◀ Back to RBBP7
RBBP4 — RBBP7
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD4 (CHD4)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 alpha (GATAD2A)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 beta (GATAD2B)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MTA2 (MTA2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD3 (CHD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD4 (CHD4)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 alpha (GATAD2A)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 beta (GATAD2B)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MTA2 (MTA2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD3 (CHD3)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC2 (HDAC2)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
RBBP4 (RBBP4)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
RBBP4 (RBBP4)
→
RBBP7 (RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC1 (HDAC1)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
RBBP7 (RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SIN3a (SIN3A)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SAP30 (SAP30)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SIN3b (SIN3B)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SAP18 (SAP18)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
SIN3a (SIN3A)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
SAP30 (SAP30)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
SIN3b (SIN3B)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
SAP18 (SAP18)
(modification, collaborate)
Zhang et al., Cell 1997, Zhang et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins:
Su(fu) (SUFU)
→
Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B)
→
Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD3/SMAD4 complex (SMAD3-SMAD4)
(modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1)
(modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Kim et al., Genes Dev 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Janknecht et al., Genes Dev 1998, Feng et al., Genes Dev 1998, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, reporter gene, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD2/PRMT5 Complex complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
PRMT5 Complex complex (PRMT5-WDR77)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD2/PRMT5 Complex complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
PRMT5 Complex complex (PRMT5-WDR77)
→
NuRD/MBD2 Complex (MeCP1) complex (MTA2-MBD2-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
-
NCI Pathway Database Hedgehog signaling events mediated by Gli proteins:
SMO/beta Arrestin2 complex (SMO-ARRB2)
→
Su(fu)/SIN3/HDAC complex complex (SUFU-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, activates)
Cheng et al., Proc Natl Acad Sci U S A 2002, Paces-Fessy et al., Biochem J 2004, Haycraft et al., PLoS Genet 2005
Evidence: mutant phenotype, reporter gene, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
GATA1/Fog1 complex (GATA1-ZFPM1)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
GATA1/Fog1 complex (GATA1-ZFPM1)
→
NuRD/MBD3 Complex/GATA1/Fog1 complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-GATA1-ZFPM1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD3 Complex/GATA1/Fog1 complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-GATA1-ZFPM1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Hong et al., EMBO J 2005, Rodriguez et al., EMBO J 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD4 (CHD4)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 alpha (GATAD2A)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 beta (GATAD2B)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD3 (CHD3)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MTA2 (MTA2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD3 (MBD3)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD4 (CHD4)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 alpha (GATAD2A)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
p66 beta (GATAD2B)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
CHD3 (CHD3)
→
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MTA2 (MTA2)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD/MBD3 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD3 (MBD3)
(modification, collaborate)
Zhang et al., Genes Dev 1999, Brackertz et al., J Biol Chem 2002, Woodage et al., Proc Natl Acad Sci U S A 1997, Tong et al., Nature 1998, Xue et al., Mol Cell 1998
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SIN3 complex complex (SIN3A-SAP18-SAP30-SIN3B)
(modification, collaborate)
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
SIN3 complex complex (SIN3A-SAP18-SAP30-SIN3B)
(modification, collaborate)
-
NCI Pathway Database Regulation of Telomerase:
NFX1/SIN3/HDAC complex complex (ZNFX1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HPV-16 E6/E6AP complex (UBE3A)
(modification, collaborate)
Liu et al., J Biol Chem 2005, Galloway et al., Cold Spring Harb Symp Quant Biol 2005
Evidence: physical interaction
-
NCI Pathway Database Regulation of Telomerase:
NFX1/SIN3/HDAC complex complex (ZNFX1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex complex (UBE3A-ZNFX1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Liu et al., J Biol Chem 2005, Galloway et al., Cold Spring Harb Symp Quant Biol 2005
Evidence: physical interaction
-
NCI Pathway Database Regulation of Telomerase:
HPV-16 E6/E6AP complex (UBE3A)
→
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex complex (UBE3A-ZNFX1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Liu et al., J Biol Chem 2005, Galloway et al., Cold Spring Harb Symp Quant Biol 2005
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
TGIF/SIN3/HDAC complex/CtBP complex (TGIF1-CTBP1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4)
(modification, inhibits)
Wotton et al., Cell 1999, Yahata et al., J Biol Chem 2000, Melhuish et al., J Biol Chem 2000, Wotton et al., Cell Growth Differ 2001, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
TGIF/SIN3/HDAC complex/CtBP complex (TGIF1-CTBP1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1)
(modification, inhibits)
Wotton et al., Cell 1999, Yahata et al., J Biol Chem 2000, Melhuish et al., J Biol Chem 2000, Wotton et al., Cell Growth Differ 2001, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NCoR1 (NCOR1)
(modification, collaborate)
Heinzel et al., Nature 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SIN3/HDAC complex/NCoR1 complex (SIN3A-SAP18-SAP30-SIN3B-NCOR1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Heinzel et al., Nature 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NCoR1 (NCOR1)
→
SIN3/HDAC complex/NCoR1 complex (SIN3A-SAP18-SAP30-SIN3B-NCOR1-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Heinzel et al., Nature 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4)
(modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SKI/SIN3/HDAC complex/NCoR1 complex (SKI-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
Cbp/p300/MSG1 complex (EP300_CREBBP-CITED1)
(modification, inhibits)
Luo et al., Genes Dev 1999, Akiyoshi et al., J Biol Chem 1999, Yahata et al., J Biol Chem 2000, Simonsson et al., J Biol Chem 2006, Tu et al., J Biol Chem 2007, Shioda et al., Proc Natl Acad Sci U S A 1998, Pouponnot et al., J Biol Chem 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
CHD4 (CHD4)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
p66 alpha (GATAD2A)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
CHD3 (CHD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
p66 beta (GATAD2B)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MTA2 (MTA2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD3 (MBD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD4 (CHD4)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 alpha (GATAD2A)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
CHD3 (CHD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD2 (MBD2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
p66 beta (GATAD2B)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MTA2 (MTA2)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
HDAC complex complex (HDAC1-HDAC2-RBBP4-RBBP7)
→
MBD3 (MBD3)
(modification, collaborate)
Le Guezennec et al., Mol Cell Biol 2006
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD2 (MBD2)
→
NuRD/MBD3/MBD3L2 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-MBD3L2-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
MBD3L2 (MBD3L2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
NuRD Complex complex (MTA2-MBD2-CHD3-CHD4-MBD3-GATAD2A-GATAD2B-RBBP7-HDAC1-RBBP4-HDAC2)
→
NuRD/MBD3/MBD3L2 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-MBD3L2-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
MBD3L2 (MBD3L2)
→
NuRD/MBD3/MBD3L2 Complex complex (MTA2-MBD3-CHD3-CHD4-GATAD2A-GATAD2B-MBD3L2-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Jin et al., J Biol Chem 2005
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Mad/Max complex (MXD1-MAX)
→
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Laherty et al., Cell 1997, Sommer et al., Curr Biol 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
Mad/Max complex (MXD1-MAX)
→
SIN3/HDAC complex/Mad/Max complex (SIN3A-SAP18-SAP30-SIN3B-MXD1-MAX-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Laherty et al., Cell 1997, Sommer et al., Curr Biol 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events mediated by HDAC Class I:
SIN3/HDAC complex complex (SIN3A-SAP18-SAP30-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SIN3/HDAC complex/Mad/Max complex (SIN3A-SAP18-SAP30-SIN3B-MXD1-MAX-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Laherty et al., Cell 1997, Sommer et al., Curr Biol 1997
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SnoN/SIN3/HDAC complex/NCoR1 complex (SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4)
(modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SnoN/SIN3/HDAC complex/NCoR1 complex (SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
→
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 complex (SMAD2-SMAD4-SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Regulation of nuclear SMAD2/3 signaling:
SMAD2/SMAD2/SMAD4 complex (SMAD2-SMAD4)
→
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 complex (SMAD2-SMAD4-SKIL-NCOR1-SIN3A-SAP30-SAP18-SIN3B-RBBP7-HDAC1-RBBP4-HDAC2)
(modification, collaborate)
Stroschein et al., Science 1999
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
RBBP4
→
RBBP7
(reaction)
Cao et al., Science 2002, Kuzmichev et al., Genes Dev 2002, Kuzmichev et al., Mol Cell 2004, Martin et al., J Biol Chem 2006, Fujita et al., Dev Cell 2007, Margueron et al., Mol Cell 2008, Foltz et al., Cell 2009, Dunleavy et al., Cell 2009, Shuaib et al., Proc Natl Acad Sci U S A 2010, McCabe et al., Proc Natl Acad Sci U S A 2012, Swalm et al., Biochem J 2013
-
Reactome Reaction:
RBBP4
→
RBBP7
(direct_complex)
-
Reactome Reaction:
RBBP4
→
RBBP7
(indirect_complex)
Okada et al., Nat Cell Biol 2006, Fujita et al., Dev Cell 2007, Perpelescu et al., J Cell Biol 2009, Foltz et al., Cell 2009, Dunleavy et al., Cell 2009, Shuaib et al., Proc Natl Acad Sci U S A 2010
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of HDAC1-MBD3-MBD2-MBD2-RBBP7-RBBP4-RCOR1-MTA2-CHD3
Humphrey et al., J Biol Chem 2001
-
IRef Biogrid Interaction:
RBBP4
—
RBBP7
(colocalization, biochemical)
Havugimana et al., Cell 2012
-
IRef Biogrid Interaction:
RBBP4
—
RBBP7
(physical association, affinity chromatography technology)
Kristensen et al., Nat Methods 2012
-
MIPS CORUM hNURF complex:
hNURF complex complex (BPTF-RBBP4-RBBP7-SMARCA1)
Barak et al., EMBO J 2003*
-
MIPS CORUM Polycomb repressive complex 2 (PRC 2):
Polycomb repressive complex 2 (PRC 2) complex (EED-EZH2-RBBP4-RBBP7-SUZ12)
Kuzmichev et al., Genes Dev 2002
-
MIPS CORUM ALL-1 supercomplex:
ALL-1 supercomplex complex (KDM1A-CHD3-CPSF2-EFTUD2-HDAC1-HDAC2-MBD3-KMT2A-MTA2-RAN-RBBP4-RBBP5-RBBP7-SAP18-SAP30-SIN3A-SMARCA2-SMARCA5-SMARCB1-SMARCC1-SMARCC2-SYMPK-TAF1-TAF12-TAF6-TAF9-TBP-WDR5)
Nakamura et al., Mol Cell 2002
-
MIPS CORUM HCF-1 complex:
HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1)
Wysocka et al., Genes Dev 2003
-
MIPS CORUM SNF2h-cohesin-NuRD complex:
SNF2h-cohesin-NuRD complex complex (BAZ1A-CHD3-HDAC1-HDAC2-MBD2-MBD3-MTA1-MTA2-RAD21-RBBP4-RBBP7-SMARCA5-SMC1A-SMC3-STAG1-STAG2)
Hakimi et al., Nature 2002
-
MIPS CORUM Sin3 complex:
Sin3 complex complex (HDAC1-HDAC2-RBBP4-RBBP7-SAP18-SAP30-SIN3A)
Zhang et al., Mol Cell 1998
-
MIPS CORUM ING2 complex:
ING2 complex complex (ARID4A-BRMS1-BRMS1L-HDAC1-HDAC2-ING2-RBBP4-RBBP7-SAP130-SAP30-SIN3A-SUDS3)
Doyon et al., Mol Cell 2006
-
MIPS CORUM mSin3A complex:
mSin3A complex complex (HDAC1-HDAC2-RBBP4-RBBP7-SIN3A)
Hassig et al., Cell 1997*
-
MIPS CORUM SIN3 complex:
SIN3 complex complex (HDAC1-HDAC2-RBBP4-RBBP7-SAP18-SAP30-SIN3A)
Zhang et al., Cell 1997
-
MIPS CORUM NuRD.1 complex:
NuRD.1 complex complex (CHD4-HDAC2-MBD3-MTA1-MTA3-RBBP4-RBBP7)
Xue et al., Mol Cell 1998
-
MIPS CORUM SAP complex (Sin3-associated protein complex):
SAP complex (Sin3-associated protein complex) complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP130-SAP30-SIN3A)
Xue et al., Mol Cell 1998
-
MIPS CORUM SAP complex (Sin3-associated protein complex):
SAP complex (Sin3-associated protein complex) complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP130-SAP30-SIN3A-SUDS3)
Fleischer et al., Mol Cell Biol 2003
-
MIPS CORUM SIN3-HDAC-SAP30-ARID4 complex:
SIN3-HDAC-SAP30-ARID4 complex complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP30-SIN3A)
Lai et al., Mol Cell Biol 2001
-
MIPS CORUM Mi2/NuRD complex:
Mi2/NuRD complex complex (CHD4-HDAC1-HDAC2-MBD3-MTA2-RBBP4-RBBP7)
Zhang et al., Cell 1998
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Zhang et al., Genes Dev 1999
-
MIPS CORUM Anti-HDAC2 complex:
Anti-HDAC2 complex complex (KDM1A-CHD3-CHD4-GSE1-GTF2I-HDAC1-HDAC2-HMG20B-MTA1-MTA2-PHF21A-RBBP4-RBBP7-RCOR1-ZMYM2-ZMYM3-SIN3A-SIN3B)
Hakimi et al., J Biol Chem 2003
-
MIPS CORUM HDAC1-associated protein complex:
HDAC1-associated protein complex complex (KDM1A-CHD3-HDAC1-MBD2-MBD3-MTA2-RBBP4-RBBP7-RCOR1)
Humphrey et al., J Biol Chem 2001
-
MIPS CORUM HDAC1-associated core complex cII:
HDAC1-associated core complex cII complex (CHD3-HDAC1-MBD2-MBD3-MTA2-RBBP4-RBBP7-RCOR1-GATAD2A-GATAD2B)
Humphrey et al., J Biol Chem 2001
-
MIPS CORUM HDAC2-asscociated core complex:
HDAC2-asscociated core complex complex (CHD3-HDAC2-MBD3-MTA2-RBBP4-RBBP7-GATAD2A-GATAD2B)
Humphrey et al., J Biol Chem 2001
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-GATAD2B-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Feng et al., Genes Dev 2001
-
MIPS CORUM MeCP1 complex:
MeCP1 complex complex (CHD4-GATAD2B-HDAC1-HDAC2-MBD2-MBD3-MTA2-RBBP4-RBBP7)
Feng et al., Mol Cell Biol 2002
-
MIPS CORUM SIN3-SAP25 complex:
SIN3-SAP25 complex complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP130-SAP18-SAP30-SIN3A-SUDS3)
Shiio et al., Mol Cell Biol 2006
-
MIPS CORUM SIN3-HDAC-SAP30-ARID4 complex:
SIN3-HDAC-SAP30-ARID4 complex complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP30-SIN3A)
Fleischer et al., Mol Cell Biol 2003
-
MIPS CORUM BRMS1-SIN3-HDAC complex:
BRMS1-SIN3-HDAC complex complex (BRMS1-HDAC1-HDAC2-RBBP4-RBBP7-SAP30-SIN3A-SIN3B)
Meehan et al., J Biol Chem 2004
-
MIPS CORUM SIN3-HDAC-SAP30-ARID4 complex:
SIN3-HDAC-SAP30-ARID4 complex complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP30-SIN3A)
Laherty et al., Mol Cell 1998
-
MIPS CORUM SIN3 complex:
SIN3 complex complex (HDAC1-HDAC2-RBBP4-RBBP7-SAP18-SAP30-SIN3A)
Kuzmichev et al., Mol Cell Biol 2002
-
MIPS CORUM SIN3-ING1b complex I:
SIN3-ING1b complex I complex (ARID4B-HDAC1-HDAC2-ING1-RBBP4-RBBP7-SAP18-SAP30-SIN3A)
Kuzmichev et al., Mol Cell Biol 2002
-
MIPS CORUM SIN3-ING1b complex II:
SIN3-ING1b complex II complex (ACTL6A-ARID1A-ARID4B-HDAC1-HDAC2-ING1-RBBP4-RBBP7-SAP18-SAP30-SIN3A-SMARCA4-SMARCB1-SMARCC1-SMARCC2-SMARCD1)
Kuzmichev et al., Mol Cell Biol 2002
-
MIPS CORUM SIN3-SAP25 complex:
SIN3-SAP25 complex complex (ARID4B-HDAC1-HDAC2-RBBP4-RBBP7-SAP130-SAP18-SAP30-SIN3A-SUDS3)
Shiio et al., Mol Cell Biol 2006
-
MIPS CORUM MTA1 complex:
MTA1 complex complex (HDAC2-MBD3-MTA1-RBBP4-RBBP7)
Yao et al., J Biol Chem 2003
-
MIPS CORUM MTA2 complex:
MTA2 complex complex (CHD4-HDAC1-HDAC2-MBD3-MTA2-RBBP4-RBBP7-SIN3A-SIN3B)
Yao et al., J Biol Chem 2003
-
MIPS CORUM MTA1-HDAC core complex:
MTA1-HDAC core complex complex (HDAC2-MTA1-RBBP4-RBBP7)
Yao et al., J Biol Chem 2003
-
MIPS CORUM hNURF complex:
hNURF complex complex (BPTF-RBBP4-RBBP7-SMARCA1)
Banting et al., Hum Mol Genet 2005*
-
MIPS CORUM Polycomb repressive complex 3 (PRC3):
Polycomb repressive complex 3 (PRC3) complex (EED-EZH2-RBBP4-RBBP7-SUZ12)
Kuzmichev et al., Mol Cell 2004
-
MIPS CORUM Polycomb repressive complex 2 (PRC2):
Polycomb repressive complex 2 (PRC2) complex (EED-EZH2-RBBP4-RBBP7-SUZ12)
Kuzmichev et al., Mol Cell 2004
-
IRef Corum Interaction:
Complex of 21 proteins
(association, chromatography technology)
Kuzmichev et al., Mol Cell 2004
-
IRef Corum Interaction:
Complex of 33 proteins
(association, ion exchange chromatography)
Hakimi et al., Nature 2002
-
IRef Corum Interaction:
Complex of 19 proteins
(association, anti bait coimmunoprecipitation)
Kuzmichev et al., Mol Cell Biol 2002
-
IRef Corum Interaction:
Complex of MBD2-HDAC2-RBBP4-MTA2-MBD3-RBBP7-HDAC1-CHD4
(association, pull down)
Zhang et al., Genes Dev 1999
-
IRef Corum Interaction:
Complex of 11 proteins
(association, chromatography technology)
Yao et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of 21 proteins
(association, anti tag coimmunoprecipitation)
Shiio et al., Mol Cell Biol 2006
-
IRef Corum Interaction:
Complex of 37 proteins
(association, cosedimentation through density gradient)
Feng et al., Genes Dev 2001
-
IRef Corum Interaction:
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Humphrey et al., J Biol Chem 2001
-
IRef Corum Interaction:
Complex of 33 proteins
(association, chromatography technology)
Kuzmichev et al., Mol Cell Biol 2002
-
IRef Corum Interaction:
Complex of 29 proteins
(association, anti bait coimmunoprecipitation)
Fleischer et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 28 proteins
(association, anti bait coimmunoprecipitation)
Fleischer et al., Mol Cell Biol 2003
-
IRef Corum Interaction:
Complex of 57 proteins
(association, affinity chromatography technology)
Nakamura et al., Mol Cell 2002
-
IRef Corum Interaction:
Complex of 19 proteins
(association, affinity chromatography technology)
Yao et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of 17 proteins
(association, anti tag coimmunoprecipitation)
Humphrey et al., J Biol Chem 2001
-
IRef Corum Interaction:
Complex of RBBP4-SIN3A-HDAC1-RBBP7-HDAC2
(association, anti bait coimmunoprecipitation)
Hassig et al., Cell 1997*
-
IRef Corum Interaction:
Complex of 17 proteins
(association, affinity chromatography technology)
Xue et al., Mol Cell 1998
-
IRef Corum Interaction:
Complex of 17 proteins
(association, anti tag coimmunoprecipitation)
Banting et al., Hum Mol Genet 2005*
-
IRef Corum Interaction:
Complex of 25 proteins
(association, mass spectrometry studies of complexes)
Doyon et al., Mol Cell 2006
-
IRef Corum Interaction:
Complex of 37 proteins
(association, anti bait coimmunoprecipitation)
Hakimi et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of HDAC1-RBBP4-SAP30-SIN3B-HDAC2-RBBP7-SIN3A-BRMS1
(association, anti tag coimmunoprecipitation)
Meehan et al., J Biol Chem 2004
-
IRef Corum Interaction:
Complex of 13 proteins
(association, affinity chromatography technology)
Yao et al., J Biol Chem 2003
-
IRef Corum Interaction:
Complex of 20 proteins
(association, anti tag coimmunoprecipitation)
Wysocka et al., Genes Dev 2003
-
IRef Corum Interaction:
Complex of 31 proteins
(association, cosedimentation through density gradient)
Humphrey et al., J Biol Chem 2001
-
IRef Corum Interaction:
Complex of ARID4B-RBBP7-HDAC1-RBBP4-SAP30-HDAC2-SAP130-SIN3A
(association, affinity chromatography technology)
Xue et al., Mol Cell 1998
-
IRef Corum Interaction:
Complex of 29 proteins
(association, anti bait coimmunoprecipitation)
Kuzmichev et al., Mol Cell Biol 2002
-
IRef Corum Interaction:
Complex of MBD3-MTA2-HDAC1-RBBP4-HDAC2-CHD4-RBBP7
(association, affinity chromatography technology)
Zhang et al., Cell 1998
-
IRef Dip Interaction:
Complex of CENPA-NPM1-RUVBL1-RBBP4-RBBP7-RUVBL2-HJURP
(tandem affinity purification)
Shuaib et al., Proc Natl Acad Sci U S A 2010
-
IRef Dip Interaction:
Complex of 21 proteins
(tandem affinity purification)
Shuaib et al., Proc Natl Acad Sci U S A 2010
-
IRef Dip Interaction:
Complex of 19 proteins
(tandem affinity purification)
Shuaib et al., Proc Natl Acad Sci U S A 2010
-
IRef Dip Interaction:
Complex of 19 proteins
(anti tag coimmunoprecipitation)
Pasini et al., Nature 2010
-
IRef Hprd Interaction:
RBBP4
—
RBBP7
(in vivo)
Nikolaev et al., Biochem Biophys Res Commun 2004
-
IRef Hprd Interaction:
Complex of 257 proteins
(in vivo)
Hakimi et al., J Biol Chem 2003
-
IRef Hprd Interaction:
Complex of 65 proteins
(in vivo)
Wade et al., Nat Genet 1999, Fujita et al., Cell 2003
-
IRef Hprd Interaction:
Complex of 243 proteins
(in vivo)
Takezawa et al., EMBO J 2007
-
IRef Hprd Interaction:
Complex of 50 proteins
(in vivo)
Yao et al., J Biol Chem 2003, Jiang et al., J Biol Chem 2004
-
IRef Hprd Interaction:
Complex of 73 proteins
(in vivo)
Zhang et al., Cell 1997
-
IRef Hprd Interaction:
Complex of 65 proteins
(in vivo)
Kuzmichev et al., Mol Cell Biol 2002
-
IRef Hprd Interaction:
Complex of 265 proteins
(in vivo)
Zhang et al., Genes Dev 1999, Humphrey et al., J Biol Chem 2001, Saito et al., J Biol Chem 2002, Zhang et al., Cell 1998, Tong et al., Nature 1998
-
IRef Hprd Interaction:
Complex of 170 proteins
(in vivo)
Wysocka et al., Genes Dev 2003
-
IRef Intact Interaction:
Complex of 15 proteins
(association, tandem affinity purification)
Saade et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of HIST1H4A-RBBP4-HAT1-RBBP7
(physical association, tandem affinity purification)
Saade et al., Proteomics 2009
-
IRef Intact Interaction:
Complex of 30 proteins
(association, tandem affinity purification)
Pichlmair et al., Nature 2012
-
IRef Intact Interaction:
Complex of 26 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of 40 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of 85 proteins
(association, anti tag coimmunoprecipitation)
Nozawa et al., Nat Cell Biol 2010
-
IRef Intact Interaction:
Complex of 39 proteins
(association, anti tag coimmunoprecipitation)
Liu et al., Nature 2012
-
IRef Intact Interaction:
Complex of 92 proteins
(association, anti tag coimmunoprecipitation)
Joshi et al., Molecular systems biology 2013
-
IRef Intact Interaction:
Complex of MTA2-ZGPAT-HDAC2-RBBP4-HDAC1-RBBP7
(association, molecular sieving)
Li et al., EMBO J 2009
-
IRef Intact Interaction:
Complex of HDAC2-HDAC1-RBBP7-BRCA2-KDM1A-MBD3-CHD3-RBBP4-MTA2
(association, anti tag coimmunoprecipitation)
Wang et al., Cell 2009
-
IRef Intact Interaction:
RBBP4
—
RBBP7
(physical association, anti bait coimmunoprecipitation)
Takezawa et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti bait coimmunoprecipitation)
Opsahl et al., Proteomics 2010
-
IRef Intact Interaction:
Complex of RBBP7-HDAC1-RBBP4
(association, anti tag coimmunoprecipitation)
Zoltewicz et al., Development 2004*
-
IRef Intact Interaction:
Complex of 12 proteins
(association, anti tag coimmunoprecipitation)
Li et al., EMBO J 2009
-
IRef Intact Interaction:
Complex of RBBP4-RCOR1-HDAC2-HDAC1-KDM1A-RBBP7-MTA2
(association, molecular sieving)
Wang et al., Cell 2009
-
IRef Intact Interaction:
Complex of GATAD2B-MBD3-RBBP7-RBBP4-MTA2-HDAC2-HDAC1-APPL1
(association, anti bait coimmunoprecipitation)
Miaczynska et al., Cell 2004
-
IRef Intact Interaction:
Complex of 23 proteins
(association, tandem affinity purification)
Foltz et al., Cell 2009
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti bait coimmunoprecipitation)
Bantscheff et al., Nat Biotechnol 2011
-
IRef Intact Interaction:
Complex of RBBP4-MTA2-MBD3-HDAC2-KDM1A-RBBP7
(association, anti tag coimmunoprecipitation)
Wang et al., Cell 2009
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti tag coimmunoprecipitation)
Wysocka et al., Genes Dev 2003
Text-mined interactions from Literome
Kim et al., Oncogene 1999
(Melanoma, Experimental...) :
These phenotypic changes of HeLa cells were apparently similar to those by
trichostatin A (TSA) , a specific
inhibitor of
histone deacetylase (HDAC)
Bocheński et al., J Physiol Pharmacol 1999
:
Pretreatment with a PAF receptor antagonist ; WEB 2170 ( 5 and 25 mg/kg ) inhibited both PAP and SAP responses to LPS ( 4 mg/kg/min ) while an inhibitor of thromboxane synthesis ; Camonagrel ( 10 and 20 mg/kg ) abolished PAP response without a major effect on
SAP response to
LPS
Eilers et al., J Biol Chem 1999
:
The interaction between Mad proteins and
HDAC1/2 is
mediated by the corepressor
mSin3A and requires sequences at the amino terminus of the Mad proteins, termed the SID, for Sin3 interaction domain, and the second of four paired amphipathic alpha-helices ( PAH2 ) in mSin3A ... The interaction between Mad proteins and
HDAC1/2 is
mediated by the corepressor
mSin3A and requires sequences at the amino terminus of the Mad proteins, termed the SID, for Sin3 interaction domain, and the second of four paired amphipathic alpha-helices ( PAH2 ) in mSin3A
Garrison et al., Arch Biochem Biophys 2000
(Breast Neoplasms...) :
Here we have directly characterized the
effects of two
HDAC inhibitors, n-butyrate and trichostatin A, on the promoter activity of the murine
AhR gene ...
