Gene interactions and pathways from curated databases and text-mining

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RBBP4 — RBBP7

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kim et al., Oncogene 1999 (Melanoma, Experimental...) : These phenotypic changes of HeLa cells were apparently similar to those by trichostatin A (TSA) , a specific inhibitor of histone deacetylase (HDAC)
Bocheński et al., J Physiol Pharmacol 1999 : Pretreatment with a PAF receptor antagonist ; WEB 2170 ( 5 and 25 mg/kg ) inhibited both PAP and SAP responses to LPS ( 4 mg/kg/min ) while an inhibitor of thromboxane synthesis ; Camonagrel ( 10 and 20 mg/kg ) abolished PAP response without a major effect on SAP response to LPS
Eilers et al., J Biol Chem 1999 : The interaction between Mad proteins and HDAC1/2 is mediated by the corepressor mSin3A and requires sequences at the amino terminus of the Mad proteins, termed the SID, for Sin3 interaction domain, and the second of four paired amphipathic alpha-helices ( PAH2 ) in mSin3A ... The interaction between Mad proteins and HDAC1/2 is mediated by the corepressor mSin3A and requires sequences at the amino terminus of the Mad proteins, termed the SID, for Sin3 interaction domain, and the second of four paired amphipathic alpha-helices ( PAH2 ) in mSin3A
Garrison et al., Arch Biochem Biophys 2000 (Breast Neoplasms...) : Here we have directly characterized the effects of two HDAC inhibitors, n-butyrate and trichostatin A, on the promoter activity of the murine AhR gene ... HDAC inhibitors increased the constitutive activity of the AhR gene promoter in a luciferase reporter construct by five- to sevenfold in a dose- and time dependent manner in several cell lines and was correlated with an increase in endogenous AhR activity in an AhR-deficient cell line
Yoshida et al., Ann N Y Acad Sci 1999 : Trichostatin A (TSA) , an inhibitor of the eukaryotic cell cycle and an inducer of morphological reversion of transformed cells, inhibits histone deacetylase (HDAC) at nanomolar concentrations
Michael et al., Mol Cell Biol 2000 : Rather, HDAC inhibitors augment CREB activity during the late attenuation phase by prolonging CREB phosphorylation on chromosomal but, remarkably, not on extrachromosomal templates
Chacon-Cruz et al., Pediatr Res 2000 : PS+SAP also inhibited the formyl peptide induced [ Ca2+ ] response of neutrophils ( p < 0.01 ), but only in the presence of external Ca2+
Juan et al., J Biol Chem 2000 : Down-regulation of p53 activity by HDACs is HDAC dosage dependent , requires the deacetylase activity of HDACs, and depends on the region of p53 that is acetylated by p300/CREB binding protein (CBP)
Paul et al., J Biol Chem 2000 (MAP Kinase Signaling System) : Acute phorbol 12-myristate 13-acetate pretreatment also inhibited TNFalpha stimulated SAP kinase activity, while chronic pretreatment reversed the effects of UTP
Ochrietor et al., Cytokine 2000 : Role of STAT3 and C/EBP in cytokine dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes ... Role of STAT3 and C/EBP in cytokine dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes
Gray et al., Cytokine 2000 : Our results indicate that in contrast to the mouse, HDAC1 is not inducible by IL-2
Xu et al., Dev Dyn 2000 : We found that basal and FGF regulated activator protein 1 (AP-1) activity in Xenopus embryo is markedly reduced by treatment of trichostatin A (TSA) , a specific inhibitor of HDAC
de Haas et al., Infect Immun 2000 : Using HDL coated magnetic beads prebound with SAP, we demonstrated that HDL bound SAP prevented the binding of LPS to HDL
Hutchinson et al., Mol Med 2000 : Gel filtration chromatography and density gradient ultracentrifugation were used to compare SAP with the closely related molecule, C-reactive protein ( CRP ; which is known to be a single pentamer ) and the effect of human serum albumin on SAP autoaggregation was investigated
Lechner et al., J Biol Chem 2000 : Thus, Sds3p plays important roles in the integrity and catalytic activity of the Rpd3p.Sin3p complex
Kim et al., J Antibiot (Tokyo) 2000 (Colorectal Neoplasms) : We investigated the mechanism by which trichostatin A (TSA) , a specific inhibitor of HDAC , induces G1 arrest in human cervix carcinoma HeLa cells ... These results suggest that the suppression of Cdk2 kinase activity due to p21 overexpression play a critical role in HDAC inhibitor induced growth inhibition
Mazumdar et al., Nat Cell Biol 2001 (Breast Neoplasms...) : HRG also promotes interaction of MTA1 with endogenous ER and association of MTA1 or HDAC with ERE-responsive target-gene promoters in vivo
Chang et al., Mol Cell Biol 2001 : In serum starved cells or during serum stimulation, the Chinese hamster dhfr gene was not derepressed by trichostatin A (TSA) , an inhibitor of histone deacetylases (HDAC)
Koumenis et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A ... In contrast, hypoxia primarily induces an interaction of p53 with mSin3A , but not with p300
Singh et al., Scand J Immunol 2001 (Acute-Phase Reaction) : Both in vivo and in vitro the maximum production of CSFs occurred 6 h after initiation of stimulation, and returned to the background levels by 48 h. Mannose 6-P, mannose 1-P and mannose, and not other sugars inhibited the SAP induced production of CSFs by macrophages which suggests that SAP interaction with macrophages was mediated by specific glycoprotein-receptors ... A neutralizing ( 100 % ) concentration of rabbit antimouse interleukin (IL)-1 polyclonal antibody had no effect on the SAP induced CSF production, indicating that it would be IL-1 independent
Kuwahara et al., Mol Cell Biol 2001 : Our findings show that an NRSE-NRSF system plays a key role in the regulation of ANP gene expression by HDAC in ventricular myocytes and provide a new insight into the role of the NRSE-NRSF system outside the nervous system
Nair et al., Cancer Lett 2001 : Trichostatin A (TSA) , an inhibitor of histone deacetylase (HDAC) , is widely used to study the role of histone acetylation in gene expression, since genes that use histone acetylation as a means of regulating expression may be up regulated when TSA is added
Finzer et al., Oncogene 2001 (Cell Transformation, Neoplastic...) : HDAC inhibition also triggered an E7-dependent degradation of pRb , while the levels of E2F remained unaffected
Osborne et al., Mol Cell Biol 2001 : Repression of HLA-DRA promoter activation by HDAC activity likely involves a YY1 binding element located in the first exon of the HLA-DRA gene ... These findings represent the first evidence that HDAC activity can repress IFN-gamma-inducible HLA class II gene expression and also demonstrate that HDAC activity can contribute to promoter repression following the establishment of a DNase I-hypersensitive chromatin conformation
Sekimata et al., J Biol Chem 2001 : This repression is attenuated by an HDAC inhibitor, trichostatin A, and is completely dependent on the interaction with MBD2
Kiela et al., Am J Physiol Gastrointest Liver Physiol 2001 : Another HDAC inhibitor, Trichostatin A (TSA), stimulated NHE3 promoter in a Ser/Thr kinase independent fashion
Ashburner et al., Mol Cell Biol 2001 : Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF induced expression of the NF-kappaB regulated interleukin-8 (IL-8) gene
Khan et al., J Biol Chem 2001 : Furthermore, PML-RARalpha blocked the interaction between Rb and HDAC ... Furthermore, PML-RARalpha blocked the interaction between Rb and HDAC
Yoshida et al., Cancer Chemother Pharmacol 2001 (Melanoma, Experimental) : Trichostatin A (TSA) and trapoxin ( TPX ), inhibitors of the eukaryotic cell cycle and inducers of morphological reversion of transformed cells, inhibit histone deacetylase (HDAC) at nanomolar concentrations
Hirschler-Laszkiewicz et al., Nucleic Acids Res 2001 : Treatment of NIH 3T3 cells with trichostatin A (TSA) , an inhibitor of histone deacetylase (HDAC) , resulted in a dose dependent increase in transcription from a rDNA reporter and from endogenous rRNA genes
Park et al., J Biol Chem 2002 (Breast Neoplasms) : However, little is known about the mechanism by which inhibition of HDAC activates TbetaRII expression
Howie et al., Blood 2002 : Molecular dissection of the signaling and costimulatory functions of CD150 ( SLAM ) : CD150/SAP binding and CD150 mediated costimulation
Aoukaty et al., J Biol Chem 2002 (Lymphoproliferative Disorders) : We report here a role for phosphoinositide 3-kinase (PI3K) in the recruitment and association of SAP/SH2D1A to 2B4 in human NK cells
Deroanne et al., Oncogene 2002 : Trichostatin-A (TSA) and suberoylanilide hydroxamic acid ( SAHA ), two HDAC inhibitors known to relieve gene silencing, were evaluated as potential antiangiogenic agents
Chazova et al., Ter Arkh 2002 (Hypertension) : With sufficient antihypertensive effect on SAP , the drug did not induce an excessive decrease of DAP and did not affect heart rate and blood biochemistry
Koyama et al., Biochem Biophys Res Commun 2002 (Leukemia, Erythroblastic, Acute) : Here we showed that HDAC inhibitors sodium butyrate, TSA, and valproate regulated the expression of Interleukin-18 (IL-18) , a cytokine with antitumor and proinflammatory properties, in human acute myeloid leukemia cell lines U937 and HEL
