1 alpha, LPS stimulated MCP-1 in BAC from the group of HIV-1 infected patients with high CD4 count was significantly higher than healthy study subjects ( p < .001 )
Yu et al., Zhonghua Yi Xue Za Zhi 1999 : L-arginine and nimodipine can markedly inhibit the expression of MCP-1 in ECs induced by LPS
Loghmani et al., Inflammation 2002 : Our results show that pleural fluid isolated human fibroblasts release IL-8 and MCP-1 upon stimulation with IL-1 beta, TNF-alpha, and LPS in both a concentration- and time dependent manner
Riese et al., Shock 2002 (Infection...) : In contrast to IL-6, LPS stimulated production of MCP-1 was significantly less in infected patients
Nitti et al., Biochem Biophys Res Commun 2002 : On the other hand, in LPS stimulated cells, the delta isoform was seen to be involved and was probably related to LPS mediated effects on MCP-1 expression and synthesis
Laudes et al., J Immunol 2002 : Although LPS or IFN-gamma alone induced some release of MCP-1 and MIP-2, pre-exposure of these monolayers to LPS or IFN-gamma, followed by addition of C5a, resulted in synergistic production of MIP-2 and MCP-1
Kadl et al., Vascul Pharmacol 2002 (Inflammation) : We found that both OxPAPC and LPS induced expression of early growth response factor 1 (EGR-1) and monocyte chemoattractant protein 1 ( MCP-1 ) in HUVEC and of JE, the mouse homologue of MCP-1, in liver and heart
Mathiak et al., Int J Mol Med 2003 : Furthermore, the potent, selective dose-response effect of P. aeruginosa LPS on MCP-1 production could help to explain the preponderance of a relentless inflammatory cellular infiltrate in diseases such as cystic fibrosis ( CF )
Heinzelmann et al., Int J Surg Investig 2001 : HBP increased the LPS induced production of IL-8, MIP-1alpha, TNF-alpha, IL-1beta, but HBP did not increase the significant LPS induced release of IL-10, monocyte chemoattractant protein MCP-1 , and IL- 12
Li et al., Anesth Analg 2003 : We conducted this study to investigate the effects of dobutamine and dopamine on lipopolysaccharide (LPS) induced MCP-1 production in human monocytic THP-1 cells ... Dobutamine inhibited LPS induced production of MCP-1 , as well as messenger RNA expression, in a dose dependent manner, whereas dopamine had no significant effect
Aldonyte et al., Respir Res 2003 (Pulmonary Disease, Chronic Obstructive...) : LPS stimulated release of IL-6 and MCP-1 was greater from COPD patient 's monocytes relative to controls, while activation of control cells resulted in enhanced secretion of ICAM-1 and MMP-9 compared to COPD patients
Olszyna et al., Eur Cytokine Netw 2003 (Endotoxemia) : LPS also induced rises in the plasma and RBC levels of monocyte chemoattractant protein (MCP)-1 , which were diminished by IC14
Arndt et al., J Biol Chem 2004 : We show here that exposure to LPS activates JNK in non suspended neutrophils and that LPS induced MCP-1 expression, but not tumor necrosis factor-alpha (TNF-alpha) or interleukin-8 (IL-8), is dependent on JNK activation ... Inhibition of Syk with piceatannol or PI3K with wortmannin inhibited LPS induced JNK activation and decreased MCP-1 expression after exposure to LPS, suggesting that both Syk and PI3K reside in a signaling pathway leading to LPS induced JNK activation in neutrophils ... Overall our data suggests that LPS induces JNK activation only in non suspended neutrophils, which proceeds through Syk- and PI3K dependent pathways, and that JNK activation is important for LPS induced MCP-1 expression but not for TNF-alpha or IL-8 expression
Cui et al., Am J Physiol Regul Integr Comp Physiol 2004 (Shock) : In additional experiments, although 24-h infusions of LeTx and Escherichia coli LPS produced similar mortality rates ( 54 and 56 %, respectively ) and times to death ( 13.2 +/- 0.8 vs. 11.0 +/- 1.7 h, respectively ) compared with controls, only LPS reduced circulating leukocytes, platelets, and IL-2 levels and increased TNF-alpha, IL-1 alpha and -1 beta, IL-6, IL-10, interferon-gamma, granulocyte macrophage-colony stimulating factor, RANTES, migratory inhibitory protein-1 alpha, -2, and -3, and monocyte chemotactic protein-1 , as well as nitrate/nitrite levels ( all P < or = 0.05 for the effects of LPS )
Bao et al., Zhonghua Er Ke Za Zhi 2003 : LPS increased the expression of collagen type IV and III in the culture medium of mesangial cells in vitro [ ( 138.75 +/- 23.23 ) ng/ml and ( 38.25 +/- 5.38 ) ng/ml ] and up-regulated the IL-1 beta and MCP-1 mRNA expression [ ( 16.91 +/- 1.68 ) % and ( 76.6 +/- 6.59 ) % ] ... Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS , which may be valuable in decreasing the progression of glomerulosclerosis
Bosco et al., J Immunol 2004 : Hypoxia also inhibited, in a time dependent fashion, MCP-1 up-regulation by IFN-gamma and LPS
Uchiyama et al., Clin Exp Pharmacol Physiol 2004 (Respiratory Distress Syndrome, Adult) : Furthermore, TMG attenuated the LPS induced increase in pulmonary expression of KC, MIP-1alpha and MCP-1 at both the transcriptional and translational levels
Shi et al., Cell Biochem Biophys 2004 (Atherosclerosis) : We observed constitutive expression of interleukin (IL)-6, IL-8, granulocyte macrophage colony stimulating factor ( GM-CSF ), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS
Kumagai et al., Invest Ophthalmol Vis Sci 2005 : Similarly, LPS increased both the release of IL-8 and MCP-1 by corneal fibroblasts as well as the amounts of the corresponding mRNAs in these cells
Li et al., Kidney Int 2005 (Inflammation) : Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS) induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 ( MCP-1 ) expression
Planavila et al., Cardiovasc Res 2005 (Cardiomegaly) : Stimulation of neonatal rat cardiomyocytes with PE and embryonic rat heart derived H9c2 cells with lipopolysaccharide (LPS) enhanced the expression of the nuclear factor (NF)-kappaB-target gene monocyte chemoattractant protein 1 ( MCP-1 )
Rosenson et al., J Lab Clin Med 2005 (Hypercholesterolemia) : In this study we investigated ( 1 ) whether statin therapy reduces lipopolysaccharide (LPS) stimulated MCP-1 production in human whole-blood samples and ( 2 ) the relationships between in vitro low-density lipoprotein (LDL) oxidation and MCP-1 production
