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IRF6 — STAT1

Text-mined interactions from Literome

Nomura et al., Toxicol Lett 1998 (Ischemic Attack, Transient) : LPS caused intranuclear translocation of NF-kappaB, and IFNgamma induced phosphorylation of Jak2 and Stat1 , followed by the translocation of Stat1 into the nucleus
Stoiber et al., J Immunol 1999 : Neutralizing Abs to IL-10 were without effect on LPS mediated suppression of Stat1 activation
Nakagawa et al., Immunity 2002 (Gram-Negative Bacterial Infections...) : Introduction of SOCS-1 inhibited LPS induced NF-kappaB and STAT1 activation in macrophages
Pan et al., Drug Metab Dispos 2003 : Consistent with this result, the chlorzoxazone 6-hydroxylase and lauric acid 11-hydroxylase activities, as CYP2E1 representative activities, were reduced markedly by LPS in Stat1 ( +/+ ) but not in Stat1 ( -/- ) mice
Kristof et al., J Biol Chem 2003 (Inflammation) : LY294002, but not wortmannin, inhibited LPS/IFN-gamma dependent STAT1 phosphorylation at Ser-727 and STAT1 activity
Nishiya et al., J Biol Chem 2004 : Finally, LPS induced effective interferon-beta production and subsequent Stat1 phosphorylation in macrophages expressing full-length TLR4 but not other cell surface TLR chimeras
Pawate et al., J Neurosci Res 2004 (Encephalitis...) : Phox inhibitors and catalase also suppressed LPS/IFNgamma induced expression of cytokines, i.e., interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)alpha and blocked LPS activation of MAP kinases ( i.e., p38 MAPK, c-Jun N-terminal kinase and extracellular signal regulated kinase ), NFkappaB, and IFNgamma induced STAT1 phosphorylation
Huang et al., Mol Pharmacol 2004 : LPS increased the phosphorylation of STAT1alpha at serine 727 in IFNgamma treated MAEC
Tanaka et al., Am J Respir Cell Mol Biol 2005 : STAT-1 and type I IFN receptor knockout mice have macrophages that are defective in IFN signaling, yet LPS stimulation induces inhibitory C/EBPbeta, demonstrating that other cytokines can induce this repressor
Qin et al., Blood 2005 : LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia
Lee et al., Biochem Pharmacol 2005 : PP1 suppressed STAT1 phosphorylation induced by LPS , but not by IFNbeta suggesting that STKs are involved in the primary downstream signaling pathways of TLR4, but not the secondary signaling pathways downstream of IFNbeta receptor
Choi et al., J Neurosci Res 2005 (Alcohol-Induced Disorders, Nervous System...) : Lipopolysaccharide (LPS), gangliosides, and interferon (IFN)-gamma induced the inflammatory activation of glia, which was differentially influenced by ethanol : 1 ) ethanol inhibited LPS- or gangliosides induced, but not IFNgamma induced, glial activation as demonstrated by the production of nitric oxide and the expression of inflammatory genes such as interleukin-1beta, tumor necrosis factor-alpha, IP-10, and CD86 ; 2 ) nuclear factor (NF)-kappaB or JAK/STAT1 pathway was necessary for LPS- or IFNgamma induced glial activation, respectively ; 3 ) ethanol inhibited LPS induced NF-kappaB activation ; and 4 ) ethanol did not significantly affect IFNgamma induced STAT1/IRF-1 activation
Guo et al., J Immunol 2005 : IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while IRF-1 and STAT1 are induced to bind to the two ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Liu et al., Zhonghua Shao Shang Za Zhi 2005 : In addition, the cells were divided into normal control, LPS stimulation, JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups ... LPS could activate JAK2, STAT1 and STAT3 within 2 hours, especially the activation of STAT3 appeared more quickly, peaking at 10 minutes after LPS stimulation ( 7.47 +/- 0.56 )