Mignot et al., Mol Microbiol 2002 : More importantly, Sap is required for the temporal control of eag, and EA1 is involved in strict feedback regulation of eag
Wu et al., J Clin Invest 2002 (Myotonia Congenita) : These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles ... These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles ... These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Zhang et al., Mol Cell Biol 2002 (Rhabdoid Tumor) : In addition, INI1/hSNF5 repressed transcription of cyclin D1 gene in MON, in a histone deacetylase (HDAC) dependent manner
Sun et al., J Biol Chem 2002 (Breast Neoplasms) : CK2 phosphorylation of HDAC2 recruited by Sp1 or Sp3 could regulate HDAC activity and alter the balance of histone deacetylase and histone acetyltransferase activities and dynamic chromatin remodeling of estrogen regulated genes
Rahman et al., Biochem Pharmacol 2002 (Pneumonia) : Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments ... Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments ... Pharmacological inhibition of HDAC leads to the increased HAT activity, AP-1 and NF-kappaB activation, and IL-8 release by H2O2 or TNF-alpha treatments
Travers et al., Exp Cell Res 2002 : Also, HDAC1 , -2, -3, and -6 complexes isolated from CD34+ UBC by immunoprecipitation were all inhibited by TSA in vitro
Ghoshal et al., Mol Cell Biol 2002 : Inhibitors of DNA methyltransferase (Dnmt) and histone deacetylases (HDAC) synergistically activate the methylated metallothionein I gene (MT-I) promoter in mouse lymphosarcoma cells
Li et al., J Biol Chem 2003 (Lymphoproliferative Disorders) : Because SAP also blocked the recruitment of SHP-2 to SLAM in these cells, we propose a dual functional role for SAP in SLAM signaling by acting both as an adaptor for FynT and an inhibitor to SHP-2 binding
Puccetti et al., Cancer Res 2002 (Leukemia, Myeloid...) : Here we report that VDR binds corepressors in a ligand dependent manner and that inhibition of HDAC activity increases VitD ( 3 ) sensitivity of HL-60 cells
Bozzo et al., Eur J Biochem 2002 : SAP1 and SAP2 were activated by up to 80 % by 5 mm Mg2+ , and demonstrated potent competitive inhibition by molybdate, but mixed and competitive inhibition by Pi, respectively
Mie Lee et al., Biochem Biophys Res Commun 2003 (Anoxia...) : Here, we found that a histone deacetylase (HDAC) inhibitor, FK228, inhibits the induction and activity of HIF-1 in response to hypoxia
Park et al., Virology 2002 : We demonstrate, therefore, that the latent isoform of LMP-1 is induced by HDAC inhibition, and that HDACI induced latent LMP-1 expression, through NF-kappaB activation, is responsible for ICAM-1 expression up-regulation and homotypic adhesion
Yamashita et al., Int J Cancer 2003 (Carcinoma, Hepatocellular...) : We analyzed the effects of TSA , a specific and potent HDAC inhibitor , on the human hepatoma cell lines HepG2 and Huh-7
Rahman et al., Blood 2003 (MAP Kinase Signaling System) : These data suggest that both TSA and NaB exert their inhibitory effects by modulating osteoclast-specific signals and that HDAC activity regulates the process of osteoclastogenesis ... These data suggest that both TSA and NaB exert their inhibitory effects by modulating osteoclast-specific signals and that HDAC activity regulates the process of osteoclastogenesis
Sakai et al., J Antibiot (Tokyo) 2002 : Although the unique effects of GEX1 compounds on cell cycle and the reporter gene expression were similar to those of trichostatin A (TSA) , an inhibitor of histone deacetylase (HDAC) , GEX1A/herboxidiene did not affect histone acetylation in cells
Xu et al., EMBO J 2003 : The interleukin-3 (IL-3) dependent expression of the Id-1 gene, encoding a helix-loop-helix ( HLH ) transcriptional inhibitor, is activated by both C/EBPbeta and STAT5 transcription factors bound to its pro-B-cell enhancer (PBE), but is inhibited by HDAC inhibitors in Ba/F3 cells
Suzuki et al., Immunology 2003 : To investigate the underlying mechanism for induction of CD86 molecules, we analysed the ability of the histone deacetylase (HDAC) inhibitor, sodium butyrate ( NaB ), to induce CD86 at the transcriptional level in HL60 cells
Sakai et al., J Biol Chem 2003 : We here show that trichostatin A (TSA) , a specific HDAC inhibitor , enhances the up-regulation of decidualization markers such as insulin-like growth factor binding protein-1 ( IGFBP-1 ) and prolactin in a dose dependent manner that is directed by 17beta-estradiol ( E ( 2 ) ) plus progesterone ( P ( 4 ) ) in cultured ESCs, but not glandular cells, both isolated from human endometrium
Sawa et al., Brain Tumor Pathol 2002 (Brain Neoplasms...) : We investigated the effects of histone deacetylase (HDAC) inhibitors such as sodium butyrate ( SB ) and trichostatin A (TSA) on the expression of vascular endothelial growth factor ( VEGF ) by human glioblastoma T98G, U251MG, and U87MG cells ... These results suggest that HDAC inhibitors reduce VEGF secretion and modulate the expression of the other VEGF family members, and therefore may inhibit angiogenesis in glioblastoma tissues
Ding et al., World J Gastroenterol 2003 (Acute Disease...) : To establish a non-traumatic, easy to induce and reproducible mouse model of severe acute pancreatitis (SAP) induced with caerulein and lipopolyasccharide (LPS)
Ryu et al., Proc Natl Acad Sci U S A 2003 : Histone deacetylase (HDAC) inhibitors augment Sp1 acetylation, Sp1 DNA binding, and Sp1 dependent gene expression and confer resistance to oxidative stress induced death in vitro and in vivo
Mayo et al., J Biol Chem 2003 (Carcinoma, Non-Small-Cell Lung...) : Because the anti-apoptotic transcription factor NF-kappa B has been shown to be under the control of HDAC mediated repression, we analyzed whether HDAC inhibitors activated NF-kappa B in NSCLC cells ... HDAC inhibitors effectively stimulated endogenous NF-kappa B-dependent gene expression by up-regulating IL-8, Bcl-XL, and MMP-9 transcripts
Zika et al., Mol Cell Biol 2003 : Inhibition of HDAC activity dramatically increases the association of NF-YB and RFX5 with CIITA , the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter ... Inhibition of HDAC activity dramatically increases the association of NF-YB and RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter ... Inhibition of HDAC activity dramatically increases the association of NF-YB and RFX5 with CIITA, the assembly of CIITA, NF-YB, and RFX5 enhanceosome, and the extent of H3 acetylation at the MHC-II promoter
Zeng et al., J Biol Chem 2003 : Laminar flow increased the activity of histone deacetylase (HDAC) and the association of p53 with HDAC1 ... Treating human umbilical vein endothelial cells with trichostatin A (TSA) , an HDAC inhibitor , abolished the flow induced p53 deacetylation at Lys-320 and Lys-373
Zhao et al., Cancer Res 2003 (Carcinoma, Pancreatic Ductal...) : In this study, we demonstrate a novel mechanism by which down-regulation of transforming growth factor beta type II receptor ( TbetaRII ) is mediated by a histone deacetylase (HDAC) in pancreatic ductal adenocarcinoma ( PDAC ) cells ... This study further suggests that the specificity of this Sp1 site for HDAC mediated repression of TbetaRII may involve the interaction of the Sp1-HDAC1 complex with components of the cognate transcriptional regulators that bind to the inverted CCAAT box
Mellgren et al., Mol Cell Endocrinol 2003 : The inhibitory effect of RIP140 was partially reversed by Trichostatin A, suggesting a role of histone deacetylase (HDAC) activity in RIP140 mediated repression of SF-1
Ju et al., Cancer Res 2003 (Ataxia Telangiectasia) : In this work, we show that p21 ( WAF1 ) induction by HDAC inhibitors ( depsipeptide and trichostatin A ) is defective in Ataxia telangiectasia ( AT ) cells but normal in matched wild-type ( WT ) cells ( human diploid fibroblasts ) ... To verify the role of ATM in this effect, we show that ectopic expression of the WT ATM gene in an AT cell line fully restores p21 ( WAF1 ) induction by the HDAC inhibitors ... Besides the p21 ( WAF1 ) promoter, activation of topoisomerase IIIalpha and SV40 promoters by the HDAC inhibitors are also decreased in the AT cell lines relative to WT cells ; thus, these findings pertain to other promoters
Shimizu et al., Nucleic Acids Res 2003 : We suggest that TBP binding is inhibited through chromatin modification by the Sin3p-Rpd3p and Isw2p complexes recruited by Ume6p
Liu et al., Cancer Res 2003 (Lung Neoplasms...) : In this study, we test the possibility that HDAC inhibitor may increase RECK expression to inhibit MMP activation and cancer cell invasion ... In this study, we test the possibility that HDAC inhibitor may increase RECK expression to inhibit MMP activation and cancer cell invasion ... To explore whether HDAC inhibitor induced inhibition of MMP-2 activation is indeed mediated via RECK, we used small interference RNA ( siRNA ) to block RECK expression and found that inhibition of RECK by siRNA abolished the inhibitory effect of TSA on MMP-2 activation
