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IRF6 — NANOS2

Text-mined interactions from Literome

Cieslik et al., J Biol Chem 2002 : Our findings implicate two distinct pathways for NOS-2 expression induced by LPS+IFN-gamma
Olszanecki et al., J Physiol Pharmacol 2002 : While none of these compounds inhibited activity of NOS-2, all with unexpectedly scattered potencies inhibited induction of NOS-2 protein in LPS treated J774.2 cells, as evidenced by Western blotting technique
Slomiany et al., IUBMB Life 2003 (Helicobacter Infections) : Using gastric mucosal cells in culture, we show that activation of PPARgamma with a specific synthetic agonist, ciglitazone, prevents in a dose dependent fashion ( up to 90.2 % ) the LPS induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in the LPS induced apoptosis ( 72.4 % ), NO generation ( 80.1 % ), and the expression of NOS-2 activity ( 90 % )
Schmidt et al., Mol Pharmacol 1992 : The serine protease inhibitor tosyl-lysyl chloromethyl ketone abolished the induction of NOS-II by INF/LPS , by depleting intracellular thiol pools and interfering with protein synthesis ... Induction of NOS-II by INF/LPS was transcriptionally based and, for maximal enzyme activity, required increased intracellular tetrahydrobiopterin levels, intracellular Ca2+ mobilization, and activation of non-L-type Ca2+ channels but, unlike the induction of macrophage mediated cytotoxicity, neither L-type-Ca2+ channels nor calmodulin
Jakubowski et al., J Physiol Pharmacol 2004 : In this study we analysed the involvement of PAF, TXA ( 2 ) and cysteinyl leukotrienes ( cysLTs ) in the acute cardiovascular effects of LPS in the isolated rat heart as well as in delayed phase of LPS response using a surrogate cellular model of the induction of NOS-2 by LPS in mouse macrophages ... Inhibition of cyclooxygenase and leukotriene pathways had no effect on NOS-2 induced by LPS ... These results indicate that PAF and TXA ( 2 ) but not cysLTs mediate the instant heart response induced by LPS, while PAF alone mediates a delayed NOS-2 induction by LPS
Hamby et al., Glia 2006 (Encephalitis) : Interestingly, immunocytochemical assessment of NOS-2 protein expression demonstrated that TGF-beta1 augmented astrocytic NO production, specifically by increasing the pool of astrocytes capable of expressing NOS-2 induced by either LPS ( approximately threefold ) or LPS plus IFNgamma ( approximately sevenfold )
Borán et al., Glia 2008 : The morphological changes and the decrease of LPS induced NOS-2 expression produced by ANP in cultured microglia are also observed by immunostaining in organotypic cultures from rat hippocampus
Chen et al., Exp Mol Pathol 2008 (Endotoxemia) : This was blocked by TREM-1 Fc/fusion protein, indicating that TREM-1 mediates LPS induced NOS-2 expression
Laskin et al., J Leukoc Biol 2010 (Acute Disease...) : In Kupffer cells, but not endothelial cells, MSP suppressed LPS induced NOS-2 expression, with no effect on COX-2
Menzies et al., Immunology 2011 : Analysis of mRNA expression, by quantitative reverse transcription-polymerase chain reaction ( qRT-PCR ), of genes associated with innate and alternative macrophage activation revealed that progesterone down-regulated LPS induced macrophage nos2 , argI and p40 ( IL-12/IL-23 ) expression and IL-4 induced argI, mrc-1 and fizz1 expression
Feinstein et al., J Biol Chem 1996 : A role for HS protein ( HSP ) 70 in NOS-2 suppression by HS is supported by the demonstration that 1 ) transfection with human HSP70 cDNA partially replicated HS effects ; 2 ) antisense, but not sense, oligonucleotides directed against rat HSP70 partially blocked HS effects ; and 3 ) rat fibroblasts stably expressing human HSP70 did not express NOS-2 in response to LPS plus cytokines
Dighiero et al., Invest Ophthalmol Vis Sci 1997 : Fibroblast growth factor-2 (FGF-2) inhibited LPS-IFN-gamma induced nitrite release and NOS-2 messenger RNA accumulation in keratocytes but not in BCE cells ... The results demonstrate that in vitro activation of keratocytes and BCE cells by LPS and cytokines induces NOS-2 expression and release of large amounts of NO
Le Page et al., Biochem Biophys Res Commun 1998 : We therefore explored the effect of these inhibitors on the activity of IRF-1 and NF kappa B transcription factors known to be involved in NOS-II induction by IFN-gamma and LPS
Feinstein et al., J Neurochem 1998 (Glioma) : LiCl also potentiated ( up to 2.7-fold ) the induction of NOS-2 expression by LPS plus interferon-gamma in C6 glioma cells but had little effect on LPS induced nitrite accumulation from mouse RAW 264.7 macrophages
Faure et al., Am J Physiol 1998 : Furthermore, the LPS-IFN-gamma induced NOS-II mRNA accumulation was sensitive to cycloheximide, suggesting that, in addition to NF-kappaB, transcriptional factors that require new protein synthesis are involved in NOS-II induction
Faure et al., J Biol Chem 1999 : Our results demonstrate that IRF-1 is necessary for NOS-2 induction by LPS and IFN-gamma and that its synthesis requires the involvement of a redox-sensitive step, the activation of tyrosine kinases, and extracellular signal regulated kinases 1/2 and p38 MAP kinases