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CASP2 — PIDD1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Caspase Cascade in Apoptosis: TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1) → Caspase 2 (CASP2) (modification, activates)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM PIDDsome complex: PIDDsome complex complex (CASP2-CRADD-PIDD1) Tinel et al., Science 2004*
• IRef Intact Interaction: CASP2 — PIDD1 (colocalization, fluorescence microscopy) Vakifahmetoglu et al., Oncogene 2006*
• IRef Intact Interaction: Complex of 19 proteins (association, anti bait coimmunoprecipitation) Vakifahmetoglu et al., Oncogene 2006*
• IRef Intact Interaction: Complex of CASP2-PIDD1-PRKDC-PIDD1-CASP2-PRKDC (association, cosedimentation) Shi et al., Cell 2009*