Leng et al., Exp Hematol 2006 (Graft vs Host Disease...) : Concomitantly, SAHA treatment inhibited phosphorylation of STAT1 and STAT3 in response to LPS and alloactivation in vitro
Prêle et al., Immunology 2006 : SOCS3 over-expression had no effect on TNF-alpha mRNA levels induced by LPS or LPS plus IL-10, or on IL-10 phosphorylation of STAT3, STAT1 and ERK1/2
Qin et al., J Immunol 2006 : IL-10 inhibits LPS induced IFN-beta gene expression and subsequent STAT-1alpha activation, but does not affect NF-kappaB activation
Arjcharoen et al., Infect Immun 2007 : Unlike the wild type, the LPS mutant could readily stimulate Y701-STAT-1 phosphorylation ( pY701-STAT-1 ) and interferon-regulatory factor 1 (IRF-1) expression, both of which are essential transcription factors of iNOS
Tamassia et al., Eur J Immunol 2007 : The IFN-gamma induced STAT1 activation and the lipopolysaccharide (LPS) induced NF-kappaB activation were not enhanced if neutrophils were exposed to both stimuli, whereas both transcription factors were activated by IFN-gamma or LPS in monocytes
Paukkeri et al., Br J Pharmacol 2007 : However, PPARalpha agonists did not alter LPS induced iNOS mRNA expression or activation of NF-kappaB or STAT1 which are important transcription factors for iNOS
Bafica et al., J Immunol 2007 (Endotoxemia) : In this study, we demonstrate that induction of LRG47 by LPS is not dependent on MyD88 signaling, but rather, requires STAT-1 and IFN-beta
Huang et al., J Clin Invest 2007 (Inflammation...) : Enforced expression of STAT1, IRF-1 , or GATA-1 enhanced phosphorylation of STAT1 , STAT3, and STAT5 in cultured Gata1-deficient murine megakaryocytes, with concomitant megakaryocyte maturation
Ha et al., J Immunol 2008 : IFN-beta gene induction by flagellin, LPS , or RANKL was dependent on STAT1 activation
Ichikawa et al., Endocrinology 2008 (Inflammation) : In RAW264.7 cells, a murine macrophage cell line, LNO ( 2 ) and OA-NO ( 2 ) inhibited the lipopolysaccharide (LPS) induced STAT1 phosphorylation and the STAT1 dependent transcriptional activity, thereby suppressing expression of its target gene such as iNOS and MCP-1 ... Knockdown of MKP-1 by MKP-1 small interfering RNA enhanced the LPS induced STAT1 phosphorylation, suggesting that MKP-1 acts as a negative regulator for LPS induced STAT signaling
Xu et al., Mol Immunol 2008 : In addition, PTP1B inhibits LPS induced Tyk2 and STAT1 activation
Tsoyi et al., Cell Signal 2008 : LPS induced NF-kappaB and STAT-1 activation was partially prevented by HO-1 overexpression ... Furthermore, HO-1 siRNA partly reversed not only the LPS induced NF-kappaB activation and STAT-1 phosphorylation but also inhibition of these actions by CKD 712
Wang et al., J Biol Chem 2009 : We found that STAT-1 , a transcription factor known to mediate iNOS induction by interferon-gamma, was more potently activated by LPS in MKP-1 ( -/- ) macrophages than in wild-type cells
Gorina et al., Glia 2011 : LPS also induced delayed Jak1/Stat1 activation, which was MyD88 independent but was not mediated by IFN-ß
Kang et al., J Ethnopharmacol 2011 (Inflammation) : The extract also inhibited LPS induced I?Ba degradation and MAPK activation as well as LPS/IFN-? induced STAT1 activation, effects observed at a higher concentration than that required to suppress iNOS
Min et al., Int Immunopharmacol 2011 (Inflammation) : Withaferin A had no effect on LPS induced Akt and ERK phosphorylation, but phosphorylation of p38 and JNK was slightly decreased by withaferin A. Withaferin A significantly inhibited LPS induced STAT1 and STAT3 phosphorylation in a dose dependent manner
