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CD8A — GZMB

Text-mined interactions from Literome

Pereira et al., J Virol 2000 (Disease Models, Animal...) : Primarily, perforin and granzyme B mediate CD8 ( + ) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown
Kelso et al., Int Immunol 2002 : When CD44 ( low ) CD62L ( high ) CD8 ( + ) lymph node T cells were activated with IL-2 and immobilized antibodies to CD3, CD8 and CD11a, expression of perforin, granzyme B and IFN-gamma mRNAs was induced by day 2, and increased in parallel with perforin dependent cytolytic activity
Figueiredo et al., Blood 2009 : The granzyme B secretion and cytolytic activity of T-helper cells are induced in a target independent way, whereas the cytotoxic activity of CD3 ( + ) and CD8 ( + ) T cells can be further enhanced in the presence of target cells
Cheng et al., Zhonghua Wai Ke Za Zhi 2009 : In group A, acute rejection was present in advance ; transplanted hearts were seriously damaged into acute rejection pathological grade 3, and CD8 ( + ) T lymphocytes infiltrated diffusely and the expression of granzyme B increased significantly as compared with other groups
Stelekati et al., Immunity 2009 (Encephalomyelitis, Autoimmune, Experimental...) : MCs regulated antigen-specific CD8 ( + ) T cell cytotoxicity by increasing granzyme B expression and by promoting CD8 ( + ) T cell degranulation
Mittal et al., Immunol Cell Biol 2012 : Furthermore, IL-27 stimulation of human naïve CD8 ( + ) T cells greatly increases expression of granzyme B