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MAPK14 — VDR
Text-mined interactions from Literome
Boland et al., Steroids 2002
:
However, the activation of
MAPK by the hormone was only partially
mediated by the
VDR and required in addition increased PKC and intracellular Ca ( 2+ )
Qi et al., J Biol Chem 2004
(Colonic Neoplasms) :
p38
MAPK activation selectively
induces cell death in K-ras mutated human colon cancer cells through regulation of
vitamin D receptor
Cordes et al., Anticancer Res 2006
(Breast Neoplasms...) :
In conclusion, it seems that the early induction of the
MAPK-cascade was
independent of the
VDR
Wu et al., Cancer Lett 2007
(MAP Kinase Signaling System) :
Both sustained ( 3 days ) and transient ( 15min ) 1,25D treatment activated JNK and ERK1/2
MAPK signaling in a nongenomic
VDR dependent manner
Xie et al., Med Oncol 2010
(Breast Neoplasms) :
These effects were blocked by the MAP kinase blocker PD98059 ( 25 µM ), indicating that
MAPK plays a role in
VDR and p21 upregulation
Zhang et al., J Cell Physiol 2010
(MAP Kinase Signaling System) :
1,25 ( OH ) ( 2 ) D ( 3 ) -mediated transcription depends upon the VDR and its heterodimeric partner the retinoid X receptor ( RXR ) so we studied whether changes in the
VDR-RXR transcription complex occur in
response to
MAPK activation
Jiang et al., Mol Cell Endocrinol 2012
(MAP Kinase Signaling System) :
PMA increased
MAPK dependent Sp3 phosphorylation,
Sp3-VDR interactions, and Sp3 binding to the hCYP24A1 promoter