◀ Back to CASP14
CASP14 — SMAD4
Text-mined interactions from Literome
Xu et al., Mol Cancer Res 2006
(Carcinoma...) :
Silencing of Bax by small interfering RNA in IOSE397 cells significantly reduced ALK7-ca induced apoptosis as measured by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay but partially
blocked ALK7-ca induced
caspase-3 activation and did not affect the down-regulation of Xiap by ALK7-ca. Dominant negative Smad2, Smad3, and
Smad4 blocked ALK7-ca regulated Xiap and Bax expression and caspase-3 activation
Huang et al., Oncol Rep 2008
(Carcinoma, Hepatocellular...) :
Western blot analysis revealed that p16 was up-regulated and
caspase 3 was
activated by silencing of
Smad4 , and the expression of p21 and wild-type p53 were not affected