Takahashi et al., Life Sci 2011 : Interferon ( IFN ) -? was identified as the major cytokine which mediates LPS induced STAT-1 activation and resultant iNOS expression
Min et al., J Pineal Res 2012 : Furthermore, melatonin inhibited LPS induced STAT1/3 phosphorylation and interferon-gamma activated sequence ( GAS ) -driven transcriptional activity
Park et al., Neurochem Int 2012 : Furthermore, ar-turmerone decreased the phosphorylation of LPS induced STAT-1
Liu et al., Chinese medicine 2012 : This study demonstrates that a-MG attenuates LPS mediated activation of MAPK, STAT1 , c-Fos, c-Jun and EIK-1, inhibiting TNF-a and IL-4 production in U937 cells
Nam et al., J Pept Sci 2012 : Western blotting revealed that LPS induced activation of STAT1 and STAT5 in macrophages was significantly inhibited by CopA3
Liu et al., PloS one 2012 : This is consistent with the finding that AG490, a specific JAK2 inhibitor, significantly inhibited LPS induced STAT1 phosphorylation with almost completely diminished iNOS expression
Lee et al., J Ethnopharmacol 2013 (Disease Models, Animal...) : Treatment of primary macrophages with TCC in vitro significantly inhibited all of the inflammatory parameters measured, including LPS induced NO and PGE ( 2 ) production, iNOS and COX-2 expression, I?Ba degradation, IKK phosphorylation, and MAPK and STAT1 activation
Liu et al., Biochem Biophys Res Commun 2013 (Hepatitis...) : We postulated that IL-30 might function through gp130 mediated signaling pathways and then demonstrated that IL-30 affects LPS induced inflammation through the STAT1 , STAT3, and ERK signaling pathways
Gong et al., Evidence-based complementary and alternative medicine : eCAM 2013 : Additionally, LPS stimulated the activation of STAT1/3 signaling concomitant with downregulated expression of Tyk inhibiting SOCS3
Nguyen et al., Oncogene 1997 : Most strikingly, induction of IRF-1 and IRF/RelA expression resulted in a significant increase in STAT1 ( p91 ) protein and increased ISGF3 DNA binding activity, suggesting that IRF-1 tumor suppressor activity may involve a novel mechanism which activates the JAK-STAT pathway through STAT1
McDonald et al., Biochemistry 1998 : To circumvent this problem, we developed an alternative procedure which allowed us to show that in neutrophils, LPS and TNFalpha induce a NF-kappaB DNA binding activity which essentially consists of p50/RelA dimers, and that IFNgamma promotes the binding of STAT1 homodimers to the IFNgamma response region of the FcgammaRI promoter
Gao et al., J Immunol 1998 : LPS induced both the tyrosine phosphorylation of Stat1alpha and the production of nitric oxide in a time- and dose dependent manner ... Cycloheximide inhibited LPS mediated Stat1alpha phosphorylation ... LPS stimulated phosphorylation of Stat1alpha in peritoneal macrophages derived from IFN-gamma-knockout mice, negating any possibility that IFN-gamma was the mediator ... By contrast, neutralizing Ig raised against mouse IFN-alphabeta inhibited both the delayed LPS mediated phosphorylation of Stat1alpha and the rapid induction of phosphorylation induced by supernatants from LPS stimulated cultures ... Collectively, these results show that LPS induced IFN-alphabeta production, Stat1alpha activation, and nitrite accumulation closely parallel one another, suggesting that indirect activation of transcription factor Stat1alpha by IFN-alphabeta is a critical determinant of LPS mediated inducible nitric oxide synthase gene expression
Cheng et al., J Interferon Cytokine Res 1998 : A requirement for Stat1 binding to ISRE for IFN-gamma and IFN regulatory factor-1 (IRF-1) binding to ISRE for LPS , poly ( I:C ), and virus has been reported