Davie et al., J Nutr 2003 (Breast Neoplasms) : A model is proposed in which inhibition of Sp1/Sp3 associated HDAC activity leads to histone hyperacetylation and transcriptional activation of the p21 ( Waf1/Cip1 ) gene ; p21 ( Waf1/Cip1 ) inhibits cyclin dependent kinase 2 activity and thereby arrests cell cycling
Koch et al., Am J Respir Cell Mol Biol 2004 : TSA ( 10 ng/ml ), an inhibitor of histone deacetylase (HDAC) , reversed the inhibitory effect of PD 098059, SB 203580, SN 50 and AS602868 on GM-CSF release
Aquilina et al., Biochem J 2003 : In the presence of physiological levels of Ca2+ , SAP was observed to exist primarily as a pentamer, reflecting its in vivo state
Wang et al., Oncogene 2003 (Carcinoma, Non-Small-Cell Lung...) : The induction of RhoB by HDAC inhibition was mediated by an inverted CCAAT box in the RhoB promoter
Donadelli et al., Mol Carcinog 2003 (Adenocarcinoma...) : In cells with an altered p53 gene, the expression of p21 ( WAF1/CIP1 ), a potent inhibitor of cyclin dependent kinases, can be induced by histone deacetylase (HDAC) inhibitors via a p53 independent pathway, which may play a critical role in arrest of cell growth
Kataoka et al., Cancer Res 2003 (Carcinoma, Hepatocellular...) : ING1b and ING2 also repressed the AFP promoter in Hep3B p53-null cell lines, and p53 coexpression enhanced this transcriptional repression
Chevallier et al., Blood 2004 (Acute Disease...) : ETO binds to the fourth zinc finger of Bcl-6, enhances Bcl-6 repression of artificial and endogenous genes in an HDAC dependent manner, and forms a complex with Bcl-6 on the promoters of its endogenous target genes in B-cell lymphoma cells
Pal et al., Mol Cell Biol 2003 : mSin3A/histone deacetylase 2- and PRMT5 containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad
Chung et al., Mol Ther 2003 (Arthritis, Rheumatoid...) : We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA ... We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA ... We found that the histone deacetylase (HDAC) inhibitors ( phenylbutyrate and trichostatin A ) causing histone hyperacetylation to modulate multiple gene expression not only induced the expression of p21 ( Cip1 ) and p16(INK4) in synovial cells but also inhibited the expression of tumor necrosis factor-alpha in affected tissues in adjuvant arthritis, an animal model of RA
Hitomi et al., FEBS Lett 2003 : Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin dependent kinase inhibitor, p21 ( WAF1/Cip1 ) ... We report here that HDAC inhibitors, trichostatin A (TSA) and sodium butyrate, activate the p15(INK4b) gene, a member of the INK4 gene family, through its promoter in HaCaT cells
Peinado et al., Mol Cell Biol 2004 : Here we show that mammalian Snail requires histone deacetylase (HDAC) activity to repress E-cadherin promoter and that treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Snail
Boston et al., Experimental biology and medicine (Maywood, N.J.) 2004 : We hypothesize that PS+SAP suppresses neutrophil activation by depletion of internal Ca ( ++ ) stores and that PS+SAP induces depletion through release of Ca ( ++ ) stores and through inhibition of Ca ( ++ ) influx
Imai et al., Mol Cell Biol 2004 : The corepressor mSin3A regulates phosphorylation induced activation, intranuclear location, and stability of AML1 ... Here, we demonstrate that the interaction between AML1 and the corepressor mSin3A is regulated by phosphorylation of AML1 and that release of AML1 from mSin3A induced by phosphorylation activates its transcriptional activity
Gui et al., Proc Natl Acad Sci U S A 2004 : Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter associated proteins, including HDAC1
Valdez et al., J Biol Chem 2004 (Autoimmune Diseases...) : Cross linking of NTB-A also induces phosphorylation of NTB-A and the association of SAP ( SLAM associated protein ), the protein absent in X-linked lymphoproliferative disease
Takaki et al., Biochem Biophys Res Commun 2004 : Cdk mediated phosphorylation of pRB regulates HDAC binding in vitro ... Phosphorylation of pRB by Cdk4-cyclin D2, Cdk2-cyclin E, and Cdk2-cyclin A inhibited association of pRB with HDAC
Liu et al., Biochem Pharmacol 2004 : Parental cells were treated with trichostatin A (TSA) , a HDAC inhibitor
Steiner et al., Biochem Biophys Res Commun 2004 : SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors ... In human cells the MVP promoter was potently stimulated by the histone deacetylase (HDAC) inhibitors butyrate ( NaB ) and trichostatin A (TSA), resulting in enhanced MVP expression ... Summarising, this study identifies variations in Sp-transcription factor binding to a single proximal GC-box element as critical for basal MVP promoter activation and its stimulation by HDAC inhibitors
Chen et al., Zhonghua Yi Xue Za Zhi 2004 (Colonic Neoplasms) : Two colon cancer cell lines ( SW1116 and Colo-320 ) were treated with the DNA methyltransferase (DNMT) inhibitor, 5-aza-2'-deoxycytidine ( 5-aza-dC ) and/or the histone deacetylase (HDAC) inhibitor , trichostatin A (TSA) or sodium butyrate ( NaBu ) ... In these two human colon cancer cell lines, HDAC inhibitors stimulate the p21 ( WAF1 ) gene expression by selectively increasing the degree of acetylation of the gene associated histones, and induce a G ( 1 ) cell cycle arrest
Dehm et al., Biochem Cell Biol 2004 (Neoplasms) : Interestingly, histone deacetylase (HDAC) inhibitors, agents with well documented anti-cancer activity, repress SRC transcription in a wide variety of human cancer cell lines
Tong et al., Biochem Biophys Res Commun 2004 (Colonic Neoplasms) : The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells ... The HDAC inhibitors butyrate and TSA blocked the TNF-alpha activation of Cox-2 protein and mRNA synthesis, and dramatically suppressed Cox-2 activity in HT-29 cells
Vulin et al., J Biol Chem 2004 : Finally, JNK/SAPK activity was found to increase in response to oxidants, and inhibition of JNK/SAP blocked TBHQ increased PAI-1-luciferase expression
Margueron et al., J Mol Endocrinol 2004 (Breast Neoplasms) : In this study, we have analysed the effects of histone deacetylase (HDAC) inhibition on estrogen receptor ( ER ) expression and on its transcriptional activity in response to antiestrogens ... In several breast cancer cell lines, trichostatin A (TSA) , a potent HDAC inhibitor , strongly decreases ERalpha expression in a dose dependent manner
Emre et al., Biochim Biophys Acta 2004 : Furthermore, treatment with trichostatin A (TSA) , a more specific inhibitor of HDAC , caused an increase in MVP protein, mRNA, and promoter activity
Simarro et al., Int Immunol 2004 : SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9 ... SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9 ... Here we demonstrate that SAP is required for phosphorylation of both SLAM and Ly9 in thymocytes and peripheral T cells ... Here we demonstrate that SAP is required for phosphorylation of both SLAM and Ly9 in thymocytes and peripheral T cells
Klampfer et al., J Biol Chem 2004 (Inflammation) : In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1 dependent gene activation ... In this study we demonstrated that inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1 dependent gene activation
Chang et al., Proc Natl Acad Sci U S A 2004 : Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN stimulated genes ( ISG )
Liu et al., Methods Mol Biol 2004 : By using the trans activating effect of trichostatin A (TSA) , a widely used HDAC inhibitor , on the telomerase reverse transcriptase ( hTERT ) gene as an example, we summarize various aspects of HDAC inhibitors and provide a general strategy for their in vitro application in studies of gene regulation
Vanhaecke et al., Biochem Pharmacol 2004 : Here, the effect on the activity and expression of several apoptosis related proteins of trichostatin A (TSA) , a well-known HDAC inhibitor , were studied in short-term ( conventional monolayer ) and long-term cultured ( collagen I gel sandwich cultures and co-cultures ) adult rat hepatocytes
Kato et al., J Biol Chem 2004 (Anoxia) : In the nucleus, HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with HIF-1alpha, HDAC7 , and p300 ... In the nucleus, HDAC7 increased transcriptional activity of HIF-1alpha through the formation of a complex with HIF-1alpha , HDAC7, and p300
Park et al., Clin Cancer Res 2004 (Neoplasms...) : These HDAC inhibitors preferentially inhibited the enzymatic activities of HDAC1 and HDAC2, as compared with the other HDAC isotypes, indicating that class I HDAC is the major target of SK-7041 and SK-7068 ... These HDAC inhibitors preferentially inhibited the enzymatic activities of HDAC1 and HDAC2 , as compared with the other HDAC isotypes, indicating that class I HDAC is the major target of SK-7041 and SK-7068
Ellenrieder et al., Gastroenterology 2004 (Carcinoma, Pancreatic Ductal...) : Erk induced KLF11 phosphorylation was examined in vitro and in vivo, and its impact on KLF11-mSin3A mediated Smad7 repression was verified in pancreatic cancer cells using site directed mutagenesis ... Expression of an Erk-insensitive KLF11 mutant restores both mSin3a binding and Smad7 repression and results in enhanced TGF-beta signaling in pancreatic cancer cells
