◀ Back to NFKB1
AKT3 — NFKB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ozes et al., Nature 1999
:
Wortmannin ( a PI(3)K inhibitor ), dominant negative PI(3)K or kinase-dead
Akt inhibits TNF mediated
NF-kappaB activation ... Constitutively active
Akt induces
NF-kappaB activity and this effect is blocked by dominant negative NIK ... Conversely, NIK activates
NF-kappaB and this is
blocked by kinase-dead
Akt ... Thus, both
Akt and NIK are
necessary for TNF activation of
NF-kappaB ... Mutation of this amino acid blocks phosphorylation by
Akt or TNF and
activation of
NF-kappaB
Madrid et al., Mol Cell Biol 2000
:
Oncogenic Ras, an upstream activator of
Akt ,
requires NF-kappaB to initiate transformation, at least partially through the ability of NF-kappaB to suppress transformation associated apoptosis ... In this study, we show that oncogenic H-Ras
requires PI3K and
Akt to stimulate the transcriptional activity of
NF-kappaB ... Our work demonstrates that, unlike activated Ras, which can stimulate parallel pathways to activate both DNA binding and the transcriptional activity of NF-kappaB,
Akt stimulates
NF-kappaB predominantly by upregulating of the transactivation potential of p65
Burow et al., Biochem Biophys Res Commun 2000
:
PI3K and
Akt stimulated
NF-kappaB activation in a dose dependent manner, suggesting a common link between these two pathways ... We demonstrate that while both TNFR1 and NIK are partially involved in
Akt induced
NF-kappaB stimulation, a dominant negative IkappaBalpha completely blocked Akt-NF-kappaB cross-talk ...
PI3K-Akt signaling
activated NF-kappaB through both TNFR signaling dependent and -independent mechanisms, potentially representing a mechanism by which Akt functions to suppress apoptosis in cancer
Rauch et al., FEBS Lett 2000
:
PDGF induced
Akt phosphorylation does not
activate NF-kappa B in human vascular smooth muscle cells and fibroblasts ... The present study investigates the
role of
Akt in the activation of
NF-kappa B by tumor necrosis factor-alpha ( TNF alpha, 10 ng/ml ) and PDGF-BB ( 20 ng/ml ) in human vascular smooth muscle cells ( SMC ), skin and foreskin fibroblasts ... These data suggest that
Akt phosphorylation is not
involved in
NF-kappa B activation in human SMC and fibroblasts
Yang et al., J Biol Chem 2001
:
Whereas constitutively active PI-3K and
Akt induce
NF-kappaB activation, Ly294002 ( a PI-3K inhibitor ), dominant negative PI-3K, and kinase-dead Akt block IFN dependent NF-kappaB activation
Pianetti et al., Oncogene 2001
(Breast Neoplasms...) :
Overexpression of Her-2/neu and EGFR-4 in Ba/F3 cells led to constitutive PI3- and
Akt kinase activities, and
induction of classical
NF-kappaB ( p50/p65 )
Factor et al., Hepatology 2001
(Liver Neoplasms, Experimental) :
Roles of
Akt/PKB and IKK complex in constitutive induction of
NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice
Zhen et al., Mol Pharmacol 2001
:
Activation of NF-kappa B by 1 microM PD168077 was attenuated in D ( 4 ) MN9D cells that were transfected with a kinase-deficient Akt but not in cells transfected with a dominant negative Ras ( N17Ras ), suggesting that
NF-kappa B activation
requires Akt but is independent of Ras
Shao et al., Cancer Res 2001
(Ovarian Neoplasms) :
To test whether
Akt is regulated by E1A and is
involved in radiation induced
NF-kappaB activity, we examined the phosphorylation status of Akt in the E1A transfectants and parental cells and in irradiated cells ... We found that dominant negative
Akt and wortmannin did not
block radiation induced
NF-kappaB activity
Thomas et al., J Biol Chem 2002
:
Finally, both PI 3-K inhibition by LY294002 and
AKT inhibition by transfection of a dominant negative enzyme
blocked RSV induced
NF-kappaB transcriptional activity
Hatano et al., Am J Physiol Gastrointest Liver Physiol 2001
:
Active
Akt induces
NF-kappa B transcriptional activity but not NF-kappa B binding activity or I kappa B degradation
Yum et al., J Immunol 2001
(Endotoxemia...) :
In the present study, we found that exposure of neutrophils to endotoxin resulted in phosphorylation of
