Mitsuda et al., Dev Biol 2005
:
While IGF-1 alone had no effect on isolated RPE , combination of FGF-2 and IGF-1 stimulated RPE cell transdifferentiation similar to the results obtained in organ cultured RPE and choroid
Mukherjee et al., Invest Ophthalmol Vis Sci 2007
:
IGF effects on RPE were evaluated in tissue culture assays that involved incubation on three-dimensional collagen matrices with responses measured as progressive reduction in matrix thickness