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DOCK4 — RAC1

Text-mined interactions from Literome

Yan et al., J Mol Biol 2006 : We have further provided evidence that the DOCK4-Ex49 binds to nucleotide free Rac as effectively as DOCK2 and DOCK4 and it is a potent Rac activator
Hiramoto et al., Exp Cell Res 2006 : Dock4 formed a complex with ELMO, and expression of active RhoG induced translocation of the Dock4-ELMO complex from the cytoplasm to the plasma membrane and enhanced the Dock4- and ELMO dependent Rac1 activation and cell migration
Upadhyay et al., Oncogene 2008 : We report that DOCK4 , a guanine nucleotide exchange factor (GEF) for Rac and a member of the CDM family of unconventional GEFs, mediates Wnt induced Rac activation in the canonical Wnt/beta-catenin pathway
Namekata et al., Proc Natl Acad Sci U S A 2010 : BDNF induces axonal sprouting through Dock dependent Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011 : Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Kiyokawa et al., Genes Dev 1998 : Activation of Rac1 by a Crk SH3 binding protein, DOCK180