Akt ,
activation of
NF-kappaB , and expression of the proinflammatory cytokines IL-1beta and TNF-alpha through PI3-K dependent pathways
Vancurova et al., J Virol 2002
(Laryngeal Neoplasms...) :
Increased
NF-kappaB activity and cytoplasmic accumulation of p21 ( CIP1/WAF1 ) might counteract death promoting effects elicited by overexpressed PTEN and
reduced activation of
Akt and STAT3 previously noted in these tissues
Mayo et al., J Biol Chem 2002
:
Although the Akt pathway has been implicated in regulating NF-kappaB activity, it is controversial as to whether
Akt activates
NF-kappaB predominantly through mechanisms that regulate nuclear translocation or transactivation potential ... Maintenance of the PTEN tumor suppressor protein is therefore required to modulate
Akt activity and to concomitantly
control the transcriptional activity of the anti-apoptotic transcription factor
NF-kappaB
Chen et al., J Biol Chem 2002
:
In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation,
NF-kappaB transactivation , and weak
Akt activation ... Taken together, these results indicate a novel regulatory mechanism for IL-1beta signaling and suggest that CaMKK dependent
Akt activation
inhibits IL-1beta induced
NF-kappaB activation through interference with the coupling of IRAK1 to MyD88
Kane et al., Mol Cell Biol 2002
:
Akt appears to function upstream of Cot, as
Akt can
enhance Cot induction of
NF-kappa B-dependent transcription, and dominant negative Cot blocks the activation of this element by Akt
Mitsiades et al., Oncogene 2002
(Multiple Myeloma) :
In contrast, IL-6 does not cause sustained
NF-kappaB activation,
induces less pronounced
Akt activation and FKHRL-1 phosphorylation than IGF-1, and increases the expression of only survivin
Bozinovski et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
Granulocyte/macrophage-colony stimulating factor ( GM-CSF ) regulates lung innate immunity to lipopolysaccharide through
Akt/Erk activation of
NFkappa B and AP-1 in vivo
Condorelli et al., FASEB J 2002
:
Here we demonstrate in neonatal rat cardiomyocytes that 1 ) TNF-alpha induces phosphorylation of AKT, activation of NF-kappaB, and the phosphorylation of JUN kinase ; 2 ) blocking
AKT activity
prevents NF-kappaB activation, suggesting a role for AKT in regulating NF-kappaB function ; 3 ) AKT and JUN are both critical for the hypertrophic effects of TNF-alpha, since dominant negative mutants of these genes are capable of inhibiting TNF-alpha induced ANF-promoter up-regulation and increase in cardiomyocyte cell size, and 4 ) blocking NF-kappaB, AKT, or JUN alone or in combination does not sensitize cardiomyocytes to the proapoptotic effects of TNF-alpha, in contrast to other cell types, suggesting a cardiac-specific pathway regulating the anti-apoptotic events induced by TNF-alpha
Figueroa et al., Exp Hematol 2002
(Anoxia) :
Genetic inhibition of
AKT resulted in significant inhibition of
NF-kappaB and HIF-1 mediated transactivation, as well as EPO gene expression, in response to hypoxia ... Overexpression of constitutively active
AKT resulted in increased
NF-kappaB and HIF-1 transactivation
Dhawan et al., Cancer Res 2002
(Disease Progression...) :
The purpose of this study was to explore the
role of
Akt in the activation of
NF-kappaB during melanoma tumor progression
Santos et al., J Biol Chem 2003
(Skin Neoplasms) :
Given the
roles of
Akt in
NF-kappa B signaling and the importance of these processes in the epidermis, a study was made into the possible alterations of the NF-kappa B pathway in transgenic mice expressing K10 in the proliferative basal layer ... It was found that the inhibition of
Akt , mediated by K10 expression,
leads to impaired
NF-kappa B activity
Lee et al., J Biol Chem 2003
:
LY294002, dominant negative ( DN ) phosphatidylinositol 3-kinase (PI3K), or
AKT ( DN )
inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active ( CA ) TLR4 ...
AKT ( DN )
blocked MyD88 induced
NFkappaB activation, suggesting that AKT is a MyD88 dependent downstream signaling component of TLR4 ...