Myzak et al., Cancer Res 2004 : Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells : SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21 ( Cip1/Waf1 ), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter
Pasini et al., EMBO J 2004 : Furthermore, we demonstrate that SUZ12 is essential for the activity and stability of the PRC2/3 complexes in mouse embryos, in tissue culture cells and in vitro ... In conclusion, our data demonstrate an essential role of SUZ12 in regulating the activity of the PRC2/3 complexes, which are required for regulating proliferation and embryogenesis
Li et al., Biochem Biophys Res Commun 2004 (Uterine Cervical Neoplasms) : However, the exact mechanism by which HDAC inhibitors induce p21WAF1/CIP1 remains unclear ... In this study, we observed that Trichostatin A (TSA) , a HDAC inhibitor , induced strikingly p21WAF1/CIP1 expression in human cervical cancer ( HeLa ) cells, and this induction correlated with downregulation of c-myc expression
Kaiser et al., BMC biology 2004 : We found that IRS-1 is an acetylated protein, of which the acetylation is increased by treatment of cells with Trichostatin A (TSA) , an inhibitor of HDAC activity
Ramakrishnan et al., Mol Biochem Parasitol 2004 : Histone deacetylase (HDAC) activity was detected in nuclear extracts from E. histolytica, and characteristically, was inhibited by trichostatin A (TSA)
Varshochi et al., J Biol Chem 2005 (Breast Neoplasms) : The fact that p21Waf1 expression is normally repressed by HDAC activity in cycling cells is further demonstrated by the finding that p21Waf1 transcription can be induced by the silencing of HDACs with small interfering RNA or treatment with HDAC inhibitors
Huang et al., J Biol Chem 2005 : In this report, we demonstrated the mechanism by which trichostatin A (TSA) , an inhibitor of HDAC , induces the expression of TbetaRII in human pancreatic cancer cell lines by modulating the transcriptional components that bind a specific DNA region of the TbetaRII promoter
Choi et al., Clin Exp Allergy 2005 (Asthma) : The purpose of this study was to determine whether treatment with trichostatin A (TSA) , a representative HDAC inhibitor , would reduce allergen induced airway inflammation in a mouse asthma model
Cardoso et al., Dev Biol 2005 : This study thus demonstrates that in vivo XNP-1 acts in association with RB, HP1 and the NuRD complex during development
Novatchkova et al., BMC bioinformatics 2005 : Recent findings point at the importance of SUMO mediated histone NAD dependent deacetylase (HDAC) recruitment in transcriptional regulation
Miard et al., Int J Obes Relat Metab Disord 2005 (Obesity) : Inhibition of HDAC activity consequently results in a strong activation of PPARgamma
Gan et al., J Biol Chem 2005 : Induction of eNOS expression by histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate was observed in all four different types of non-endothelial cells examined
Taylor et al., Infect Immun 2005 (Candidiasis, Vulvovaginal) : SAP5 expression was induced soon after infection, whereas SAP4 was expressed at later times and in fewer cells compared with SAP5
Liu et al., Mol Endocrinol 2005 : Consistent with this corepressor function, depletion of endogenous mSin3A by small interfering RNA was sufficient to enhance prolactin gene expression by 70 %, comparable to the induction by the HDAC inhibitor, trichostatin A
Marks et al., Cell cycle (Georgetown, Tex.) 2005 (Neoplasms) : We also found that thioredoxin (TRX) might play a significant role in HDAC inhibitor induced cell death, and HDAC inhibitors increase TRX levels in normal cells but not transformed cells, which is likely to be one of the reasons why HDAC inhibitors preferentially kill cancer cells
Kawamura et al., J Biol Chem 2005 : Treatment of ES cells with trichostatin A (TSA) , a specific HDAC inhibitor , induced acetylation of histone-3/4 near GATA sites within the atrial natriuretic factor promoter
Lu et al., Biochem Biophys Res Commun 2005 : Reporter gene analysis demonstrated that both Emu and 3'-IgH enhancer activities were repressed significantly by TSA mediated HDAC inhibition
Komata et al., Int J Oncol 2005 (Brain Neoplasms...) : Furthermore, caspase inhibition assay indicated that HDAC inhibitor induced apoptosis was caspase dependent ... Taken together, the HDAC inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9 dependent apoptosis with or without p21 mediated G1 arrest in human malignant glioma cells
Gobinet et al., Biochemistry 2005 : The use of trichostatin A (TSA) , a specific inhibitor of HDAC activity, confirmed that HDACs significantly contribute to the intrinsic transrepressive activity of SHP
Veerhuis et al., Neurobiol Dis 2005 : Also, SAP and C1q enhanced PrP-peptide fibril formation as revealed by electron microscopy and thioflavin S-based quantitative assays
Wang et al., J Immunol 2005 : However, mycobacterial infection or TLR2 stimulation up-regulated expression of mammalian Sin3A, a corepressor that is required for MHC class II repression by HDAC ... However, mycobacterial infection or TLR2 stimulation up-regulated expression of mammalian Sin3A , a corepressor that is required for MHC class II repression by HDAC
Drummond et al., Clin Cancer Res 2005 (Neoplasms, Experimental) : ErbB2 overexpressing human cancers represent potentially sensitive targets for therapy by candidate histone deacetylase (HDAC) inhibitors as we have shown that HDAC inhibitors can selectively reduce ErbB2 expression by repressing the ErbB2 promoter and accelerating the decay of cytoplasmic ErbB2 transcripts
Rocchi et al., Oncol Rep 2005 (Neuroblastoma) : p21Waf1/Cip1 is a common target induced by short-chain fatty acid HDAC inhibitors ( valproic acid, tributyrin and sodium butyrate ) in neuroblastoma cells
Peltonen et al., Pigment Cell Res 2005 (Melanoma) : We have studied the cellular effects of trichostatin A (TSA) , a HDAC inhibitor , in a panel of melanoma cell lines and its mechanism of action in relation to p53 ... Inhibiting p53 function by a dominant negative p53 ( p53 ( 175His ) ) confirmed that the HDAC inhibitor induced apoptosis was independent of wild-type p53 , even though TSA slightly activated p53 in a reporter assay
Singh et al., Oncogene 2005 (Breast Neoplasms) : HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ... HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ... HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway ... HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Gurvich et al., FASEB J 2005 (Abnormalities, Drug-Induced...) : Unbiased microarray analysis revealed that the effects of VPA and trichostatin A (TSA) , a structurally unrelated HDAC inhibitor , are strikingly concordant
Yang et al., EMBO J 2005 : However, in the basal state, its activity is repressed by SUMO dependent histone deacetylase (HDAC) recruitment
Rössig et al., J Exp Med 2005 (Ischemia) : To define the mechanisms by which HDAC inhibition prevents endothelial differentiation, we determined the expression of homeobox transcription factors and demonstrated that HoxA9 expression is down-regulated by HDAC inhibitors
Zhang et al., Cell Death Differ 2006 : In contrast, HDAC1 overexpression distinctly reduced Bmf expression ... Taken together, FK228 and CBHA activate Bmf transcription by histone hyperacetylation at its promoter region, and inhibition of this action decreased their proapoptotic activity, thereby highlighting a central role of Bmf in HDAC inhibitor mediated apoptosis
Place et al., Biochem Pharmacol 2005 : HDAC inhibition prevents NF-kappa B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I kappa B alpha
Shetty et al., Mol Cell Biol 2005 (Breast Neoplasms) : Indeed, HDAC inhibitors activate NF-kappaB and p53 and upregulate DR5 expression ... Indeed, HDAC inhibitors activate NF-kappaB and p53 and upregulate DR5 expression ... Indeed, HDAC inhibitors activate NF-kappaB and p53 and upregulate DR5 expression
Kang et al., EMBO J 2005 : Accordingly, HDAC4 or 5 is required for efficient TGF-beta mediated inhibition of Runx2 function and is involved in osteoblast differentiation
Yamaguchi et al., J Biol Chem 2005 : We investigated whether HDAC inhibitors blocked AP-1 mediated activation of COX-2 transcription ... Chromatin immunoprecipitation assays indicated that HDAC inhibitors suppressed c-Jun binding to the COX-2 promoter and thereby blocked transcription ... Chromatin immunoprecipitation assays indicated that HDAC inhibitors suppressed c-Jun binding to the COX-2 promoter and thereby blocked transcription ... HDAC inhibitors suppressed the induction of both cyclin D1 and collagenase-1 transcription by inhibiting the binding of c-Jun to the respective promoters
Chuang et al., Blood 2005 (Lymphohistiocytosis, Hemophagocytic) : Interestingly, EBV LMP1 could transcriptionally inhibit the expression of SAP/SH2D1A and activate downstream molecules ERK and interferon-gamma (IFN-gamma)
