◀ Back to CDKN1A

CDKN1A — HES1

Text-mined interactions from Literome

Castella et al., Mol Cell Biol 2000 : HES-1 expression strongly repressed transcription of the p21 ( cip1 ) promoter, a cyclin-cyclin dependent kinase inhibitor up regulated during NGF induced differentiation, and the H-3/4 domain is necessary for this repression
Kabos et al., J Biol Chem 2002 : Blocking HES1 expression initiates GABAergic differentiation and induces the expression of p21 ( CIP1/WAF1 ) in human neural stem cells ... Here we show that the HLH transcription factor HES1 regulates the proliferation of human neural stem cells and that blocking its expression stimulates the expression of cyclin dependent kinase inhibitor p21 ( CIP1/WAF1 )
Tremblay et al., J Biol Chem 2009 (Fanconi Anemia...) : Here we show that the FA core complex contributes to transcriptional regulation of HES1-responsive genes, including HES1 and the cyclin dependent kinase inhibitor p21 ( cip1/waf1 )
Kannan et al., J Exp Med 2013 (Leukemia, Myeloid, Acute) : Induced activation through any of the Notch receptors ( Notch1-4 ), or through the Notch target Hairy/Enhancer of Split 1 (HES1) , consistently leads to AML growth arrest and caspase dependent apoptosis, which are associated with B cell lymphoma 2 (BCL2) loss and enhanced p53/p21 expression