HDAC inhibitors
increased the constitutive activity of the
AhR gene promoter in a luciferase reporter construct by five- to sevenfold in a dose- and time dependent manner in several cell lines and was correlated with an increase in endogenous AhR activity in an AhR-deficient cell line
Yoshida et al., Ann N Y Acad Sci 1999
:
Trichostatin A (TSA) , an inhibitor of the eukaryotic cell cycle and an inducer of morphological reversion of transformed cells,
inhibits histone deacetylase (HDAC) at nanomolar concentrations
Michael et al., Mol Cell Biol 2000
:
Rather,
HDAC inhibitors
augment CREB activity during the late attenuation phase by prolonging CREB phosphorylation on chromosomal but, remarkably, not on extrachromosomal templates
Chacon-Cruz et al., Pediatr Res 2000
:
PS+SAP also
inhibited the formyl peptide induced [
Ca2+ ] response of neutrophils ( p < 0.01 ), but only in the presence of external Ca2+
Juan et al., J Biol Chem 2000
:
Down-regulation of
p53 activity by HDACs is
HDAC dosage
dependent , requires the deacetylase activity of HDACs, and depends on the region of p53 that is acetylated by p300/CREB binding protein (CBP)
Paul et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Acute phorbol 12-myristate 13-acetate pretreatment also inhibited
TNFalpha stimulated
SAP kinase activity, while chronic pretreatment reversed the effects of UTP
Ochrietor et al., Cytokine 2000
:
Role of
STAT3 and C/EBP in cytokine dependent expression of the mouse
serum amyloid P-component (SAP) and C-reactive protein (CRP) genes ...
Role of STAT3 and
C/EBP in cytokine dependent expression of the mouse
serum amyloid P-component (SAP) and C-reactive protein (CRP) genes
Gray et al., Cytokine 2000
:
Our results indicate that in contrast to the mouse,
HDAC1 is not
inducible by
IL-2
Xu et al., Dev Dyn 2000
:
We found that basal and FGF regulated activator protein 1 (AP-1) activity in Xenopus embryo is markedly reduced by treatment of
trichostatin A (TSA) , a specific
inhibitor of
HDAC
de Haas et al., Infect Immun 2000
:
Using HDL coated magnetic beads prebound with SAP, we demonstrated that HDL bound
SAP prevented the binding of
LPS to HDL
Hutchinson et al., Mol Med 2000
:
Gel filtration chromatography and density gradient ultracentrifugation were used to compare SAP with the closely related molecule, C-reactive protein ( CRP ; which is known to be a single pentamer ) and the
effect of human serum
albumin on
SAP autoaggregation was investigated
Lechner et al., J Biol Chem 2000
:
Thus,
Sds3p plays important roles in the integrity and catalytic activity of the
Rpd3p.Sin3p complex
Kim et al., J Antibiot (Tokyo) 2000
(Colorectal Neoplasms) :
We investigated the mechanism by which
trichostatin A (TSA) , a specific
inhibitor of
HDAC , induces G1 arrest in human cervix carcinoma HeLa cells ... These results suggest that the suppression of
Cdk2 kinase activity due to p21 overexpression
play a critical role in
HDAC inhibitor induced growth inhibition
Mazumdar et al., Nat Cell Biol 2001
(Breast Neoplasms...) :
HRG also
promotes interaction of MTA1 with endogenous ER and association of MTA1 or
HDAC with ERE-responsive target-gene promoters in vivo
Chang et al., Mol Cell Biol 2001
:
In serum starved cells or during serum stimulation, the Chinese hamster dhfr gene was not derepressed by
trichostatin A (TSA) , an
inhibitor of
histone deacetylases (HDAC)
Koumenis et al., Mol Cell Biol 2001
(Cell Transformation, Neoplastic) :
At the molecular level, DNA damage
induces the interaction of
p53 with the transcriptional activator p300 as well as with the transcriptional corepressor
mSin3A ... In contrast, hypoxia primarily
induces an interaction of
p53 with
mSin3A , but not with p300
Singh et al., Scand J Immunol 2001
(Acute-Phase Reaction) :
Both in vivo and in vitro the maximum production of CSFs occurred 6 h after initiation of stimulation, and returned to the background levels by 48 h. Mannose 6-P, mannose 1-P and mannose, and not other sugars inhibited the SAP induced production of CSFs by macrophages which suggests that
SAP interaction with macrophages was
mediated by specific
glycoprotein-receptors ... A neutralizing ( 100 % ) concentration of rabbit antimouse interleukin (IL)-1 polyclonal antibody had no effect on the
SAP induced
CSF production, indicating that it would be IL-1 independent
Kuwahara et al., Mol Cell Biol 2001
:
Our findings show that an NRSE-NRSF system plays a key role in the
regulation of
ANP gene expression by
HDAC in ventricular myocytes and provide a new insight into the role of the NRSE-NRSF system outside the nervous system
Nair et al., Cancer Lett 2001
:
Trichostatin A (TSA) , an
inhibitor of
histone deacetylase (HDAC) , is widely used to study the role of histone acetylation in gene expression, since genes that use histone acetylation as a means of regulating expression may be up regulated when TSA is added
Finzer et al., Oncogene 2001
(Cell Transformation, Neoplastic...) :
HDAC inhibition also
triggered an E7-dependent degradation of
pRb , while the levels of E2F remained unaffected
Osborne et al., Mol Cell Biol 2001
:
Repression of
HLA-DRA promoter activation by
HDAC activity likely involves a YY1 binding element located in the first exon of the HLA-DRA gene ... These findings represent the first evidence that
HDAC activity can
repress IFN-gamma-inducible HLA class II gene expression and also demonstrate that HDAC activity can contribute to promoter repression following the establishment of a DNase I-hypersensitive chromatin conformation
Sekimata et al., J Biol Chem 2001
:
This repression is attenuated by an
HDAC inhibitor, trichostatin A, and is completely
dependent on the interaction with
MBD2
Kiela et al., Am J Physiol Gastrointest Liver Physiol 2001
:
Another
HDAC inhibitor, Trichostatin A (TSA),
stimulated NHE3 promoter in a Ser/Thr kinase independent fashion
Ashburner et al., Mol Cell Biol 2001
:
Finally, we show that inhibition of
HDAC activity with TSA
causes an increase in both basal and TNF induced expression of the NF-kappaB regulated
interleukin-8 (IL-8) gene
Khan et al., J Biol Chem 2001
:
Furthermore,
PML-RARalpha blocked the interaction between Rb and
HDAC ... Furthermore,
PML-RARalpha blocked the interaction between Rb and
HDAC
Yoshida et al., Cancer Chemother Pharmacol 2001
(Melanoma, Experimental) :
Trichostatin A (TSA) and trapoxin ( TPX ), inhibitors of the eukaryotic cell cycle and inducers of morphological reversion of transformed cells,
inhibit histone deacetylase (HDAC) at nanomolar concentrations
Hirschler-Laszkiewicz et al., Nucleic Acids Res 2001
:
Treatment of NIH 3T3 cells with
trichostatin A (TSA) , an
inhibitor of
histone deacetylase (HDAC) , resulted in a dose dependent increase in transcription from a rDNA reporter and from endogenous rRNA genes
Park et al., J Biol Chem 2002
(Breast Neoplasms) :
However, little is known about the mechanism by which inhibition of
HDAC activates
TbetaRII expression
Howie et al., Blood 2002
:
Molecular dissection of the signaling and costimulatory functions of CD150 ( SLAM ) :
CD150/SAP binding and
CD150 mediated
costimulation
Aoukaty et al., J Biol Chem 2002
(Lymphoproliferative Disorders) :
We report here a
role for
phosphoinositide 3-kinase (PI3K) in the recruitment and association of
SAP/SH2D1A to 2B4 in human NK cells
Deroanne et al., Oncogene 2002
:
Trichostatin-A (TSA) and suberoylanilide hydroxamic acid ( SAHA ), two
HDAC inhibitors known to relieve gene silencing, were evaluated as potential antiangiogenic agents
Chazova et al., Ter Arkh 2002
(Hypertension) :
With sufficient antihypertensive effect on
SAP , the drug did not
induce an excessive decrease of
DAP and did not affect heart rate and blood biochemistry
Koyama et al., Biochem Biophys Res Commun 2002
(Leukemia, Erythroblastic, Acute) :
Here we showed that
HDAC inhibitors sodium butyrate, TSA, and valproate
regulated the expression of
Interleukin-18 (IL-18) , a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL
Mignot et al., Mol Microbiol 2002
:
More importantly,
Sap is required for the temporal control of eag, and
EA1 is
involved in strict feedback regulation of eag
Wu et al., J Clin Invest 2002
(Myotonia Congenita) :
These findings suggest that the combined effects of class II
HDAC deficiency and
p38 MAPK
activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles ... These findings suggest that the combined effects of class II
HDAC deficiency and p38
MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles ... These findings suggest that the combined effects of class II
HDAC deficiency and p38 MAPK activation
lead to potent upregulation of
MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Zhang et al., Mol Cell Biol 2002
(Rhabdoid Tumor) :
In addition, INI1/hSNF5 repressed transcription of
cyclin D1 gene in MON, in a
histone deacetylase (HDAC) dependent manner
Sun et al., J Biol Chem 2002
(Breast Neoplasms) :
CK2 phosphorylation of
HDAC2 recruited by Sp1 or Sp3 could
regulate HDAC activity and alter the balance of histone deacetylase and histone acetyltransferase activities and dynamic chromatin remodeling of estrogen regulated genes
Rahman et al., Biochem Pharmacol 2002
(Pneumonia) :
Pharmacological inhibition of
HDAC leads to the increased HAT activity,
AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments ... Pharmacological inhibition of
HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and
IL-8 release by H2O2 or TNF-alpha treatments ... Pharmacological inhibition of
HDAC leads to the increased HAT activity, AP-1 and
NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Travers et al., Exp Cell Res 2002
:
Also,
HDAC1 , -2, -3, and -6 complexes isolated from CD34+ UBC by immunoprecipitation were all
inhibited by
TSA in vitro
Ghoshal et al., Mol Cell Biol 2002
:
Inhibitors of DNA methyltransferase (Dnmt) and
histone deacetylases (HDAC) synergistically
activate the methylated
metallothionein I gene (MT-I) promoter in mouse lymphosarcoma cells
Li et al., J Biol Chem 2003
(Lymphoproliferative Disorders) :
Because SAP also blocked the recruitment of SHP-2 to SLAM in these cells, we propose a dual functional
role for
SAP in
SLAM signaling by acting both as an adaptor for FynT and an inhibitor to SHP-2 binding
Puccetti et al., Cancer Res 2002
(Leukemia, Myeloid...) :
Here we report that
VDR binds corepressors in a ligand dependent manner and that inhibition of
HDAC activity
increases VitD ( 3 ) sensitivity of HL-60 cells
Bozzo et al., Eur J Biochem 2002
:
SAP1 and
SAP2 were
activated by up to 80 % by 5 mm
Mg2+ , and demonstrated potent competitive inhibition by molybdate, but mixed and competitive inhibition by Pi, respectively
Mie Lee et al., Biochem Biophys Res Commun 2003
(Anoxia...) :
Here, we found that a
histone deacetylase (HDAC) inhibitor, FK228,
inhibits the induction and activity of
HIF-1 in response to hypoxia
Park et al., Virology 2002
:
We demonstrate, therefore, that the latent isoform of LMP-1 is induced by
HDAC inhibition, and that HDACI induced latent LMP-1 expression, through NF-kappaB activation, is
responsible for
ICAM-1 expression up-regulation and homotypic adhesion
Yamashita et al., Int J Cancer 2003
(Carcinoma, Hepatocellular...) :
We analyzed the effects of
TSA , a specific and potent
HDAC inhibitor , on the human hepatoma cell lines HepG2 and Huh-7
Rahman et al., Blood 2003
(MAP Kinase Signaling System) :
These data suggest that both TSA and
NaB exert their inhibitory effects by modulating osteoclast-specific signals and that
HDAC activity
regulates the process of osteoclastogenesis ... These data suggest that both
TSA and NaB exert their inhibitory effects by modulating osteoclast-specific signals and that
HDAC activity
regulates the process of osteoclastogenesis
Sakai et al., J Antibiot (Tokyo) 2002
:
Although the unique effects of GEX1 compounds on cell cycle and the reporter gene expression were similar to those of
trichostatin A (TSA) , an
inhibitor of
histone deacetylase (HDAC) , GEX1A/herboxidiene did not affect histone acetylation in cells
Xu et al., EMBO J 2003
:
The interleukin-3 (IL-3) dependent expression of the
Id-1 gene, encoding a helix-loop-helix ( HLH ) transcriptional inhibitor, is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE), but is
inhibited by
HDAC inhibitors in Ba/F3 cells
Suzuki et al., Immunology 2003
:
To investigate the underlying mechanism for induction of CD86 molecules, we analysed the ability of the
histone deacetylase (HDAC) inhibitor, sodium butyrate ( NaB ), to
induce CD86 at the transcriptional level in HL60 cells
Sakai et al., J Biol Chem 2003
:
We here show that
trichostatin A (TSA) , a specific
HDAC inhibitor , enhances the up-regulation of decidualization markers such as insulin-like growth factor binding protein-1 ( IGFBP-1 ) and prolactin in a dose dependent manner that is directed by 17beta-estradiol ( E ( 2 ) ) plus progesterone ( P ( 4 ) ) in cultured ESCs, but not glandular cells, both isolated from human endometrium
Sawa et al., Brain Tumor Pathol 2002
(Brain Neoplasms...) :
We investigated the
effects of
histone deacetylase (HDAC) inhibitors such as sodium butyrate ( SB ) and trichostatin A (TSA) on the expression of
vascular endothelial growth factor ( VEGF ) by human glioblastoma T98G, U251MG, and U87MG cells ... These results suggest that
HDAC inhibitors
reduce VEGF secretion and modulate the expression of the other VEGF family members, and therefore may inhibit angiogenesis in glioblastoma tissues
Ding et al., World J Gastroenterol 2003
(Acute Disease...) :
To establish a non-traumatic, easy to induce and reproducible mouse model of
severe acute pancreatitis (SAP) induced with caerulein and
lipopolyasccharide (LPS)
Ryu et al., Proc Natl Acad Sci U S A 2003
:
Histone deacetylase (HDAC) inhibitors
augment Sp1 acetylation,
Sp1 DNA binding, and Sp1 dependent gene expression and confer resistance to oxidative stress induced death in vitro and in vivo
Mayo et al., J Biol Chem 2003
(Carcinoma, Non-Small-Cell Lung...) :
Because the anti-apoptotic transcription factor NF-kappa B has been shown to be under the control of HDAC mediated repression, we analyzed whether
HDAC inhibitors
activated NF-kappa B in NSCLC cells ...