AKT ( CA ) was
sufficient to induce
NFkappaB activation and COX-2 expression ... DHA also suppressed
NFkappaB activation
induced by TLR4 ( CA ), but not MyD88 ( CA ) or
AKT ( CA ), suggesting that the molecular targets of DHA are signaling components upstream of MyD88 and AKT
Kumar et al., Neoplasia (New York, N.Y.) 2003
(Prostatic Neoplasms) :
Overexpression of constitutively active
Akt , but not the kinase dead mutant of Akt,
activated the basal
NFkappaB transcriptional activity
Li et al., Infect Immun 2003
:
The dominant negative mutant of
Akt partially
inhibited the
NF-kappa B luciferase activity evoked by LPS and IL-1 beta ... Further, these studies suggest that PI3-kinase is an important mediator of LPS and IL-1 beta signaling leading to NF-kappa B activation in endothelial cells and that
Akt is
necessary but not sufficient for
NF-kappa B activation by TLR4
Cenni et al., Biochem J 2003
:
We also demonstrate that
Akt activity is
necessary for IL-1 dependent
NF-kappaB transactivation, since a kinase-defective mutant of Akt impairs IRAK2- and MyD88 dependent, but not IRAK1 dependent, NF-kappaB activity, as monitored by a gene reporter assay ... However, NF-kappaB binding to DNA was not affected by inhibition of Akt, indicating that
Akt regulates
NF-kappaB at a level distinct from the dissociation of p65 from IkappaBalpha and its translocation to the nucleus, possibly involving phosphorylation of the p65 transactivation domain
Gustin et al., J Biol Chem 2004
:
Phosphatidylinositol (PI)
3-kinase/Akt signaling
activates NF-kappa B through pleiotropic, cell type-specific mechanisms ... Thus, noncoordinate expression of I kappa B kinases plays a role in determining the cell type-specific
role of
Akt in
NF-kappa B activation
Chandrasekar et al., J Biol Chem 2004
(Arteriosclerosis...) :
However, treatment with pertussis toxin ( G ( i ) inhibitor ), wortmannin or LY294002 ( phosphatidylinositol 3-kinase ( PI3K inhibitors ) ), or Akt inhibitor or overexpression of dominant negative ( dn ) PI3K gamma, dnPDK-1, kinase-dead ( kd )
Akt , kdIKK-beta, dnIKK-gamma, dnI kappa B-alpha, or dnI kappa B-beta significantly
attenuated CXCL16 induced
NF-kappa B activation
Imose et al., Liver Int 2003
(Liver Failure) :
The inducible activation of
NF-kappaB and constitutive
activation of
Akt regulate hepatocyte survival against TNF-alpha, which occurs independent of Bcl-2 families
Afaq et al., Toxicol Appl Pharmacol 2004
(Edema...) :
In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of
Akt at threonine308 and
activation of
nuclear factor kappa B (NF-kappaB)
Richmond et al., Novartis Found Symp 2004
(Cell Transformation, Neoplastic...) :
We have shown that the constitutive activation of NF-kappaB in human melanoma tumours is accompanied by constitutive activation of the
NF-kappaB inducing kinase (NIK) as well as the constitutive
activation of
AKT
Saleem et al., Oncogene 2004
(Edema...) :
We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA induced ( i ) activation of PI3K, ( ii ) phosphorylation of
Akt at Thr ( 308 ), ( iii )
activation of
NF-kappaB and IKKalpha, and ( iv ) degradation and phosphorylation of IkappaBalpha
Wang et al., Lab Invest 2004
(Brain Neoplasms...) :
Functional correlation between
Akt activation and the
activation of
NFkappaB was confirmed in U251MG GBM cells in which inhibition of Akt activation either by stable expression of PTEN or by the PI3-kinase inhibitors, wortmannin and LY294002, led to a concomitant decrease in NFkappaB binding activity ... Thus, our results demonstrate that constitutive activation of Akt and NFkappaB, but not Stat3, contributes significantly to the progression of diffuse gliomas, and activation of
Akt may
lead to
NFkappaB activation in high-grade gliomas
Hsieh et al., Cell Signal 2004
(MAP Kinase Signaling System) :
In accordance with these findings, BK-induced phosphorylation of p42/p44 MAPK and
Akt and
activation of
NF-kappaB was attenuated by prior treatment with PD98059, LY294002, and helenalin, respectively
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2004
:
Our results indicate that EGF and IL-1beta stimulate two essential signals for iNOS induction in IEC-6 cells : the upregulation of IL-1R1 through
PI3-kinase/Akt and the
activation of
NF-kappaB through IkappaB kinase, respectively
Palamakumbura et al., J Biol Chem 2004
:
