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MYO6 — ROCK1

Text-mined interactions from Literome

Shimizu et al., Am J Respir Crit Care Med 2001 (Disease Models, Animal...) : Activated ROCK inhibits myosin phosphatase, and this in turn induces phosphorylation of the myosin light chain ( MLC )
Avizienyte et al., Mol Biol Cell 2004 (Colonic Neoplasms...) : Inhibitors of MEK, ROCK , or MLCK also suppress peripheral accumulation of phospho-myosin and Src induced formation of integrin dependent adhesions, whereas at the same time restoring E-cadherin redistribution to regions of cell-cell contact
Rösel et al., Mol Cancer Res 2008 (Neoplasm Invasiveness...) : Using confocal and traction force microscopy, we showed that an up-regulation of Rho/ROCK signaling leads to increased cytoskeletal dynamics, myosin light chain localization, and increased tractions at the leading edge of the cells and that all of these contributed to increased cell invasiveness in a three-dimensional collagen matrix
Narumiya et al., Cancer Metastasis Rev 2009 (Cell Transformation, Neoplastic...) : mDia and ROCK are downstream effectors of Rho mediating Rho action on the actin cytoskeleton ; mDia produces actin filaments by nucleation and polymerization and ROCK activate myosin to cross-link them for induction of actomyosin bundles and contractility
Mong et al., J Immunol 2009 (Inflammation) : In endothelial cells ( ECs ), activation of ROCK regulates myosin L chain ( MLC ) phosphorylation, stress fiber formation and permeability increases during inflammation
Lartey et al., Reproduction 2009 : Agonist activated RHO proteins bind to effector kinases such as RHO kinase ( ROCK ) and diaphanous proteins ( DIAPH ) to regulate smooth muscle contraction by two mechanisms : ROCK activates smooth muscle myosin either by direct phosphorylation at Ser19/Thr18 or through inhibition of myosin phosphatase which is a trimeric protein regulated by ROCK and by other protein kinases
Lynch et al., Carcinogenesis 2012 (Disease Progression...) : Specifically, inhibition of ROCK1 and MAPK1 reduces phosphorylation levels of the motor protein myosin light chain ( MLC ) leading to a significant inhibition of the invasive and migratory potential of neuroblastoma cells