Kurobe et al., Dev Comp Immunol 2005 : LPS induced the expression of inflammation related genes, such as IL-1beta, monocyte chemotactic protein 1 and collagenase
Ellaban et al., Cell Immunol 2004 (Cecal Diseases...) : Production of IL-10 and the IL-1 receptor antagonist, MIP-2, and MCP-1 in response to LPS stimulation was equivalent to the amount produced by naive macrophages
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1 , cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Hasan et al., BMC immunology 2005 (Tuberculosis...) : In response to LPS stimulation, patients with pulmonary tuberculosis showed increased CCL2 and TNFalpha responses as compared with the extra-pulmonary group
Wurfel et al., J Immunol 2005 : Functional relevance for one gene confirmed to be expressed at a higher level in lps ( high ), adipophilin, was inferred when reduction in adipophilin mRNA by small interfering RNA in the human monocyte-like cell line THP-1 resulted in a modest but significant reduction in LPS induced MCP-1 mRNA expression ... These data illustrate a novel approach to the identification of factors that determine interindividual variability in innate immune inflammatory responses and identify adipophilin as a novel potential regulator of LPS induced MCP-1 production in human monocytes
Jantaratnotai et al., Life Sci 2006 : Moreover, the levels of mRNA expressions of MCP-1 and IL-6 induced by LPS were also prominently decreased in the presence of C. comosa extract
Villiger et al., J Immunol 1992 (Synovitis) : Stimulation of synoviocytes with IL-1, TNF-alpha, LPS , platelet derived growth factor, and transforming growth factor-beta-1, but not with basic fibroblast growth factor causes a marked increase in MCP-1 mRNA levels
Patton et al., Int Immunopharmacol 2006 (Atherosclerosis...) : In the present study, the combined effects of nicotine and bacterial LPS on the expression of IL-6, IL-8, GRO-alpha and MCP-1 in cell lines of human coronary artery endothelial cells ( HCAEC ) and pulmonary monocytes ( THP-1 ) were examined by quantitative real-time PCR and ELISA
Xue et al., J Pharmacol Exp Ther 2006 : Tipifarnib also inhibited LPS induced secretion of MMP-9, IL-6, MCP-1 , and IL-1beta in THP-1 cells ... In primary human peripheral blood mononuclear cells, dose dependent inhibition of LPS induced tumor necrosis factor (TNF)-alpha, IL-6, MCP-1 , and IL-1beta by tipifarnib was observed with no evidence of cytotoxicity
Kim et al., Biochem Biophys Res Commun 2006 (Inflammation) : It also decreases LPS induced expression of inducible nitric oxide synthase and production of nitric oxide, and reduces LPS induced secretion of tumor necrosis factor-alpha and monocyte chemoattractant protein-1
Nencioni et al., Blood 2006 : LPS induced CCL-2/MCP-1 and CCL5/RANTES secretions by DCs were prevented by DC treatment with bortezomib
Wehrwein et al., Cardiovascular diabetology 2006 (Diabetes Mellitus, Type 1) : Monocytes were isolated from controls and T1D patients and the LPS stimulated increase of IL-6, CXCL8, monocyte chemotactic protein 1 ( CCL2, MCP-1 ) and superoxide dismutase ( SOD 2 ), as well as the LPS mediated decrease of apolipoprotein E (Apo E) in primary human monocytes from controls and T1D patients was determined ... CCL2 and IL-6 secretion in response to LPS was found significantly reduced in monocytes from T1D patients when compared to controls whereas basal CCL2 release was similar in control and T1D cells
Tukov et al., Toxicol In Vitro 2006 (Inflammation) : APAP also attenuated LPS induced increases in IL-10 and MCP-1
Spooner et al., Mol Immunol 2007 (Leukemia P388) : To examine the roles of the C/EBPbeta transactivation and regulatory domains in LPS induced MCP-1 and IL-6 expression, we expressed various N-terminal truncations and deletions of C/EBPbeta in P388 murine B lymphoblasts, which lack endogenous C/EBPbeta expression and are normally unresponsive to LPS for expression of IL-6 and MCP-1
Yeh et al., Int Immunopharmacol 2006 (Disease Models, Animal...) : The results indicated that XBS down-regulated the LPS induced expression of TNF-alpha, IL-1beta, IL-6, KC, MIP-2, and MCP-1
Lu et al., Invest Ophthalmol Vis Sci 2006 : Triptolide and dexamethasone each inhibited in a concentration dependent manner the LPS induced release of IL-6, G-CSF, MCP-1 , and IL-8 by corneal fibroblasts
Cui et al., Ophthalmic Res 2007 (Disease Models, Animal...) : These findings indicate that berberine dose-dependently inhibited the expression of MCP-1 and CINC-1 induced by LPS and diminished the anterior uveitis
Ramana et al., Cytokine 2006 : Inhibition of AR by three distinct AR inhibitors sorbinil, tolrestat or zopolrestat suppressed the LPS induced production of inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, IFN-gamma, and chemokine MCP-1 in murine peritoneal macrophages
Fontana et al., Rejuvenation Res 2007 (Obesity, Morbid...) : At baseline, LPS stimulated MCP-1 production and PMAI stimulated IFNgamma production by PBMCs were 93.6 % +/- 4.9 % and 88.8 % +/- 9.6 % lower, respectively, in obese than in lean subjects ( p < 0.03 ) ... Weight loss completely restored LPS stimulated MCP-1 production and PMA+I stimulated IFNgamma production in obese subjects to normal
Yeh et al., Life Sci 2007 (Edema...) : Hesperidin downregulate the LPS induced expression of TNF-alpha, IL-1 beta, IL-6, KC, MIP-2, MCP-1 , and IL-12
Spooner et al., Cytokine 2007 : C/EBPbeta serine 64, a phosphoacceptor site, has a critical role in LPS induced IL-6 and MCP-1 transcription ... In comparison to wild type C/EBPbeta, which robustly supports the LPS induced expression of IL-6 and MCP-1 , C/EBPbeta ( S64A ) was severely impaired in its ability to support the LPS induced transcription of IL-6 and MCP-1