Kaneda et al., Circ Res 2005 : We have now applied DCS to H9C2 rat embryonic cardiomyocytes incubated with or without trichostatin A (TSA) , a specific inhibitor of histone deacetylase (HDAC) activity
Takahashi et al., Br J Haematol 2005 (Acute Disease...) : We verified that the repression activity of AML1B , the isoform of AML1, is dependent on HDAC activity by using HDAC inbitor trichostatin A in GAL4 reporter assays
Cho et al., J Cell Biochem 2005 : Trichostatin A (TSA) , another HDAC inhibitor , also increased osteogenic differentiation, whereas valpromide ( VPM ), a structural analog of VPA which does not possess HDAC inhibitory effects, did not show any effect on osteogenic differentiation on hADSC
Graham et al., Cell cycle (Georgetown, Tex.) 2005 : In addition, HDAC inhibitors induce NFkappaB binding to the DR5 gene and DR5 expression, contributing to HDAC inhibitor induced apoptosis ... In addition, HDAC inhibitors induce NFkappaB binding to the DR5 gene and DR5 expression, contributing to HDAC inhibitor induced apoptosis
Somech et al., J Cell Sci 2005 : We further show that LAP2beta interacts at the nuclear envelope with HDAC3, a class-I histone deacetylase, and that TSA ( an HDAC inhibitor ) abrogates LAP2beta 's repressive activity
Laribee et al., Biochim Biophys Acta 2005 : Finally, we show that HDAC activity is required for association of RNA polymerase II with the PU.1 promoter
Duong et al., Oncogene 2006 : ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors
Tsuyama et al., Biochem Biophys Res Commun 2005 (Multiple Myeloma) : Expression of p53 , a direct target gene of Bcl6, was downregulated in the IL-6 stimulated cells, and this process was impaired by an HDAC inhibitor
Todoerti et al., Br J Haematol 2005 (Multiple Myeloma) : The HDAC inhibitor, trichostatin A, reduced MMSET I repression activity and in vitro co-immunoprecipitation analyses indicated that MMSET I specifically recruits HDAC1 and mSin3b, but not HDAC2 or HDAC4
Chen et al., Chin J Cancer 2005 (Ovarian Neoplasms) : This study was to evaluate enhancive effect of trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , on the transfection efficiency of adenovirus in ovarian carcinoma cell line A2780, and explore its possible application to adenovirus based gene therapy
Zhang et al., Nucleic Acids Res 2005 : The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes ... Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes
Dai et al., Mol Cell Biol 2005 : Mrj also decreased NFATc3 occupancy of the tumor necrosis factor-alpha promoter in cardiomyocytes in an HDAC dependent manner, and Mrj blocked calcineurin induced cardiomyocyte hypertrophic growth
Carrozza et al., Biochim Biophys Acta 2005 : Dep1 and Sds3 , unique components of Rpd3L, were required for Rpd3L integrity and HDAC activity
Hernández-Muñoz et al., Mol Cell Biol 2005 : Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1
Skov et al., Cancer Res 2005 (Neoplasms) : HDAC inhibitor treatment induced glycogen synthase kinase-3 ( GSK-3 ) activity and down-regulation of GSK-3 by small interfering RNA or by different inhibitors showed that GSK-3 activity is essential for the induced MICA/B expression
Pazmany et al., J Neuroimmunol 2006 : Trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , abrogates the TGF-beta1 mediated repression of the IFN-gamma induced CIITA in EOC20
Kee et al., Circulation 2006 (Aortic Valve Stenosis...) : The expressions of atrial natriuretic factor, alpha-tubulin, beta-myosin heavy chain , and interstitial fibrosis were reduced by HDAC inhibition
Earel et al., Cancer Res 2006 (Urinary Bladder Neoplasms) : HDAC inhibition, especially with sodium butyrate and trichostatin A, led to increased TRAIL-R2 gene transcription that correlated with increased TRAIL-R2 surface expression
Myzak et al., FASEB J 2006 (Cell Transformation, Neoplastic...) : In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet resulted in levels of acetylated histones and p21 ( WAF1 ) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls
Witta et al., Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : The zinc finger transcriptional repressor, ZEB1, inhibits E-cadherin expression by recruiting histone deacetylases (HDAC)
Chuang et al., Nucleic Acids Res 2006 : We herein demonstrate that the HDAC inhibitor, trichostatin A (TSA), increases the level of acetylated GCMa and that HDAC1, 3, 4 and 5 interact with and deacetylate GCMa ... Our studies support that trophoblastic fusion in placental morphogenesis depends on the regulation of GCMa activity by HAT and HDAC
Zhao et al., Mol Cell Biol 2006 : Here we found that an inhibitor of HDAC , depsipeptide ( FR901228 ), but not trichostatin A (TSA), induces p21 ( Waf1/Cip1 ) expression through both p53 and Sp1/Sp3 pathways in A549 cells ( which retain wild-type p53 )
Armstrong et al., J Infect Dis 2006 (Disease Models, Animal...) : Here, we show that serum amyloid P component (SAP), a normal human plasma protein, specifically protects mice against the lethal toxicity of Stx2, both when injected into wild-type mice and when expressed transgenically ; in the presence of human SAP , there was greatly reduced in vivo localization of Stx2 to the kidneys, suggesting a possible mechanism of protection
Woo et al., Exp Mol Pathol 2007 (Leukemia) : The objective of the present study was to investigate the effect of trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , on the cell growth and apoptosis and its effect on the telomerase activity in human leukemic cell line U937
Sato et al., Int J Oncol 2006 (Carcinoma, Squamous Cell...) : Moreover, these events were associated with an enhancement of reactive oxygen species ( ROS ) generation and caspase-3 activation by HDAC inhibitors
Ma et al., Int J Oncol 2006 : Additionally, PHI reduced the expression of HDAC and increased the level of acetyl transferase p300, in favor of accumulation of acetylated histones
Beklemisheva et al., Anticancer Res 2006 (Prostatic Neoplasms) : PHI inhibited the activity of HDAC and remodeled chromatins to activate p21 for cell cycle arrest, underlying an epigenetic mechanism regulating the growth of prostate cancer cells
Hernandez et al., Prostate 2006 (Prostatic Neoplasms) : The impact of Trichostatin A (TSA) , an inhibitor of HDAC , on exogenous and endogenous cx43 gene transcription was examined by the luciferase assay, Northern blot, nuclear run-on, Western blot, and chromatin immunoprecipitation assays
Carta et al., Blood 2006 (Calcium Signaling) : In the present study, we investigated the effects of 2 HDAC inhibitors on IL-1beta secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 ... These HDAC inhibitors do not affect the synthesis or intracellular localization of IL-1beta but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes
Furuno et al., Biochem Biophys Res Commun 2006 : Although the essential role of SUZ12 in regulating the activity of the PRC2/3 complexes has been demonstrated, additional function of this protein was suggested
Goto et al., J Bone Miner Res 2006 : The results establish that Sp1 proteins regulate COL11A2 transcription by binding to its proximal promoter and directly interacting with CBP, p300, and HDAC
Zhang et al., Int J Radiat Oncol Biol Phys 2006 : To explore their effects on ionizing radiation ( IR ), we examined whether the HDAC inhibitors m-carboxycinnamic acid bis-hydroxamide ( CBHA ) and depsipeptide FK228 affect H2AX phosphorylation ( gamma-H2AX ), a landmark of DNA double-strand breaks after IR exposure ... The results of this study suggest that HDAC inhibitors enhance IR-induced gamma-H2AX , most likely through histone hyperacetylation, and radiosensitize various cancers
Kwon et al., Biochim Biophys Acta 2006 : We report here that retinoic acids ( RA ) as well as Trichostatin A (TSA) , an inhibitor of histone deacetylase (HDAC) , regulate PDK4 gene expression
Schoeftner et al., EMBO J 2006 : Xist expression early in ES cell differentiation establishes a chromosomal memory, which allows efficient H2A ubiquitination in differentiated cells and is independent of silencing and PRC2
Macdonald et al., Scand J Immunol 2006 : The SAP-monocyte interaction was calcium independent and readily inhibited by C1q
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006 (Cell Transformation, Neoplastic...) : NaB or combination of the MEK inhibitor PD98059 with NaB could increase the differentiation of the SKM-1 cells and up-regulated the levels of the P21 and HDAC protein, but the effect of combination of NaB with PD98059 was higher than that of NaB alone
Sato et al., Int J Oncol 2006 (Biliary Tract Neoplasms) : In addition, the restored DPD expression level was more strongly induced by the histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), than 5-aza-C treatment
Zhang et al., Apoptosis 2006 : We recently found that the HDAC inhibitors induce a BH3-only protein Bmf in human squamous carcinoma SAS cells
Kammanadiminti et al., J Biol Chem 2006 (Colitis) : Overexpression of wild type Hsp27 amplified the effects of SAP, whereas a phosphorylation-deficient mutant of Hsp27 abrogated SAP induced NF-kappaB inhibition
