UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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FGA — ITGAM

Pathways - manually collected, often from reviews:

NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphaM/beta2 Integrin complex (PLAUR-PLAU-ITGAM-ITGB2) → Fibrinogen complex (FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPA/uPAR/alphaM/beta2 Integrin complex (PLAUR-PLAU-ITGAM-ITGB2) → uPA/uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-PLAU-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: Fibrinogen complex (FGA-FGG-FGB) → uPA/uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-PLAU-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: Fibrinogen complex (FGA-FGG-FGB) → alphaM/beta2 Integrin/Fibrinogen complex (ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Solovjov et al., J Biol Chem 2005, Wright et al., Proc Natl Acad Sci U S A 1988, Zhou et al., J Biol Chem 1994, Diamond et al., J Cell Biol 1993, Diamond et al., J Cell Biol 1993
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: Fibrinogen complex (FGA-FGG-FGB) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
Solovjov et al., J Biol Chem 2005, Wright et al., Proc Natl Acad Sci U S A 1988, Zhou et al., J Biol Chem 1994, Diamond et al., J Cell Biol 1993, Diamond et al., J Cell Biol 1993
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: alphaM/beta2 Integrin/Fibrinogen complex (ITGAM-ITGB2-FGA-FGG-FGB) → alphaM/beta2 Integrin complex (ITGAM-ITGB2) (modification, collaborate)
Solovjov et al., J Biol Chem 2005, Wright et al., Proc Natl Acad Sci U S A 1988, Zhou et al., J Biol Chem 1994, Diamond et al., J Cell Biol 1993, Diamond et al., J Cell Biol 1993
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: uPA/uPAR/alphaM/beta2 Integrin complex (PLAUR-PLAU-ITGAM-ITGB2) → Fibrinogen complex (FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: uPA/uPAR/alphaM/beta2 Integrin complex (PLAUR-PLAU-ITGAM-ITGB2) → uPA/uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-PLAU-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: Fibrinogen complex (FGA-FGG-FGB) → uPA/uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-PLAU-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Zhang et al., Inflamm Res 2003
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: Fibrinogen complex (FGA-FGG-FGB) → uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: Fibrinogen complex (FGA-FGG-FGB) → alphaM/beta2 Integrin/uPAR complex (ITGAM-ITGB2-PLAUR) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction
NCI Pathway Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling: uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-ITGAM-ITGB2-FGA-FGG-FGB) → alphaM/beta2 Integrin/uPAR complex (ITGAM-ITGB2-PLAUR) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: Fibrinogen complex (FGA-FGG-FGB) → uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-ITGAM-ITGB2-FGA-FGG-FGB) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: Fibrinogen complex (FGA-FGG-FGB) → alphaM/beta2 Integrin/uPAR complex (ITGAM-ITGB2-PLAUR) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction
NCI Pathway Database Beta2 integrin cell surface interactions: uPAR/alphaM/beta2 Integrin/Fibrinogen complex (PLAUR-ITGAM-ITGB2-FGA-FGG-FGB) → alphaM/beta2 Integrin/uPAR complex (ITGAM-ITGB2-PLAUR) (modification, collaborate)
Simon et al., J Biol Chem 2000, Sitrin et al., J Clin Invest 1996
Evidence: physical interaction