Tsai et al., J Cell Biochem 2008 : We tested the hypothesis, and explored the underlining mechanisms that cilostazol, a phosphodiesterase 3 inhibitor with antiplatelet and antithrombotic properties, inhibits lipopolysaccharide (LPS) induced MCP-1 and MMP-9 expression ... In monocytic THP-1 cells, cilostazol and N6,O2'-dibutyryl-cAMP ( dioctanoyl-cAMP, a cAMP analog ) dose-dependently inhibited LPS induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1 ... Cilostazol significantly inhibited LPS induced activation of p38, JNK, and nuclear factor-kappaB, and the respective inhibitors of p38 and JNK greatly reduced the level of LPS induced MCP-1 and MMP-9, suggesting the involvement of the p38 and JNK pathways ... In conclusion, cilostazol administered with LPS in vivo reduced neointimal hyperplasia and macrophage infiltration in the balloon injured rabbit aorta ; in vitro, cilostazol inhibits LPS induced MCP-1 and MMP-9 expression
Xing et al., Shock 2007 : The antioxidants dimethyl sulfoxide ( DMSO ), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS) induced MCP-1 production in either whole blood or isolated blood cells
Ka et al., Arthritis Res Ther 2007 (Disease Models, Animal...) : Monocyte chemoattractant protein-1 ( MCP-1 ) and osteopontin (OPN) expressions either in the baseline ( normal culture ) condition or in the presence of LPS were evaluated by real-time PCR, ELISA, or western blot analysis ... First, either in the baseline condition or in the presence of LPS , NZB/W MCs produced significantly higher levels of MCP-1 and OPN than the DBA/W MC controls
Park et al., J Pineal Res 2007 : Stimulation of PBMCs by LPS induced the secretion of CCL2 ( 2334.3 +/- 161.4 pg/mL, mean +/- S.E.M. ), whereas melatonin pretreatment ( 153.0 +/- 3.8 pg/mL ) inhibited the LPS induced secretion of CCL2 ... Taken together, these results suggest that melatonin may have a suppressive effect on LPS induced expression of CC chemokine genes, especially CCL2 and CCL5, which may explain its beneficial effects in the treatment of various inflammatory conditions
Elizur et al., Am J Respir Cell Mol Biol 2008 : Using a transformed murine Clara cell line ( C22 ), we observed that both LPS and TNF-alpha induced production of keratinocyte derived chemokine ( KC ) and monocyte chemoattractant protein (MCP)-1
Son et al., Cancer Biol Ther 2007 (Carcinoma...) : ID8 cells constitutively expressed CXCL16 and CCL2 , but only CCL2 expression was enhanced by LPS , IL-1 and TNF
Zhou et al., Am J Physiol Endocrinol Metab 2007 (Obesity) : Furthermore, basal and LPS induced MCP-1 secretion levels were the same for both adipose F4/80 ( + ) and CD34 ( + ) cells, whereas adipose CD34 ( + ) cells have twofold higher cell numbers ( 30 % of total SVF cells ) compared with F4/80 ( + ) macrophages ( 15 % )
Jönsson et al., Swed Dent J Suppl 2007 : The enhanced MCP-1 expression in response to LPS suggests that PDL cells contribute to the recruitment of leukocytes in periodontal inflammation
Tsai et al., Toxicon 2007 : The K49-PLA markedly reduced LPS stimulated production of NO, MCP-1 , RANTES, and iNOS
Berbaum et al., Cytokine 2008 : Our study showed that monocyte chemoattractant protein-1 ( MCP-1 ) and tumor necrosis factor ( TNF-alpha ) were both released in a time dependent manner from both RAW 264.7 macrophages and N-11 microglia upon stimulation with BSA-AGE or lipopolysaccharide (LPS) , which was used as a positive control
Nagarajan et al., J Nutr 2008 (Atherosclerosis) : In an in vitro LPS induced inflammation model, soy isoflavones ( genistein, daidzein, and equol alone or in combination ) dose dependently inhibited LPS induced MCP-1 secretion by macrophages, suggesting a role for soy isoflavones for the protective in vivo effects
Hughes et al., Circ Res 2008 (Inflammation) : Pretreatment of macrophages with 500 nmol/L S1P markedly reduced LPS mediated secretion of tumor necrosis factor-alpha, monocyte chemoattractant protein-1 , and interleukin-12
Kawanishi et al., Cell Biochem Funct 2008 : It is known that lipopolysaccharide (LPS) induced monocyte chemotactic protein (MCP)-1 secretion from tissues recruits monocytes from the circulation, but the mechanism of the LPS induced MCP-1 production in skeletal muscle is largely unexplained ... To clarify the effect of LPS on MCP-1 production in skeletal muscle cells, C2C12 cells from a mouse skeletal muscle cell line, and RAW 264.7 cells from a mouse macrophage cell line, were used to assess production of LPS induced MCP-1 , nitric oxide ( NO ) and interferon (IFN)-beta ... In C2C12 cells, LPS stimulation increased MCP-1 production ( p < 0.01 ), but combined treatment with LPS and NO inducer, diethylammonium ( Z ) -1- ( N, N-diethylamino ) diazen-1-ium-1,2-diolate ( NONOate ), significantly inhibited its production ( p < 0.01 ) ... These data suggest that the reduced NO production in response to LPS may depend on low expression of CD14 on the cell surface of skeletal muscle, and that it may enhance LPS induced MCP-1 production
Bhavsar et al., Thorax 2008 (Asthma) : The inhibition of LPS induced interleukin (IL)1beta, IL6, IL8, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha release by dexamethasone ( 10 ( -6 ) M ) was significantly less in macrophages from patients with severe asthma than in macrophages from patients with non-severe asthma
Jönsson et al., Arch Oral Biol 2008 : LPS induced MCP-1 and IL-6 production is not reversed by oestrogen in human periodontal ligament cells ... Here we investigate if the inflammation promoter lipopolysaccharide (LPS) affects PDL cell production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 ( MCP-1 ), C-reactive protein (CRP) and/or normal functional PDL cell characteristics such as collagen synthesis and cell proliferation and if oestrogen modulates the effects of LPS ... LPS increased also MCP-1 production which was unaffected by E2 ... LPS stimulates PDL cell IL-6 and MCP-1 production but has no effect on the normal physiological properties of PDL cells
Kolios et al., Mol Cell Biochem 2008 (Liver Diseases) : Pre-treatment with Wortmannin significantly ( P < 0.05 ) inhibited LPS induced secretion of MCP-1 and NO in a concentration dependent manner
Roach et al., Shock 2009 : Heme oxygenase-1 expression decreased LPS stimulated secretion of MCP-1 , IL-6, IL-10, and TNF-alpha at both 4 and 24 h in murine and human macrophages