Chen et al., Mol Cell Biol 2006 : SAP promotes SLAM family receptor induced protein tyrosine phosphorylation, due to its capacity to recruit the Src related kinase FynT
Kim et al., Biochem Biophys Res Commun 2006 : Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin ... Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin ... Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin
Qiu et al., Biochem Biophys Res Commun 2006 : We also found that TSA , a HDAC inhibitor that stimulates histone acetylation of the SM22alpha locus, further enhances the transactivational activity of Smad2, Smad3 and Smad4, and relieves the inhibitory effect of Smad6, Smad7, and the dominant negative mutants of Smads
Ivanov et al., Oncogene 2007 : Involvement of HDAC activity in STAT1 regulation was validated by TSA inhibition and chromatin immunoprecipitation ( ChIP ) assay
Okamoto et al., J Atheroscler Thromb 2006 : Our goal was to investigate the effect of trichostatin A (TSA) , a specific and potent HDAC inhibitor , on the proliferation of vascular smooth muscle cells ( VSMCs ) isolated from rat thoracic aorta ... TSA suppressed the HDAC activity of VSMCs in a dose dependent manner and inhibited VSMC proliferation as demonstrated by cell number counting and the degree of [ 3H ] thymidine incorporation ... Finally, TSA inhibited HDAC activity of VSMCs from p21 ( WAF1 ) knock-out mice but had no effect on VSMC proliferation in these animals
Topark-Ngarm et al., J Biol Chem 2006 (Neuroblastoma) : Therefore, it seems likely that the NuRD complex may be involved in transcriptional repression of CTIP2 target genes and contribute to the function ( s ) of CTIP2 within a neuronal context
Qian et al., Cancer Res 2006 (Carcinoma, Renal Cell...) : In the current study, we investigated the molecular link between HIF-1 alpha inhibition and HDAC inhibition
Chen et al., Pharmazie 2006 (Leukemia, Promyelocytic, Acute) : In this study, it was investigated whether trichostatin A (TSA) , a specific histone deacetylase (HDAC) inhibitor and a new anticancer drug, could improve the anticancer activity of low concentrations of Cur in human leukemia cells ( HL-60 )
Nakagawa et al., J Mol Cell Cardiol 2006 (Cardiomegaly...) : These findings show that ET-1 induced CaMK signaling disrupts class II HDAC-NRSF repressor complexes, thereby enabling activation of ANP and BNP gene transcription in ventricular myocytes, and shed light on a novel mechanism by which the fetal cardiac gene program is reactivated
Mantovani et al., Vascul Pharmacol 2006 (Cardiovascular Diseases...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Chang et al., J Neurochem 2006 : NGF caused a rapid but transient HDAC dependent increase in inducible cAMP element repressor (ICER) expression, but ICER expression was sustained with increased cAMP ... Depletion of ICER from PC12 cells indicated that HDAC dependent ICER induction is responsible for the delay in CRE dependent transcription after NGF treatment
Yasuda et al., Pancreas 2006 (Bacterial Infections...) : These results suggest that HMGB1 may act as a key mediator for inflammation and organ failure in SAP
Shaw et al., Circ Res 2006 : The histone deacetylase (HDAC) inhibitor Trichostatin A ( TSA 10 nM ) suppressed the inhibitory actions of NF-kappaB on Bnip3 gene transcription
Guo et al., Mol Cells 2006 : Our data indicate that IFNgamma and STAT dependent gene transcription requires the participation of HDAC , as does the IFNalpha-STAT pathway
Keslacy et al., Mol Pharmacol 2007 (Inflammation) : It is noteworthy that IFNgamma decreases TNFalpha induced histone acetyl transferase ( HAT ) and increases histone deacetylase (HDAC) activities
Yoshikawa et al., J Am Soc Nephrol 2007 : It was shown that trichostatin A (TSA) , an HDAC inhibitor , prevented TGF-beta1 induced EMT in cultured human renal proximal tubular epithelial cells
Geng et al., Cancer Res 2006 (Carcinoma, Non-Small-Cell Lung...) : In contrast, treatment with LBH589 followed by irradiation resulted in HDAC4 confinement to the cytoplasm, indicating that HDAC inhibition affects the nuclear localization of HDAC4
Mauceri et al., J Neurochem 2007 : On the contrary, SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is responsible for both the disruption of NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane ... On the contrary, SAP97-Ser232 phosphorylation occurs within the postsynaptic compartment and is responsible for both the disruption of NR2A/SAP97 complex and, consequently, for NR2A insertion in the postsynaptic membrane
Portal et al., Proc Natl Acad Sci U S A 2006 : Consistent with EBNALP coactivation being mediated by nuclear HDAC4 depletion, HDAC4 overexpression increased nuclear HDAC4 and specifically repressed EBNA2 dependent activation as well as EBNALP dependent coactivation
van der Linden et al., EMBO J 2007 (Calcium Signaling) : Here, we show that KIN-29 regulates these processes by phosphorylating the HDA-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of HDA-4 and an MEF-2 MADS domain transcription factor
Endt et al., Eur J Immunol 2007 : IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12 , the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha ... IL-2 stimulation leads to an up-regulation of SAP expression, which can be enhanced by IL-12, the stimulation of TLR3 by polyinosinic-polycytidylic acid ( poly ( I:C ) ) and to a lesser extent by IFN-alpha
Gopal et al., Cell cycle (Georgetown, Tex.) 2006 (Inflammation) : The resulting depletion of cellular HDAC1 levels lead to a consequent depletion of HDAC1 associated with the CDKN1A gene promoter and increased expression of its protein product, p21 ( WAF1/CIP1 )
Kovács et al., Cell Biochem Funct 2008 : In the present experiments the effect of trichostatin A (TSA) , a HDAC inhibitor was studied on the incorporation of 3H-palmitic acid and 32P to the phospholipids ( PI, PIP, PS, PC, PA, PE ) of Tetrahymena pyriformis, considering earlier observations on the microtubular system 's influence on signalling in this unicellular eukaryote
McCausland et al., J Immunol 2007 : SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase
Myzak et al., Experimental biology and medicine (Maywood, N.J.) 2007 : In the present investigation, we sought to test whether SFN also might inhibit HDAC activity in vivo
Larsen et al., Diabetologia 2007 : HDAC inhibition reduced cytokine mediated decrease in insulin secretion and increase in iNOS levels, NO formation and apoptosis ... HDAC inhibition reduced cytokine mediated decrease in insulin secretion and increase in iNOS levels, NO formation and apoptosis
Kammanadiminti et al., Infect Immun 2007 : Moreover, inhibiting the classical pathway of NF-kappaB activation did not affect SAP induced MCP-1 expression ... Instead, we find that SAP induced MCP-1 expression is dependent on posttranslational modification of the NFkappaB p65 subunit
Hitomi et al., FEBS Lett 2007 : Treatment with a histone deacetylase (HDAC) inhibitor has activated the expression of p15(INK4b) in wild-type MEFs but has no effect in MEFs lacking Oct-1, suggesting that Oct-1 represses p15(INK4b) gene expression in an HDAC dependent manner
Trivedi et al., Nat Med 2007 (Cardiomegaly) : Hdac2 deficiency or chemical histone deacetylase (HDAC) inhibition prevented the re-expression of fetal genes and attenuated cardiac hypertrophy in hearts exposed to hypertrophic stimuli
Annicotte et al., Bull Cancer 2007 (Neoplasms, Hormone-Dependent...) : Moreover, PPARgamma activity is enhanced in the presence of HDAC inhibitors
Villar et al., Infect Immun 2007 (Candidiasis, Oral) : Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and protease Sap5p
Hatayama et al., Biochem Biophys Res Commun 2007 (Adenocarcinoma...) : Thus butyrate, an HDAC inhibitor, inhibits proliferation of LS174T cells but stimulates MUC2 production in individual cells
Kim et al., J Cell Biochem 2007 : In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells
Ocker et al., Int J Biochem Cell Biol 2007 : Several studies have shown that HDAC inhibitors strongly activate the expression of the cyclin dependent kinase inhibitor p21 ( cip1/waf1 ) through ( i ) enhanced histone acetylation around the p21 ( cip1/waf1 ) promoter and ( ii ) the Sp1 sites on the p21 ( cip1/waf1 ) promoter releasing the repressor HDAC1 from its binding
Huh et al., J Biol Chem 2007 : HDAC inhibition promoted the expression of Wnt-5a , which is known to inhibit type II collagen expression, and knockdown of Wnt-5a blocked the ability of HDAC inhibitors to suppress type II collagen expression ... In addition, the induction of Wnt-5a expression by HDAC inhibitors was associated with acetylation of the Wnt-5a promoter
Hatjiharissi et al., Cancer Res 2007 (Waldenstrom Macroglobulinemia) : Other proteins up-regulated by > 1.3-fold included cyclin dependent kinases, apoptosis regulators, and histone deacetylases (HDAC)
Nakajima et al., Pancreas 2007 (Acute Disease...) : Apoptosis of ileal mucosa was accelerated in SAP , and VEGF significantly reduced the apoptosis ... Microvessel counts were significantly reduced in SAP , and VEGF significantly increased them