Here we report, for the first time, that the lysyl oxidase propeptide, and not the lysyl oxidase enzyme, inhibits ras dependent transformation as determined by effects on cell proliferation assays, growth in soft agar, and
Akt dependent
induction of
NF-kappaB activity
Ahn et al., Cell Physiol Biochem 2005
:
Wortmannin inhibited NF-kappaB binding and transcriptional activity without inhibiting NF-kappaB translocation to the nucleus, indicating that
PI3K/Akt signaling
activates NF-kappaB transcriptional activity directly
Fan et al., Oncogene 2005
:
The ability of HGF/SF to activate
NF-kappaB signaling was
dependent on
c-Akt -- > Pak1 ( p21 associated kinase-1 ) signaling ( with Pak1 downstream of c-Akt ) and was inhibited by the tumor suppressor PTEN ( phosphatase and tensin homolog )
Petlickovski et al., Blood 2005
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
This response was characterized by transient phosphorylation of extracellular signal related kinase ( ERK ) and
Akt ( protein kinase B [ PKB ] ), lack of activation of c-JUN NH2-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ), and variable
activation of phospholipase Cgamma2 ( PLCgamma2 ) and
nuclear factor-kappaB (NF-kappaB)
Lee et al., Clin Cancer Res 2005
(Stomach Neoplasms) :
An in vitro study showed that
NF-kappaB activity in gastric cancer cells is controlled by and
controls Akt
Jeong et al., Oncogene 2005
(Cell Transformation, Viral) :
Activated
AKT regulates
NF-kappaB activation, p53 inhibition and cell survival in HTLV-1 transformed cells
Mehta et al., J Immunol 2005
(MAP Kinase Signaling System) :
Neither overexpression or inhibition of MEK, Ras, or
Akt affected HB-EGF mediated inhibition of
NF-kappaB activation
Wang et al., Cancer Res 2005
(MAP Kinase Signaling System) :
Because PTEN is a well-known phosphatase involved in the regulation of phosphatidylinositol 3-kinase (PI-3K)/Akt signaling pathway, taken together with the evidence that
PI-3K/Akt plays an important role in the activation of AP-1 and
NF-kappaB during tumor development, we anticipate that inhibition of AP-1 and NF-kappaB by tumor suppressor p53 seems to be mediated via PTEN, which may be a novel mechanism involved in anticancer activity of p53 protein
Newcomb et al., J Biol Chem 2005
:
Inhibition of PI 3-kinase and
Akt attenuated RV39 induced
NF-kappaB transactivation and IL-8 expression
Bhattacharya et al., Apoptosis 2005
:
DN-Akt , as well as the PI3-kinase inhibitors,
prevented Akt activation and subsequent translocation of
NF-kappaB to the nucleus
Davies et al., Mol Cell Biol 2005
:
In fibroblasts lacking TRAF2 or in carcinoma cells in which TRAF2 has been depleted by RNA interference, the CD40 mediated activation of
NF-kappaB and JNK is significantly reduced, and the activation of p38 and
Akt is severely
impaired
Sugimori et al., J Bone Miner Metab 2005
:
BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through
PI3K/Akt mediated
NF-kappaB activation ... We investigated the involvement of phosphatidylinositol 3-kinase
(PI3K)/Akt mediated
NF-kappaB activation by BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511 ... Thus, BMP-2 induced
NF-kappaB activation is
mediated by
PI3K/Akt signaling
Choi et al., Mol Cells 2005
(MAP Kinase Signaling System) :
Even though the crucial involvement of the PI3-kinase/Akt pathway in the anti-apoptotic activation of NF-kB is well known, the exact
role of PDK-1 as well as
PI3-kinase/Akt in
NF-kB activation is not understood
Kobashi et al., Circ Res 2005
(Atherosclerosis) :
We conclude that inhibition of
NF-kappaB and
activation of
Akt phosphorylation may mediate adiponectin inhibition of atherosclerosis
Liu et al., J Virol 2005
:
These results show that
Akt plays a role in the Ad vector activation of
NFkappaB and CXCL10 expression
Narayan et al., Mol Cell Biol 2006
:
We previously demonstrated a
role for the serine/threonine kinase
Akt in CD28 mediated
NF-kappaB induction ... Using a CARMA1-deficient T-cell line, we have now found that the CARMA complex is required for
induction of
NF-kappaB by
Akt , in cooperation with protein kinase C activation ... Furthermore, using a novel selective inhibitor of Akt, we confirm that
Akt plays a modulatory role in
NF-kappaB induction by the TCR and CD28
Hsieh et al., J Cell Physiol 2006
:
Moreover, S1P stimulated activation of NF-kappaB promoter activity was blocked by phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 and helenalin, but not by U0126, suggesting that
involvement of
PI3K/Akt in the activation of
NF-kappaB
Hennig et al., J Nutr Biochem 2006
(Inflammation) :
Furthermore, inhibition of ERK activity by PD98059 and
PI3K/Akt activity by LY294002 or wortmannin significantly
reduced the LA-induced activation of
nuclear factor kappa B (NF-kappaB)
Gustin et al., J Biol Chem 2006
:
Constitutively active
Akt augments non-canonical
NF-kappaB activity, whereas kinase dead Akt or inhibition of phosphatidylinositol 3-kinase have the opposite effect ... These observations show that
Akt plays a role in activation of basal and induced non-canonical
NF-kappaB activity
Islam et al., Cancer Chemother Pharmacol 2007
:
Therefore, 5-FU was suggested to inhibit the LPS induced NO production in activated macrophages through preventing
Akt dependent
NF-kappaB activation
Nanua et al., Am J Respir Cell Mol Biol 2006
:
Quercetin also inhibited TNF-alpha induced PI 3-kinase activity,
Akt phosphorylation, intracellular H ( 2 ) O ( 2 ) production,
NF-kappaB transactivation , IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway
Parsa et al., PLoS Pathog 2006
(Gram-Negative Bacterial Infections) :
Inhibition of
PI3K/Akt resulted in suppression of F. novicida
induced cytokine production through the inhibition of
NFkappaB
Hwang et al., Carcinogenesis 2007
:
Taken together, 9Z,11E-CLA
inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and
PI3K-Akt signaling in TPA treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects
Rajaram et al., J Immunol 2006
(Gram-Negative Bacterial Infections) :
Analysis of the mechanism of Akt influence on cytokine response demonstrated that
Akt promotes
NF-kappaB activation
Chiou et al., Pediatr Res 2006
:
Activated-Akt can
activate downstream signal protein [ p70S6 K,
nuclear factor (NF)-kappaB , and extracellular signal regulated kinase ( ERK ) ], increasing the cyclin D1 level and suppressing the transcription of p27Kip1 to enable cell cycle entry
Chen et al., Biochem Pharmacol 2007
(Lung Neoplasms) :
Pretreatment of cells with tangeretin inhibited IL-1beta induced p38 MAPK, JNK, and
AKT phosphorylation and the downstream
activation of
NF-kappaB
El-Rayes et al., Cancer Res 2006
(Pancreatic Neoplasms) :
In the BxPC-3 cell line, significant down-regulation of EGFR, phosphorylated
Akt ,
NF-kappaB activation , and survivin was observed in the cells treated with the combination compared with the erlotinib treated cells
Nakata et al., Arterioscler Thromb Vasc Biol 2007
:
Inhibition of
Akt by dominant negative Akt
suppressed atorvastatin induced nNOS expression as well as Akt and
NF-kappaB activation ... Inhibition of
NF-kappaB by dominant negative IkappaB also
attenuated atorvastatin induced nNOS expression and NF-kappaB activation, but not
Akt activation
Liao et al., Neurochem Int 2007
:
The inductive action of manganese was accompanied by generation of oxidative stress,
activation of mitogen activated protein kinases ( MAPKs ),
AKT , and protein kinase C-alpha (PKC-alpha), and increased
NF-kappaB and AP-1 DNA binding activities
Zhang et al., J Appl Physiol 2007
(Hepatopulmonary Syndrome) :
These changes were associated with a reduction in circulating TNF levels and
NF-kappaB activation and complete
inhibition of
Akt activation
Liu et al., Mol Immunol 2007
:
Further studies show that the triptolide mediated inhibitory effects of LPS induced activation of phosphatidylinositol-3 kinase
(PI3-K)/Akt and nuclear
NF-kappaB activation are involved in down-regulation of COX-2 and CCR7 expression resulting in impaired migration to secondary lymphoid organs of DC
Wang et al., Biochem Biophys Res Commun 2007
(Lung Neoplasms) :
The results show that
Akt contributes to TNF induced
NF-kappaB activation in lung cancer cells through regulating phosphorylation of the p65/RelA subunit of NF-kappaB ... Although individually blocking IKK or
Akt partially
suppressed TNF induced
NF-kappaB activation, concurrent suppression of these pathways completely inhibited TNF induced NF-kappaB activation and downstream anti-apoptotic gene expression, and synergistically potentiated TNF induced cytotoxicity
Zhang et al., Proc Natl Acad Sci U S A 2007
(Inflammation...) :
Lipoic acid dependent
Akt phosphorylation and
inhibition of