Reale et al., Brain Behav Immun 2009 (Parkinson Disease) : Basal and LPS induced levels of MCP-1 , RANTES, MIP-1alpha, IL-8, IFNgamma, IL-1beta and TNFalpha were significantly higher in PD patients than in HC subjects ( p < 0.001 ), as determined by RT-PCR and Elisa methods
Zhu et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2008 : To investigate the effect of cryptoporus polysaccharide ( CP ) on lipopolysaccharide(LPS) induced production of monocyte chemoattractant protein-1 ( MCP-1 ) in human lung epithelial A549 cells ... However, CP 100 microg/L or dexamethasone 1 micromol/L significantly inhibited the protein concentration and mRNA expression of MCP-1 induced by LPS
Kim et al., Mol Cells 2008 : Rosmarinic acid down-regulates the LPS induced production of monocyte chemoattractant protein-1 ( MCP-1 ) and macrophage inflammatory protein-1alpha ( MIP-1alpha ) via the MAPK pathway in bone-marrow derived dendritic cells ... In addition, rosmarinic acid reduced cell migration by inducing the expression of a specific chemokine receptor on LPS induced mature BMDCs. Rosmarinic acid also significantly reduced the expressions of MCP-1 and MIP-lalpha induced by LPS in BMDCs and inhibited LPS induced activation of MAPK and the nuclear translocation of NF-kappaB
Wandler et al., Mol Cell Endocrinol 2008 (Inflammation) : Non stimulated, ethanol incubations up to 24h increased adiponectin release and mRNA expression ( p < 0.01 ) and decreased IL-6 release in both short-term [ 1.5h ] ( p < 0.05 ) and long-term [ 24h ] ( p < 0.01 ) incubations. Ethanol decreased LPS stimulated IL-6, IL-8, TNF-alpha, and MCP-1 dose-dependently ( all p < 0.01 ). Ethanol decreased CD68 mRNA ( p < 0.001 ), which correlated with the investigated adipokines ( p < 0.05 ) but not adiponectin ( p > 0.05 )
Anand et al., Mol Immunol 2009 (MAP Kinase Signaling System...) : LPS induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB dependent pathway ... However, the mechanism involved in LPS induced MCP-1 production in endothelial cells is not well understood ... Using human microvascular endothelial cells ( HMVEC ), we analyzed the involvement of the non-receptor tyrosine kinase, Pyk2, in LPS mediated MCP-1 production ... Inhibition of Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly attenuated LPS induced Pyk2 tyrosine phosphorylation, p38 MAP kinase ( MAPK ) activation, NF-kappaB activation, and MCP-1 expression ... Furthermore, specific inactivation of Pyk2 activity by transducing microvascular endothelial cells with catalytically inactive Pyk2 mutant ( AAV-Pyk2MT ) or Pyk2-specific siRNA significantly blocked LPS induced MCP-1 production ... In summary, our data suggest a critical role for the Pyk2 mediated pathway involving p38 MAP kinase and NF-kappaB in LPS induced MCP-1 production in human microvascular endothelial cells
Luo et al., Mol Immunol 2009 (Acute Lung Injury...) : Meanwhile, GSTP1 prevented LPS induced TNF-alpha, IL-1beta, MCP-1 and NO production
Kopp et al., Obesity (Silver Spring) 2009 : The effects of lipopolysaccharide (LPS) , flagellin, Poly ( U ), Poly ( I:C ), macrophage activating lipopeptide-2 ( MALP2 ), Pam3Cys, and CpG on the release of interleukin-6 (IL-6), resistin, and monocyte chemoattractant protein-1 ( MCP-1 ) were determined by enzyme linked immunosorbent assay ( ELISA ) ... Whereas basal and LPS induced IL-6 release is higher in preadipocytes, basal and LPS induced MCP-1 release is higher in mature adipocytes
Ishikado et al., Atherosclerosis 2009 (Inflammation) : Furthermore, we found that SPC effectively inhibited the MCP-1 expression induced by palmitate or LPS in a dose dependent manner
Liang et al., J Cell Mol Med 2009 (Inflammation) : Based on the screening results of these analogues, five active compounds A01, A03, A13, B18 and C22 were investigated to inhibit TNF-alpha and IL-6 release in a dose dependent manner, three of which further demonstrated inhibitory effects on LPS induced TNF-alpha, IL-1beta, IL-6, MCP-1 , COX-2, PGES, iNOS and p65 NF-kappaB mRNA production
Chung et al., Mol Cells 2009 : Microarray results showed that the induction of monocyte chemoattractant protein-1alpha ( MCP-1alpha ) and macrophage inflammatory protein-1alpha ( MIP-1alpha ), MIP-1beta, MIP-1gamma, regulated upon activation, normal T-cell expressed and secreted ( RANTES ), macrophage inflammatory protein-2 ( MIP-2 ), and interferon-gamma inducible protein 10 ( IP 10 ) by A. actinomycetemcomitans LPS was increased to 12.5, 1.53, 9.09, 17.3, 2.82, 16.1, and 18.1 folds at 18 h, respectively
Hasan et al., PloS one 2009 : LPS stimulated CXCL9 was greatest in SevTB and LPS induced CCL2 was increased in PTB as compared with LNTB patients
Zemans et al., Cell Immunol 2009 : We have shown that the mitogen activated protein kinase ( MAPK ) c-Jun NH ( 2 ) terminal kinase ( JNK ) is activated by LPS in neutrophils and plays a critical role in monocyte chemoattractant protein (MCP)-1 expression and actin assembly ... Furthermore, LPS induced actin polymerization as well as MCP-1 , tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta expression are dependent on Tec kinase activity
Schwacha et al., J Surg Res 2010 (Burns) : LPS induced TNF-alpha, IL-6, IL-10, MCP-1 , KC, and nitric oxide production in both cell populations, however, IL-6, IL-10, MCP-1, and KC levels were suppressed in burn wound cell cultures
Harama et al., J Immunol 2009 (Arthritis, Experimental...) : The pretreatment of a mouse macrophage cell line, RAW264.7, with a subcytotoxic dose of SubAB triggered UPR and inhibited LPS induced MCP-1 and TNF-alpha production associated with inhibition of NF-kappaB activation
Kopp et al., Eur J Clin Invest 2009 (Diabetes Mellitus, Type 2) : LPS induced release of monocytic MCP-1 and TNF was significantly and positively correlated with serum triglyceride levels in 30 patients with T2D
Zahner et al., Biochem J 2009 (Nephritis) : Selectively overexpressing the various EP receptors in these cells then allows the effects on the LPS induced CCL2 expression to be examined ... Overexpression of EP1, as well as EP3, had no effect on LPS induced Ccl2 mRNA expression ... In contrast, overexpression of EP2, as well as EP4, significantly decreased LPS induced CCL2 expression
Datta et al., Atherosclerosis 2010 (Inflammation) : It also reduced the secretion of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 ( MCP-1 ) from THP-1 macrophages even when administered post-LPS and abolished the 18-fold increase in LPS induced mRNA levels for MCP-1 in THP-1 cells
Zhong et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 : To examine the synergistic effect of recombinant human high mobility group box 1 (HMGB1) protein and lipopolysaccharides (LPS) on the release of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in human umbilic vein endothelial cells ( HUVECs ), and explore the role of mitogen activated protein kinases ( MAPK ) signal transduction in cytokine release ... Stimulation of the HUVECs with LPS ( 10 ng < ml ) or HMGB1 ( 15 ng/ml ) alone resulted in significantly increased levels of IL-8 and MCP-1 ( P < 0.01 ), which were further increased after costimulation with LPS and HMGB1, suggesting a synergistic effect between HMGB1 and LPS ( P < 0.01 )
Wang et al., Cytokine 2010 : Our results show that ApoA-I significantly decreased LPS induced MCP-1 release from THP-1 cells and ox-LDL induced THP-1 migration ratio ( P < 0.01, respectively )
Ma et al., Mol Biol Rep 2010 : Notably, LPS , either alone or together with FasL, significantly stimulated type II AEC apoptosis and the release of tumor necrosis factor-alpha ( TNF-a ) and monocyte chemoattractant protein 1 ( MCP-1 ) ( P < 0.05 versus the control without treatment )
Szajnik et al., Oncogene 2009 (Carcinoma...) : In MyD88 ( + ) SCOV3 cells, LPS or PTX binding to TLR4 induced IRAK4 activation and cJun phosphorylation, activated the NF-kappaB pathway and promoted interleukin (IL)-8, IL-6, vascular endothelial growth factor and monocyte chemotactic protein-1 production and resistance to drug induced apoptosis
Kopp et al., Endocrinology 2010 (Inflammation...) : In human adipocytes isolated from noninflamed adipose tissue, LPS and Pam ( 3 ) Cys, but not MALP-2, are potent inducers of IL-6 and MCP-1
Yang et al., Arthritis Rheum 2010 (Arthritis) : Estrogen deficiency in ArKO mice was associated with significant increases in LPS induced serum interleukin-6 (IL-6), tumor necrosis factor, monocyte chemotactic protein 1 , and interferon-gamma levels, which were significantly abrogated by administration of 16alpha-LE2, but not 8beta-VE2
Ma et al., Immunology 2010 : Exogenous CGRP and CGRP receptor antagonists, in a concentration dependent manner, stimulated, inhibited or had no effect on basal or LPS induced release of monocyte chemoattractant protein-1 , IL-1beta, IL-6, tumour necrosis factor-alpha and IL-10 in RAW macrophages
Standiford et al., J Biol Chem 1991 : MCP-1 production from A549 cells could be induced by lipopolysaccharide (LPS) stimulated alveolar macrophage ( AM ) -conditioned media, but not by LPS alone
Ryan et al., Pflugers Arch 2010 : IL-6 release into the medium was increased > 50-fold over 24 h with LPS and TNFalpha, while MCP-1 release was increased 23- and 40-fold by TNFalpha and LPS , respectively
Arranz et al., Age (Dordrecht, Netherlands) 2010 (Inflammation) : Chemokine responses in regard to KC, MCP-1, MIP1ß, and RANTES were more variable, though similar secretion of LPS induced KC and MCP-1 and ConA induced MCP-1, MIP-1ß, and RANTES was found in long lived and middle aged mice
Jiang et al., J Mol Endocrinol 2010 : In this study, we investigated the effect of estrogen on LPS induced monocyte chemoattractant protein-1 ( MCP-1 ; listed as CCL2 in the MGI database ) production in vascular smooth muscle cells ( VSMCs ) ... LPS significantly enhances MCP-1 production and this is dependent on nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS enhanced MCP-1 production ... On the contrary, 17beta-estradiol ( E ( 2 ) ) inhibits LPS induced MCP-1 production in a time- and dose dependent manner, which is related to the suppression of p65 translocation to nucleus
Krakauer et al., Mediators Inflamm 2010 (Hypothermia...) : LPS ( 80 microg/mouse ) caused 48 % lethality and induced high levels of IL-6 and MCP-1
Remppis et al., Mediators Inflamm 2010 : Rhizoma Coptidis inhibits LPS induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB dependent pathway ... Incubation with Rhizoma coptidis and berberine strongly inhibited LPS induced monocyte chemoattractant protein (MCP)-1 production in RAW cells ... Rhizoma coptidis extract inhibits LPS induced MCP-1/CCL2 production in vitro via an AP-1 and NFkappaB dependent pathway
Shah et al., Pediatr Res 2010 (Chorioamnionitis...) : Inhibition of IL-1 signaling with recombinant human IL-1 receptor antagonist ( rhIL-1ra ) did not attenuate LPS induced increase in MCP-1 or MCP-2 expression ... LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung ... LPS induction of MCP-1 is not IL-1 dependent in fetal sheep
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : We found that LPS stimulated the expression of TNF-alpha, IL-1beta, IL-6, MCP-1 and iNOS in murine microglia and astrocytes in which MAP kinases, NF-kappaB and AP-1 were differentially involved ... Resveratrol inhibited LPS induced expression and release of TNF-alpha, IL-6, MCP-1 , and iNOS/NO in both cell types with more potency in microglia, and inhibited LPS induced expression of IL-1beta in microglia but not astrocytes
Hoo et al., Nutrition & metabolism 2010 : Treatment with Rx, which included calycosin-7-ß-D-glucoside ( 0.9 % ), ononin ( 1.2 % ), calycosin ( 4.53 % ) and formononetin ( 1.1 % ), significantly reduced the secretion of pro-inflammatory cytokines ( TNF-a, IL-6 and MCP-1 ) in human THP-1 macrophages and lipopolysaccharide (LPS) induced activation of NF-?B in mouse RAW-Blue macrophages in a dose dependent manner
Outtz et al., J Immunol 2010 (Inflammation) : Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10, MCP-1 , monokine induced by IFN-?, and TNF-a in macrophages in response to LPS/IFN-?