HDAC inhibitors effectively
stimulated endogenous
NF-kappa B-dependent gene expression by up-regulating IL-8, Bcl-XL, and MMP-9 transcripts
Zika et al., Mol Cell Biol 2003
:
Inhibition of
HDAC activity dramatically
increases the association of NF-YB and RFX5 with
CIITA , the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter ... Inhibition of
HDAC activity dramatically
increases the association of
NF-YB and RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter ... Inhibition of
HDAC activity dramatically
increases the association of NF-YB and
RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter
Zeng et al., J Biol Chem 2003
:
Laminar flow
increased the activity of
histone deacetylase (HDAC) and the association of p53 with
HDAC1 ... Treating human umbilical vein endothelial cells with
trichostatin A (TSA) , an
HDAC inhibitor , abolished the flow induced p53 deacetylation at Lys-320 and Lys-373
Zhao et al., Cancer Res 2003
(Carcinoma, Pancreatic Ductal...) :
In this study, we demonstrate a novel mechanism by which down-regulation of
transforming growth factor beta type II receptor ( TbetaRII ) is
mediated by a
histone deacetylase (HDAC) in pancreatic ductal adenocarcinoma ( PDAC ) cells ... This study further suggests that the specificity of this Sp1 site for
HDAC mediated repression of
TbetaRII may involve the interaction of the Sp1-HDAC1 complex with components of the cognate transcriptional regulators that bind to the inverted CCAAT box
Mellgren et al., Mol Cell Endocrinol 2003
:
The inhibitory effect of RIP140 was partially reversed by Trichostatin A, suggesting a
role of
histone deacetylase (HDAC) activity in RIP140 mediated repression of
SF-1
Ju et al., Cancer Res 2003
(Ataxia Telangiectasia) :
In this work, we show that
p21 ( WAF1 )
induction by
HDAC inhibitors ( depsipeptide and trichostatin A ) is defective in Ataxia telangiectasia ( AT ) cells but normal in matched wild-type ( WT ) cells ( human diploid fibroblasts ) ... To verify the role of ATM in this effect, we show that ectopic expression of the WT ATM gene in an AT cell line fully restores
p21 ( WAF1 )
induction by the
HDAC inhibitors ... Besides the p21 ( WAF1 ) promoter,
activation of
topoisomerase IIIalpha and SV40 promoters by the
HDAC inhibitors are also decreased in the AT cell lines relative to WT cells ; thus, these findings pertain to other promoters
Shimizu et al., Nucleic Acids Res 2003
:
We suggest that
TBP binding is
inhibited through chromatin modification by the
Sin3p-Rpd3p and Isw2p complexes recruited by Ume6p
Liu et al., Cancer Res 2003
(Lung Neoplasms...) :
In this study, we test the possibility that
HDAC inhibitor may
increase RECK expression to inhibit MMP activation and cancer cell invasion ... In this study, we test the possibility that
HDAC inhibitor may increase RECK expression to
inhibit MMP activation and cancer cell invasion ... To explore whether
HDAC inhibitor induced inhibition of
MMP-2 activation is indeed
mediated via RECK, we used small interference RNA ( siRNA ) to block RECK expression and found that inhibition of RECK by siRNA abolished the inhibitory effect of TSA on MMP-2 activation
Davie et al., J Nutr 2003
(Breast Neoplasms) :
A model is proposed in which inhibition of Sp1/Sp3 associated
HDAC activity
leads to histone hyperacetylation and transcriptional activation of the
p21 ( Waf1/Cip1 ) gene ; p21 ( Waf1/Cip1 ) inhibits cyclin dependent kinase 2 activity and thereby arrests cell cycling
Koch et al., Am J Respir Cell Mol Biol 2004
:
TSA ( 10 ng/ml ), an
inhibitor of
histone deacetylase (HDAC) , reversed the inhibitory effect of PD 098059, SB 203580, SN 50 and AS602868 on GM-CSF release
Aquilina et al., Biochem J 2003
:
In the
presence of physiological levels of
Ca2+ ,
SAP was observed to exist primarily as a pentamer, reflecting its in vivo state
Wang et al., Oncogene 2003
(Carcinoma, Non-Small-Cell Lung...) :
The
induction of
RhoB by
HDAC inhibition was mediated by an inverted CCAAT box in the RhoB promoter
Donadelli et al., Mol Carcinog 2003
(Adenocarcinoma...) :
In cells with an altered p53 gene, the expression of
p21 ( WAF1/CIP1 ), a potent inhibitor of cyclin dependent kinases, can be
induced by
histone deacetylase (HDAC) inhibitors via a p53 independent pathway, which may play a critical role in arrest of cell growth
Kataoka et al., Cancer Res 2003
(Carcinoma, Hepatocellular...) :
ING1b and
ING2 also
repressed the
AFP promoter in Hep3B p53-null cell lines, and p53 coexpression enhanced this transcriptional repression
Chevallier et al., Blood 2004
(Acute Disease...) :
ETO binds to the fourth zinc finger of Bcl-6, enhances
Bcl-6 repression of artificial and endogenous genes in an
HDAC dependent manner, and forms a complex with Bcl-6 on the promoters of its endogenous target genes in B-cell lymphoma cells
Pal et al., Mol Cell Biol 2003
:
mSin3A/histone deacetylase 2- and PRMT5 containing Brg1 complex is
involved in transcriptional repression of the Myc target gene
cad
Chung et al., Mol Ther 2003
(Arthritis, Rheumatoid...) :
We found that the
histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only
induced the expression of
p21 ( Cip1 ) and p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA ... We found that the
histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only
induced the expression of p21 ( Cip1 ) and
p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA ... We found that the
histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also
inhibited the expression of
tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA
Hitomi et al., FEBS Lett 2003
:
Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and
activate the
cyclin dependent kinase inhibitor, p21 ( WAF1/Cip1 ) ... We report here that
HDAC inhibitors, trichostatin A (TSA) and sodium butyrate,
activate the
p15(INK4b) gene, a member of the INK4 gene family, through its promoter in HaCaT cells
Peinado et al., Mol Cell Biol 2004
:
Here we show that mammalian Snail
requires histone deacetylase (HDAC) activity to repress
E-cadherin promoter and that treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Snail
Boston et al., Experimental biology and medicine (Maywood, N.J.) 2004
:
We hypothesize that
PS+SAP suppresses neutrophil activation by depletion of internal Ca ( ++ ) stores and that
PS+SAP induces depletion through release of Ca ( ++ ) stores and through inhibition of Ca ( ++ ) influx
Imai et al., Mol Cell Biol 2004
:
The corepressor
mSin3A regulates phosphorylation induced activation, intranuclear location, and stability of
AML1 ... Here, we demonstrate that the interaction between AML1 and the corepressor
mSin3A is regulated by phosphorylation of AML1 and that release of
AML1 from mSin3A
induced by phosphorylation activates its transcriptional activity
Gui et al., Proc Natl Acad Sci U S A 2004
:
Histone deacetylase (HDAC) inhibitor
activation of
p21WAF1 involves changes in promoter associated proteins, including HDAC1
Valdez et al., J Biol Chem 2004
(Autoimmune Diseases...) :
Cross linking of
NTB-A also
induces phosphorylation of NTB-A and the association of
SAP ( SLAM associated protein ), the protein absent in X-linked lymphoproliferative disease
Takaki et al., Biochem Biophys Res Commun 2004
:
Cdk mediated phosphorylation of
pRB regulates
HDAC binding in vitro ... Phosphorylation of
pRB by Cdk4-cyclin D2, Cdk2-cyclin E, and Cdk2-cyclin A
inhibited association of pRB with
HDAC
Liu et al., Biochem Pharmacol 2004
:
Parental cells were treated with
trichostatin A (TSA) , a
HDAC inhibitor
Steiner et al., Biochem Biophys Res Commun 2004
:
SP-transcription factors are involved in basal
MVP promoter activity and its
stimulation by
HDAC inhibitors ... In human cells the
MVP promoter was potently
stimulated by the
histone deacetylase (HDAC) inhibitors butyrate ( NaB ) and trichostatin A (TSA), resulting in enhanced MVP expression ... Summarising, this study identifies variations in Sp-transcription factor binding to a single proximal GC-box element as critical for basal
MVP promoter activation and its
stimulation by
HDAC inhibitors
Chen et al., Zhonghua Yi Xue Za Zhi 2004
(Colonic Neoplasms) :
Two colon cancer cell lines ( SW1116 and Colo-320 ) were treated with the
DNA methyltransferase (DNMT) inhibitor, 5-aza-2'-deoxycytidine ( 5-aza-dC ) and/or the
histone deacetylase (HDAC) inhibitor , trichostatin A (TSA) or sodium butyrate ( NaBu ) ... In these two human colon cancer cell lines,
HDAC inhibitors
stimulate the
p21 ( WAF1 ) gene expression by selectively increasing the degree of acetylation of the gene associated histones, and induce a G ( 1 ) cell cycle arrest
Dehm et al., Biochem Cell Biol 2004
(Neoplasms) :
Interestingly,
histone deacetylase (HDAC) inhibitors, agents with well documented anti-cancer activity,
repress SRC transcription in a wide variety of human cancer cell lines
Tong et al., Biochem Biophys Res Commun 2004
(Colonic Neoplasms) :
The
HDAC inhibitors butyrate and TSA
blocked the
TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells ... The
HDAC inhibitors butyrate and TSA
blocked the TNF-alpha activation of
Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells
Vulin et al., J Biol Chem 2004
:
Finally, JNK/SAPK activity was found to increase in response to oxidants, and inhibition of
JNK/SAP blocked TBHQ increased
PAI-1-luciferase expression
Margueron et al., J Mol Endocrinol 2004
(Breast Neoplasms) :
In this study, we have analysed the
effects of
histone deacetylase (HDAC) inhibition on
estrogen receptor ( ER ) expression and on its transcriptional activity in response to antiestrogens ... In several breast cancer cell lines,
trichostatin A (TSA) , a potent
HDAC inhibitor , strongly decreases ERalpha expression in a dose dependent manner
Emre et al., Biochim Biophys Acta 2004
:
Furthermore, treatment with
trichostatin A (TSA) , a more specific
inhibitor of
HDAC , caused an increase in MVP protein, mRNA, and promoter activity
Simarro et al., Int Immunol 2004
:
SAP increases FynT kinase activity and is
required for phosphorylation of
SLAM and Ly9 ...
SAP increases FynT kinase activity and is
required for phosphorylation of SLAM and
Ly9 ... Here we demonstrate that
SAP is
required for phosphorylation of both
SLAM and Ly9 in thymocytes and peripheral T cells ... Here we demonstrate that
SAP is
required for phosphorylation of both SLAM and
Ly9 in thymocytes and peripheral T cells
Klampfer et al., J Biol Chem 2004
(Inflammation) :
In this study we demonstrated that inhibitors of
histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid,
prevented IFNgamma induced JAK1 activation,
STAT1 phosphorylation, its nuclear translocation, and STAT1 dependent gene activation ... In this study we demonstrated that inhibitors of
histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid,
prevented IFNgamma induced
JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1 dependent gene activation
Chang et al., Proc Natl Acad Sci U S A 2004
:
Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was
essential for transcriptional induction of
IFN stimulated genes ( ISG )
Liu et al., Methods Mol Biol 2004
:
By using the trans activating effect of
trichostatin A (TSA) , a widely used
HDAC inhibitor , on the telomerase reverse transcriptase ( hTERT ) gene as an example, we summarize various aspects of HDAC inhibitors and provide a general strategy for their in vitro application in studies of gene regulation
Vanhaecke et al., Biochem Pharmacol 2004
:
Here, the effect on the activity and expression of several apoptosis related proteins of
trichostatin A (TSA) , a well-known
HDAC inhibitor , were studied in short-term ( conventional monolayer ) and long-term cultured ( collagen I gel sandwich cultures and co-cultures ) adult rat hepatocytes
Kato et al., J Biol Chem 2004
(Anoxia) :
In the nucleus,
HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with HIF-1alpha,
HDAC7 , and p300 ... In the nucleus,
HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with
HIF-1alpha , HDAC7, and p300
Park et al., Clin Cancer Res 2004
(Neoplasms...) :
These
HDAC inhibitors preferentially
inhibited the enzymatic activities of
HDAC1 and HDAC2, as compared with the other HDAC isotypes, indicating that class I HDAC is the major target of SK-7041 and SK-7068 ... These
HDAC inhibitors preferentially
inhibited the enzymatic activities of HDAC1 and
HDAC2 , as compared with the other HDAC isotypes, indicating that class I HDAC is the major target of SK-7041 and SK-7068
Ellenrieder et al., Gastroenterology 2004
(Carcinoma, Pancreatic Ductal...) :
Erk induced KLF11 phosphorylation was examined in vitro and in vivo, and its impact on
KLF11-mSin3A mediated
Smad7 repression was verified in pancreatic cancer cells using site directed mutagenesis ... Expression of an Erk-insensitive
KLF11 mutant
restores both
mSin3a binding and Smad7 repression and results in enhanced TGF-beta signaling in pancreatic cancer cells
Myzak et al., Cancer Res 2004
:
Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells :
SFN dose-dependently increased TOPflash reporter activity and
inhibited HDAC activity, there was an increase in acetylated histones and in p21 ( Cip1/Waf1 ), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter
Pasini et al., EMBO J 2004
:
Furthermore, we demonstrate that
SUZ12 is
essential for the activity and stability of the
PRC2/3 complexes in mouse embryos, in tissue culture cells and in vitro ... In conclusion, our data demonstrate an essential
role of
SUZ12 in regulating the activity of the
PRC2/3 complexes, which are required for regulating proliferation and embryogenesis
Li et al., Biochem Biophys Res Commun 2004
(Uterine Cervical Neoplasms) :
However, the exact mechanism by which
HDAC inhibitors
induce p21WAF1/CIP1 remains unclear ... In this study, we observed that
Trichostatin A (TSA) , a
HDAC inhibitor , induced strikingly p21WAF1/CIP1 expression in human cervical cancer ( HeLa ) cells, and this induction correlated with downregulation of c-myc expression
Kaiser et al., BMC biology 2004
:
We found that IRS-1 is an acetylated protein, of which the acetylation is increased by treatment of cells with
Trichostatin A (TSA) , an
inhibitor of
HDAC activity
Ramakrishnan et al., Mol Biochem Parasitol 2004
:
Histone deacetylase (HDAC) activity was detected in nuclear extracts from E. histolytica, and characteristically, was
inhibited by
trichostatin A (TSA)
Varshochi et al., J Biol Chem 2005
(Breast Neoplasms) :
The fact that
p21Waf1 expression is normally
repressed by
HDAC activity in cycling cells is further demonstrated by the finding that p21Waf1 transcription can be induced by the silencing of HDACs with small interfering RNA or treatment with HDAC inhibitors
Huang et al., J Biol Chem 2005
:
In this report, we demonstrated the mechanism by which
trichostatin A (TSA) , an
inhibitor of
HDAC , induces the expression of TbetaRII in human pancreatic cancer cell lines by modulating the transcriptional components that bind a specific DNA region of the TbetaRII promoter
Choi et al., Clin Exp Allergy 2005
(Asthma) :
The purpose of this study was to determine whether treatment with
trichostatin A (TSA) , a representative
HDAC inhibitor , would reduce allergen induced airway inflammation in a mouse asthma model
Cardoso et al., Dev Biol 2005
:
This study thus demonstrates that in vivo
XNP-1 acts in association with RB, HP1 and the
NuRD complex during development
Novatchkova et al., BMC bioinformatics 2005
:
Recent findings point at the importance of
SUMO mediated
histone NAD dependent deacetylase (HDAC) recruitment in transcriptional regulation
Miard et al., Int J Obes Relat Metab Disord 2005
(Obesity) :
Inhibition of
HDAC activity consequently
results in a strong activation of
PPARgamma
Gan et al., J Biol Chem 2005
:
Induction of
eNOS expression by
histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate was observed in all four different types of non-endothelial cells examined
Taylor et al., Infect Immun 2005
(Candidiasis, Vulvovaginal) :
SAP5 expression was
induced soon after infection, whereas
SAP4 was expressed at later times and in fewer cells compared with SAP5
Liu et al., Mol Endocrinol 2005
:
Consistent with this corepressor function, depletion of endogenous
mSin3A by small interfering RNA was
sufficient to enhance
prolactin gene expression by 70 %, comparable to the induction by the HDAC inhibitor, trichostatin A
Marks et al., Cell cycle (Georgetown, Tex.) 2005
(Neoplasms) :
We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor induced cell death, and
HDAC inhibitors
increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors preferentially kill cancer cells
Kawamura et al., J Biol Chem 2005
:
Treatment of ES cells with
trichostatin A (TSA) , a specific
HDAC inhibitor , induced acetylation of histone-3/4 near GATA sites within the atrial natriuretic factor promoter
Lu et al., Biochem Biophys Res Commun 2005
:
Reporter gene analysis demonstrated that both Emu and 3'-IgH enhancer activities were repressed significantly by
TSA mediated
HDAC inhibition
Komata et al., Int J Oncol 2005
(Brain Neoplasms...) :
Furthermore, caspase inhibition assay indicated that
HDAC inhibitor induced apoptosis was
caspase dependent ... Taken together, the
HDAC inhibitors, N-butyric acid and trichostatin A,
induce caspase-8- but not caspase-9 dependent apoptosis with or without p21 mediated G1 arrest in human malignant glioma cells
Gobinet et al., Biochemistry 2005
:
The use of
trichostatin A (TSA) , a specific
inhibitor of
HDAC activity, confirmed that HDACs significantly contribute to the intrinsic transrepressive activity of SHP
Veerhuis et al., Neurobiol Dis 2005
:
Also,
SAP and C1q
enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays
Wang et al., J Immunol 2005
:
However, mycobacterial infection or TLR2 stimulation up-regulated expression of mammalian Sin3A, a corepressor that is required for
MHC class II repression by
HDAC ... However, mycobacterial infection or
TLR2 stimulation
up-regulated expression of mammalian
Sin3A , a corepressor that is required for MHC class II repression by HDAC
Drummond et al., Clin Cancer Res 2005
(Neoplasms, Experimental) :
ErbB2 overexpressing human cancers represent potentially sensitive targets for therapy by candidate histone deacetylase (HDAC) inhibitors as we have shown that
HDAC inhibitors can selectively
reduce ErbB2 expression by repressing the ErbB2 promoter and accelerating the decay of cytoplasmic ErbB2 transcripts
Rocchi et al., Oncol Rep 2005
(Neuroblastoma) :
p21Waf1/Cip1 is a common target
induced by short-chain fatty acid
HDAC inhibitors ( valproic acid, tributyrin and sodium butyrate ) in neuroblastoma cells
Peltonen et al., Pigment Cell Res 2005
(Melanoma) :
We have studied the cellular effects of
trichostatin A (TSA) , a
HDAC inhibitor , in a panel of melanoma cell lines and its mechanism of action in relation to p53 ... Inhibiting p53 function by a dominant negative p53 ( p53 ( 175His ) ) confirmed that the
HDAC inhibitor induced apoptosis was
independent of wild-type
p53 , even though TSA slightly activated p53 in a reporter assay
Singh et al., Oncogene 2005
(Breast Neoplasms) :
HDAC inhibitors
synergized with TRAIL by inducing DRs
DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ...
HDAC inhibitors
synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and
DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ...
HDAC inhibitors
synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and
DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ...
HDAC inhibitors
synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through
NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Gurvich et al., FASEB J 2005
(Abnormalities, Drug-Induced...) :
Unbiased microarray analysis revealed that the effects of VPA and
trichostatin A (TSA) , a structurally unrelated
HDAC inhibitor , are strikingly concordant
Yang et al., EMBO J 2005
:
However, in the basal state, its activity is repressed by
SUMO dependent
histone deacetylase (HDAC) recruitment
Rössig et al., J Exp Med 2005
(Ischemia) :
To define the mechanisms by which HDAC inhibition prevents endothelial differentiation, we determined the expression of homeobox transcription factors and demonstrated that
HoxA9 expression is
down-regulated by
HDAC inhibitors
Zhang et al., Cell Death Differ 2006
:
In contrast,
HDAC1 overexpression distinctly
reduced Bmf expression ... Taken together, FK228 and CBHA activate Bmf transcription by histone hyperacetylation at its promoter region, and inhibition of this action decreased their proapoptotic activity, thereby highlighting a central
role of
Bmf in
HDAC inhibitor mediated apoptosis
Place et al., Biochem Pharmacol 2005
:
HDAC inhibition
prevents NF-kappa B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I kappa B alpha
Shetty et al., Mol Cell Biol 2005
(Breast Neoplasms) :
Indeed,
HDAC inhibitors
activate NF-kappaB and
p53 and upregulate DR5 expression ... Indeed,
HDAC inhibitors
activate NF-kappaB and p53 and upregulate
DR5 expression ... Indeed,
HDAC inhibitors
activate NF-kappaB and p53 and upregulate DR5 expression
Kang et al., EMBO J 2005
:
Accordingly,
HDAC4 or 5 is
required for efficient TGF-beta mediated inhibition of
Runx2 function and is involved in osteoblast differentiation
Yamaguchi et al., J Biol Chem 2005
:
We investigated whether
HDAC inhibitors
blocked AP-1 mediated activation of
COX-2 transcription ... Chromatin immunoprecipitation assays indicated that
HDAC inhibitors
suppressed c-Jun binding to the COX-2 promoter and thereby blocked transcription ... Chromatin immunoprecipitation assays indicated that
HDAC inhibitors
suppressed c-Jun binding to the
COX-2 promoter and thereby blocked transcription ...