Tabe et al., Cell Death Differ 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Induction of ANXA1 mRNA was associated with histone acetylation in ANXA1 promoter and reversal of the HDAC dependent suppression of C/EBPalpha by AML1-ETO with direct recruitment of C/EBPalpha to ANXA1 promoter
Serakinci et al., Regen Med 2006 : This repression is overcome by treatment with Trichostatin A (TSA) , an HDAC inhibitor , concomitant with increases in promoter-specific histone acetylation and increases in Pol II and TFIIB tracking
de Boer et al., Tissue Eng 2006 (Skull Fractures) : As reported previously, inhibition of so-called histone deacetylases ( HDACs ) stimulates osteoblast maturation, and in this report, we investigated whether trichostatin A (TSA) , a widely used HDAC inhibitor , can be implemented in bone tissue engineering
Schwechter et al., Invest Ophthalmol Vis Sci 2007 : The retinal ganglion cell line RGC-5 was treated with trichostatin A (TSA) , other HDAC inhibitors , and staurosporine ; differentiation, neuritogenesis, neurotrophic factor dependence, and dependence on RNA transcription were assessed
Dashwood et al., Semin Cancer Biol 2007 (Neoplasms) : SFN has been shown to inhibit histone deacetylase (HDAC) activity in human colon and prostate cancer lines, with an increase in global and local histone acetylation status, such as on the promoter regions of P21 and bax genes
Matsuoka et al., Biochem Pharmacol 2007 : Previous studies have shown that HDAC inhibitors selectively inhibit IL-2 gene expression, but the mechanism of this inhibition remains to be elucidated
Plaster et al., Dev Dyn 2007 : Together, these results reveal novel in vivo roles for REREa in HDAC mediated regulation of Fgf signaling
Nencioni et al., Clin Cancer Res 2007 : Here, we have evaluated the effects of two HDAC inhibitors currently in clinical use, sodium valproate and MS-275, on human monocyte derived DCs
Kato et al., Leukemia 2007 (Genetic Predisposition to Disease) : In this study, we were able to increase the expression levels of MICA and MICB on leukemic cell lines and patients ' leukemic cells by treatment with trichostatin A (TsA) , a histone deacetylase (HDAC) inhibitor
Matsuoka et al., Eur J Pharmacol 2007 (Thrombocytopenia) : Here, we report that GATA-1 and 10 haematopoietic factors ( SCL, NF-E2, EKLF, Pleckstrin, Thrombin-R, LMO2, PU.1, Fli-1, AML1, and TCF11 ) are transcriptionally repressed by HDAC inhibitors in a similar pattern ( R > 0.98 ), and putative GATA-1 binding sites are found in almost all promoters of these genes ... Further, this report also asserts that HDAC inhibitor increases megakaryocyte counts and inhibits GATA-1 gene expression in rat spleen ... Together, these results suggest that HDAC inhibitors inhibit GATA-1 gene expression by decreasing the transactivation function of GATA-1 itself, and that this may in turn lead to a delay in megakaryocyte maturation and finally cause thrombocytopenia
Bode et al., Immunology 2007 : In contrast, HDAC inhibitors had no effects on upstream nuclear factor-kappaB and mitogen activated protein kinase activation
Schnekenburger et al., Biochim Biophys Acta 2007 : These results show that by blocking the modification of histone marks, HDAC1 plays a central role in Cyp1a1 expression and that its removal is a necessary but not sufficient condition for Cyp1a1 induction, underscoring the requirement for a concerted series of chromatin remodeling events to complete the initial steps of gene trans-activation by the Ah receptor
Chen et al., Mol Cell Biol 2007 : Here we show that HDAC inhibitors suppressed the expression of steroidogenic gene CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes ... Reducing SKP1A expression with small interfering RNA resulted in recovery of SF-1 levels, demonstrating that the activity of SCF E3 ubiquitin ligase is required for the SF-1 degradation induced by HDAC inhibitors
Frye et al., PloS one 2007 : The Myc induced switch from mono- to di-methylated H4K20 required HDAC activity and was blocked by the HDAC inhibitor trichostatin A (TSA)
Rao et al., Biochem Biophys Res Commun 2007 : Trichostatin-A (TSA) , a histone deacetylase (HDAC) inhibitor , results in enhanced acetylation of core histones thereby disrupting chromatin organization within living cells
Sun et al., Proc Natl Acad Sci U S A 2007 : Either inhibition of HDAC activity or knockdown of HDAC expression led to marked induction of p21 and pten gene expression and dramatically reduced neural stem cell proliferation, suggesting that the TLX interacting HDACs play an important role in neural stem cell proliferation
Enya et al., J Leukoc Biol 2008 (Melanoma) : Trichostatin A (TSA) , an inhibitor of histone deacetylase (HDAC) , greatly augmented the IL-1 alpha promoter activity in A375-6 cells to the level comparable with that in A375-R8 cells
Veis et al., Mol Cell Biol 2007 : Since the removal of Sin3 is independent of Ndd1 recruitment and Cdc28/Clb activity it represents a unique regulatory step which is distinct from transcriptional activation
Li et al., Gastroenterology 2007 (Carcinoma, Hepatocellular...) : The histone deacetylase (HDAC) inhibitor Tricostatin A partially blocked the TGFbeta1 inhibition of CYP7A1 mRNA expression, whereas TGFbeta1 decreased histone 3 acetylation in the CYP7A1 chromatin ... The histone deacetylase (HDAC) inhibitor Tricostatin A partially blocked the TGFbeta1 inhibition of CYP7A1 mRNA expression, whereas TGFbeta1 decreased histone 3 acetylation in the CYP7A1 chromatin ... This study provides the first evidence that TGFbeta1 represses CYP7A1 gene transcription in human hepatocytes by a mechanism involving Smad3 dependent inhibition of HNF4alpha and HDAC remodeling of CYP7A1 chromatin
Pulukuri et al., J Biol Chem 2007 (Neoplasm Invasiveness...) : Induction of uPA expression by histone deacetylase (HDAC) inhibitors trichostatin A (TSA), sodium butyrate, and scriptaid was observed in all three different types of human cancer cells examined ... In vitro Matrigel invasion assays showed that induction of uPA expression by HDAC inhibitors in human cancer cells resulted in a significant increase of cancer cell invasion
Chen et al., Ann Hematol 2008 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive...) : Thus, the HDAC inhibitors activate p38 in a manner different from the activin A pathway
Vinh et al., J Vasc Res 2008 (Aortic Aneurysm, Abdominal...) : In vitro, MCT-1 inhibited HDAC activity in rVSMCs, and MMP-2 expression and proteolytic activity in hVSMCs ... In vitro, MCT-1 inhibited HDAC activity in rVSMCs, and MMP-2 expression and proteolytic activity in hVSMCs
Pisalyaput et al., J Neurochem 2008 : Interestingly, SAP did not induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways ... Interestingly, SAP did not induce caspase and calpain activation, suggesting that C1q neuroprotection is in distinct from caspase and calpain pathways
Li et al., Immunity 2007 : Furthermore, SAP was critical for IL-4 production by T-CD4 T cells, but the PKCtheta deficiency did not alter the ability of T-CD4 T cells to produce cytokines
el-Kashef et al., Pulm Pharmacol 1991 : Atropine or secoverine ( SEC ) inhibited equally the PVR and SAP responses to ACh
Andresen et al., J Immunol 2007 : NF-kappaB activity can be induced by HDAC treatment
Natesampillai et al., Am J Physiol Endocrinol Metab 2008 : Histone-deacetylase (HDAC) inhibitors stimulated LDLR/luc five- to sixfold and StAR/luc and CYP11A/luc activity twofold ( P < 0.001 ) and partially reversed suppression by all three KLFs ( P < 0.001 )
Condorelli et al., Br J Pharmacol 2008 (Neuroblastoma) : Accordingly, HDAC inhibitor induced cell killing and p21/Waf1/Cip1 upregulation is impaired in p53i-cells
Zhang et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Researches have shown that ING2 can activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
McGee et al., Diabetes 2008 : Overexpression of HDAC5 represses GLUT4 reporter gene expression, and HDAC inhibition in human primary myotubes increases endogenous GLUT4 gene expression ... Overexpression of HDAC5 represses GLUT4 reporter gene expression, and HDAC inhibition in human primary myotubes increases endogenous GLUT4 gene expression
Ozaki et al., Cancer Sci 2008 : HDAC inhibitors potentiated both the phosphorylation of histone H2AX on serine-139 ( a marker of DNA double-strand breaks ) as well as the accumulation of reactive oxygen species induced by DNA damaging agents in tumor cells
To et al., Mol Cancer Res 2008 : In the remaining cell lines, HDAC1 binding in association with the repressive Me3-K9 H3 mark apparently constrains the effect of HDAC inhibition on ABCG2 expression
Matsuoka et al., Biol Pharm Bull 2008 (Thrombocytopenia) : Histone deacetylase (HDAC) inhibitors repress interleukin-2 (IL-2) gene expression in T cells and possess immunosuppressive activity in vivo ... In addition to its immunosuppressive activity, HDAC inhibitors block GATA binding protein-1 (GATA-1) gene expression in megakaryocytes and elicit thrombocytopenia
Yarosh et al., Cancer Res 2008 (Breast Neoplasms) : TBX3 repression to its targets is dependent on HDAC activity