van der Veen et al., Ann Rheum Dis 2011 (Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis...) : In glomerular endothelial cells, AR-447 reduced LPS induced secretion of IL-6 and IL-8, but not of MCP-1
Bassaganya-Riera et al., J Biol Chem 2011 (Inflammation) : ABA suppresses LPS induced prostaglandin E ( 2 ) and MCP-1 production via a PPAR ?-dependent mechanism possibly involving activation of PPAR ? and suppression of NF-?B and nuclear factor of activated T cells
Puntambekar et al., Brain Behav Immun 2011 : LPS induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine dependent ... Inhibiting ODC by co-injecting DFMO decreased LPS induced CCL2 expression and macrophage influx into the CNS, without altering LPS induced microglial or macrophage activation
Reale et al., BMC neuroscience 2011 : In the simultaneous quantification we found significantly higher levels of constitutively and LPS induced MCP-1 , MIP-1a, IL-8 and IL-18, and lower RANTES and IFN? levels released by PBMC of SC patients compared with HC ... In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS induced production of RANTES and IL-18 was increased, while both basal and LPS induced MCP-1 production was decreased
El-Hage et al., Immunol Invest 2011 : Exposing astrocytes to the TLR agonists LTA ( TLR2 ), poly I:C ( TLR3 ), LPS ( TLR4 ) and unmethylated CpG ODN ( TLR9 ) resulted in increased secretion of MCP-1/CCL2 and elevations in reactive oxygen species
Takada et al., Oncogene 2011 (Lung Diseases, Interstitial) : Importantly, human alveolar macrophages showed enhanced LPS induced FOSL1 and CCL2 expression after gefitinib treatment
Li et al., Oncogene 2011 (Neoplasms) : Here, we showed that serum amyloid-A (SAA) and cathelicidin ( LL-37 ) stimulated M-CSF and MCP-1 expression with or without lipopolysaccharide (LPS) administration ; conversely, lipoxin-A ( 4 ) ( LXA ( 4 ) ) and annexin-A1 (ANXA1) inhibited LPS induced M-CSF and MCP-1 production by human ( HepG2 ) and mouse ( H22 ) hepatocellular carcinoma cells (HCCs)
van Zoelen et al., Mol Immunol 2011 (Pneumonia) : Murine alveolar macrophage-like cells released significant amounts of MCP-1 upon stimulation with LPS or LTA in vitro
Iglesias-Gato et al., Phytother Res 2012 (Inflammation) : Additionally, Prostasanr reduced the constitutive secretion of monocyte chemotactic protein-1 (MCP-1), the LPS induced secretion of IL-12 and inhibited MCP-1 and granulocyte-macrophage colony stimulating factor ( GM-CSF ) production in the presence of LPS on PC-3 cells
Liao et al., Mol Med 2011 (Carotid Artery Diseases...) : Knockdown of BRAP led to attenuated HASMC proliferation and reduced secretion of monocyte chemoattractant protein-1 ( MCP-1 ) and interleukin-8 (IL-8) in response to LPS
Wei et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : Finally, TTM significantly inhibited LPS induced increases of serum levels of soluble ICAM-1, MCP-1 , and TNF-a ( ANOVA, P < 0.05 )
Thorley et al., PloS one 2011 : In ATII cells, JNK was significantly more important than p38 and ERK in LPS induced MCP-1 release
Sica et al., J Immunol 1990 : TNF and LPS , unlike IL-6, also induced MCAF/MCP-1/TDCF gene expression
Buenestado et al., Br J Pharmacol 2012 : Roflumilast and roflumilast N-oxide concentration-dependently reduced the LPS stimulated release of CCL2 , CCL3, CCL4, CXCL10 and TNF-a from human lung macrophages, whereas that of CXCL1 or CXCL8 was not altered ... Roflumilast and roflumilast N-oxide reduced LPS induced release of CCL2 , 3, 4, CXCL10 and TNF-a in human lung macrophages
Tang et al., PloS one 2011 : Furthermore, mLITAF was found to mediate LPS induced CCL2 gene transcription with the cooperation of mSTAT6B leading to CCL2 protein expression ... mLITAF/mSTAT6B complex is proposed to play a role in LPS induced CCL2 expression and possibly other cytokines
Lu et al., Zhongguo Zhong Yao Za Zhi 2011 : LPS activated the innate immunity and increased the secretion of IL-8, TNF-alpha and MCP-1
Dutra et al., PloS one 2011 (Colitis) : In addition, euphol decreased LPS induced MCP-1 , TNF-a, IL-6 and IFN-?, but increased IL-10 secretion from bone marrow derived macrophages in vitro
Park et al., PloS one 2011 : Additionally, stattic ( a STAT3 inhibitor ) inhibited LPS induced iNOS and MCP-1 gene expression
Kimura et al., Exp Eye Res 2012 : LPS induced the release of interleukin (IL)-6, IL-8, MCP-1 , RANTES, IP-10, eotaxin, and IL-12 from corneal fibroblasts ... LPS , poly ( I:C ), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents
Dou et al., Biol Pharm Bull 2011 : Lipopolysaccharide (LPS) , TLR4 ligand, was therefore designed to active TLR4 signaling pathway, and Cha Fex significantly inhibited the LPS induced production of tumor necrosis factor-alpha ( TNF-a ), interleukin 6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) in peritoneal macrophages and murine macrophage cell line RAW264.7
Wang et al., Biochemistry 2012 : Furthermore, LL-23A9, like LL-23, maintained superior protective MCP-1 production, while LL-23V9 was strongly immunosuppressive, preventing baseline MCP-1 induction and substantially reducing LPS stimulated MCP-1 production
Mora et al., Cell cycle (Georgetown, Tex.) 2012 : For this purpose, we investigated the effect of bindarit on the LPS induced production of inflammatory cytokines ( MCP-1 and MCPs, IL-12ß/p40, IL-6 and IL-8/KC ) in both a mouse leukaemic monocyte-macrophage cell line and bone marrow derived macrophages ( BMDM ) ... Bindarit inhibits the LPS induced MCP-1 and IL-12ß/p40 expression without affecting other analyzed cytokines
Min et al., J Pineal Res 2012 : In our studies, we show that melatonin blocked lipopolysaccharide (LPS) induced CCL2 ( monocyte chemotactic protein-1 ; MCP-1 ), CCL5 ( Regulated upon Activation, Normal T-cell Expressed, and Secreted ), and CCL9 ( macrophage inflammatory protein-1? ) chemokine mRNA expression in BV2 murine microglial cells
