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IL8 — PIK3R1
Text-mined interactions from Literome
Al-Okla et al., Cell Microbiol 1999
:
However,
PI-3K activation is not
involved in
IL-8 release
Dong et al., Cancer Res 2001
(Carcinoma, Squamous Cell...) :
Hepatocyte growth factor/scatter factor induced activation of MEK and
PI3K signal pathways
contributes to expression of proangiogenic cytokines
interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma ... Inhibitors of MEK ( U0126 ) and
PI3K ( LY294002 ) blocked p42/p44 ( erk ) and Akt, respectively, and partially
blocked HGF induced production of
IL-8 and VEGF, whereas the combination of U0126 and LY294002 completely inhibited expression of IL-8 and VEGF by UMSCC-11A
Shenoy et al., J Immunol 2003
:
Inhibition of
PI3K activity
blocked MBP stimulated O ( 2 ) ( - ) production, but not degranulation or
IL-8 production
Huang et al., FEMS Microbiol Lett 2005
(Inflammation) :
We show here that inhibition of
PI3K in T84 intestinal epithelial cells
results in augmentation of Salmonella induced
interleukin-8 (IL-8) production at the level of both protein and mRNA
Newcomb et al., J Biol Chem 2005
:
Phosphatidylinositol 3-kinase is
required for rhinovirus induced airway epithelial cell
interleukin-8 expression
Rhee et al., J Biol Chem 2006
:
Additionally, we determine that blocking
PI3K activation
reduces interleukin-8 production induced by flagellin in human colonic epithelial cells
Wrann et al., J Immunol 2007
(Sepsis) :
In addition,
PI3K inhibition
resulted in strongly elevated TLR-4 mediated generation of IL-1beta and
IL-8 in neutrophils when these cells were co-stimulated with C5a
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008
(Hyperglycemia) :
Resveratrol inhibits high glucose induced
PI3K/Akt/ERK dependent
interleukin-17 expression in primary mouse cardiac fibroblasts
Snoeks et al., Infect Immun 2008
:
Additionally, inhibition of
PI3K attenuated LPS induced proinflammatory
interleukin-8 (IL-8)
Yang et al., Microvasc Res 2009
(AIDS Dementia Complex) :
Inhibitors of STAT1, mitogen activated protein kinase kinase ( MEK ) ( PD98059 ), and phosphatidyl inositol 3 kinase
(PI3K) ( LY294002 ), blocked gp120 induced STAT1 activation and significantly
diminished IL-8- , IL-6-, and gp120 induced monocyte adhesion and migration across in vitro BBB models
Takeshima et al., BMC microbiology 2009
(Helicobacter Infections) :
PI3K inhibitor suppressed H. pylori
induced p65 phosphorylation and NF-kappaB transactivation, as well as
interleukin-8 expression
Fernandes et al., Mol Biol Cell 2009
:
Although Akt is also activated in response to proteasome inactivation, we found that the
PI3K dependent up-regulation of
IL-8 is independent of 3-phosphoinositide dependent protein kinase ( PDK)1 and Akt
Westra et al., BMC musculoskeletal disorders 2010
(Arthritis...) :
THP-1 and SF macrophages produced high levels of VEGF,
IL-8 , and MMP-9, and VEGF protein production was significantly
inhibited by
PI3K-inhibitor , and by both CaMKII inhibitors
Lin et al., J Biol Chem 2011
:
Thrombin induced IL-8/CXCL8 release and
IL-8/CXCL8-luciferase activity were
attenuated by a
PI3K inhibitor ( LY294002 ), an Akt inhibitor ( 1-L-6-hydroxymethyl-chiro-inositol-2- ( ( R ) -2-O-methyl-3-O-octadecylcarbonate ) ), and the dominant negative mutants of Rac1 ( RacN17 ) and Akt ( AktDN )
Bhattacharyya et al., J Biol Chem 2011
(Cystic Fibrosis...) :
However, overexpressing SHIP1 or inhibition of
PI3K in CF cells
suppressed IL-8 expression
Zhang et al., J Cell Physiol 2012
(Carcinoma, Non-Small-Cell Lung...) :
EGF stimulated
IL-8 production, phosphorylation of Akt and Erk, and cell proliferation and movement could be
inhibited by EGFR inhibitor ( Erlotinib ),
PI3K inhibitor ( GDC-0941 BEZ-235 and SHBM1009 ), and ERK1/2 inhibitor ( PD98059 )
Lai et al., International journal of biological sciences 2011
:
Moreover, we demonstrated that
IL-8 activated
PI3K following the same kinetics observed from IL-8 induction of cytoskeletal rearrangement, suggesting the participation of PI3K in these processes
Wu et al., Particle and fibre toxicology 2012
(MAP Kinase Signaling System) :
Pharmacological inhibition of ERK kinase and
PI3K activity
blocked DEP induced
IL-8 and IL-1ß expression
Britschgi et al., Cancer Cell 2012
(Breast Neoplasms...) :
Mechanistically,
PI3K/mTOR inhibition
increased IRS1 dependent activation of JAK2/STAT5 and secretion of
IL-8 in several cell lines and primary breast tumors
Knall et al., Proc Natl Acad Sci U S A 1997
:
Recently we reported that
IL-8 caused the activation of the Ras/Raf/extracellular signal regulated kinase ( ERK ) pathway in human neutrophils and that this activation was
dependent on
PI3K activity
Bavelloni et al., J Cell Sci 1999
(Osteosarcoma) :
Phosphatidylinositol 3-kinase translocation to the nucleus is
induced by
interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells