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EGFR — MUC5AC

Text-mined interactions from Literome

Takeyama et al., Proc Natl Acad Sci U S A 1999 (Hyperplasia) : Selective EGF-R tyrosine kinase inhibitors blocked MUC5AC expression induced by EGF-R ligands
Burgel et al., J Immunol 2001 (Asthma...) : Because an epidermal growth factor receptor (EGFR) cascade induces MUC5AC mucin in airways, and because EGFR is up-regulated in asthmatic airways, we examined the effect of eosinophils on MUC5AC mucin production in NCI-H292 cells ( a human airway epithelial cell line that produces mucins )
Gray et al., Mol Pharmacol 2004 : However, neither inhibition of epidermal growth factor receptor (EGFR) activation with the tyrosine kinase inhibitor 4- ( 3-chloroanilino ) -6,7-dimethoxyquinazoline HCl ( AG-1478 ) or EGFR blocking antibody nor inhibition of extracellular signal regulated kinase/P-38 mitogen activated protein kinases with specific inhibitors blocked IL-1beta stimulation of MUC5AC mucin production
Słomiany et al., J Physiol Pharmacol 2005 : Gastric mucin secretion in response to beta-adrenergic G protein coupled receptor activation is mediated by SRC kinase dependent epidermal growth factor receptor transactivation
Griffin et al., Cell Microbiol 2007 : We now show that a large of number of stimuli relevant to the cystic fibrosis lung - neutrophil elastase, LPS, Pam3Cys-Ser- ( Lys ) 4 Hydrochloride ( a lipopeptide analogue ), CpG DNA ( which mimics bacterial DNA ) and cystic fibrosis bronchoalveolar lavage fluid - can activate MUC1 and 2 expression as well as MUC5AC expression in lung epithelial cells via an EGFR dependent mechanism
Hegab et al., Chest 2007 (Bronchial Neoplasms...) : Both in vivo and in vitro, the induction of MUC5AC and mucin synthesis were inhibited by niflumic acid, and/or a selective EGFR tyrosine kinase inhibitor, AG-1478
Casalino-Matsuda et al., Am J Respir Cell Mol Biol 2009 : We have previously shown that ROS induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen activated protein kinase ( MAPK ) activation
Binker et al., Biochem Biophys Res Commun 2009 (Pulmonary Disease, Chronic Obstructive) : Finally, we observed that EGFR/PI3K/Rac1/NADPH/ROS/MMP-9 regulate MUC5AC production in LPS challenged NCI-H292 cells
Yu et al., Mol Cell Biochem 2011 : MUC5AC expression is regulated by epidermal growth factor receptor (EGFR) which can be activated by reactive oxygen species ( ROS )