HDAC inhibitors
suppressed the induction of both
cyclin D1 and collagenase-1 transcription by inhibiting the binding of c-Jun to the respective promoters
Chuang et al., Blood 2005
(Lymphohistiocytosis, Hemophagocytic) :
Interestingly, EBV
LMP1 could transcriptionally
inhibit the expression of
SAP/SH2D1A and activate downstream molecules ERK and interferon-gamma (IFN-gamma)
Kaneda et al., Circ Res 2005
:
We have now applied DCS to H9C2 rat embryonic cardiomyocytes incubated with or without
trichostatin A (TSA) , a specific
inhibitor of
histone deacetylase (HDAC) activity
Takahashi et al., Br J Haematol 2005
(Acute Disease...) :
We verified that the repression activity of
AML1B , the isoform of AML1, is
dependent on
HDAC activity by using HDAC inbitor trichostatin A in GAL4 reporter assays
Cho et al., J Cell Biochem 2005
:
Trichostatin A (TSA) , another
HDAC inhibitor , also increased osteogenic differentiation, whereas valpromide ( VPM ), a structural analog of VPA which does not possess HDAC inhibitory effects, did not show any effect on osteogenic differentiation on hADSC
Graham et al., Cell cycle (Georgetown, Tex.) 2005
:
In addition,
HDAC inhibitors
induce NFkappaB binding to the DR5 gene and
DR5 expression, contributing to HDAC inhibitor induced apoptosis ... In addition,
HDAC inhibitors
induce NFkappaB binding to the DR5 gene and DR5 expression, contributing to HDAC inhibitor induced apoptosis
Somech et al., J Cell Sci 2005
:
We further show that LAP2beta interacts at the nuclear envelope with HDAC3, a class-I histone deacetylase, and that
TSA ( an
HDAC inhibitor ) abrogates LAP2beta 's repressive activity
Laribee et al., Biochim Biophys Acta 2005
:
Finally, we show that
HDAC activity is
required for association of
RNA polymerase II with the PU.1 promoter
Duong et al., Oncogene 2006
:
ERalpha and
ERbeta expression and transcriptional activity are differentially
regulated by
HDAC inhibitors
Tsuyama et al., Biochem Biophys Res Commun 2005
(Multiple Myeloma) :
Expression of
p53 , a direct target gene of Bcl6, was downregulated in the IL-6 stimulated cells, and this process was
impaired by an
HDAC inhibitor
Todoerti et al., Br J Haematol 2005
(Multiple Myeloma) :
The
HDAC inhibitor, trichostatin A,
reduced MMSET I repression activity and in vitro co-immunoprecipitation analyses indicated that MMSET I specifically recruits HDAC1 and mSin3b, but not HDAC2 or HDAC4
Chen et al., Chin J Cancer 2005
(Ovarian Neoplasms) :
This study was to evaluate enhancive effect of
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , on the transfection efficiency of adenovirus in ovarian carcinoma cell line A2780, and explore its possible application to adenovirus based gene therapy
Zhang et al., Nucleic Acids Res 2005
:
The ErbB3 binding protein Ebp1 interacts with
Sin3A to
repress E2F1 and AR-mediated transcription ... Functionally,
Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and
E2F1 regulated genes ... Functionally,
Sin3A enhanced the ability of Ebp1 to repress transcription of
androgen receptor (AR) and E2F1 regulated genes
Dai et al., Mol Cell Biol 2005
:
Mrj also decreased NFATc3 occupancy of the tumor necrosis factor-alpha promoter in cardiomyocytes in an
HDAC dependent manner, and Mrj blocked calcineurin induced cardiomyocyte hypertrophic growth
Carrozza et al., Biochim Biophys Acta 2005
:
Dep1 and
Sds3 , unique components of Rpd3L, were
required for Rpd3L integrity and
HDAC activity
Hernández-Muñoz et al., Mol Cell Biol 2005
:
Association of
BMI1 with polycomb bodies is dynamic and
requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1
Skov et al., Cancer Res 2005
(Neoplasms) :
HDAC inhibitor treatment
induced glycogen synthase kinase-3 ( GSK-3 ) activity and down-regulation of GSK-3 by small interfering RNA or by different inhibitors showed that GSK-3 activity is essential for the induced MICA/B expression
Pazmany et al., J Neuroimmunol 2006
:
Trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , abrogates the TGF-beta1 mediated repression of the IFN-gamma induced CIITA in EOC20
Kee et al., Circulation 2006
(Aortic Valve Stenosis...) :
The expressions of atrial natriuretic factor, alpha-tubulin,
beta-myosin heavy chain , and interstitial fibrosis were
reduced by
HDAC inhibition
Earel et al., Cancer Res 2006
(Urinary Bladder Neoplasms) :
HDAC inhibition, especially with sodium butyrate and trichostatin A,
led to increased
TRAIL-R2 gene transcription that correlated with increased TRAIL-R2 surface expression
Myzak et al., FASEB J 2006
(Cell Transformation, Neoplastic...) :
In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of
HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet
resulted in levels of acetylated histones and
p21 ( WAF1 ) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls
Witta et al., Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
The zinc finger transcriptional repressor, ZEB1,
inhibits E-cadherin expression by recruiting
histone deacetylases (HDAC)
Chuang et al., Nucleic Acids Res 2006
:
We herein demonstrate that the
HDAC inhibitor, trichostatin A (TSA),
increases the level of acetylated
GCMa and that HDAC1, 3, 4 and 5 interact with and deacetylate GCMa ... Our studies support that trophoblastic fusion in placental morphogenesis depends on the
regulation of
GCMa activity by HAT and
HDAC
Zhao et al., Mol Cell Biol 2006
:
Here we found that an inhibitor of
HDAC , depsipeptide ( FR901228 ), but not trichostatin A (TSA),
induces p21 ( Waf1/Cip1 ) expression through both p53 and Sp1/Sp3 pathways in A549 cells ( which retain wild-type p53 )
Armstrong et al., J Infect Dis 2006
(Disease Models, Animal...) :
Here, we show that serum amyloid P component (SAP), a normal human plasma protein, specifically protects mice against the lethal toxicity of Stx2, both when injected into wild-type mice and when expressed transgenically ; in the
presence of human
SAP , there was greatly reduced in vivo localization of
Stx2 to the kidneys, suggesting a possible mechanism of protection
Woo et al., Exp Mol Pathol 2007
(Leukemia) :
The objective of the present study was to investigate the effect of
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , on the cell growth and apoptosis and its effect on the telomerase activity in human leukemic cell line U937
Sato et al., Int J Oncol 2006
(Carcinoma, Squamous Cell...) :
Moreover, these events were associated with an enhancement of reactive oxygen species ( ROS ) generation and
caspase-3 activation by
HDAC inhibitors
Ma et al., Int J Oncol 2006
:
Additionally,
PHI reduced the expression of
HDAC and increased the level of acetyl transferase p300, in favor of accumulation of acetylated histones
Beklemisheva et al., Anticancer Res 2006
(Prostatic Neoplasms) :
PHI inhibited the activity of
HDAC and remodeled chromatins to activate p21 for cell cycle arrest, underlying an epigenetic mechanism regulating the growth of prostate cancer cells
Hernandez et al., Prostate 2006
(Prostatic Neoplasms) :
The impact of
Trichostatin A (TSA) , an
inhibitor of
HDAC , on exogenous and endogenous cx43 gene transcription was examined by the luciferase assay, Northern blot, nuclear run-on, Western blot, and chromatin immunoprecipitation assays
Carta et al., Blood 2006
(Calcium Signaling) :
In the present study, we investigated the
effects of 2
HDAC inhibitors on
IL-1beta secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 ... These
HDAC inhibitors do not
affect the synthesis or intracellular localization of
IL-1beta but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes
Furuno et al., Biochem Biophys Res Commun 2006
:
Although the essential
role of
SUZ12 in regulating the activity of the
PRC2/3 complexes has been demonstrated, additional function of this protein was suggested
Goto et al., J Bone Miner Res 2006
:
The results establish that Sp1 proteins
regulate COL11A2 transcription by binding to its proximal promoter and directly interacting with CBP, p300, and
HDAC
Zhang et al., Int J Radiat Oncol Biol Phys 2006
:
To explore their effects on ionizing radiation ( IR ), we examined whether the
HDAC inhibitors m-carboxycinnamic acid bis-hydroxamide ( CBHA ) and depsipeptide FK228
affect H2AX phosphorylation ( gamma-H2AX ), a landmark of DNA double-strand breaks after IR exposure ... The results of this study suggest that
HDAC inhibitors
enhance IR-induced
gamma-H2AX , most likely through histone hyperacetylation, and radiosensitize various cancers
Kwon et al., Biochim Biophys Acta 2006
:
We report here that retinoic acids ( RA ) as well as
Trichostatin A (TSA) , an
inhibitor of
histone deacetylase (HDAC) , regulate PDK4 gene expression
Schoeftner et al., EMBO J 2006
:
Xist expression early in ES cell differentiation establishes a chromosomal memory, which allows efficient H2A ubiquitination in differentiated cells and is
independent of silencing and
PRC2
Macdonald et al., Scand J Immunol 2006
:
The
SAP-monocyte interaction was calcium independent and readily
inhibited by
C1q
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006
(Cell Transformation, Neoplastic...) :
NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and
up-regulated the levels of the P21 and
HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone
Sato et al., Int J Oncol 2006
(Biliary Tract Neoplasms) :
In addition, the restored
DPD expression level was more strongly
induced by the
histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), than 5-aza-C treatment
Zhang et al., Apoptosis 2006
:
We recently found that the
HDAC inhibitors
induce a BH3-only protein
Bmf in human squamous carcinoma SAS cells
Kammanadiminti et al., J Biol Chem 2006
(Colitis) :
Overexpression of wild type Hsp27 amplified the effects of SAP, whereas a phosphorylation-deficient mutant of Hsp27 abrogated
SAP induced
NF-kappaB inhibition
Chen et al., Mol Cell Biol 2006
:
SAP promotes
SLAM family receptor induced protein tyrosine phosphorylation, due to its capacity to recruit the Src related kinase FynT
Kim et al., Biochem Biophys Res Commun 2006
:
Involvement of HDAC1 and the PI3K/PKC signaling pathways in
NF-kappaB activation by the
HDAC inhibitor apicidin ...
Involvement of
HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the
HDAC inhibitor apicidin ...
Involvement of HDAC1 and the
PI3K/PKC signaling pathways in NF-kappaB activation by the
HDAC inhibitor apicidin
Qiu et al., Biochem Biophys Res Commun 2006
:
We also found that
TSA , a
HDAC inhibitor that stimulates histone acetylation of the SM22alpha locus, further enhances the transactivational activity of Smad2, Smad3 and Smad4, and relieves the inhibitory effect of Smad6, Smad7, and the dominant negative mutants of Smads
Ivanov et al., Oncogene 2007
:
Involvement of
HDAC activity in
STAT1 regulation was validated by TSA inhibition and chromatin immunoprecipitation ( ChIP ) assay
Okamoto et al., J Atheroscler Thromb 2006
:
Our goal was to investigate the effect of
trichostatin A (TSA) , a specific and potent
HDAC inhibitor , on the proliferation of vascular smooth muscle cells ( VSMCs ) isolated from rat thoracic aorta ...
TSA suppressed the
HDAC activity of VSMCs in a dose dependent manner and inhibited VSMC proliferation as demonstrated by cell number counting and the degree of [ 3H ] thymidine incorporation ... Finally,
TSA inhibited
HDAC activity of VSMCs from p21 ( WAF1 ) knock-out mice but had no effect on VSMC proliferation in these animals
Topark-Ngarm et al., J Biol Chem 2006
(Neuroblastoma) :
Therefore, it seems likely that the
NuRD complex may be
involved in transcriptional repression of
CTIP2 target genes and contribute to the function ( s ) of CTIP2 within a neuronal context
Qian et al., Cancer Res 2006
(Carcinoma, Renal Cell...) :
In the current study, we investigated the molecular link between
HIF-1 alpha inhibition and
HDAC inhibition
Chen et al., Pharmazie 2006
(Leukemia, Promyelocytic, Acute) :
In this study, it was investigated whether
trichostatin A (TSA) , a specific
histone deacetylase (HDAC) inhibitor and a new anticancer drug, could improve the anticancer activity of low concentrations of Cur in human leukemia cells ( HL-60 )
Nakagawa et al., J Mol Cell Cardiol 2006
(Cardiomegaly...) :
These findings show that ET-1 induced
CaMK signaling
disrupts class II
HDAC-NRSF repressor complexes, thereby enabling activation of ANP and BNP gene transcription in ventricular myocytes, and shed light on a novel mechanism by which the fetal cardiac gene program is reactivated
Mantovani et al., Vascul Pharmacol 2006
(Cardiovascular Diseases...) :
CRP and
SAP are produced primarily in the liver in
response to
IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Chang et al., J Neurochem 2006
:
NGF caused a rapid but transient
HDAC dependent increase in
inducible cAMP element repressor (ICER) expression, but ICER expression was sustained with increased cAMP ... Depletion of ICER from PC12 cells indicated that
HDAC dependent
ICER induction is responsible for the delay in CRE dependent transcription after NGF treatment
Yasuda et al., Pancreas 2006
(Bacterial Infections...) :
These results suggest that
HMGB1 may
act as a key mediator for inflammation and organ failure in
SAP
Shaw et al., Circ Res 2006
:
The
histone deacetylase (HDAC) inhibitor Trichostatin A ( TSA 10 nM )
suppressed the inhibitory actions of NF-kappaB on
Bnip3 gene transcription
Guo et al., Mol Cells 2006
:
Our data indicate that
IFNgamma and STAT dependent gene transcription
requires the participation of
HDAC , as does the IFNalpha-STAT pathway
Keslacy et al., Mol Pharmacol 2007
(Inflammation) :
It is noteworthy that
IFNgamma decreases TNFalpha induced histone acetyl transferase ( HAT ) and
increases histone deacetylase (HDAC) activities
Yoshikawa et al., J Am Soc Nephrol 2007
:
It was shown that
trichostatin A (TSA) , an
HDAC inhibitor , prevented TGF-beta1 induced EMT in cultured human renal proximal tubular epithelial cells
Geng et al., Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
In contrast, treatment with LBH589 followed by irradiation resulted in HDAC4 confinement to the cytoplasm, indicating that
HDAC inhibition
affects the nuclear localization of
HDAC4
Mauceri et al., J Neurochem 2007
:
On the contrary,
SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is
responsible for both the disruption of
NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane ... On the contrary,
SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is
responsible for both the disruption of
NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane
Portal et al., Proc Natl Acad Sci U S A 2006
:
Consistent with EBNALP coactivation being mediated by nuclear HDAC4 depletion,
HDAC4 overexpression
increased nuclear
HDAC4 and specifically repressed EBNA2 dependent activation as well as EBNALP dependent coactivation
van der Linden et al., EMBO J 2007
(Calcium Signaling) :
Here, we show that KIN-29 regulates these processes by phosphorylating the HDA-4 class II
histone deacetylase (HDAC) and
inhibiting the gene repression functions of HDA-4 and an MEF-2 MADS domain
transcription factor
Endt et al., Eur J Immunol 2007
:
IL-2 stimulation leads to an up-regulation of
SAP expression, which can be
enhanced by
IL-12 , the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha ...
IL-2 stimulation
leads to an up-regulation of
SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha
Gopal et al., Cell cycle (Georgetown, Tex.) 2006
(Inflammation) :
The resulting depletion of cellular
HDAC1 levels
lead to a consequent depletion of
HDAC1 associated with the CDKN1A gene promoter and increased expression of its protein product, p21 ( WAF1/CIP1 )
Kovács et al., Cell Biochem Funct 2008
:
In the present experiments the effect of
trichostatin A (TSA) , a
HDAC inhibitor was studied on the incorporation of 3H-palmitic acid and 32P to the phospholipids ( PI, PIP, PS, PC, PA, PE ) of Tetrahymena pyriformis, considering earlier observations on the microtubular system 's influence on signalling in this unicellular eukaryote
McCausland et al., J Immunol 2007
:
SAP regulation of follicular helper CD4 T cell development and humoral immunity is
independent of
SLAM and Fyn kinase
Myzak et al., Experimental biology and medicine (Maywood, N.J.) 2007
:
In the present investigation, we sought to test whether
SFN also might
inhibit HDAC activity in vivo
Larsen et al., Diabetologia 2007
:
HDAC inhibition
reduced cytokine mediated decrease in
insulin secretion and increase in iNOS levels, NO formation and apoptosis ...
HDAC inhibition reduced cytokine mediated decrease in insulin secretion and
increase in
iNOS levels, NO formation and apoptosis
Kammanadiminti et al., Infect Immun 2007
:
Moreover, inhibiting the classical pathway of NF-kappaB activation did not affect
SAP induced
MCP-1 expression ... Instead, we find that
SAP induced
MCP-1 expression is dependent on posttranslational modification of the NFkappaB p65 subunit
Hitomi et al., FEBS Lett 2007
:
Treatment with a histone deacetylase (HDAC) inhibitor has activated the expression of p15(INK4b) in wild-type MEFs but has no effect in MEFs lacking Oct-1, suggesting that Oct-1 represses
p15(INK4b) gene expression in an
HDAC dependent manner
Trivedi et al., Nat Med 2007
(Cardiomegaly) :
Hdac2 deficiency or chemical
histone deacetylase (HDAC) inhibition prevented the re-expression of fetal genes and attenuated cardiac hypertrophy in hearts exposed to hypertrophic stimuli
Annicotte et al., Bull Cancer 2007
(Neoplasms, Hormone-Dependent...) :
Moreover,
PPARgamma activity is enhanced in the
presence of
HDAC inhibitors
Villar et al., Infect Immun 2007
(Candidiasis, Oral) :
Mucosal tissue invasion by Candida albicans is associated with
E-cadherin degradation,
mediated by transcription factor Rim101p and protease
Sap5p
Hatayama et al., Biochem Biophys Res Commun 2007
(Adenocarcinoma...) :
Thus butyrate, an
HDAC inhibitor, inhibits proliferation of LS174T cells but
stimulates MUC2 production in individual cells
Kim et al., J Cell Biochem 2007
:
In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of
cyclin D3 in
response to
HDAC inhibitors in human colon cancer cells
Ocker et al., Int J Biochem Cell Biol 2007
:
Several studies have shown that
HDAC inhibitors strongly
activate the expression of the cyclin dependent kinase inhibitor
p21 ( cip1/waf1 ) through ( i ) enhanced histone acetylation around the p21 ( cip1/waf1 ) promoter and ( ii ) the Sp1 sites on the p21 ( cip1/waf1 ) promoter releasing the repressor HDAC1 from its binding
Huh et al., J Biol Chem 2007
:
HDAC inhibition
promoted the expression of
Wnt-5a , which is known to inhibit type II collagen expression, and knockdown of Wnt-5a blocked the ability of HDAC inhibitors to suppress type II collagen expression ... In addition, the
induction of
Wnt-5a expression by
HDAC inhibitors was associated with acetylation of the Wnt-5a promoter
Hatjiharissi et al., Cancer Res 2007
(Waldenstrom Macroglobulinemia) :
Other proteins up-regulated by > 1.3-fold included
cyclin dependent kinases, apoptosis regulators, and
histone deacetylases (HDAC)
Nakajima et al., Pancreas 2007
(Acute Disease...) :
Apoptosis of ileal mucosa was accelerated in
SAP , and
VEGF significantly
reduced the apoptosis ... Microvessel counts were significantly reduced in
SAP , and
VEGF significantly
increased them
Tabe et al., Cell Death Differ 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Induction of ANXA1 mRNA was associated with histone acetylation in ANXA1 promoter and reversal of the
HDAC dependent suppression of
C/EBPalpha by AML1-ETO with direct recruitment of C/EBPalpha to ANXA1 promoter
Serakinci et al., Regen Med 2006
:
This repression is overcome by treatment with
Trichostatin A (TSA) , an
HDAC inhibitor , concomitant with increases in promoter-specific histone acetylation and increases in Pol II and TFIIB tracking
de Boer et al., Tissue Eng 2006
(Skull Fractures) :
As reported previously, inhibition of so-called histone deacetylases ( HDACs ) stimulates osteoblast maturation, and in this report, we investigated whether
trichostatin A (TSA) , a widely used
HDAC inhibitor , can be implemented in bone tissue engineering
Schwechter et al., Invest Ophthalmol Vis Sci 2007
:
The retinal ganglion cell line RGC-5 was treated with
trichostatin A (TSA) , other
HDAC inhibitors , and staurosporine ; differentiation, neuritogenesis, neurotrophic factor dependence, and dependence on RNA transcription were assessed
Dashwood et al., Semin Cancer Biol 2007
(Neoplasms) :
SFN has been shown to
inhibit histone deacetylase (HDAC) activity in human colon and prostate cancer lines, with an increase in global and local histone acetylation status, such as on the promoter regions of P21 and bax genes
Matsuoka et al., Biochem Pharmacol 2007
:
Previous studies have shown that
HDAC inhibitors selectively
inhibit IL-2 gene expression, but the mechanism of this inhibition remains to be elucidated
Plaster et al., Dev Dyn 2007
:
Together, these results reveal novel in vivo roles for REREa in
HDAC mediated regulation of
Fgf signaling
Nencioni et al., Clin Cancer Res 2007
:
Here, we have evaluated the
effects of two
HDAC inhibitors currently in clinical use, sodium valproate and MS-275, on human monocyte derived
DCs
Kato et al., Leukemia 2007
(Genetic Predisposition to Disease) :
In this study, we were able to increase the expression levels of MICA and MICB on leukemic cell lines and patients ' leukemic cells by treatment with
trichostatin A (TsA) , a
histone deacetylase (HDAC) inhibitor
Matsuoka et al., Eur J Pharmacol 2007
(Thrombocytopenia) :
Here, we report that
GATA-1 and 10 haematopoietic factors ( SCL, NF-E2, EKLF, Pleckstrin, Thrombin-R, LMO2, PU.1, Fli-1, AML1, and TCF11 ) are transcriptionally
repressed by
HDAC inhibitors in a similar pattern ( R > 0.98 ), and putative GATA-1 binding sites are found in almost all promoters of these genes ... Further, this report also asserts that
HDAC inhibitor increases megakaryocyte counts and
inhibits GATA-1 gene expression in rat spleen ... Together, these results suggest that
HDAC inhibitors
inhibit GATA-1 gene expression by decreasing the transactivation function of GATA-1 itself, and that this may in turn lead to a delay in megakaryocyte maturation and finally cause thrombocytopenia
Bode et al., Immunology 2007
:
In contrast,
HDAC inhibitors
had no effects on upstream nuclear factor-kappaB and
mitogen activated protein kinase activation
Schnekenburger et al., Biochim Biophys Acta 2007
:
These results show that by blocking the modification of histone marks,
HDAC1 plays a central role in
Cyp1a1 expression and that its removal is a necessary but not sufficient condition for Cyp1a1 induction, underscoring the requirement for a concerted series of chromatin remodeling events to complete the initial steps of gene trans-activation by the Ah receptor
Chen et al., Mol Cell Biol 2007
:
Here we show that
HDAC inhibitors
suppressed the expression of steroidogenic gene
CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes ... Reducing SKP1A expression with small interfering RNA resulted in recovery of SF-1 levels, demonstrating that the activity of SCF E3 ubiquitin ligase is required for the
SF-1 degradation
induced by
HDAC inhibitors
Frye et al., PloS one 2007
:
The Myc induced switch from mono- to di-methylated H4K20 required
HDAC activity and was
blocked by the HDAC inhibitor
trichostatin A (TSA)
Rao et al., Biochem Biophys Res Commun 2007
:
Trichostatin-A (TSA) , a
histone deacetylase (HDAC) inhibitor , results in enhanced acetylation of core histones thereby disrupting chromatin organization within living cells
Sun et al., Proc Natl Acad Sci U S A 2007
:
Either inhibition of
HDAC activity or knockdown of HDAC expression
led to marked induction of
p21 and pten gene expression and dramatically reduced neural stem cell proliferation, suggesting that the TLX interacting HDACs play an important role in neural stem cell proliferation
Enya et al., J Leukoc Biol 2008
(Melanoma) :
Trichostatin A (TSA) , an
inhibitor of
histone deacetylase (HDAC) , greatly augmented the IL-1 alpha promoter activity in A375-6 cells to the level comparable with that in A375-R8 cells
Veis et al., Mol Cell Biol 2007
:
Since the removal of
Sin3 is
independent of Ndd1 recruitment and
Cdc28/Clb activity it represents a unique regulatory step which is distinct from transcriptional activation
Li et al., Gastroenterology 2007
(Carcinoma, Hepatocellular...) :
The
histone deacetylase (HDAC) inhibitor Tricostatin A partially
blocked the
TGFbeta1 inhibition of CYP7A1 mRNA expression, whereas TGFbeta1 decreased histone 3 acetylation in the CYP7A1 chromatin ... The
histone deacetylase (HDAC) inhibitor Tricostatin A partially
blocked the TGFbeta1 inhibition of
CYP7A1 mRNA expression, whereas TGFbeta1 decreased histone 3 acetylation in the CYP7A1 chromatin ... This study provides the first evidence that TGFbeta1 represses CYP7A1 gene transcription in human hepatocytes by a mechanism involving
Smad3 dependent inhibition of HNF4alpha and
HDAC remodeling of CYP7A1 chromatin
Pulukuri et al., J Biol Chem 2007
(Neoplasm Invasiveness...) :
Induction of
uPA expression by
histone deacetylase (HDAC) inhibitors trichostatin A (TSA), sodium butyrate, and scriptaid was observed in all three different types of human cancer cells examined ... In vitro Matrigel invasion assays showed that
induction of
uPA expression by
HDAC inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion
Chen et al., Ann Hematol 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) :
Thus, the
HDAC inhibitors
activate p38 in a manner different from the activin A pathway
Vinh et al., J Vasc Res 2008
(Aortic Aneurysm, Abdominal...) :
In vitro,
MCT-1 inhibited
HDAC activity in rVSMCs, and MMP-2 expression and proteolytic activity in hVSMCs ... In vitro,
MCT-1 inhibited
HDAC activity in rVSMCs, and MMP-2 expression and proteolytic activity in hVSMCs
Pisalyaput et al., J Neurochem 2008
:
Interestingly,
SAP did not
induce caspase and
calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways ... Interestingly,
SAP did not
induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways
Li et al., Immunity 2007
:
Furthermore,
SAP was
critical for
IL-4 production by T-CD4 T cells, but the PKCtheta deficiency did not alter the ability of T-CD4 T cells to produce cytokines
el-Kashef et al., Pulm Pharmacol 1991
:
Atropine or secoverine ( SEC ) inhibited equally the PVR and
SAP responses to
ACh
Andresen et al., J Immunol 2007
:
NF-kappaB activity can be
induced by
HDAC treatment
Natesampillai et al., Am J Physiol Endocrinol Metab 2008
:
Histone-deacetylase (HDAC) inhibitors
stimulated LDLR/luc five- to sixfold and StAR/luc and CYP11A/luc activity twofold ( P < 0.001 ) and partially reversed suppression by all three KLFs ( P < 0.001 )
Condorelli et al., Br J Pharmacol 2008
(Neuroblastoma) :
Accordingly,
HDAC inhibitor induced cell killing and
p21/Waf1/Cip1 upregulation is
impaired in p53i-cells
Zhang et al., Cancer Lett 2008
(Carcinoma, Hepatocellular...) :
Researches have shown that
ING2 can
activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
McGee et al., Diabetes 2008
:
Overexpression of HDAC5 represses
GLUT4 reporter gene expression, and
HDAC inhibition in human primary myotubes
increases endogenous GLUT4 gene expression ... Overexpression of
HDAC5 represses GLUT4 reporter gene expression, and
HDAC inhibition in human primary myotubes
increases endogenous GLUT4 gene expression
Ozaki et al., Cancer Sci 2008
:
HDAC inhibitors
potentiated both the phosphorylation of
histone H2AX on serine-139 ( a marker of DNA double-strand breaks ) as well as the accumulation of reactive oxygen species induced by DNA damaging agents in tumor cells
To et al., Mol Cancer Res 2008
:
In the remaining cell lines, HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the
effect of
HDAC inhibition on
ABCG2 expression
Matsuoka et al., Biol Pharm Bull 2008
(Thrombocytopenia) :
Histone deacetylase (HDAC) inhibitors
repress interleukin-2 (IL-2) gene expression in T cells and possess immunosuppressive activity in vivo ... In addition to its immunosuppressive activity,
HDAC inhibitors
block GATA binding protein-1 (GATA-1) gene expression in megakaryocytes and elicit thrombocytopenia
Yarosh et al., Cancer Res 2008
(Breast Neoplasms) :
TBX3 repression to its targets is
dependent on
HDAC activity
Yamaguchi et al., Mol Carcinog 2008
(Neoplasm Metastasis) :
Histone deacetylase (HDAC) inhibitors, but not DNA methyltransferase inhibitor upregulated maspin, and HDAC1
inhibited the transactivation of
maspin promoter
Politis et al., FEBS Lett 2008
(Neuroblastoma) :
Our findings suggest that
Cend1 is an important molecular
target for
HDAC inhibition
Ohno et al., Mech Dev 2008
:
Finally, using zygotic mutations in both genes, we show that the gradual loss of function of
PRC2 activity
leads first to a loss of histone H3 K27 methylation and only at a later stage to a gradual loss of
PRC1 binding to chromatin
Jiang et al., J Exp Biol 2008
(Cardiovascular Diseases) :
Based on the fact that the binding of MeCP2 with the EC-SOD was completely suppressed by AZC and trichostatin A
[TSA , a
histone deacetylase (HDAC) inhibitor ], it is indicated that DNA methylation and HDAC mediate the binding of MeCP2 with EC-SOD gene ... Based on the fact that the binding of MeCP2 with the EC-SOD was completely suppressed by AZC and trichostatin A [TSA, a histone deacetylase (HDAC) inhibitor ], it is indicated that DNA methylation and
HDAC mediate the binding of
MeCP2 with EC-SOD gene
Oh et al., Biochem Biophys Res Commun 2008
:
Histone deacetylase (HDAC) inhibitors induce autophagy, and
HDAC6 , one of class II HDAC isotypes, is directly
involved in autophagic degradation in the cell
Dayangaç-Erden et al., Adv Ther 2008
(Spinal Muscular Atrophies of Childhood) :
These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the
effect of certain
HDAC inhibitors on
SMN2 gene expression
Scuto et al., Blood 2008
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
We investigated the mechanism of action of
LBH589 , a novel broad-spectrum
HDAC inhibitor belonging to the hydroxamate class, in Philadelphia chromosome negative ( Ph ( - ) ) acute lymphoblastic leukemia ( ALL )
Henkens et al., Toxicol Lett 2008
:
The protein production of the gap junction component Cx26 was downregulated, whereas
Cx32 expression was upregulated in
response to
HDAC-inhibition
Roy et al., J Cell Biochem 2008
:
When overexpressed in Balb/c-3T3 cells or mouse embryo fibroblasts,
HDAC5 substantially
reduced the activity of the
cyclin D3 promoter and the abundance of endogenous cyclin D3 protein
Ishdorj et al., J Biol Chem 2008
(Neoplasms) :
Reducing the expression of HDAC1 significantly lowered
LPA induced
HDAC activity and increased histone acetylation ...