Hu et al., Clin Exp Immunol 2012 (Fibrosis...) : Furthermore, over-expression of SP-D reduced significantly the LPS induced expression of MCP-1 in transfected cells
Zhai et al., Mol Biol Rep 2012 (Glomerulonephritis, Membranoproliferative...) : We found that after LPS treatment for 14 weeks, LPS increased MCP-1 protein expression in kidney, which was significantly suppressed by antioxidant PDTC ... Based on these data we infer that PDTC inhibits LPS induced MCP-1 expression, secretion and function through inhibition of NF-?B and p38 MAPK activity ... Our results indicate that LPS induces MCP-1 mainly through activating NF-?B and its downstream MAPK, and that such effect was inhibited by PDTC, suggesting the efficacy of PDTC in preventing kidney fibrosis in lupus-prone mice
Zhang et al., Cell Mol Neurobiol 2012 (Astrocytoma...) : Curcumin inhibits LPS induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells ... This study investigated the inhibitory effect of curcumin on lipopolysacharide (LPS) induced chemokine CCL2 ( or monocyte chemoattractant protein-1, MCP-1 ) production and whether the effect is mediated by mitogen activated protein kinases ( MAPKs ) in the rat astrocytoma cell C6 ... Additionally, the c-jun N-terminal kinase ( JNK ) inhibitor ( SP600125 ) dose-dependently inhibited LPS induced CCL2 upregulation, whereas the MAPK kinase ( MEK ) inhibitor ( PD98059 ) only had a mild effect and the p38 MAPK inhibitor ( SB203580 ) had no effect
Eleftheriadis et al., Hippokratia 2011 : LPS also increased considerably MCP-1 , but CoCl ( 2 ) decreased it
Reynolds et al., Am J Pathol 2012 (Anti-Glomerular Basement Membrane Disease...) : WKY.LCrgn1 BMDMs showed a significant reduction in Fc receptor mediated oxidative burst, phagocytosis of opsonised polystyrene beads, and LPS induced levels of MCP-1 secretion and iNOS mRNA expression compared with WKY rats
Nebel et al., Swed Dent J Suppl 2012 (Disease Models, Animal...) : In Paper I, effects of estrogen on E. coli LPS induced PDL cell production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 ( MCP-1 ) and C-reactive protein (CRP) are assessed, by using ELISA
Zhu et al., PloS one 2012 : Our results show that artemisinin significantly inhibited LPS induced production of tumor necrosis factor-alpha ( TNF-a ), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide ( NO )
Joo et al., Gut and liver 2012 : U0126 ( an inhibitor of MEK-1/2 ) suppressed the LPS induced IL-12p40, IL-6, MCP-1 , ICAM-1, and VCAM-1 mRNA accumulation in BMMs
Tang et al., Curr Mol Med 2012 : In the following study, our findings indicate that UV-induced p53 accumulation in mouse macrophages significantly decreases LPS induced CCL2 production, and that p53 binds to CCL2 5'UTR in the region ( 16-35 ) ... Treatment of p53-deficient mouse primary macrophages with synthetic p53pep170 was found to decrease LPS induced production of CCL2 without association with cellular endogenous p53
Xu et al., PloS one 2012 (MAP Kinase Signaling System) : Western blot analysis suggested that both NF-?B and ERK/MAPKs pathway were involved in the LPS induced upregulation of MCP-1 in DSCs ... Our results demonstrate that LPS induces upregulation of MCP-1 in DSCs, which may play a critical role in inhibiting the cytotoxicity of NK cells partly by promoting SOCS3 expression
Burns et al., Brain Res 2012 (Inflammation...) : The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-a, IL-1ß, and MCP-1 production by primary astrocytes
Wight et al., Biochem Biophys Res Commun 2012 (Neurodegenerative Diseases) : Resveratrol inhibited LPS induced production of nitric oxide ( NO ) ; the cytokines tumor necrosis factor-alpha ( TNF-a ), interleukin 1-beta ( IL-1ß ), and IL-6 ; and the chemokine monocyte chemotactic protein-1 (MCP-1) , which play critical roles in innate immunity, by astrocytes
Tsutsuki et al., Infect Immun 2012 : SubAB pretreatment of macrophages inhibited lipopolysaccharide (LPS) induced production of both monocyte chemoattractant protein 1 ( MCP-1 ) and tumor necrosis factor a (TNF-a)
Thota et al., Reprod Sci 2013 : In the presence of LPS , vitamin D caused dose dependent decreases in the messenger RNA expression of MCP-1 , IL-1ß, IL-13, TNF-a, TLR-4, and TLR-5, the contractile associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells ... Western analysis showed that vitamin D decreased MCP-1 , TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1ß
Juman et al., Biol Pharm Bull 2012 (Hypertrophy) : CAPE significantly suppressed the levels of lipopolysaccharide (LPS) induced interleukin (IL)-1-beta, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 from a macrophage cell line, RAW264.7
Zhong et al., Mol Med Report 2013 : In the current study, we investigated the effect of curcumin on the production of MCP-1 induced by lipopolysaccharide (LPS) in macrophages and the possible mechanisms involved ... Additionally, zinc protoporphyrin, a heme oxygenase-1 (HO-1) inhibitor, blocked the inhibitory effect of curcumin on the LPS induced MCP-1 expression ... Furthermore, additional experiments indicated that the inhibitory effect of curcumin on LPS induced MCP-1 expression was significantly attenuated in the presence of N-acetylcysteine ( an effective ROS scavenger )
Ro et al., Transplantation 2012 : Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1 , interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Wei et al., J Anesth 2013 : Propofol at clinically relevant concentrations attenuated LPS induced MCP-1 mRNA expression and secretion by inhibiting the phosphorylation of p38 MAPK, SAPK/JNK, ATF-2, and c-Jun exerting its anti-inflammatory effects in AECs
Song et al., Eur J Pharmacol 2013 (Sepsis) : Intravenous injection of bis-N-norgliovictin 1h before LPS challenge dose-dependently inhibited LPS induced increases in serum levels of TNF-a, IL-6, MCP-1 and IL-10, attenuated liver and lung injury and diminished M1 macrophage polarization in liver
