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CTNNB1 — IRS1

Text-mined interactions from Literome

Chen et al., J Biol Chem 2005 : IRS-1 is required for IGF-1 mediated nuclear translocation of beta-catenin, resulting in the activation of the beta-catenin target genes ... This possibility is supported by the demonstration that enforced nuclear localization of IRS-1 causes nuclear translocation of beta-catenin and transformation of normal mouse embryo fibroblasts ( colony formation in soft agar )
Bommer et al., J Biol Chem 2010 (Cell Transformation, Neoplastic...) : We demonstrate expression of IRS1 can be directly activated by beta-catenin , likely in part via beta-catenin/TCF binding to TCF consensus binding elements located in the first intron and downstream of the IRS1 transcriptional start site