NF-kappaB activity were abolished by the PI3K inhibitors LY294002 and wortmannin
Li et al., Arterioscler Thromb Vasc Biol 2007
(Atherosclerosis...) :
JAK1/TYK2 leads to STAT3 activation,
Akt dependent
NF-kappaB activation, and phosphorylation of extracellular signal regulated kinase 1/2 and mitogen activated kinase p38
Julien et al., Oncogene 2007
(Carcinoma, Squamous Cell...) :
Activation of
NF-kappaB by
Akt upregulates Snail expression and induces epithelium mesenchyme transition ... Here, we show that Snail activation and consequent repression of E-cadherin may depend on
AKT mediated
nuclear factor-kappaB (NF-kappaB) activation , and that NF-kappaB induces Snail expression
Nakamura et al., Rheumatol Int 2007
(Sjogren's Syndrome) :
Chemical inhibition of
PI3K-Akt by LY294002/wortmannin did not affect EGF mediated NF-kappaB p65 nuclear translocation ; and
NF-kappaB inhibition by Bay 11-7082 did not
suppress Akt phosphorylation
Tsai et al., Int Immunopharmacol 2007
:
YC-1, in a cGMP independent manner,
inhibited lipopolysaccharide induced
Akt activation, IkappaBalpha degradation and
NF-kappaB translocation, all of which are associated with co-stimulatory molecules expression
Belaiba et al., Mol Biol Cell 2007
(Anoxia) :
Together, these findings provide a novel mechanism in which hypoxia induces HIF-1alpha mRNA expression via the
PI3K/AKT pathway and
activation of
NFkappaB
Jeong et al., Virology 2008
:
Since
AKT inhibitors simultaneously
inhibit NF-kappaB and activate p53, these drugs should be promising candidates for HTLV-1 associated cancer therapy
Kwon et al., Biochem Biophys Res Commun 2008
:
Moreover, inhibitors of Ras ( sulindac sulfide and farnesyltransferase inhibitor I ) or
PI3K/Akt ( wortmannin ),
reduced the amounts of Akt1 and Ki-Ras in the nucleus as well as partial
NF-kappaB activity
Reddy et al., J Cell Physiol 2008
:
Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via
PI3K-Akt dependent
NF-kappaB activation
Zhao et al., Biochem Pharmacol 2008
:
The pharmacological inhibitor of phosphatidylinositol 3-kinase (PI3K) ( wortmannin ) and dominant negative forms of p85 ( the regulatory subunit of PI3K ) or Akt enhance, while constitutive active forms of p110 ( the catalytic subunit of PI3K ) or
Akt inhibit ,
NF-kappaB activation and the target gene interleukin (IL)-8 induced by MDP
Lin et al., Rheumatol Int 2008
(Chondrosarcoma...) :
Using chondrosarcoma cells stimulated with IL-1beta, the effects of GLN on the mRNA and protein levels of MMP-3, the
activation of JNK, ERK, p38,
NF-kappaB , and AP-1, the nuclear translocation of NF-kappaB/Rel family members, and
PI3-kinase/Akt activation were studied
Dolga et al., J Alzheimers Dis 2008
(Alzheimer Disease...) :
It was previously shown that activation of TNF-R2 signaling, which includes phosphorylation of protein kinase B
(PKB)/Akt and
activation of nuclear factor-kappa B
(NF-kappaB) , protects neurons against ischemic or excitotoxic insults
Lu et al., Cell Physiol Biochem 2008
:
Inhibition of
AKT activity by a dominant negative AKT construct or by a PI3K inhibitor
reduced active
NF-kappaB and STAT3 expression without significantly altering the activity of the latter
Liu et al., Cell Microbiol 2008
(Coxsackievirus Infections...) :
Furthermore, silencing
NF-kappaB with siRNAs significantly
inhibited the phosphorylation of FAK and
Akt , but not their total expression levels, indicating that NF-kappaB activation is required for the IGTP induced activation of FAK and PI3K/Akt
Dan et al., Genes Dev 2008
(Prostatic Neoplasms) :
Akt dependent regulation of
NF-{kappa}B is controlled by mTOR and Raptor in association with IKK ... The mTOR associated protein Raptor is required for the ability of
Akt to
induce NF-kappaB activity
Henning et al., J Immunol 2008
:
Finally, we report for the first time that SP-A decreases the phosphorylation of
Akt , a major cell
regulator of
NF-kappaB and potentially MAPKs
Vender et al., Neurosurgery 2008
(Pituitary Neoplasms) :
Pharmacological or molecular inhibition of
Akt similarly
reduced GH3 viability and
NFkappaB binding, suggesting that constitutive activation of NFkappaB may be, at least in part, mediated by Akt
Kuo et al., Blood 2008
(Lymphoma, B-Cell, Marginal Zone...) :
In B-cell lymphoma Pfeiffer cells, BAFF activated NF-kappaB and
AKT ; the activated
NF-kappaB up-regulated BCL10, and the activated AKT caused formation of BCL10/BCL3 complexes that translocated to the nucleus