LPA induction of
HDAC activity was blocked by the LPA receptor antagonist, Ki16425, or by inhibiting receptor activation with pertussis toxin ... Reducing the expression of the LPA receptor
LPA ( 1 ) also
blocked LPA induced
HDAC activation ... Finally,
LPA attenuated the ability of the HDAC inhibitor to reduce
HDAC activity
Chabane et al., Osteoarthritis Cartilage 2008
:
In the present study, we determined the effect of
trichostatin A (TSA) and butyric acid ( BA ), two
histone deacetylase (HDAC) inhibitors , on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants
Sargeant et al., Cancer Res 2008
(Adenocarcinoma...) :
OSU-HDAC42 , a
histone deacetylase inhibitor , blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model
Iacopino et al., Int J Oncol 2008
(Prostatic Neoplasms) :
The goal of this study was to assess the
effects of an
HDAC inhibitor, valproic acid ( VA ), on proliferation, androgen-sensitivity, androgen receptor levels and
E-cadherin ( E-cad ) expression in human prostate cancer cells ... The goal of this study was to assess the
effects of an
HDAC inhibitor, valproic acid ( VA ), on proliferation, androgen-sensitivity,
androgen receptor levels and E-cadherin ( E-cad ) expression in human prostate cancer cells
Kim et al., Eur J Pharmacol 2008
(Brain Neoplasms...) :
A structurally distinct
HDAC inhibitor, trichostatin A, also
caused a significant concentration dependent induction of melatonin
MT(1) receptor mRNA expression, suggesting involvement of an epigenetic mechanism
Wang et al., Biochim Biophys Acta 2008
:
Specifically,
HDAC3 and HDAC4
inhibited the
p16(INK4a) promoter activity
Furukawa et al., Jpn J Pharmacol 1991
:
Before atropine, topical application of hexamethonium at the locus for stimulation of intracardiac parasympathetic nerves to the SA ( SAP stimulation ) or AV nodal region ( AVP stimulation ) abolished almost totally negative chronotropic responses to
SAP and cervical vagus stimulation or negative dromotropic
responses to
AVP and cervical vagus stimulation, respectively
Schmeck et al., J Immunol 2008
:
Legionella induced histone modification as well as
HAT-/HDAC dependent
IL-8 release could also be shown in primary lung epithelial cells
Haudek et al., Proc Natl Acad Sci U S A 2008
(Cardiomyopathies...) :
However, unlike wild-type mice,
SAP in FcRgamma ( -/- ) mice failed to inhibit the development of fibrosis and cardiac dysfunction and did not
diminish the numbers of alpha-smooth muscle actin ( + ) and
CD34 ( + ), CD45 ( + ) fibroblasts that were typical for I/RC
Li et al., Cell Signal 2008
(Lymphoproliferative Disorders) :
Expression of
SAP in the A20 B cell line
led to a marked reduction in
Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR) ... Expression of
SAP in the A20 B cell line
led to a marked reduction in Blnk phosphorylation, a decrease in
Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR)
Chavey et al., Mol Pharmacol 2008
(Breast Neoplasms) :
Moreover, run-on and transfection experiments demonstrated that
IL-8 induction by
HDAC inhibitors was transcriptional and involved mainly the nuclear factor-kappaB (NF-kappaB) site of the IL-8 promoter ...
HDAC inhibitors triggered IKK phosphorylation and
up-regulated p65 nuclear translocation, although they decreased the protein levels of IkappaBalpha, which accounts for NF-kappaB activation ...
HDAC inhibitors
triggered IKK phosphorylation and up-regulated p65 nuclear translocation, although they decreased the protein levels of IkappaBalpha, which accounts for NF-kappaB activation ... In summary, our results demonstrate that
NF-kappaB pathway
repression by
HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells ... In summary, our results demonstrate that NF-kappaB pathway repression by
HDAC is
responsible for the low expression of
IL-8 in ERalpha positive breast cancer cells
Scognamiglio et al., Biochim Biophys Acta 2008
:
HDAC-class II specific inhibition involves
HDAC proteasome dependent degradation
mediated by
RANBP2
Thomas et al., Bioorg Med Chem 2008
(Lung Neoplasms) :
Prodrug incubation with beta-glucuronidase in the culture media led efficiently to the release of the parent drug and thereby restoring its ability to decrease cell proliferation, to inhibit
HDAC and to
induce E-Cadherin expression
Xu et al., Cancer Res 2008
(Breast Neoplasms) :
Here, we show that the
histone deacetylase (HDAC) inhibitors
induce TRAIL in human breast cancer cells
Thangaraju et al., Biochem J 2009
(Colonic Neoplasms) :
Heterologous expression of
SLC5A8 in the human colon cancer cell line SW480
leads to inhibition of
HDAC activity when cultured in the presence of pyruvate
Han et al., Zhonghua Gan Zang Bing Za Zhi 2008
:
To study the
effects of
trichostatin A (TSA) on protein-protein interaction between HBx and
histone deacetylase protein 1 (HDAC1)
De Lucia et al., Proc Natl Acad Sci U S A 2008
:
The
PHD-PRC2 activity
increases H3K27me3 throughout the locus to levels sufficient for stable silencing
Lin et al., Brain Res 2008
:
In this study, we determined the
effects of a
histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), on neuronal
mu-opioid receptor (MOR) gene expression using human neuronal NMB cells, endogenously expressing MOR
Li et al., Cell Signal 2009
(Lymphoproliferative Disorders) :
Depletion of
SAP by siRNA
caused a significant decrease in
NCK1 tyrosine phosphorylation as well as the phosphorylation of other T cell receptor ( TCR ) downstream proteins such as LAT and SLP-76
Huang et al., J Cell Physiol 2009
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Moreover,
c-Jun did not alter growth inhibition and apoptotic induction by histone deacetylase (HDAC) inhibitors ( apicidin, sodium butyrate, and MS275 ) treatment, but
inhibited HDAC inhibitors induced erythroid differentiation
Chou et al., FEBS Lett 2008
:
HDAC inhibition
upregulates the expression of angiostatic
ADAMTS1
Margueron et al., Mol Cell 2008
:
While
PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown
affects global
H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly
Kundakovic et al., Mol Pharmacol 2009
:
The results suggest that
HDAC and DNMT inhibitors
activate reelin and
GAD67 expression through similar mechanisms ... The results suggest that
HDAC and DNMT inhibitors
activate reelin and GAD67 expression through similar mechanisms
Noh et al., Biochem Biophys Res Commun 2009
:
Herein, we report that
trichostatin A (TSA) , an
HDAC inhibitor , induces a delay at the G(2)/M transition, chromosome missegregation and multi-nucleation, and thereby leads to cell death by promoting exit from aberrant mitosis without spindle checkpoint
Kishigami et al., Methods Mol Biol 2009
:
In particular, we focus on a new, more efficient mouse cloning protocol using
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , which increases both in vitro and in vivo developmental rates from twofold to fivefold
Wang et al., Growth Factors 2009
:
To investigate the functional involvement of HDACs in the signaling pathway of FGF2 and IL-1beta, we examined the
effects of
HDAC inhibition on activities of
FGF2 or IL-1beta on gene expression of MMP-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 ( ADAMTS5 ), collagen type II, and aggrecan ... To investigate the functional involvement of HDACs in the signaling pathway of FGF2 and IL-1beta, we examined the
effects of
HDAC inhibition on activities of FGF2 or
IL-1beta on gene expression of MMP-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 ( ADAMTS5 ), collagen type II, and aggrecan
Chabane et al., J Cell Biochem 2009
:
We show here that inhibitors of
histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid ( BA ), and valproic acid ( BA )
prevented IL-1 induced
mPGES-1 protein expression in human synovial fibroblasts
Kim et al., Exp Mol Med 2008
(Stomach Neoplasms) :
We previously reported that
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1 non expressing gastric cancer cells
Liu et al., J Physiol 2009
:
The protein kinase PKD1 has recently been linked to slow fibre-type gene expression in fast skeletal muscle through phosphorylation of class II histone deacetylase (HDAC) molecules, resulting in nuclear efflux of
HDAC and consequent
activation of the transcription factor
MEF2
Baltus et al., J Biol Chem 2009
:
Herein we show that the
mSin3A-HDAC complex positively
regulates Nanog expression in ES cells through Sox2, a critical ES cell transcription factor and regulator of Nanog ... Herein we show that the
mSin3A-HDAC complex positively
regulates Nanog expression in ES cells through Sox2, a critical ES cell transcription factor and regulator of Nanog ... Our data demonstrate that the mSin3A-HDAC complex can positively regulate Nanog expression under proliferating conditions and that this activity is complementary to
mSin3A mediated p53 dependent silencing of
Nanog during differentiation ... Our data demonstrate that the
mSin3A-HDAC complex can positively
regulate Nanog expression under proliferating conditions and that this activity is complementary to mSin3A mediated p53 dependent silencing of Nanog during differentiation
Zhao et al., Cells Tissues Organs 2009
:
We investigated the expression of a number of genes involved in embryonic development after treatment with
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , in the limbs of chicken embryos
Xiao et al., Mol Cancer Ther 2009
(Adenocarcinoma, Follicular...) :
We have previously shown that
Notch1 may function as a tumor suppressor and that
histone deacetylase (HDAC) inhibitors can
induce Notch1 expression in some endocrine cancers ... These results indicate that
HDAC inhibitors
activate Notch1 signaling in thyroid cancer cells and lead to the suppression of proliferation by cell cycle arrest
Nian et al., Environ Mol Mutagen 2009
(Neoplasms) :
In mouse preclinical models,
SFN inhibited
HDAC activity and induced histone hyperacetylation coincident with tumor suppression
Niesen et al., Biol Pharm Bull 2009
(Carcinoma, Non-Small-Cell Lung...) :
HDAC inhibitors that can be used to treat patients may
augment the expression of tumor cell
MHC class II , and the results suggest an opportunity to determine the immunological consequences of HDAC inhibitor treatment in tumor therapy
Yap et al., Anticancer Res 2009
(Ovarian Neoplasms) :
Cells from insensitive ovarian cancer cells, SKOV3 and HEY, were cultured with and without the
DNA methyltransferase (DNMT) inhibitor, 5-aza-2'-deoxycytidine ( AzaC ) and the
histone deacetylase (HDAC) inhibitor , trichostatin (TSA)
Morita et al., J Neurosci Res 2009
:
In addition,
HDAC inhibitors
enhanced serotonin stimulated
BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha reduced neurosteroid production in the glioma cells
von Burstin et al., Gastroenterology 2009
(Lung Neoplasms...) :
In line, mesenchymal pancreatic cancer specimens and primary cell lines from genetically engineered Kras ( G12D ) mice showed
HDAC dependent down-regulation of
E-cadherin and high metastatic potential
Sun et al., J Immunol 2009
:
In this study we report that
HDAC inhibition acetylates and
activates STAT-3 , which regulates DCs by promoting the transcription of IDO ... These findings demonstrate a novel functional role for posttranslational modification of STAT-3 through acetylation and provide mechanistic insights into
HDAC inhibition
mediated immunoregulation by induction of
IDO
Choi et al., J Immunol 2009
:
Importantly,
histone deacetylase (HDAC) inhibitors significantly
enhanced IFN-gamma-inducible gene expression in trophoblast cells, but not fibroblasts ... We propose that
HDAC mediated inhibition of
IFN-gamma-inducible gene expression in mouse trophoblast cells may contribute to successful pregnancy by preventing activation of IFN-gamma responses that might otherwise facilitate the destruction of the placenta
Baumeister et al., Mol Cancer Ther 2009
:
Our studies reveal that
HDAC inhibitors specifically
induce GRP78 , and the induction level is amplified by ER stress
Kim et al., Mol Cancer Res 2009
:
Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer drugs, recent reports show that
P-glycoprotein (P-gp) is
induced by
HDAC inhibitor treatment in cancer cells, resulting in multidrug resistance of cancer cells to other chemotherapeutic agents ... In this study, we investigated the molecular mechanism of
HDAC inhibitor
induction of
P-gp expression ... Furthermore, specific down-regulation of HDAC1, but not HDAC2, by RNA silencing was enough to induce P-gp expression in HeLa cells, strongly supporting the essential
role of
HDAC1 in
HDAC inhibitor induction of P-gp ... Furthermore, specific down-regulation of HDAC1, but not HDAC2, by RNA silencing was enough to induce P-gp expression in HeLa cells, strongly supporting the essential role of HDAC1 in
HDAC inhibitor
induction of
P-gp
Kumamoto et al., Int J Cancer 2009
(Colonic Neoplasms...) :
MMP13 expression was further induced by coexpression of ING2 with HDAC1 or with mSin3A, suggesting that the
ING2-HDAC1-mSin3A complex members
regulates expression of
MMP13
Zhang et al., Hepatology research : the official journal of the Japan Society of Hepatology 2009
:
Methods
: Trichostatin A (TSA) , a potent
HDAC-specific inhibitor , was administrated to mice with cecal ligation and puncture (CLP) induced sepsis
Choo et al., Bone 2009
:
NFATc1 mediates
HDAC dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
Saito et al., Oncogene 2009
(Stomach Neoplasms) :
Analyses of chromatin modification show that DNA demethylation and
HDAC inhibition at Alu repeats
activates silenced
miR-512-5p by RNA polymerase II
Farhana et al., Mol Cancer Ther 2009
:
SHP and
Sin3A expression are
essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation,
c-Fos/c-Jun expression, and cellular apoptosis ... SHP and
Sin3A expression are
essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation,
c-Fos/c-Jun expression, and cellular apoptosis ... We examined the
effect of loss of SHP and
Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in
c-Fos and c-Jun expression ... We examined the
effect of loss of SHP and
Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and
c-Jun expression ... We examined the
effect of loss of SHP and
Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated
nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression
Sangha et al., Curr Opin Oncol 2009
(Carcinoma, Non-Small-Cell Lung...) :
Two treatment strategies, in development, seem particularly appealing for further study :
insulin-like growth factor receptor ( IGF-1R ) and
histone deacetylase (HDAC) inhibition ... Two treatment strategies, in development, seem particularly appealing for further study
: insulin-like growth factor receptor ( IGF-1R ) and
histone deacetylase (HDAC) inhibition
Dubois et al., Mol Biochem Parasitol 2009
:
Trichostatin A (TSA) , valproic acid ( VPA ) and suberoylanilide hydroxamic acid ( SAHA )
inhibited global
HDAC activity at all life-cycle stages
Norian et al., Journal of oncology 2009
:
We found that
HDAC inhibition in B-CLL cells
led to increased
TRAIL receptor expression, increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis ... We found that
HDAC inhibition in B-CLL cells led to increased TRAIL receptor expression,
increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis
Hong et al., FASEB J 2009
(Osteoarthritis) :
When expressed in these cells,
HDAC1 and HDAC2
repressed aggrecan and collagen 2 ( alpha1 ) expression but differed in their repression of collagen 9 ( alpha1 ), collagen 11 ( alpha1 ), dermatopontin, and cartilage oligomeric matrix protein ( COMP )
Zhou et al., Nucleic Acids Res 2009
:
We also find that Lsh requires
histone deacetylase (HDAC) activity to
repress p16(INK4a) and treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Lsh ... We also find that
Lsh requires
histone deacetylase (HDAC) activity to repress p16(INK4a) and treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Lsh
Tang et al., Acta Biochim Biophys Sin (Shanghai) 2009
:
Here, we try to reveal how PRC2,
PRC2 mediated repressive histone marker
H3K27me3 , and active histone marker histone H4 acetylation ( acH4 ) regulate the CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... Here, we try to reveal how
PRC2 , PRC2 mediated repressive histone marker H3K27me3, and active histone marker histone H4 acetylation ( acH4 )
regulate the
CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... These results suggested that the histone modification including
PRC2 mediated repressive histone marker
H3K27me3 and active histone marker acH4 may involve in CD11b transcription during HL-60 leukemia cells reprogramming to terminal differentiation
Feng et al., FEBS J 2009
(Lung Neoplasms) :
We also show that
histone deacetylase (HDAC) 3 and HDAC4
inhibited p16(INK4a) promoter activity in a dose dependent manner
Lee et al., Cancer prevention research (Philadelphia, Pa.) 2009
(Prostatic Neoplasms) :
In an in vitro HDAC activity assay, the selenoamino acids, MSC and selenomethionine, had no effect at concentrations up to 2.5 mmol/L, whereas
MSP and KMSB both
inhibited HDAC activity
Zhang et al., J Biol Chem 2009
:
Our results suggest that reduced expression of
PRC2 component genes in cloned embryos
results in defective modification of
H3K27me3 to the differentiation related genes in pluripotent ICM cells
Ellison-Zelski et al., Mol Cell Biol 2009
:
Reduction of
Sin3A expression by RNA interference specifically
inhibits estrogen induced repression of
ESR1
Ma et al., Chin J Cancer 2009
(Neoplasm Invasiveness...) :
HDAC suppresses the activation of
PPARgamma through a series of molecular mechanisms
Song et al., Cardiovasc Res 2010
:
In this study, we investigated the effect of
trichostatin A (TSA) , a potent
HDAC inhibitor , on the proliferation and migration of vascular smooth muscle cells ( VSMCs ), and we examined the role of reduced Trx1 levels in this effect
Pang et al., American journal of physiology. Renal physiology 2009
(Fibrosis...) :
In this study, we investigated the effect of
trichostatin A (TSA) , a specific
histone deacetylase (HDAC) inhibitor , on the activation of renal interstitial fibroblasts in a rat renal interstitial fibroblast line ( NRK-49F ) and the development of renal fibrosis in a murine model of unilateral ureteral obstruction ( UUO )
Zhang et al., J Biol Chem 2009
:
This is also the first report of
HDAC regulation of
PDGF-R alpha transcription
Davies et al., Cancer Lett 2010
(Breast Neoplasms) :
Using HDAC activity assays,
TRG inhibited
HDAC activity in cells and in cell lysates, similar to that observed with TSA
Kee et al., J Mol Cell Cardiol 2009
(Cardiomegaly) :
Recently, we reported that
histone deacetylase (HDAC) inhibitors block cardiac hypertrophy and that activation of
HDAC2 , one of the class I HDACs, is
required for hypertrophy ... These results suggest that
KLF4 , a novel anti-hypertrophic transcriptional regulator,
mediates the
HDAC inhibitor induced prevention of cardiac hypertrophy
Catalioto et al., Exp Cell Res 2009
:
HDAC inhibitors
induced a significant reduction of the expression of the transcription factor
C/EBPalpha , an early marker of differentiation, and a diminution of fibronectin immunoreactivity was also observed
Chehl et al., HPB (Oxford) 2009
:
Tq also increased
p21 WAF1 expression,
inhibited histone deacetylase (HDAC) activity, and induced histone hyperacetylation
Almeida et al., Neurotox Res 2010
:
Both NGF and
BDNF counteracted the increase in the levels of histone H3 and H4 acetylations and
reduced histone deacetylase (HDAC) activity induced by 3-NP ... Both
NGF and BDNF counteracted the increase in the levels of histone H3 and H4 acetylations and
reduced histone deacetylase (HDAC) activity induced by 3-NP
Kamei et al., Journal of hepato-biliary-pancreatic sciences 2010
(Acute Disease...) :
TREM-1 may
act as an important mediator for inflammation and organ injury in
SAP
Ho et al., J Nutr 2009
(Genomic Instability...) :
We have previously found that
sulforaphane (SFN) , a compound found in cruciferous vegetables,
inhibits HDAC activity in human colorectal and prostate cancer cells
Pilling et al., PloS one 2009
:
In addition, IL-4, IL-12, IL-13, IFN-gamma, and
SAP differentially
regulate the expression of CD32,
CD163 , CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and
SAP differentially
regulate the expression of
CD32 , CD163, CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and
SAP differentially
regulate the expression of CD32, CD163, CD172a, and
CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and
SAP differentially
regulate the expression of CD32, CD163,
CD172a , and CD206 on both macrophages and fibrocytes
Kim et al., BMB Rep 2009
(Carcinoma, Hepatocellular...) :
HDAC inhibitors markedly
induced Egr-1 expression during the early period, after which expression levels decreased
Huang et al., Neurobiol Aging 2011
(Parkinson Disease) :
Moreover,
UCN directly
inhibited the
histone deacetylase (HDAC) activity and induced a robust increase in histone H3 acetylation levels
Krishnan et al., Oncogene 2010
(Colonic Neoplasms) :
Further studies revealed modulation of claudin-1 mRNA stability by its 3'-UTR as the major mechanism underlying
HDAC dependent
claudin-1 expression
Seong et al., Hum Mol Genet 2010
(Disease Models, Animal...) :
Supporting a direct stimulatory role, full-length recombinant
huntingtin significantly
increased the histone H3K27 tri-methylase activity of reconstituted
PRC2 in vitro, and structure-function analysis demonstrated that the polyglutamine region augmented full-length huntingtin PRC2 stimulation, both in Hdh ( Q111 ) EBs and in vitro, with reconstituted PRC2
Cayo et al., American journal of translational research 2009
:
We hypothesized that the
HDAC inhibitor Sodium Butyrate ( NaB ) might
activate Notch1 in pheochromocytoma resulting in altered tumor cell proliferation
