Mizuchi et al., Biochem Biophys Res Commun 2005
:
BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells ... Here we demonstrate that the inducible expression of BCR/ABL in a murine hematopoietic cell line, TonB210, leads to the activation of the Ras family small GTPase Rap1 , which is inhibited by the ABL kinase inhibitor imatinib
Nolz et al., J Cell Biol 2008
:
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G mediated activation of Rap1