◀ Back to ABL1

ABL1 — TYR

Text-mined interactions from Literome

Dorey et al., Oncogene 2001 : Phosphorylation of Tyr412 can occur autocatalytically by a trans-mechanism and cause activation of otherwise inactive c-Abl , suggesting a positive feedback loop on c-Abl activity ... Tyr412 is therefore necessary both for activity and for regulation of c-Abl , by stabilizing the inactive or the active conformation of the enzyme in a phosphorylation dependent manner
Yu et al., J Biol Chem 2004 : c-Abl mediated phosphorylation of topo I Tyr268 in vitro and in cells conferred activation of the topo I isomerase function
Holcomb et al., J Biol Chem 2006 : Our findings indicate that regulated protein degradation by the proteasome specifically controls cell death through regulation of Abl mediated Crk Tyr221 phosphorylation and assembly of the CAS-Crk signaling scaffold