Song et al., J Cereb Blood Flow Metab 2008
(Disease Models, Animal...) :
The role of
Akt signaling in oxidative stress
mediates NF-kappaB activation in mild transient focal cerebral ischemia ... Inhibition of
Akt phosphorylation
induced decreases in sequential
NF-kappaB signaling after 30 mins of tFCI at 1 h
García et al., Leuk Res 2009
(Lymphoma) :
PI3K/Akt inhibition modulates multidrug resistance and
activates NF-kappaB in murine lymphoma cell lines
Ogunwobi et al., Mol Cell Endocrinol 2008
(Adenocarcinoma...) :
Glycine extended gastrin stimulates proliferation via JAK2- and
Akt dependent
NF-kappaB activation in Barrett 's oesophageal adenocarcinoma cells
Hosotani et al., J Dermatol 2008
:
Exogenous IL-18 augmented phosphorylation of
Akt and
activation of
NF-kappaB
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by
NF-kappaB in metastatic prostate cancer cells
Oh et al., Apoptosis 2008
(Leukemia) :
Furthermore, we have shown that overexpression of Bcl-2 and active Akt ( myr-Akt ) in U937 cells inhibited the induction of apoptosis, activation of caspase-3, and PLC-gamma1 cleavage by withaferin A. Taken together, our results indicated that the JNK and
Akt pathways and
inhibition of
NF-kappaB activity were key regulators of apoptosis in response to withaferin A in human leukemia U937 cells
Fan et al., J Biol Chem 2009
(MAP Kinase Signaling System...) :
The ability of Src to enhance SF stimulation of NF-kappaB activity was due, in part, to its ability to stimulate
Akt and IkappaB kinase activity ; and Src mediated stimulation of
NF-kappaB was
due , in part, to a Rac1/MKK3/6/p38 pathway and was Akt dependent
Shant et al., Exp Cell Res 2009
(Colonic Neoplasms) :
Akt dependent
NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress induced apoptosis ... We hypothesized that bile acid induced EGFR activation also mediates cell survival by downstream
Akt regulated activation of
NF-kappaB ... Collectively, these observations indicate that, downstream of EGFR, bile acid induced colon cancer cell survival is mediated by
Akt dependent
NF-kappaB activation
Minhajuddin et al., J Biol Chem 2009
:
Furthermore, we observed that expression of the constitutively active form of PKC-delta or
Akt was
sufficient to induce
NF-kappaB activation and ICAM-1 expression, and that co-expression of mTOR suppressed these responses
Shao et al., Inflamm Res 2008
:
Platonin
inhibits LPS induced
NF-kappaB by preventing activation of
Akt and IKKbeta in human PBMC
Kim et al., J Cell Physiol 2009
(Calcium Signaling...) :
5'-N-ethylcarboxamide induces IL-6 expression via MAPKs and
NF-kappaB activation through
Akt , Ca ( 2+ ) /PKC, cAMP signaling pathways in mouse embryonic stem cells ... In conclusion, NECA stimulated IL-6 expression via MAPK and
NF-kappaB activation through
Akt , Ca ( 2+ ) /PKC, and cAMP signaling pathways in mouse ES cells
Noman et al., Innate Immun 2009
:
Thalidomide prevented the activation of
nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide
inhibited LPS induced phosphorylation of
AKT , p38 and stress activated protein kinase ( SAPK ) /JNK
Jo et al., J Dermatol 2009
(Melanosis) :
Akt activation
plays an important role in the activation of the transcription factor
nuclear factor (NF)-kappaB and subsequent elevation of iNOS expression
Hong et al., J Exp Clin Cancer Res 2009
(Carcinoma, Squamous Cell...) :
All of these findings suggest that
Akt inhibition could
induce the MErT through decreased
NF-kappaB signaling and downregulation of Snail and Twist in OSCC cells
Gadgeel et al., Cancer 2009
(Carcinoma, Non-Small-Cell Lung...) :
Akt activates
nuclear factor kappa B (NF-kappaB) , which transcribes genes important for cell survival, invasion, and metastasis
Giri et al., Anticancer Res 2009
(Colonic Neoplasms) :
There was also a marked reduction of cyclin dependent kinase (CDK)2, CDK4 and cyclin B expression and up-regulation of CDK inhibitors ( p21, p27 ) and p53, accompanied by attenuation of
Akt signaling and
nuclear factor-kappa B (NF-kappaB) activation
Ottonello et al., Br J Pharmacol 2009
:
The activity of oxaprozin was related to inhibition of
Akt activation that, in turn,
prevented p38 MAPK, IKK and
NF-kappaB activation
Park et al., Carcinogenesis 2009
(Breast Neoplasms...) :
KPS-A decreased PMA induced transcriptional activation of