Cao et al., Proc Natl Acad Sci U S A 2009
(Disease Models, Animal...) :
We identified
trichostatin A (TSA) , a
pan-HDAC ( histone deacetylase )
inhibitor , as a compound that affected both body curvature and laterality
Enose-Akahata et al., PLoS Pathog 2009
(Paraparesis, Tropical Spastic) :
High expression of CD244 and
SAP regulated
CD8 T cell responses of patients with HTLV-I associated neurologic disease
Kakihana et al., J Thorac Oncol 2009
(Carcinoma, Non-Small-Cell Lung...) :
In contrast to H460 and H661, H157 cells were resistant to
E-cadherin up-regulation by
HDAC inhibitors
Giommarelli et al., Cell Mol Life Sci 2010
:
The enhancement of antiproliferative and proapoptotic activity of
HDAC inhibitors by curcumin is
mediated by
Hsp90 inhibition
Sayan et al., Biochem Biophys Res Commun 2010
:
In this study we tested the abilities of different
HDAC inhibitors to
induce TAp63 expression ... We discovered that two
HDAC inhibitors belonging to the hydroxamate group, namely TSA and LBH589, are the most efficient
inducers of
TAp63 expression
Jung et al., Cell Mol Life Sci 2010
:
Similarly,
HDAC inhibitors
induced cellular senescence through downregulation of PcGs and upregulation of
JMJD3
Shen et al., Cell 2009
:
In vitro
JMJ inhibits
PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically,
JMJ is
required for efficient binding of
PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Li et al., Cancer Res 2010
(Colonic Neoplasms) :
HDAC depletion relieved
HDAC mediated transcriptional inhibition of the
cyclin dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G(2) phase of the cell cycle
Pasini et al., Nature 2010
:
JARID2 regulates binding of the
Polycomb repressive complex 2 to target genes in ES cells
Lee et al., Biochim Biophys Acta 2010
(Anoxia) :
This repression was reversed by the
HDAC inhibitor, trichostatin A (TSA) and
HIF-1 inhibitor , YC-1
Shimizu et al., J Biol Chem 2010
:
Thus,
HDAC4 is a basal repressor of MMP-13 transcription, and PTH
regulates HDAC4 to control MMP-13 promoter activity ... Thus,
HDAC4 is a basal repressor of MMP-13 transcription, and
PTH regulates HDAC4 to control MMP-13 promoter activity
Zhu et al., J Biol Chem 2010
:
This study was undertaken to investigate the contribution of histone deacetylase (HDAC) to TNF-alpha expression in cardiomyocytes and the signaling mechanism of
LPS induced
HDAC activation ... Furthermore, our data reveal that
LPS induced
HDAC activity is mediated through reactive oxygen species from mitochondria and c-Src signaling
Rai et al., PloS one 2010
(Disease Models, Animal...) :
Two new pimelic diphenylamide
HDAC inhibitors
induce sustained
frataxin upregulation in cells from Friedreich 's ataxia patients and in a mouse model
Li et al., Genes Dev 2010
:
Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as
Jarid2 knockdown
reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access
Komorowsky et al., J Cell Mol Med 2009
:
Therefore, we hypothesized that
histone deacetylating enzymes (HDAC) , which modulate the accessibility of transcriptionally active promoter regions, might
play a role in the regulation of
CTGF gene expression ... Taken together, our data indicate that the
effect of
HDAC inhibitors on
CTGF expression is largely cell dependent in non-tumour cells
Smith et al., Chem Biol 2010
:
Loss of
ING2 disrupts the in vivo binding of the
Sin3 complex to the p21 promoter, an important target gene for cell growth inhibition by SAHA
Swingler et al., Biochem J 2010
:
The present study demonstrates that
MMP28 expression is
induced by
HDAC ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box ... Transient transfection assays have shown that the
induction of
MMP28 expression by the
HDAC inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box
Wei et al., J Neuroimmunol 2010
:
The results suggest that inhibition of
HDAC activity and BDNF-TrkB autocrine loop are
involved in regulation of astrocytic
BDNF transcription, whereas the mechanisms for elevated constitutive gene BDNF expression of LEW/N astrocytes remain to be investigated
Xia et al., Development 2010
(Polycystic Kidney Diseases) :
Kidney-specific knockout of Mef2c, or genetrap-inactivation of a MEF2C transcriptional target, MIM, resulted in extensive renal tubule dilation and cysts, whereas Hdac5 heterozygosity or treatment with
TSA , an
HDAC inhibitor , reduced cyst formation in Pkd2 ( -/- ) mouse embryos
Hughes et al., Cancer Treat Res 2009
(Bone Neoplasms...) :
Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a
role for
HDAC in regulating
Notch pathway expression in osteosarcoma
Zhou et al., J Cell Physiol 2010
(Fibrosis...) :
Corneal fibroblasts were treated with TGFbeta, a known profibrotic and anti-inflammatory factor in wound healing, in the absence or presence of
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor
Ford et al., Chest 2010
(Pulmonary Disease, Chronic Obstructive) :
In an open-label study, low-dose theophylline when added to inhaled FP
increased total
HDAC activity in peripheral blood monocytes ninefold ( P < .01 ) compared with FP alone from the same patients with
COPD
Nuutinen et al., Neurosci Lett 2010
(Alzheimer Disease) :
We have observed earlier that
histone deacetylase (HDAC) inhibitors can
induce the expression of
clusterin in several neuroblastoma and glioma cell lines ... Another clinically used
HDAC inhibitor, the cancer drug, Vorinostat ( SAHA, suberoylanilide hydroxamic acid ), also robustly
stimulated the expression of
clusterin in human astrocytes
Zhou et al., Hepatobiliary Pancreat Dis Int 2010
(Acute Disease...) :
We assessed the
effects of the inhibitor of
MCP-1 , Bindarit, on
SAP and explored the mechanisms underlying SAP
Zhang et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
Luciferase assay demonstrated an
activation of
NF-kappaB by
HDAC inhibition
Wang et al., Biochem Pharmacol 2010
:
Here we demonstrate that ferritin H mRNA and protein are induced by
histone deacetylase inhibitors (
HDAC inhibitors ), a promising class of anti-cancer drugs, in cultured human cancer cells
Liu et al., Cancer Cell 2010
(Leukemia, Myeloid) :
Our results provide evidence that the mechanisms of
Sp1/NFkappaB/HDAC/miR-29b dependent
KIT overexpression contribute to leukemia growth and can be successfully targeted by pharmacological disruption of the Sp1/NFkappaB/HDAC complex or synthetic miR-29b treatment in KIT-driven AML
Adenuga et al., Arch Biochem Biophys 2010
:
Furthermore,
HDAC2 phosphorylation was
required for
HDAC2 interaction with transcription factors, co-repressor complex formation, CBP recruitment, acetylation on lysine residues and modulates transrepression activity
Dovey et al., Proc Natl Acad Sci U S A 2010
:
Deletion of HDAC1, but not
HDAC2 ,
causes a significant reduction in the HDAC activity of
Sin3A , NuRD, and CoREST corepressor complexes ... Deletion of HDAC1, but not
HDAC2 ,
causes a significant reduction in the
HDAC activity of Sin3A, NuRD, and CoREST corepressor complexes
Jeon et al., Mol Cancer Ther 2010
(Neoplasm Invasiveness...) :
In conclusion, the inhibition of
HDAC successfully
restored the expression of
RECK under hypoxic conditions
Song et al., Pediatr Res 2010
:
We hypothesized that absence of
angiotensin (Ang) II in angiotensinogen (AGT)-deficient mice leads to defects in ureteric bud ( UB ) branching and that RAS genes are critically
dependent on
histone deacetylase (HDAC) activity
Liu et al., J Cell Biochem 2010
:
Here, we found that an inhibitor of
histone deacetylase (HDAC) , trichostatin A (TSA), can not repress LPS induced COX-2 but it
increased the
COX-2 level in RAW264.7 cells
Su et al., Oncogene 2010
(Sarcoma, Synovial) :
In this study, we report a central
role of the
transcription factor , early growth response-1 (EGR1), in the regulation of
HDAC inhibitor induced apoptotic cell death in synovial sarcoma ... Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of
PTEN contributes to
HDAC inhibitor induced apoptosis in synovial sarcoma
Takizawa et al., Drug Metab Dispos 2010
:
However, the
effects of
HDAC inhibitors on
CYP2B induction are still not fully understood ... In this study, we investigated the
effect of
HDAC inhibitors on CAR mediated
CYP2B induction ...
HDAC inhibitors diminished the binding between CAR and HDAC1 and
augmented the binding of
steroid receptor coactivator-1 (SRC-1) to CAR ... These results provide novel insight into the mechanism by which
HDAC inhibitors
affect gene expression of
CYP2B6
Yusuf et al., J Immunol 2010
:
These data illustrate complexities of
SAP dependent
SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T ( FH ) cell and GC T ( FH ) cell differentiation
Alamdari et al., Am J Physiol Regul Integr Comp Physiol 2010
(Disease Models, Animal...) :
Treatment of rats with dexamethasone increased expression of p300 and HAT activity, reduced expression of
HDAC3 and -6, and
inhibited HDAC activity
Yoshikawa et al., Eur J Pharmacol 2010
(MAP Kinase Signaling System) :
In this study, we found that
tricostatin A (TSA) , an
HDAC inhibitor , prevented transforming growth factor beta1 ( TGF-beta1 ) -induced apoptosis in cultured human renal proximal tubular epithelial cells ( RPTECs )
Lee et al., Mol Cell Biochem 2010
(Stomach Neoplasms) :
TSA , a
HDAC inhibitor , decreased HGF induced HADC-5 expression and also repressed uPA and MMP-9 expression
Lei et al., Int J Biochem Cell Biol 2010
:
Three structurally unrelated
HDAC inhibitors completely
suppress transforming growth factor-beta1 ( TGF-beta1 ) -induced EMT in AML-12 murine hepatocytes and primary mouse hepatocytes
Cheng et al., J Cereb Blood Flow Metab 2011
(Brain Ischemia...) :
Earlier studies show that
SIK1 inhibits
histone deacetylase (HDAC) activities by acting as a class IIa HDAC kinase ... The SIK1 siRNA also exacerbated OGD induced neuronal death in the presence of
trichostatin A (TSA) , an
HDAC inhibitor , and decreased histone H3 acetylation at 4 hours reoxygenation in TSA treated neurons
Tian et al., Ann N Y Acad Sci 2010
:
Taken together, these findings suggest that inhibition of
HDAC activity by TSA
activates Bdnf transcription and a compensatory change in HDAC1 expression in neurons ... Taken together, these findings suggest that inhibition of
HDAC activity by TSA
activates Bdnf transcription and a compensatory change in
HDAC1 expression in neurons
Verykokakis et al., Immunity 2010
:
Here we showed that Id3 ( -/- )
CD8 ( + ) T cells had an innate-like phenotype and
required SAP for their development
Shimizu et al., Leukemia 2010
(Lymphoma, B-Cell) :
HDAC inhibitors, valproic acid ( VPA ) and romidepsin,
increased CD20 expression at protein and mRNA levels in B-cell lymphoma cell lines with relatively low CD20 expression levels ... In mouse lymphoma models,
HDAC inhibitors
enhanced CD20 expression along with histone hyperacetylation in transplanted cells, and acted synergistically with rituximab to retard their growth
Pietrella et al., Infect Immun 2010
(Inflammation) :
In particular Sap1,
Sap2 , and Sap6 significantly
induced interleukin-1ß (IL-1ß) , tumor necrosis factor alpha ( TNF-a ), and IL-6 production ... In particular Sap1,
Sap2 , and Sap6 significantly
induced interleukin-1ß (IL-1ß), tumor necrosis factor alpha ( TNF-a ), and
IL-6 production
Negishi et al., PloS one 2010
:
Levels of both
Zfp277 and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs, but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant
restored the binding of
PRC2 but not PRC1 to the Ink4a/Arf locus
Torres et al., Int J Oncol 2010
(Neuroblastoma) :
In this study, we investigated the effect of trichostatin A or
TSA ( an
HDAC inhibitor ), and epoxomycin ( a proteasome inhibitor ) on MYCN and p53 expression in MYCN amplified neuroblastoma cells
Mulder et al., J Alzheimers Dis 2010
(Alzheimer Disease) :
In conclusion, these data suggest that local production of
SAP and CRP in the AD brain does not substantially
contribute to the
CSF levels
Feng et al., J Immunol 2010
:
Using the HDAC inhibitor trichostatin A, we demonstrate that ISRE,
IFNA , and IL6 promoters
require HDAC activity for transactivation and transcription, whereas TNFa does not
Evankovich et al., J Biol Chem 2010
(Reperfusion Injury) :
Levels of acetylated
HMGB1 increased with a concomitant decrease in total nuclear
HDAC activity, suggesting that suppression in HDAC activity contributes to the increase in acetylated HMGB1 release after oxidative stress in hepatocytes
Simboeck et al., J Biol Chem 2010
(MAP Kinase Signaling System) :
Taken together we have revealed a cross-talk of reversible phosphorylation and acetylation signals that controls the
activation of
p21 by
HDAC inhibitors and identify the phosphatase PP2A as chromatin associated transcriptional repressor in mammalian cells
Huang et al., Mol Pharmacol 2011
:
This finding, together with the
HDAC inhibitor
induced up-regulation of KLF4 and
E-cadherin , suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... This finding, together with the
HDAC inhibitor
induced up-regulation of KLF4 and
E-cadherin , suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... This finding, together with the
HDAC inhibitor
induced up-regulation of
KLF4 and E-cadherin, suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... Evidence indicates that this up-regulation of H3K4 methylation was attributable to the suppressive
effect of these
HDAC inhibitors on the expression of
RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of Sp1 expression
Wang et al., J Cereb Blood Flow Metab 2011
(Brain Edema...) :
Our findings suggest that BBB protection by VPA involves
HDAC inhibition
mediated suppression of NF-?B activation,
MMP-9 induction, and tight junction degradation ... Our findings suggest that BBB protection by VPA involves
HDAC inhibition
mediated suppression of NF-?B activation,
MMP-9 induction, and tight junction degradation
Weems et al., J Biol Chem 2011
:
In this paper, we have tested the hypothesis that differentiation dependent
GLUT4 gene expression in 3T3-L1 adipocytes is
dependent on the nuclear concentration of a class II
histone deacetylase (HDAC) protein, HDAC5
Ferland et al., Neuroscience 2011
:
In addition, since histone deacetylases ( HDACs ) contribute to the acetylation state of histones, we investigated the effects of two
HDAC inhibitors, sodium butyrate, a class I and II global HDAC inhibitor, and sirtinol, a class III
sirtuin inhibitor , on acetylation of histone 3 (H3) and H4
Aldana-Masangkay et al., J Biomed Biotechnol 2011
(Neoplasms) :
Furthermore,
HDAC6 is
required for the activation of heat-shock factor 1 (HSF1), an activator of heat-shock protein encoding genes ( HSPs ) and
CYLD , a cylindromatosis tumor suppressor gene ... Furthermore,
HDAC6 is
required for the activation of
heat-shock factor 1 (HSF1) , an activator of heat-shock protein encoding genes ( HSPs ) and CYLD, a cylindromatosis tumor suppressor gene
LeBoeuf et al., Dev Cell 2010
:
Mutant embryos display increased levels of acetylated
p53 , which opposes p63 functions, and p53 is
required for
HDAC inhibitor mediated p21 expression in keratinocytes
Huang et al., Biochem Pharmacol 2011
(Carcinoma, Non-Small-Cell Lung) :
In addition,
MTX also
increased E-cadherin expression through inhibition of
histone deacetylase (HDAC) activity and downregulation of polycomb group protein enhancer of zeste homologue 2 (EZH2)
Kim et al., Int J Oncol 2011
(Neoplasms) :
In addition,
multidrug resistance protein 2 (MRP2) expression is selectively
attenuated by
HDAC inhibitors, especially SAHA and TSA, in KBV20C cells, whereas MDR1 and BCRP expressions are not affected
Liao et al., J Biol Chem 2011
(Breast Neoplasms) :
PC4 functions are beyond
TSA induced phosphatase release, PI3K mediated Sp1 phosphorylation, and
HDAC1/2/mSin3A co-repressor release indicating its role as linker coactivator of Sp1 and the transcriptional machinery
Garlanda et al., Curr Pharm Des 2011
(Atherosclerosis...) :
CRP and
SAP are produced primarily in the liver in
response to
IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Findeisen et al., Arterioscler Thromb Vasc Biol 2011
(Disease Models, Animal...) :
HDAC inhibition
resulted in a transcriptional and posttranscriptional regulation of the
cyclin dependent kinase inhibitors p21 ( Cip1 ) and p27 ( Kip ) ... Furthermore,
HDAC inhibition
repressed mitogen induced cyclin D1 mRNA expression and
cyclin D1 promoter activity
Ramakrishna et al., J Biol Chem 2011
(Neoplasms) :
SDS3 is a key component of the
histone deacetylase (HDAC) dependent
Sin3A co-repressor complex, serving to maintain its HDAC activity ... The deubiquitinating activity of
USP17 on SDS3 negatively
regulates SDS3 associated
HDAC activity
Chen et al., Hepatology 2011
(Carcinoma, Hepatocellular...) :
Our data indicate that
HDAC inhibitors transcriptionally
activated casein kinase ( CK ) 2a expression through increased association of acetylated histone H3 with the CK2a gene promoter
Jin et al., Journal of gynecologic oncology 2010
:
Importantly, both
HDAC inhibitors dose-dependently
inhibited the expression of the antiapoptotic proteins Bcl-2 and
x-linked inhibitor of apoptosis protein ( XIAP ) ... Importantly, both
HDAC inhibitors dose-dependently
inhibited the expression of the antiapoptotic proteins
Bcl-2 and x-linked inhibitor of apoptosis protein ( XIAP )
Wang et al., PloS one 2011
(Adenocarcinoma...) :
Several compounds in the categories of
HSP90 inhibitor,
HDAC inhibitor , PPAR agonist, PI3K inhibitor, passed our screening to be the leading candidates
Consalvi et al., Mol Med 2011
(Muscular Dystrophies...) :
Studies performed in mouse models of Duchenne muscular dystrophy (DMD) indicate that
dystrophin deficiency
leads to deregulated
HDAC activity, which perturbs downstream networks and can be restored directly, by HDAC blockade, or indirectly, by reexpression of dystrophin
Hnilicová et al., PloS one 2011
:
In addition,
HDAC inhibition
reduced co-transcriptional association of the splicing regulator
SRp40 with the target fibronectin exon
Mercado et al., Biochem Biophys Res Commun 2011
(Pulmonary Disease, Chronic Obstructive) :
Although Nrf2 protein was clearly stabilized after hydrogen peroxide ( H ( 2 ) O ( 2 ) ) stimulation in a bronchial epithelial cell line ( BEAS2B ), Nrf2 stability was decreased and Nrf2 acetylation increased in the
presence of an
HDAC inhibitor,
trichostatin A (TSA)
Shi et al., J Cell Physiol 2011
:
We also observed that
HDAC inhibitors
enhanced the expression of
Fgf4 and a subset of pluripotency genes in differentiated ESCs, but reduced their expression in undifferentiated and less differentiated ESCs
Park et al., Mol Cells 2011
:
Nocodazole treatment induced G2/M arrest but co-treatment with
TSA , an
HDAC inhibitor , delayed cell cycle progression
Robert et al., Nature 2011
(Chromosomal Instability) :
We also find that
HDAC inhibition
triggers Sae2 degradation by promoting autophagy that affects the DNA damage sensitivity of hda1 and rpd3 mutants
Clarke et al., Mol Nutr Food Res 2011
(Hyperplasia...) :
The ability of
SFN to
inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts as a chemoprevention agent ... SFN treatment also selectively decreased
HDAC activity, and Class I and II HDAC proteins, increased acetylated histone H3 at the promoter for P21,
induced p21 expression and increased tubulin acetylation in prostate cancer cells ... In PrEC cells,
SFN caused only a transient reduction in
HDAC activity with no change in any other endpoints tested
Suzuki et al., J Biol Chem 2011
(Cell Transformation, Neoplastic...) :
Furthermore, the inhibition of MEK or
HDAC restored
Cbp expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation
WEI et al., Nan Fang Yi Ke Da Xue Xue Bao 2011
:
To investigate the mechanism of
trichostatin A(TSA) , a
histone deacetylase (HDAC) inhibitor , in inhibiting the activation of CD(4) ( + ) T cells in mice
Matsuzaki et al., Environ Health Prev Med 2003
:
Previously, we demonstrated that
HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally
induce the cyclin dependent kinase inhibitor
p21 ( WAF1/Cip1 ), a downstream target gene of p53, in a p53 independent manner ... Furthermore, we have recently shown that
HDAC inhibitors
activate Gadd45, another downstream target gene of p53, and
p19(INK4d) , a gene functionally similar to p16(INK4a)
Matsuzaki et al., Environ Health Prev Med 2005
:
We recently showed that
histone deacetylase (HDAC) inhibitors, promising chemopreventive and chemotherapeutical agents,
induce p15(INK4b) and p19(INK4d) gene expression and cause growth arrest, suggesting that both genes are important molecular targets for HDAC inhibitors ... We recently showed that
histone deacetylase (HDAC) inhibitors, promising chemopreventive and chemotherapeutical agents,
induce p15(INK4b) and
p19(INK4d) gene expression and cause growth arrest, suggesting that both genes are important molecular targets for HDAC inhibitors
Tae et al., Nucleic Acids Res 2011
(Leukemia...) :
Furthermore, inhibition of
BRD7 expression
reduces PRMT5 and
PRC2 recruitment to ST7 and RBL2 promoters ; however, only ST7 becomes transcriptionally derepressed
Zeng et al., Cancer Res 2011
:
We show that p53 is required for both
HDAC and PcG to
repress Arf expression ... We show that
p53 is
required for both
HDAC and PcG to repress Arf expression
Pang et al., J Cell Biochem 2011
:
Inhibition of
HDAC activity with trichostatin A (TSA),
blocked cell proliferation, decreased expression of Cyclin D1, a positive cell cycle regulator, and increased expression of
p27 and p57, two negative cell cycle regulators
Schwalbe et al., J Biol Chem 1990
:
Furthermore,
SAP had little or no effect on the ability of C4BP to bind
C4b
Fujisawa et al., Journal of translational medicine 2011
(Disease Models, Animal...) :
In contrast,
HDAC inhibition did not
increase IL-13Ra2 in normal cell lines ...
