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CD8A — FAS

Text-mined interactions from Literome

Rich et al., J Virol 1999 : Antiretroviral cytolytic T-lymphocyte nonresponsiveness : FasL/Fas mediated inhibition of CD4 ( + ) and CD8 ( + ) antiviral T cells by viral antigen positive veto cells
Suzuki et al., J Immunol 2000 : In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic CD8 ( + ) T cells requires Fas ( CD95/APO-1 ) expression by the adoptive hosts
Barral et al., J Autoimmun 2006 (Diabetes Mellitus, Type 1...) : Not only absence of MHC-I and Fas upregulation, but also resistance to cytokine induced killing of beta-cells and a complete lack of CXCL-10 ( IP10 ) production in islets led to a lack of islet infiltration and impaired activation of autoaggressive CD4 ( + ) and CD8 ( + ) T-cells in these mice
Zhang et al., J Clin Invest 2007 (Influenza, Human...) : Elevated levels of IL-10 early in the response was key to the loss of CD4 ( + ) T cells, whereas CD8 ( + ) T cell deletion was dependent on a prolonged TNF-alpha response, IL-10, and upregulation of Fas
Alla et al., Cancer Lett 2008 (Neoplasms) : Its expression in tumors protects tumor cells from CD95 mediated apoptosis and the cytotoxic activity of tumor specific CD8 ( + ) T cells
Lohman et al., J Virol 1996 (Acute Disease...) : Thus, CD95 is not required for the immune downregulation of the CD8+-T-lymphocyte response following acute LCMV infection
Shustov et al., J Immunol 1998 (Acute Disease...) : Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease : up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production ... Thus, in this in vivo model of alloantigen immune responsiveness, Fas/FasL up-regulation is critically dependent on Ag-specific ( donor ) CD8+ T cell activation and IFN-gamma production