Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Quemener et al., Cancer Res 2007 (Breast Neoplasms...) : Enhanced EMMPRIN expression in a tumorigenic breast epithelial cell line NS2T2A increased the levels of uPA , uPA receptor, and the uPA inhibitor plasminogen activator inhibitor-1 ( PAI-1 ), as measured by quantitative reverse transcription-PCR, Western blot, and plasminogen-casein zymography ... Additionally, overexpression of EMMPRIN in NS2T2A cells increased uPA levels in cocultured endothelial cells, showing a paracrine regulation loop involving a tumor-stroma interaction
Lescaille et al., BMC cancer 2012 (Carcinoma, Squamous Cell...) : In this study, the role of EMMPRIN in regulating uPA and invasion was investigated in oral squamous cell carcinoma ( OSCC ) progression ... The paracrine regulation of uPA by EMMPRIN was investigated by treating culture cells with EMMPRIN enriched membrane vesicles