Shi et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 (Hyperglycemia) : Pretreatment with high glucose significantly promoted LPS induced NF-?B nuclear translocation ( P < 0.01 ) and the mRNA expression and secretion of MCP-1 and IL-6
Qin et al., Glia 2013 (Nerve Degeneration) : Diphenyliodonium ( DPI ), an NOX inhibitor, blocked LPS induced activation of microglia and production of ROS, TNFa, IL-1ß, and MCP-1
Pattison et al., FEBS Lett 2013 : Furthermore we find that IL-10 knockout increases MCP-1 production in response to LPS , which may reflect an ability of IL-10 to repress IFNß production
Liang et al., Arch Pharm Res 2013 : We found that SsnB dose-dependently attenuated the LPS induced expression of interleukin (IL)-1ß and monocyte chemoattractant protein 1 both at the transcription and translation levels in HUVEC
Meng et al., Acta Pharmacol Sin 2013 : The LPS induced overexpression of MCP-1 and TNF-a, and NO production were attenuated by pretreatment with the ERK inhibitor PD98059, the p38 MAPK inhibitor SB203580, the NF-?B inhibitor PDTC or anti-TLR4 antibody, but not with the JNK inhibitor SP600125.Conclusion : Cur suppresses LPS induced overexpression of inflammatory mediators in VSMCs in vitro via inhibiting the TLR4-MAPK/NF-?B pathways, partly due to block of NADPH mediated intracellular ROS production
Chai et al., PloS one 2013 (Plaque, Atherosclerotic) : In THP-1 cells NA suppressed LPS induced mRNA transcription of MCP-1 by 76.6±12.2 % ( P < 0.01 ) and TNFa by 56.1±11.5 % ( P < 0.01 ), yet restored LPS induced suppression of PPAR? transcription by 536.5±46.4 % ( P < 0.001 ) and its downstream effector CD36 by 116.8±19.8 % ( P < 0.01 )
Liang et al., PloS one 2013 : In human myotubes, LPS increased JNK phosphorylation and MCP-1 and IL-6 gene expression
Brieland et al., Am J Respir Cell Mol Biol 1995 : We determined that stimulation of resident rat PAMs with bacterial lipopolysaccharide (LPS) , murine tumor necrosis factor-alpha, or human interleukin-1 beta resulted in the inducible expression of MCP-1 mRNA and the secretion of biologically active MCP-1
Frazier-Jessen et al., J Immunol 1995 (Arteriosclerosis) : 17 beta-estradiol ( E2 ) inhibited LPS stimulated JE/MCP-1 mRNA expression in ANA-1 and J774A.1 murine macrophage cell lines and in thioglycolate elicited murine peritoneal macrophages ... Progesterone failed to inhibit LPS induced JE/MCP-1 mRNA expression ... Immunohistochemical analysis revealed the presence of estrogen receptors in ANA-1 cells, indicating that E2 inhibition of LPS induced JE/MCP-1 mRNA expression in murine macrophages may be mediated through the estrogen receptor
Li et al., Mol Cell Biochem 1994 (Glioblastoma) : The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS) , phorbol esters ( TPA ) and several cytokines
Leonard et al., Adv Exp Med Biol 1993 : In order of increasing effect, IL-2 + IFN gamma, IL-1 alpha, and LPS caused monocyte secretion of MCP-1 ... Composition of the culture medium was especially critical for LPS induced secretion of MCP-1 , which was greatly enhanced by FCS and by Iscove 's DMEM compared to RPMI 1640 ... IL-4 inhibited LPS induced secretion of both MCP-1 and NAP-1 ... LPS induced secretion of MCP-1 was much greater for monocytes cultured several days in CSF-1 than for freshly isolated monocytes
Hanazawa et al., Infect Immun 1993 (Periodontal Diseases) : P-LPS induced the MCP-1 gene expression in a dose- and treatment time dependent manner
Sylvester et al., J Immunol 1993 : Our study was designed to determine if LPS also caused an increase in MCP-1 and to measure associated changes in concentrations of antibody and immune complex
Shyy et al., Biochem Biophys Res Commun 1993 : This is in accordance with the observation that LPS induced the expression of monocyte chemotactic protein-1 in desensitized cells ... Thus, a third signal transduction pathway other than protein kinase C or tyrosine kinase is involved in the LPS induced monocyte chemotactic protein-1 expression in human endothelial cell
Xia et al., Am J Physiol 1993 : LPS stimulation ( 1 microgram/ml for 40 or 80 min ) increased MCP-1 , IL-1 beta, and TNF-alpha mRNA expression, which was found predominately in peritubular capillary endothelial cells by in situ hybridization
Meda et al., J Immunol 1996 : The effect of Abeta ( 25-35 ) on MCP-1 secretion was neither mimicked by a scrambled analogue nor affected by polymyxin B sulfate, even though the latter almost completely abolished the effect of LPS on MCP-1 expression
Yano et al., J Immunol 1996 : Unstimulated, highly purified blood monocytes did not produce MCP-1 spontaneously, while LPS treatment induced the production of MCP-1 and its mRNA expression ... All Th2 cytokines tested suppressed LPS induced MCP-1 production and its mRNA expression, although the suppressive effect of IL-13 was weaker than that of IL-4 or IL-10
Tsao et al., Circulation 1997 : The expression of MCP-1 in SMCs and chemotactic activity in the conditioned medium were induced by lipopolysaccharide (LPS) or by oxidized LDL but not native LDL
Lee et al., J Korean Med Sci 1998 : To investigate whether MCP-1 , CINC, RANTES, osteopontin and ICAM-1 mRNA could be induced in cultured rat mesangial cells by interleukin-1beta(IL-1beta), tumor necrosis factor-alpha (TNF-alpha) and lipopolysaccharide (LPS) , and whether MCP-1 and CINC gene expression could be modulated by dexamethasone, Northern blot assays were performed ... TNF-alpha and LPS also induced MCP-1 and ICAM-1 gene expression
Bauermeister et al., Nephrol Dial Transplant 1998 (Peritonitis) : Distinct regulation of IL-8 and MCP-1 by LPS and interferon-gamma treated human peritoneal macrophages
Haupt et al., Infection 1998 (Peritonitis) : When IL-10 was added, LPS stimulated TNF-alpha production was reduced towards baseline levels, LPS induced MCP-1 production was reduced by 37 % ... IFN-gamma did not affect LPS induced TNF-alpha and MCP-1 production, but increased baseline MCP-1 production