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DNMT1 — MYLIP

Text-mined interactions from Literome

Benetti et al., Nature structural & molecular biology 2008 : These results identify a pathway by which miR-290 directly regulates Rbl2 dependent Dnmt expression, indirectly affecting telomere-length homeostasis
Lu et al., J Virol 2010 : We show that ectopic expression of miR-K12-4-5p reduces Rbl2 protein expression and increases DNMT1 , -3a, and -3b mRNA levels relative to the levels for control cells
Pan et al., J Immunol 2010 (Lupus Erythematosus, Systemic) : Additionally, inhibition of miR-21 and miR-148a expression in CD4+ T cells from patients with lupus could increase DNMT1 expression and attenuate DNA hypomethylation
Huang et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : The forced expression of miR-152 in liver cell lines resulted in a marked reduction of the expression of DNMT1 at both the mRNA and protein levels by directly targeting the 3 ' untranslated regions of DNMT1
Zhao et al., Arthritis Rheum 2011 (Lupus Erythematosus, Systemic) : We demonstrated that miR-126 directly inhibits Dnmt1 translation via interaction with its 3'-untranslated region, and that overexpression of miR-126 in CD4+ T cells can significantly reduce Dnmt1 protein levels
Zhu et al., Med Oncol 2012 (Stomach Neoplasms) : Furthermore, ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation, but no obvious change was found in apoptosis rate ... Additionally, the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer, and this may in turn result in over-expression of DNMT1 and promote DNA hypermethylation
Zeng et al., FEBS Lett 2012 (Cholangiocarcinoma...) : In this study, we found that miR-124 was down-regulated in HCV-ICC and the induction of DNMT1 by HCVc mediated the suppression of miR-124
Chavali et al., Biochem Biophys Res Commun 2012 (Diabetes Mellitus...) : We tested the hypothesis that miR-133a regulates DNA methylation by inhibiting Dnmt-1 ( maintenance ) and Dnmt-3a and -3b ( de novo ) methyl transferases in diabetic hearts by using Ins2 ( +/- ) Akita ( diabetic ) and C57BL/6J ( WT ), mice and HL1 cardiomyocytes ... The results revealed that miR-133a is inhibited but Dnmt-1 and -3b are induced in Akita suggesting that attenuation of miR-133a induces both maintenance ( Dnmt-1 ) - and de novo - methylation ( Dnmt-3b ) in diabetes
Bourguignon et al., J Biol Chem 2012 (Carcinoma, Squamous Cell...) : Our results demonstrate that the anti-miR-302 inhibitor not only enhances the expression of AOF1/AOF2 and DNMT1 but also abrogates the production of cIAP-1, cIAP-2, and XIAP and HA-CD44v3 mediated cancer stem cell functions
Ji et al., Carcinogenesis 2013 (Cell Transformation, Neoplastic) : Our results showed that the expression of miRNA-152 (miR-152) was specifically downregulated in NiS transformed cells via promoter DNA hypermethylation, whereas ectopic expression of miR-152 in NiS transformed cells resulted in a marked reduction of DNMT1 expression ... Moreover, inhibition of miR-152 expression in 16HBE cells could increase DNMT1 expression and result in an increase in DNA methylation, DNMT1 and MeCP2 binding to miR-152 promoter, indicating an interaction between miR-152 and DNMT1 is regulated by a double negative circuit
Qin et al., J Dermatol Sci 2013 (Lupus Erythematosus, Systemic) : Overexpression of miR-29b resulted in significant reduction of sp1 and DNMT1 expression ... Our study suggests that miR-29b negatively regulates DNMT1 expression by targeting sp1 in T cells ... The overexpression of miR-29b contributes to the reduction of DNMT1 levels and thereby DNA hypomethylation in SLE
Li et al., Blood 2013 (Leukemia, Myeloid, Acute) : Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a , HDAC3, KIT, CCND1, and MDM2 directly, and increases PTEN indirectly