NF-kappaB and AP-1 and
inhibited PMA induced phosphorylation of ERK1/2 and
Akt
Jiang et al., J Hepatol 2009
:
The JAK/STAT- and
PI3K/Akt dependent pathways,
NF-kappaB activation and expression of the anti-apoptotic proteins Mcl-1 and A1 were evaluated
Yamazaki et al., J Immunol 2009
:
These results suggested that loss of GRP78 by SubAB leads to transient phosphorylation of
Akt and consequent
activation of
NF-kappaB through the ATF6 branch of the UPR
Bai et al., Int J Cancer 2009
(Cell Transformation, Neoplastic) :
Akt mediated regulation of
NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt ... Previous studies suggest that
Akt regulates transcriptional activity of the
nuclear factor-kappaB (NFkappaB) by inducing phosphorylation and subsequent degradation of inhibitor of kappaB ( IkappaB ) ... Our data suggest that the
stimulation of
NFkappaB by
Akt is dependent on the phosphorylation of p65 at S534, mediated by IKK ( IkappaB kinase) alpha and beta
Ke et al., Neurosci Res 2009
(Gliosis...) :
A2aR-selective antagonist Sch58261 decreased GFAP expression in a dose- and time dependent manner with increased activation of
Akt , and induced
activation of
NF-kappaB
Kim et al., Toxicological sciences : an official journal of the Society of Toxicology 2009
:
The MT-III induced antiapoptotic effects and increase in
NF-kappaB activity were
blocked by specific inhibitors of TrkA, phosphatidylinositol-3 kinase (PI3K),
Akt , or NF-kappaB, indicating that MT-III provides neuronal protection by activating NF-kappaB through the TrkA/PI3K/Akt signaling pathway
Fu et al., J Vet Med Sci 2009
(Inflammation) :
Vaspin did not inhibit the TNF-alpha ( 20 min ) activation of JNK, p38 and
NF-kappaB , but only slightly
inhibited Akt
Bandyopadhaya et al., Can J Microbiol 2009
(Cholera) :
Analysis of the mechanisms of Akt influences on cytokine response demonstrates that
Akt promotes
NF-kappaB activation
Chen et al., Molecular cancer 2010
(Carcinoma, Non-Small-Cell Lung...) :
The combination of GGTI-298 and TRAIL was more effective than each single agent in decreasing the levels of IkappaBalpha and p-Akt, implying that GGTI298/TRAIL activates
NF-kappaB and
inhibits Akt
Park et al., Toxicol In Vitro 2010
(Carcinoma, Squamous Cell...) :
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and
AKT , and
activation of
NF-kappaB
Wang et al., Chin Med Sci J 2009
:
The inhibition of phosphorylated
Akt by LY294002
led to the inhibition of
NF-kappaB in a dose dependent manner ... S. aureus induces apoptosis of U937 cells by inhibiting
Akt regulated
NF-kappaB
Tsou et al., J Cell Biochem 2010
:
TNF-alpha mediated an increase of NF-kappaB-specific DNA-protein complex formation, p65 translocation into nucleus,
NF-kappaB-luciferase activity was
inhibited by KP392,
Akt inhibitor, and rapamycin
Zhang et al., Diabetes Obes Metab 2010
(Diabetes Mellitus, Experimental...) :
Western blot analysis showed that TSN treatment enhanced
Akt phosphorylation and
inhibited NF-kappaB phosphorylation in cardiac tissues
Wang et al., J Biol Chem 2010
:
Shear induced interleukin-6 synthesis in chondrocytes : roles of E prostanoid ( EP ) 2 and EP3 in cAMP/protein kinase A- and
PI3-K/Akt dependent
NF-kappaB activation
Chen et al., J Biol Chem 2010
(Colorectal Neoplasms) :
rHSP90alpha induced the activities of ERK,
PI3K/Akt , and NF-kappaB p65, but only
NF-kappaB activation was
involved in HSP90alpha induced integrin alpha(V) expression
Yeh et al., J Surg Res 2010
(Myocardial Reperfusion Injury) :
Exogenous bradykinin administration was associated with the myocardial apoptotic response by inhibition of
NF-kappaB translocation, inflammatory cytokine production,
Akt activation , and elevation of the Bcl-2/Bax ratio via a NO-mediated pathway
Gong et al., Biol Pharm Bull 2010
(Pancreatic Neoplasms) :
Activation of p65
NF-kappaB was
dependent on the phosphorylation of
PI3K/Akt
Iyer et al., J Immunol 2011
:
Antioxidant c-FLIP inhibits Fas ligand induced
NF-kappaB activation in a phosphatidylinositol
3-kinase/Akt dependent manner
Banerjee et al., Breast Cancer Res Treat 2012
(Breast Neoplasms...) :
Moreover, previous studies have shown that Pg extracts decrease inflammation in lung cancer cell lines by inhibiting phosphatidylinositol-3,4,5-trisphosphate ( PI3K ) -dependent phosphorylation of
AKT in vitro and
inhibiting the activation of
NF-kB in vivo