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IL2 — LTB

Text-mined interactions from Literome

Zinetti et al., Cytokine 1998 (Sepsis) : Neither the pro-inflammatory cytokines interleukin 2 (IL-2) , TNF-alpha nor LPS alone or in combination with interferon gamma (IFN-gamma) had any effect on LT-beta mRNA expression
Klausner et al., Cancer 1990 (Hypertension, Pulmonary) : Pretreatment with the lipoxygenase inhibitor diethylcarbamazine ( DEC ; n = 6 ) reduced baseline plasma LTB4 levels and prevented the IL-2 induced increases in LTB4 in plasma and lung lymph ( P less than 0.05 )
Rola-Pleszczynski et al., Union Med Can 1989 : In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus infected or tumor target cells
Rola-Pleszczynski et al., Prostaglandins Leukot Med 1986 : Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin
Rola-Pleszczynski et al., J Immunol 1987 : Recent evidence also indicates that LTB4 can directly affect the production of cytokines such as interleukin 1 (IL 1) or interleukin 2 (IL 2) and interferon-gamma (IFN-gamma)
Arcoleo et al., Int J Immunopharmacol 1995 : However, LTB4 augmented ConA spleen cell production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) from Th1 cells and interleukin-4 (IL-4) and interleukin-10 (IL-10) from Th2 cells more than the controls treated with ConA alone
Stanková et al., J Immunol 1993 : LTB4 induced increased shedding of the IL-2R alpha in the culture supernatants and a modest induction of IL-2R alpha protein expression on monocytes ... On the other hand, although LTB4 could stimulate the cell membrane expression of IL-2R beta and the accumulation of IL-2R beta mRNA, LTB4 did not significantly affect IL-2R beta gene transcription