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CREB1 — CRH

Text-mined interactions from Literome

Kishimoto et al., Nat Genet 2000 (Edema...) : Corticotropin releasing hormone (Crh) , a 41-residue polypeptide, activates two G-protein coupled receptors, Crhr1 and Crhr2, causing ( among other transductional events ) phosphorylation of the transcription factor Creb
Sarkar et al., Brain Res 2002 : These data demonstrate that i.c.v. alpha-MSH administration increases the phosphorylation of CREB in several subdivisions of the PVN including TRH and CRH neurons in the medial and periventricular parvocellular subdivisions, suggesting that phosphorylation of CREB may be necessary for alpha-MSH induced activation of the TRH and CRH genes
McEvoy et al., Ann N Y Acad Sci 2002 (Arthritis, Rheumatoid...) : Using primary synovial tissue endothelial cells, we demonstrate that CRH induces specific CREB-1 and ATF-2 binding to the NURR1 promoter
Kasagi et al., J Neuroendocrinol 2002 : These findings indicate that CRF may down-regulate CRF-R1 mRNA expression via a cAMP-PKA mediated mechanism in rat anterior pituitary cells, and that CREB may mediate at least a portion of this inhibitory effect
McEvoy et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : Nuclear extracts were analyzed by electrophoretic mobility shift assays to determine functional cAMP response element binding protein ( CREB ) activity in response to CRH and PGE ( 2 ) in isolated primary synovial cell populations
Bayatti et al., Endocrinology 2005 : At the level of intracellular signaling, short-term application of WIN-55,212-2 inhibited CRH induced cAMP accumulation and CREB phosphorylation
Kageyama et al., Mol Cell Endocrinol 2007 : Bisindolylmaleimide partially inhibited the CRF mediated increase in CREB phosphorylation, but only in AtT-20 cells, suggesting that the protein kinase C pathway is involved in regulation of CREB phosphorylation via CRF1 receptor but not CRF2 receptor
Liu et al., Endocrinology 2008 : Although PMA potentiated the effect of low forskolin concentrations on CRH transcription and CREB phosphorylation, there was no correlation between phosphorylated CREB levels and activation of CRH transcription ... In addition, the data indicate that phosphorylated CREB is essential but not sufficient for activation of CRH transcription, suggesting that full promoter stimulation requires the interaction of phosphorylated CREB with a coactivator
Liu et al., Endocrinology 2010 : We have recently shown that phospho-cAMP response element binding protein ( CREB ) is essential but not sufficient for activation of CRH transcription, suggesting the requirement of a coactivator
Stern et al., PloS one 2011 (MAP Kinase Signaling System) : Corticotropin releasing factor induced CREB activation in striatal neurons occurs via a novel Gß? signaling pathway ... Thus, we aimed to elucidate the signaling pathway by which CRF activates CREB in striatal neurons ... Here we describe a novel neuronal signaling pathway whereby CRF leads to a rapid Gß?- and MEK dependent increase in CREB phosphorylation
Stern et al., Eur J Neurosci 2011 : Corticotropin releasing factor and urocortin I activate CREB through functionally selective Gß? signaling in hippocampal pyramidal neurons ... Here we elucidate molecular mechanisms by which CRF and UCN induce phosphorylation of the activity dependent transcription factor CREB , a molecule critical for numerous forms of neuronal plasticity
Itoi et al., Endocrinology 1996 (Hypoglycemia) : Antisense oligodeoxyribonucleotides ( oligos ) directed against c-fos, c-jun, or the cAMP response element binding protein ( CREB ) mRNA were injected into both PVN before insulin induced hypoglycemia to assess whether activator protein-1 or CREB mediates transcriptional activation of CRF during hypoglycemia ... These results suggest that protein kinase A may transduce intracellular signals in CRF neurons under physiological conditions and raises the possibility that CREB may be involved in stress induced CRF gene expression
Waeber et al., Mol Endocrinol 1998 : Transcriptional activation of the macrophage migration-inhibitory factor gene by the corticotropin releasing factor is mediated by the cyclic adenosine 3',5'- monophosphate responsive element binding protein CREB in pituitary cells