HDAC inhibitors dramatically sensitized cancer cells to immunotoxin in the cytotoxicity assay in vitro and
increased IL-13Ra2 in the tumors subcutaneously implanted in the immunodeficient animals but not in normal mice tissues
Hu et al., Blood 2011
:
HDAC inhibition using suberoylanilide hydroxamic acid or MS-275 significantly
increased MCSFR and GMCSFR expression in leukemia cell lines that express PU.1 and mutated or translocated RUNX1
Xiong et al., Mol Carcinog 2012
(Colorectal Neoplasms) :
The present study shows that
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , leads to the hyperacetylation of histones associated with the SOCS1 and SOCS3 promoters, but not the SHP1 promoter in CRC cells
Abdou et al., J Biol Chem 2011
:
Thus, although
mSin3A/HDAC1 interacted readily with LAP/LAP* in addition to LIP and that expression of LAP/LAP* was
sufficient to recruit
HDAC1 to the C/ebpa promoter, mutations in C/ebpß that abrogated HDAC1 association to LAP/LAP* in the absence of LIP provided no additional stimulation of differentiation or transcription beyond the deletion of LIP alone
Ramsey et al., Cancer Res 2011
(Carcinoma, Squamous Cell) :
Repression of proapoptotic
Bcl-2 family member genes including p53 upregulated modulator of apoptosis ( PUMA ) by
p63/HDAC is required for survival of SCC cells
Schmitges et al., Mol Cell 2011
:
In addition to H3K4me3,
PRC2 is
inhibited by
H3K36me2/3 ( i.e., both H3K36me2 and H3K36me3 )
Zhou et al., Blood 2011
(Leukemia, Myeloid, Acute) :
We show that disruption of
PRC2 , either by DZNep treatment or EZH2 knockdown, reactivates TXNIP,
inhibits thioredoxin activity, and increases reactive oxygen species ( ROS ), leading to apoptosis
Chen et al., J Cell Biochem 2011
:
HDAC inhibition
increases the up-regulation of
GATA4 , MEF2C, Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ...
HDAC inhibition
increases the up-regulation of GATA4,
MEF2C , Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ...
HDAC inhibition
increases the up-regulation of GATA4,
MEF2C , Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ... Notably,
HDAC inhibitors
led to noticeable
HDAC4 degradation, which was effectively prevented by MG132
Barnhart et al., J Cell Biol 2011
:
Furthermore,
HJURP recruitment to endogenous centromeres
required the
Mis18 complex
Burba et al., PloS one 2011
:
Our results show that
HDAC blockade
leads to phenotype changes in
CD34 ( + ) cells with enhanced self renewal and cardioprotection
Sakharkar et al., Alcohol Clin Exp Res 2012
:
Here, we investigated the involvement of amygdaloid
histone deacetylases (HDAC) induced epigenetic changes in
rapid ethanol tolerance (RET)
Zijlstra et al., Eur Respir J 2012
(Asthma) :
Furthermore,
IL-17A reduced
HDAC activity, and overexpression of HDAC2 reversed IL-17A induced GC insensitivity
Pufahl et al., J Cell Mol Med 2012
:
5-LO promoter activity and mRNA expression were
up-regulated by the class I
HDAC inhibitors apicidin and MS-275 but not by class II inhibitors
Hsu et al., Biochim Biophys Acta 2011
:
In the present study, we explored the actions of
trichostatin A (TSA) , a potent
HDAC inhibitor , on lipopolysaccharide (LPS) induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells ( HUVECs )
Wang et al., Development 2011
:
Skor2 overexpression suppresses
BMP signaling in an
HDAC dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression ... Skor2 overexpression suppresses BMP signaling in an
HDAC dependent manner and stimulates
Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression ...
Skor2 overexpression suppresses BMP signaling in an
HDAC dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression
Yang et al., Cell Transplant 2012
:
This study was to investigate the effect of
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , on cardiac differentiation of bone marrow mesenchymal stem cells ( MSCs ) in vitro
Koon et al., Am J Pathol 2011
(Colitis) :
Because histone deacetylase (HDAC) modulates transcription of several genes involved in inflammation, we investigated
participation of
HDAC in SP-induced
CCN1 expression in human colonic epithelial NCM460 cells overexpressing NK-1R ( NCM460-NK-1R ) and in primary colonocytes ...
HDAC overexpression
activated basal and SP-induced
CCN1 promoter activity ... Thus, SP-mediated
CCN1 expression in the inflamed human and mouse colon
involves increased
HDAC activity
Wang et al., Nucleic Acids Res 2012
:
We found that
trichostatin A (TSA) , an
inhibitor of
HDAC ( histone deacetylase ), induces p16(INK4A) expression in an HBP1 dependent manner
Holmes et al., Virology 2011
(HIV Infections) :
We discovered that
Foxp3 inhibited cellular
HDAC activity in T cells, and mutations in the forkhead domain that ablate Foxp3 function also abolished its ability to inhibit HDAC
Zhang et al., Nat Med 2011
(Chronic Disease...) :
In wild-type but not Gad2 knockout mice,
HDAC inhibitors strongly
increased GAD65 activity, restored GABA synaptic function and relieved sensitized pain behavior
Zhang et al., Oncogene 2012
(Lymphoma, Non-Hodgkin) :
Here, we investigated mechanisms of
miR-15a/16-1 transcriptional
repression and its epigenetic regulation by c-Myc and
histone deacetylase (HDAC) in MCL
Zhang et al., J Biol Chem 2011
:
We show that
CDYL dramatically
enhances the methyltransferase activity of
PRC2 toward oligonucleosome substrates in vitro ...
CDYL is
required for chromatin targeting and maximal enzymatic activity of
PRC2 at their common target sites
Tseng et al., PloS one 2011
:
Inhibition of
HDAC function
resulted in aberrant expression of Notch1 and
BMP2 , two genes known to be required for tail regeneration ... Inhibition of
HDAC function
resulted in aberrant expression of
Notch1 and BMP2, two genes known to be required for tail regeneration
Alam et al., J Biol Chem 2011
(Inflammation) :
Importantly,
HDAC3 was
essential for the constitutive transcription of PI3K and
IRF3 , which might be responsible for the basal level of galectin-9 expression ... Importantly,
HDAC3 was
essential for the constitutive transcription of
PI3K and IRF3, which might be responsible for the basal level of galectin-9 expression
McCormack et al., Leukemia 2012
(Leukemia, Myeloid, Acute) :
Our results suggest the concomitant targeting of
MDM2-p53 and
HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML ... Our results suggest the concomitant targeting of
MDM2-p53 and
HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML
Koseki et al., Int J Neuropsychopharmacol 2012
(Psychomotor Agitation) :
It also prevented the
PCP induced decrease of acetylated Lys9 in histone H3-positive cells and increase of the
histone deacetylase (HDAC)5 level in the prefrontal cortex
Sampath et al., Blood 2012
(Leukemia, Lymphocytic, Chronic, B-Cell) :
HDAC inhibition triggered the accumulation of the transcriptionally activating chromatin modification H3K4me2 and
restored the expression of
miR-15a , miR-16, and miR-29b in approximately 35 % of samples
Mulder et al., Exp Neurol 2012
(Alzheimer Disease) :
Further,
SAP-C1q increased
SCARB1 expression in control astrocytes when combined with Aßoligo
Erlich et al., Br J Cancer 2012
(Carcinoma, Squamous Cell...) :
Importantly, we observed intratumoural
HDAC inhibition and
PI3K inhibition as assessed by histone H3 acetylation status and phospho-AKT staining, respectively
Mannava et al., Blood 2012
(Multiple Myeloma) :
Instead, KLF9 levels correlated with bortezomib dependent inhibition of
histone deacetylases (HDAC) and were
increased by the HDAC inhibitor
LBH589 ( panobinostat )
Calfa et al., Hippocampus 2012
:
HDAC activity is
required for
BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons
Neri et al., Mol Cell Biol 2012
:
Myc regulates the transcription of the
PRC2 gene to control the expression of developmental genes in embryonic stem cells
Cho et al., Clin Exp Allergy 2012
(Nasal Polyps) :
The aim of this study was to study the effect of
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , on transforming growth factor ( TGF ) -ß1 induced myofibroblast differentiation and ECM accumulation in nasal polyp derived fibroblasts ( NPDFs )
Li et al., Int Immunopharmacol 2012
:
This study aimed to examine the molecular mechanism of the inflammatory responses caused by cigarette smoke extract (CSE) and the effects of erythromycin ( EM ) on
CSE induced
HDAC protein expression in human macrophages in vitro
Li et al., Cancer Lett 2012
(Bone Neoplasms...) :
Pharmacologic inhibitor of
HDAC , trichostatin A (TSA)
promoted p53-p300 interaction and recruitment of p53 Lys-382 to promoter regions of its target genes p21 and Puma, consequently inducing apoptosis and stabilizing the acetylation of p53 at Lys-382 together with the upregulation of p21 and Puma, which were impaired in EFTs cells after the knockdown of p53 expression
Bajbouj et al., J Neurooncol 2012
(Glioblastoma) :
As expected,
TSA promoted the accumulation of total acetylated histones H3 and H4 and a decrease in endogenous
HDAC activity
Zhang et al., J Pharmacol Exp Ther 2012
(Myocardial Infarction...) :
In addition, infarcted mice received a daily intraperitoneal injection of
TSA ( 0.1 mg/kg ), a selective
HDAC inhibitor
Vrba et al., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011
:
HDAC inhibitors sodium butyrate and sodium valproate do not
affect human
ncor1 and ncor2 gene expression in HL-60 cells ...
HDAC inhibitors sodium butyrate and sodium valproate do not
affect human ncor1 and
ncor2 gene expression in HL-60 cells ... Both
HDAC inhibitors
caused a significant increase in
NCF2 mRNA levels without affecting NCOR1 or NCOR2 mRNA levels
Vilas-Zornoza et al., Leukemia 2012
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
Here, we analyzed the therapeutic effect of
LBH589 , a class I-II
HDAC inhibitor , in acute lymphoblastic leukemia ( ALL )
Lee et al., Proc Natl Acad Sci U S A 2012
:
The OSS induced
HDAC signaling and EC responses are
mediated by phosphatidylinositol
3-kinase/Akt
Kerr et al., Cell Death Differ 2012
:
Furthermore, we found that the
histone deacetylase (HDAC) inhibitor Vorinostat ( SAHA )
enhances the acetylation of Ku70, thereby disrupting the
FLIP/Ku70 complex and triggering FLIP polyubiquitination and degradation by the proteasome
Lee et al., J Physiol 2012
:
In addition,
HDAC6 inhibition
blocked the up-regulation of
SGK in animals exposed to acute stress
Yi et al., Chemotherapy 2012
(Carcinoma...) :
DNMT inhibitors and
HDAC inhibitors
regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo ... DNMT inhibitors and
HDAC inhibitors
regulate E-cadherin and
Bcl-2 expression in endometrial carcinoma in vitro and in vivo
Shimizu-Hirota et al., Genes Dev 2012
:
In turn,
MT1-MMP dependent PI3Kd activation
regulates the immunoregulatory
Mi-2/NuRD nucleosome remodeling complex that is responsible for controlling macrophage immune response ... In turn, MT1-MMP dependent
PI3Kd activation
regulates the immunoregulatory
Mi-2/NuRD nucleosome remodeling complex that is responsible for controlling macrophage immune response
Yan et al., Oncogene 2013
:
Here we found that
histone deacetylase (HDAC) inhibitors
suppress both wild-type and mutant
p53 transcription in time- and dose dependent manners
Li et al., Epigenetics 2012
(Colonic Neoplasms...) :
However,
histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate ( NaBt ) significantly
increased Wnt5a mRNA expression in SW620
Dang et al., Gastroenterology research and practice 2012
:
Severe acute pancreatitis (SAP) can
cause intestinal barrier dysfunction ( IBD ) , which significantly increases the disease severity and risk of mortality
Alamdari et al., Metabolism 2013
(Muscular Atrophy) :
In recent studies, inhibition of p300/HAT expression and activity and stimulation of
SIRT1 dependent
HDAC activity reduced glucocorticoid induced catabolic response in skeletal muscle, providing further evidence that hyperacetylation plays a role in muscle wasting
Buurman et al., Gastroenterology 2012
(Carcinoma, Hepatocellular...) :
In cell lines, inhibition of
HDAC significantly
increased levels of
hsa-miR-449a ... In cell lines, inhibition of
HDAC significantly
increased levels of
hsa-miR-449a
Shi et al., Biochem J 2012
:
We demonstrated that the transcriptional repression of
Foxk1 is
dependent on the
Sin3-Sds3 repression complex, and knockdown of Sds3 results in cell-cycle arrest
Vogelauer et al., J Biol Chem 2012
:
In contrast, free
CoA , like unconjugated butyrate,
inhibits HDAC activity in vitro
Vitoriano-Souza et al., PloS one 2012
:
With regard to cytokines, the
SAP led to production of
interleukin (IL)-2 , IL-6, and IL-4 ... With regard to cytokines, the
SAP led to production of interleukin (IL)-2, IL-6, and
IL-4 ... With regard to cytokines, the
SAP led to production of interleukin (IL)-2,
IL-6 , and IL-4
Gu et al., Anticancer Drugs 2012
(Neuroblastoma) :
Our studies showed that inhibition of
HDAC decreased NB proliferation, and
induced caspase activity and G1 growth arrest
Zhang et al., Neuroscience 2012
(Disease Models, Animal) :
These results demonstrate that VPA appears to protect RGCs from ONC by inhibiting neuronal apoptosis possibly via the activation of
BDNF-TrkB signaling and
HDAC inhibition ... These results demonstrate that VPA appears to protect RGCs from ONC by inhibiting neuronal apoptosis possibly via the activation of
BDNF-TrkB signaling and
HDAC inhibition
Lu et al., Toxicol Mech Methods 2012
(Carbon Tetrachloride Poisoning...) :
The results suggested that oxidative stress in CCl ( 4 ) -exposed mice
induce the expression of
HDAC2 , while inhibition of
HDAC result in exacerbated liver injury
Gammoh et al., Autophagy 2012
(Neoplasms) :
In this study, we show that
HDAC inhibition triggers autophagy by suppressing MTOR and
activating the autophagic kinase
ULK1
Yang et al., Cancer Biol Ther 2012
(Glioblastoma) :
In addition, siRNA silencing of
Sin3B induced an increase in the expression of
c-Myc and Sin3A, which contributed to increased expression of Mad4 ... The association of c-IAP1 with Sin3B or Mad4 suggested that Sin3B might interfere with the binding of c-IAP1 to Mad4 ; however, overexpression of
Sin3B did not
affect the interaction between Mad4 and
c-IAP1 ... Exogenous expression of
Sin3B also
inhibited c-IAP1 mediated degradation of Mad1,
TRAF2 , c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity ... Exogenous expression of
Sin3B also
inhibited c-IAP1 mediated degradation of Mad1, TRAF2, c-IAP2 and
ASK1 , known targets of c-IAP1 E3 ligase activity ... Exogenous expression of
Sin3B also
inhibited c-IAP1 mediated degradation of Mad1, TRAF2,
c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity
He et al., PLoS Genet 2012
:
One possible role of
PRC2 mediated
H3K27me3 in the leaf-to-callus transition might relate to elimination of leaf features by silencing leaf-regulatory genes, as most leaf-preferentially expressed regulatory genes could not be silenced in the leaf explants of clf swn
Hsing et al., American journal of physiology. Renal physiology 2012
(Acute Kidney Injury) :
In vitro, the effects of DEX or trichostatin A (
TSA , an
HDAC inhibitor ) on TNF-a, monocyte chemotactic protein ( MCP-1 ), BMP-7, and HDAC mRNA expression in LPS stimulated rat renal tubular epithelial NRK52E cells, was determined using real-time PCR
Nagathihalli et al., Mol Cancer Ther 2012
(Carcinoma, Non-Small-Cell Lung...) :
Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through
HDAC mediated downregulation of
E-cadherin
Backues et al., Autophagy 2012
:
The
Ume6-Sin3-Rpd3 complex
regulates ATG8 transcription to control autophagosome size
Debeb et al., Stem Cells 2012
(Breast Neoplasms...) :
Moreover, while
HDAC inhibitors upregulated ß-catenin expression and significantly
increased WNT reporter activity, a TCF4 dominant negative construct abolished HDAC-inhibitor induced expansion of CSCs
Huang et al., Stem Cells 2012
:
UCN directly
inhibited the
histone deacetylase (HDAC) activity and induced a robust increase in histone H3 acetylation levels
Jensen et al., Mol Immunol 2013
(Calcium Signaling...) :
A NKG2D dependent cytolytic assay and staining with a recombinant NKG2D-Fc fusion protein showed that calcium chelation impaired the functional ability of
NKG2D-ligands induced by
HDAC-inhibitor treatment ... The
HDAC-inhibitor induced cell surface expression of
ULBP2 , but not MICA/B, was sensitive to treatment calmidazolium and trifluoperazine, two agents known to block calcium signaling ... The
HDAC-inhibitor induced cell surface expression of ULBP2, but not
MICA/B , was sensitive to treatment calmidazolium and trifluoperazine, two agents known to block calcium signaling ... However, binding of galectin-1 to cell surface glycoproteins was not critical for constitutive or
HDAC-inhibitor induced MICA/B and
ULBP2 cell surface expression ... However, binding of galectin-1 to cell surface glycoproteins was not critical for constitutive or
HDAC-inhibitor induced
MICA/B and ULBP2 cell surface expression
Otsuji et al., PloS one 2012
:
Histone H3 acetylation was induced chemically by treating primitive hESC/hiPSC-CMs with
Trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , resulting in an immediate increase in global cardiac gene expression
Zhang et al., Asian Pac J Cancer Prev 2012
(Lung Neoplasms) :
In this study, we investigated the effect of
trichostatin A (TSA) , one such
HDAC inhibitor , in combination with docetaxel ( TXT ), a cytotoxic chemotherapy agent or erlotinib, a novel molecular target therapy drug, on lung cancer A549 cells
Shi et al., J Dermatol Sci 2012
(Dermatitis, Allergic Contact) :
Trichostatin A (TSA) , a potent
HDAC inhibitor , has anti-tumor and anti-inflammatory effects
Ivanova et al., Arch Toxicol 2013
(Leukemia, Promyelocytic, Acute...) :
We identified a chiral VPA derivative, ( S ) -2-pentyl-4-pentynoic acid, previously characterized as
HDAC inhibitor that
induced massive
programmed cell death in a strongly enantioselective manner in U937 histiocytic lymphoma cells and NB4 acute promyelocytic leukemia cells
Schmidt et al., Diabetes Technol Ther 2012
(Diabetes Mellitus, Type 1) :
Conclusions : This study documents persisting beneficial
effects of
SAP on
HbA1c , treatment satisfaction, magnitude of diabetes related problems, and fear of hypoglycemia 36 months after therapy start
Saito et al., Osteoarthritis Cartilage 2013
(MAP Kinase Signaling System) :
HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM )
suppressed CTS induced expression of
RUNX-2 , ADAMTS-5, and MMP-3 at both the mRNA and protein levels within 1h ...
HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM )
suppressed CTS induced expression of RUNX-2,
ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ...
HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM )
suppressed CTS induced expression of RUNX-2,
ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ...
HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM )
suppressed CTS induced expression of RUNX-2, ADAMTS-5, and
MMP-3 at both the mRNA and protein levels within 1h ... The CTS induced expression of
RUNX-2 and ADAMTS-5 was
suppressed by
HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes ... The CTS induced expression of RUNX-2 and
ADAMTS-5 was
suppressed by
HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes
Duan et al., Prostate 2013
(Prostatic Neoplasms) :
While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of
PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and
involves E2F and histone H3K4me3 methylase MLL1 complex
Zhang et al., Cancer Cell 2012
(Lymphoma, B-Cell) :
We investigated the transcriptional and epigenetic
repression of
miR-29 by MYC,
HDAC3 , and EZH2 in mantle cell lymphoma and other MYC associated lymphomas
Soriano et al., J Neurochem 2013
:
We found that, while HDAC5 and HDAC4 mutants lacking their N-terminal phosphorylation sites ( HDAC4 ( MUT ), HDAC5 ( MUT ) ) are constitutively nuclear, co-expression with SMRT renders them exportable by signals that trigger SMRT export, such as synaptic activity,
HDAC inhibition , and
Brain Derived Neurotrophic Factor (BDNF) signaling
Ballaré et al., Nature structural & molecular biology 2012
:
These findings show that the interaction of
Phf19 with H3K36me2 and H3K36me3 is
essential for
PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells ... These findings show that the interaction of Phf19 with
H3K36me2 and H3K36me3 is
essential for
PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells
Han et al., Radiation oncology (London, England) 2012
(Carcinoma, Non-Small-Cell Lung...) :
X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory
effect of
HDAC on
Axin , upregulate Axin expression and induce apoptosis of lung cancer cells
Hidalgo et al., Cell stem cell 2012
:
Epigenomic and gene expression changes induced by Ezh1 deletion in senesced HSCs demonstrated that
Ezh1 mediated
PRC2 activity catalyzes monomethylation and dimethylation of H3K27
Tang et al., Journal of the American Heart Association 2012
:
However, inhibition of
HDAC activity did not
suppress Notch activation of the HRT target genes ... Although
CBF-1 mediated Notch signaling was
increased by
HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated
Notch signaling was
increased by
HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although
CBF-1 mediated Notch signaling is not
suppressed by
HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 ) ... Although CBF-1 mediated
Notch signaling is not
suppressed by
HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )
Madapura et al., Cell cycle (Georgetown, Tex.) 2012
:
Modifying
p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was
sufficient to upregulate
SAP expression, indicating that SAP is a target of p53 in T cells
Mims et al., Leukemia 2013
(Leukemia, Myeloid, Acute) :
Thus,
HDAC inhibition may
increase miR-29b expression
Shah et al., Dev Dyn 2013
:
These effects of VPA were mimicked by
Trichostatin A (TSA) , a well established
pan-HDAC inhibitor , but not by valpromide, which is structurally similar to VPA but does not inhibit HDACs
Wessels et al., Immunobiology 2013
:
The
effects of
histone deacetylase (HDAC)-inhibition by trichostatin A (TSA) on
IL-1ß and TNFa expression and their promoter structures were measured in promyeloid HL-60 cells
Shi et al., Biochem Biophys Res Commun 2013
:
Synergistic
induction of
miR-126 by hypoxia and
HDAC inhibitors in cardiac myocytes ... Here we provide the first evidence that hypoxia and
HDAC inhibitors selectively and synergistically
stimulate expression of
miR-126 in cardiac myocytes ...
MiR-126 expression was increased 1.7-fold ( p < 0.05 ) after 1h of hypoxic exposure and this was further
enhanced to 3.0-fold ( p < 0.01 ) by simultaneously blocking
HDAC with the pan-HDAC inhibitor Tricostatin A (TSA)
Iordache et al., International journal of molecular sciences 2012
:
RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as VE-cadherin, CD133,
CXCR4 and Tie-2 ... RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as VE-cadherin, CD133, CXCR4 and
Tie-2 ... RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as
VE-cadherin , CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as
VE-cadherin , CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as VE-cadherin, CD133,
CXCR4 and Tie-2 ... RT-PCR assay showed that
HDAC inhibitors
down-regulated the expression of endothelial genes such as VE-cadherin,
CD133 , CXCR4 and Tie-2 ... Furthermore, flow cytometry analysis illustrated that
HDAC inhibitors selectively
reduce the expression of VEGFR(2), CD117,
VE-cadherin , and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that
HDAC inhibitors selectively
reduce the expression of VEGFR(2), CD117, VE-cadherin, and
ICAM-1 , whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that
HDAC inhibitors selectively
reduce the expression of
VEGFR(2) , CD117, VE-cadherin, and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that
HDAC inhibitors selectively
reduce the expression of VEGFR(2),
CD117 , VE-cadherin, and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells
Li et al., Blood 2013
(Leukemia, Myeloid, Acute) :
Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because
miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a,
HDAC3 , KIT, CCND1, and MDM2 directly, and increases PTEN indirectly
Zhou et al., Leukemia 2013
(Leukemia, Myeloid, Acute) :
HDAC inhibition by SNDX-275 ( Entinostat )
restores expression of silenced leukemia associated transcription factors
Nur77 and Nor1 and of key pro-apoptotic proteins in AML ... We here report that inhibition of
histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275
restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor
TRAIL , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of
histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275
restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors
c-Jun and JunB, and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of
histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275
restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and
JunB , and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of
histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275
restored the expression of
Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1
Cai et al., Mol Cell 2013
:
Ectopically expressed
PHF1 induced Tudor dependent stabilization of
PRC2 complexes on bulk chromatin and mediated spreading of PRC2 and H3K27me3 into H3K36me3 containing chromatin regions
Chan et al., Stem Cells 2013
:
Depletion of
PRDM14 reduces
PRC2 binding at these loci and the concomitant reduction of H3K27me3 modification ... In addition, we show that PRDM14 recruits
PRC2 to
repress a key mesenchymal gene
ZEB1 , which enhances mesenchymal-to-epithelial transition in the initiation event of iPSC reprogramming
Bellucci et al., PloS one 2013
(Breast Neoplasms) :
Activation of
p21 by
HDAC inhibitors requires acetylation of H2A.Z
Vasilatos et al., Carcinogenesis 2013
(Breast Neoplasms) :
Taken together, these results provide novel mechanistic insight into the breast cancer subtype dependent
role of
LSD1 in mediating
HDAC activity and therapeutic efficacy of HDAC inhibitor
Liu et al., Acta Neurobiol Exp (Wars) 2012
:
Inhibition of
HDAC by trichostatin A (TSA) blocked the proliferation,
increased neuronal differentiation and decreased astrocyte differentiation of the NPCs ... These findings collectively demonstrate that in the situation of not affecting survival and migration,
HDAC inhibition may
induce more
neuronal differentiation
Lee et al., Circ Res 2013
(Disease Models, Animal...) :
HDAC inhibition promoted MR acetylation, leading to decreased transcriptional activity of MR. Knockdown or inhibition of
HDAC3 resulted in reduced expression of MR target genes induced by mineralocorticoids
Ye et al., J Cell Sci 2013
:
HDAC5-deficient mice have reduced cardiac
PTB protein abundance, and
HDAC inhibition in myocytes causes a reduction in endogenous expression of cellular FLICE-like inhibitory protein ( cFLIP ) and caspase dependent cleavage of PTB
Chen et al., Carcinogenesis 2013
(Bone Marrow Neoplasms...) :
Thus,
HDAC8 plays an important role in the modulation of
SOCS1 and SOCS3 by curcumin ... Thus,
HDAC8 plays an important role in the modulation of SOCS1 and
SOCS3 by curcumin
Fragola et al., PLoS Genet 2013
:
These results indicate that
PRC2 mediated
H3K27 trimethylation is required on a highly selective core of Polycomb targets whose repression enables TF-dependent cell reprogramming
Sachweh et al., Cell death & disease 2013
:
Incompatible
effects of p53 and
HDAC inhibition on
p21 expression and cell cycle progression
Brett et al., Current treatment options in oncology 2013
:
Similarly, cell cycle inhibitors targeting
cyclin dependent kinases as well as
HDAC inhibitors have shown promise in early studies
Giudice et al., PloS one 2013
(Carcinoma, Squamous Cell...) :
Paradoxically, inhibition of
HDAC also
induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of
BMI-1 , an oncogene associated with tumor aggressiveness, and expression of the vimentin mesenchymal marker ... Paradoxically, inhibition of
HDAC also
induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of BMI-1, an oncogene associated with tumor aggressiveness, and expression of the vimentin mesenchymal marker ... Paradoxically, inhibition of
HDAC also
induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of BMI-1, an oncogene associated with tumor aggressiveness, and expression of the
vimentin mesenchymal marker
Lewis et al., Science 2013
(Brain Neoplasms...) :
We find that
H3K27M inhibits the enzymatic activity of the
Polycomb repressive complex 2 through interaction with the EZH2 subunit
Khan et al., FEBS Lett 2013
:
HDAC inhibitors
prevent the induction of the immediate-early gene
FOSL1 , but do not alter the nucleosome response ...
HDAC inhibitors
prevent FOSL1 gene induction and the association of HDAC1, 2 and 3 with the gene body ...
HDAC inhibitors
prevent FOSL1 gene induction and the association of
HDAC1 , 2 and 3 with the gene body
Fernández-Alvarez et al., Oncogenesis 2012
:
We also examined the acetylation status of the COX-2 promoter and the
effects of
histone deacetylase (HDAC) inhibitors on
COX-2 expression
Sato et al., PloS one 2013
:
Trichostatin A (TSA) , an
HDAC inhibitor , enhanced lipopolysaccharide (LPS) induced production of IL-6 in OP9 preadipocytes but not the mature adipocytes
Valdora et al., International journal of molecular sciences 2013
:
On the other hand, the treatment of MB cells with
Trichostatin A (TSA) , a potent
inhibitor of
histone deacetylases (HDAC) , was able to restore both DKK3 mRNA and protein
Liu et al., Journal of inflammation (London, England) 2013
:
In addition,
HDAC inhibitors significantly
inhibited poly ( I:C ) -induced
IL-6 production in both of the epithelial cells
Xu et al., Frontiers in pharmacology 2013
:
The
effects of
HDAC inhibition on
connexin43 (Cx43) expression and functional GJ assembly were examined in primary cultured neonatal mouse ventricular myocytes
Yang et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2013
(Disease Models, Animal...) :
To observe the effects of Qingyi Granule ( QYG ) on the changes of total protein expressions in the pancreatic tissue of rats with
severe acute pancreatitis (SAP) induced by
sodium taurocholate (STC)
Lin et al., Inflammation 1990
:
Purified mouse
interferon-beta (IFN-beta) , but not IFN-alpha, also
induced SAP production
Lodrini et al., Nucleic Acids Res 2013
(Neuroblastoma) :
In profiling studies,
histone deacetylase (HDAC) inhibitor treatment most strongly
induced miR-183
Huang et al., Cell death & disease 2013
(Disease Models, Animal...) :
Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of
Fas in the
presence of an
HDAC inhibitor
Scuto et al., Cell death & disease 2013
(Lymphoma) :
SIRT1 activation enhances
HDAC inhibition
mediated upregulation of
GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells
Yen et al., Cancer Gene Ther 2013
:
IDO shRNA
induced tumor infiltrating
CD8? and CD4? T cells, whereas
OSU-HDAC42 treatment induced tumor infiltrating CD4? T cells
Cho et al., Immune network 2013
:
Both IL-4 and
HDAC inhibitors
suppressed COX-2 expression in dose dependent manners
Zhou et al., PloS one 2013
:
C. parvum infection suppressed transcription of the
mir-424-503 gene in a NF-kB- and
HDAC dependent manner
Gao et al., J Immunol 2013
:
In this study, we investigated the
role of
histone deacetylase (HDAC) activity in
TRIM22 induction by IFN-? and its underlying mechanism ... We found that the
HDAC activity, especially that conferred by HDAC6, was
required for IFN-? induced
TRIM22 transcription
Aldiri et al., Development 2013
(Wnt Signaling Pathway) :
We also show that
Wnt/ß-catenin signaling acting through the receptor Frizzled 5, but independent of Sox2,
regulates expression of key
PRC2 subunits in the developing retina
Liu et al., Toxicol Lett 2013
(Adenocarcinoma...) :
Trichostatin A (TSA) , a classical
HDAC inhibitor , has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis
Derkacheva et al., EMBO J 2013
:
While
p55 is not
essential for the in vitro enzymatic activity of
PRC2 , plant MSI1 was required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower ... While p55 is not essential for the in vitro enzymatic activity of PRC2, plant
MSI1 was
required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION
PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower
Gopal et al., Cancer Genet 2013
(Stomach Neoplasms) :
Our reporter assays and gene reactivation studies using 5-aza-2'-deoxycytidine, a DNA demethylating agent, and
trichostatin A (TSA) , a
histone deacetylase (HDAC) inhibitor , demonstrated that epigenetic mechanisms are involved in the down-regulation of SOSTC1 expression
Shakespear et al., J Biol Chem 2013
(Inflammation) :
A novel class IIa-selective
HDAC inhibitor
reduced recombinant human
HDAC7 enzyme activity as well as TLR induced production of inflammatory mediators in thioglycollate elicited peritoneal macrophages ... A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for
HDAC dependent
TLR-inducible promoter activity and for Hdac7- and HIF-1a mediated trans-activation
Nogee et al., Am J Perinatol 1988
(Hyaline Membrane Disease...) :
SAP-35 expression is
enhanced by 3'-5'-cyclic adenosine monophosphate and
epidermal growth factor during perinatal differentiation of type II epithelial cells
Siripont et al., Cell Immunol 1988
:
Binding of
SAP to M phi
required Ca2+ or
Mg2+ and was inhibited at a pH less than or equal to 5.6 ... Binding of
SAP to M phi
required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6
Ozkan et al., J Trauma 1987
:
Reversal of
SAP induced immunosuppression and
SAP detection by a monoclonal antibody
Sarlo et al., Cell Immunol 1985
:
The mouse macrophage line P388D1, also could bind SAP and display enhanced
IL-1 production in
response to
SAP
Korewicki et al., Cor Vasa 1985
(Coronary Disease...) :
The
effects of intravenous nitroglycerin ( NTG ), trimetaphan ( TMP ), and
phentolamine (PTL) on pulmonary artery diastolic pressure ( PADP ),
systemic arterial pressure (SAP) , cardiac index ( CI ) and systemic vascular resistance ( SVR ) in patients ( 12 in each treated group ) with chronic ischaemic heart failure are analyzed
Sipe et al., Ann N Y Acad Sci 1982
(Acute Disease...) :
Unlike SAA synthesis, BCG-preinfection fails to synergistically augment the
LPS induced
SAP response
Bugni et al., Am Heart J 1980
(Arterial Occlusive Diseases...) :
The
effect of mean
systemic arterial pressure (SAP) on myocardial O2 consumption ( MVO2 )
coronary blood flow (CBF) and the reduction of left ventricular ( LV ) reserve capacity resulting from coronary artery occlusion was studied in 25 open-chest pentobarbital anesthetized dogs with fixed cardiac output and controlled heart rate ( HR ) and SAP
Büscher et al., Mol Cell Biol 1995
:
Both
CSF-1 and LPS rapidly activate the MAPK network and
induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and
TCF/SAP ... Both CSF-1 and
LPS rapidly activate the MAPK network and
induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and
TCF/SAP
Nawaz et al., Mol Gen Genet 1994
:
The yeast
SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively
regulates the activities of
GAL4 and the HAP1 activator ... The yeast
SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively
regulates the activities of GAL4 and the
HAP1 activator ... The yeast
SIN3 gene product negatively
regulates the activity of the human
progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ...
SIN3 positively
regulates the transcriptional activities of
GAL4 and the HAP1 activator ...
SIN3 positively
regulates the transcriptional activities of GAL4 and the
HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for
SIN3 mediated regulation of hPR, GAL4, and the
HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for
SIN3 mediated regulation of hPR,
GAL4 , and the HAP1 activator
García de Frutos et al., J Immunol 1994
:
Even though C4BP, C4 ( H2O ), and SAP form a multimolecular complex in fluid phase,
SAP was found to
inhibit binding of
C4BP to immobilized C4 ( H2O ) ... Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory
effect of
SAP on
C4BP binding to C4 ( H2O )
Ku et al., Cytokine 1993
(Carcinoma, Hepatocellular...) :
By contrast, gene expression of the major APR of the mouse,
serum amyloid P-component (SAP) , a structural homologue of CRP, increased in
response to either
IL-1 or IL-6 under the same conditions ... By contrast, gene expression of the major APR of the mouse,
serum amyloid P-component (SAP) , a structural homologue of CRP, increased in
response to either IL-1 or
IL-6 under the same conditions
Husøy et al., Carcinogenesis 1993
(Cell Transformation, Neoplastic) :
The
effects of 12-O-tetradecanoylphorbol-13-acetate ( TPA ), 12-deoxyphorbol-13-phenylacetate ( DOPP ), 12-deoxyphorbol-13-phenylacetate-20-acetate ( DOPP A ),
sapintoxin D (SAP D) and sapintoxin A (SAP A) on the decrease in [ 125I ] epidermal growth factor (EGF) binding ( indicating protein kinase C activation ), suppression of gap junctional intercellular communication ( GJIC ) and induction of
morphological cell transformation (MCT) in Syrian hamster embryo (SHE) cells were investigated
Tsai et al., J Biol Chem 1993
:
Binding of
ARF1 and -3, but not ARF5, was
enhanced by
SAP ... Binding of ARF1 and -3, but not
ARF5 , was
enhanced by
SAP ... B36, an inactive derivative of BFA, did not inhibit
SAP dependent binding of
ARF1 and -3
Molewijk et al., Psychopharmacologia 1995
:
The 5-HT2C/1B receptor agonist
m-CPP , the inverse BZD receptor agonists FG 7142 and DMCM, and the alpha 2-adrenoceptor antagonist yohimbine, to all of which putative anxiogenic effects have been ascribed,
had no effect on
SAP directed towards the prod
Rao et al., Oncogene 1996
(Cell Transformation, Neoplastic...) :
This constant expression profile, coupled with the observation that over-expression of
mSin3A does not
augment the anti-Myc activity of
Mxi1-SR in the rat embryo fibroblast ( REF ) transformation assay, suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function ... This constant expression profile, coupled with the observation that over-expression of
mSin3A does not
augment the
anti-Myc activity of Mxi1-SR in the rat embryo fibroblast ( REF ) transformation assay, suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function
Zahedi et al., J Biol Chem 1996
:
Binding of
SAP to type IV collagen was
inhibited by both
SAP and C-reactive protein (CRP)
Zahedi et al., J Biol Chem 1997
:
Competition binding assays indicate that the binding of
SAP to laminin is
inhibited by both
SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine ... Competition binding assays indicate that the binding of
SAP to laminin is
inhibited by both SAP and its analog, C-reactive protein, as well as
phosphatidylethanolamine
Whitmarsh et al., Mol Cell Biol 1997
:
In contrast,
SAP-1 is
activated by
ERK and p38 MAP kinases but not by JNK
Jin et al., Mol Cell Biol 1998
:
Incubation of human colon carcinoma SW620 cells in 100-ng/ml
trichostatin A (TSA) , a specific
HDAC inhibitor , increased the steady-state level of MDR1 mRNA 20-fold
de Haas et al., J Immunol 1998
:
In search for the LPS binding site of SAP, we found that
pep27-39 , a 13-mer peptide consisting of amino acids 27-39 of SAP, competitively
inhibited the binding of LPS to
SAP ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that
SAP could not
prevent binding of LPS to soluble
CD14 , in contrast to pep27-39 ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that
SAP could not
prevent binding of
LPS to soluble CD14, in contrast to pep27-39
Liedtke et al., Oncogene 1998
(Cell Transformation, Neoplastic) :
Regulation of
Bcr-Abl induced
SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase ... Regulation of
Bcr-Abl induced
SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase