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EGFR — IGF2

Text-mined interactions from Literome

Knowlden et al., Endocrinology 2005 (Breast Neoplasms) : IGF-II activated both IGF-IR and EGFR in Tam-R cells, whereas only activation of IGF-IR was observed in wild-type cells ... IGF-II promoted direct association of c-SRC with IGF-IR, phosphorylated c-SRC, and increased EGFR phosphorylation at tyrosine 845, a c-SRC dependent phosphorylation site ... Similarly, in T47D-R cells, AG1024 and SU6656 inhibited basal and IGF-II induced phosphorylation of c-SRC and EGFR , and SU6656 reduced TGFalpha induced EGFR activity ... These results suggest the existence of a unidirectional IGF-IR/EGFR cross-talk mechanism whereby IGF-II , acting through the IGF-IR, regulates basal and ligand activated EGFR signaling and cell proliferation in a c-SRC dependent manner in Tam-R cells
Morgillo et al., Clin Cancer Res 2007 (Carcinoma, Non-Small-Cell Lung...) : Treatment with gefitinib, but not cetuximab, induced EGFR : IGF-IR heterodimerization and activation of IGF-IR and its downstream signaling mediators, resulting in increased survivin expression in NSCLC cell lines with high levels of IGF-IR expression
Song et al., Endocrinology 2007 (Breast Neoplasms) : Using MCF-7 breast cancer cells, we for the first time demonstrated that a sequential activation of IGF-IR, MMP, and EGFR existed in E2 and IGF-I actions, which was supported by evidence that the selective inhibitors of IGF-IR and MMP or knockdown of IGF-IR all inhibited E2- or IGF-I induced EGFR phosphorylation
Barnes et al., Clin Cancer Res 2007 (Head and Neck Neoplasms) : Stimulation of head and neck cancer cells with either IGF or EGF resulted in IGF-IR and EGFR heterodimerization, but only IGF caused activating phosphorylation of both receptors
Li et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : In addition, the enhanced phosphorylation of EGF-R in VSMC from SHR compared with WKY was also attenuated by inhibitors of AT(1), ET ( A ), ET ( B ), and EGF-R but not by inhibitors of platelet derived growth factor receptor or insulin-like growth factor receptor
Shaw et al., Br J Cancer 2011 (Adenoma...) : We show here that, in murine intestinal adenomas acutely exposed to a small molecular inhibitor of EGFR ( gefitinib ), there is concurrent suppression of EGFR downstream signalling and induction of IGF signalling