Yamaguchi et al., Mol Carcinog 2008 (Neoplasm Metastasis) : Histone deacetylase (HDAC) inhibitors, but not DNA methyltransferase inhibitor upregulated maspin, and HDAC1 inhibited the transactivation of maspin promoter
Politis et al., FEBS Lett 2008 (Neuroblastoma) : Our findings suggest that Cend1 is an important molecular target for HDAC inhibition
Ohno et al., Mech Dev 2008 : Finally, using zygotic mutations in both genes, we show that the gradual loss of function of PRC2 activity leads first to a loss of histone H3 K27 methylation and only at a later stage to a gradual loss of PRC1 binding to chromatin
Jiang et al., J Exp Biol 2008 (Cardiovascular Diseases) : Based on the fact that the binding of MeCP2 with the EC-SOD was completely suppressed by AZC and trichostatin A [TSA , a histone deacetylase (HDAC) inhibitor ], it is indicated that DNA methylation and HDAC mediate the binding of MeCP2 with EC-SOD gene ... Based on the fact that the binding of MeCP2 with the EC-SOD was completely suppressed by AZC and trichostatin A [TSA, a histone deacetylase (HDAC) inhibitor ], it is indicated that DNA methylation and HDAC mediate the binding of MeCP2 with EC-SOD gene
Oh et al., Biochem Biophys Res Commun 2008 : Histone deacetylase (HDAC) inhibitors induce autophagy, and HDAC6 , one of class II HDAC isotypes, is directly involved in autophagic degradation in the cell
Dayangaç-Erden et al., Adv Ther 2008 (Spinal Muscular Atrophies of Childhood) : These results suggest that EBV transformed lymphoblastoid cell lines are not suitable for studying the effect of certain HDAC inhibitors on SMN2 gene expression
Scuto et al., Blood 2008 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : We investigated the mechanism of action of LBH589 , a novel broad-spectrum HDAC inhibitor belonging to the hydroxamate class, in Philadelphia chromosome negative ( Ph ( - ) ) acute lymphoblastic leukemia ( ALL )
Henkens et al., Toxicol Lett 2008 : The protein production of the gap junction component Cx26 was downregulated, whereas Cx32 expression was upregulated in response to HDAC-inhibition
Roy et al., J Cell Biochem 2008 : When overexpressed in Balb/c-3T3 cells or mouse embryo fibroblasts, HDAC5 substantially reduced the activity of the cyclin D3 promoter and the abundance of endogenous cyclin D3 protein
Ishdorj et al., J Biol Chem 2008 (Neoplasms) : Reducing the expression of HDAC1 significantly lowered LPA induced HDAC activity and increased histone acetylation ... LPA induction of HDAC activity was blocked by the LPA receptor antagonist, Ki16425, or by inhibiting receptor activation with pertussis toxin ... Reducing the expression of the LPA receptor LPA ( 1 ) also blocked LPA induced HDAC activation ... Finally, LPA attenuated the ability of the HDAC inhibitor to reduce HDAC activity
Chabane et al., Osteoarthritis Cartilage 2008 : In the present study, we determined the effect of trichostatin A (TSA) and butyric acid ( BA ), two histone deacetylase (HDAC) inhibitors , on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants
Sargeant et al., Cancer Res 2008 (Adenocarcinoma...) : OSU-HDAC42 , a histone deacetylase inhibitor , blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model
Iacopino et al., Int J Oncol 2008 (Prostatic Neoplasms) : The goal of this study was to assess the effects of an HDAC inhibitor, valproic acid ( VA ), on proliferation, androgen-sensitivity, androgen receptor levels and E-cadherin ( E-cad ) expression in human prostate cancer cells ... The goal of this study was to assess the effects of an HDAC inhibitor, valproic acid ( VA ), on proliferation, androgen-sensitivity, androgen receptor levels and E-cadherin ( E-cad ) expression in human prostate cancer cells
Kim et al., Eur J Pharmacol 2008 (Brain Neoplasms...) : A structurally distinct HDAC inhibitor, trichostatin A, also caused a significant concentration dependent induction of melatonin MT(1) receptor mRNA expression, suggesting involvement of an epigenetic mechanism
Wang et al., Biochim Biophys Acta 2008 : Specifically, HDAC3 and HDAC4 inhibited the p16(INK4a) promoter activity
Furukawa et al., Jpn J Pharmacol 1991 : Before atropine, topical application of hexamethonium at the locus for stimulation of intracardiac parasympathetic nerves to the SA ( SAP stimulation ) or AV nodal region ( AVP stimulation ) abolished almost totally negative chronotropic responses to SAP and cervical vagus stimulation or negative dromotropic responses to AVP and cervical vagus stimulation, respectively
Schmeck et al., J Immunol 2008 : Legionella induced histone modification as well as HAT-/HDAC dependent IL-8 release could also be shown in primary lung epithelial cells
Haudek et al., Proc Natl Acad Sci U S A 2008 (Cardiomyopathies...) : However, unlike wild-type mice, SAP in FcRgamma ( -/- ) mice failed to inhibit the development of fibrosis and cardiac dysfunction and did not diminish the numbers of alpha-smooth muscle actin ( + ) and CD34 ( + ), CD45 ( + ) fibroblasts that were typical for I/RC
Li et al., Cell Signal 2008 (Lymphoproliferative Disorders) : Expression of SAP in the A20 B cell line led to a marked reduction in Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR) ... Expression of SAP in the A20 B cell line led to a marked reduction in Blnk phosphorylation, a decrease in Akt activation, and a near-complete ablation of phosphorylation of the MAP kinases Erk1/2, p38 and JNK upon colligation of FcgammaRIIB with the B cell receptor (BCR)
Chavey et al., Mol Pharmacol 2008 (Breast Neoplasms) : Moreover, run-on and transfection experiments demonstrated that IL-8 induction by HDAC inhibitors was transcriptional and involved mainly the nuclear factor-kappaB (NF-kappaB) site of the IL-8 promoter ... HDAC inhibitors triggered IKK phosphorylation and up-regulated p65 nuclear translocation, although they decreased the protein levels of IkappaBalpha, which accounts for NF-kappaB activation ... HDAC inhibitors triggered IKK phosphorylation and up-regulated p65 nuclear translocation, although they decreased the protein levels of IkappaBalpha, which accounts for NF-kappaB activation ... In summary, our results demonstrate that NF-kappaB pathway repression by HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells ... In summary, our results demonstrate that NF-kappaB pathway repression by HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells
Scognamiglio et al., Biochim Biophys Acta 2008 : HDAC-class II specific inhibition involves HDAC proteasome dependent degradation mediated by RANBP2
Thomas et al., Bioorg Med Chem 2008 (Lung Neoplasms) : Prodrug incubation with beta-glucuronidase in the culture media led efficiently to the release of the parent drug and thereby restoring its ability to decrease cell proliferation, to inhibit HDAC and to induce E-Cadherin expression
Xu et al., Cancer Res 2008 (Breast Neoplasms) : Here, we show that the histone deacetylase (HDAC) inhibitors induce TRAIL in human breast cancer cells
Thangaraju et al., Biochem J 2009 (Colonic Neoplasms) : Heterologous expression of SLC5A8 in the human colon cancer cell line SW480 leads to inhibition of HDAC activity when cultured in the presence of pyruvate
Han et al., Zhonghua Gan Zang Bing Za Zhi 2008 : To study the effects of trichostatin A (TSA) on protein-protein interaction between HBx and histone deacetylase protein 1 (HDAC1)
De Lucia et al., Proc Natl Acad Sci U S A 2008 : The PHD-PRC2 activity increases H3K27me3 throughout the locus to levels sufficient for stable silencing
Lin et al., Brain Res 2008 : In this study, we determined the effects of a histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), on neuronal mu-opioid receptor (MOR) gene expression using human neuronal NMB cells, endogenously expressing MOR
Li et al., Cell Signal 2009 (Lymphoproliferative Disorders) : Depletion of SAP by siRNA caused a significant decrease in NCK1 tyrosine phosphorylation as well as the phosphorylation of other T cell receptor ( TCR ) downstream proteins such as LAT and SLP-76
Huang et al., J Cell Physiol 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Moreover, c-Jun did not alter growth inhibition and apoptotic induction by histone deacetylase (HDAC) inhibitors ( apicidin, sodium butyrate, and MS275 ) treatment, but inhibited HDAC inhibitors induced erythroid differentiation
Chou et al., FEBS Lett 2008 : HDAC inhibition upregulates the expression of angiostatic ADAMTS1
Margueron et al., Mol Cell 2008 : While PRC2-Ezh2 catalyzes H3K27me2/3 and its knockdown affects global H3K27me2/3 levels, PRC2-Ezh1 performs this function weakly
Kundakovic et al., Mol Pharmacol 2009 : The results suggest that HDAC and DNMT inhibitors activate reelin and GAD67 expression through similar mechanisms ... The results suggest that HDAC and DNMT inhibitors activate reelin and GAD67 expression through similar mechanisms
Noh et al., Biochem Biophys Res Commun 2009 : Herein, we report that trichostatin A (TSA) , an HDAC inhibitor , induces a delay at the G(2)/M transition, chromosome missegregation and multi-nucleation, and thereby leads to cell death by promoting exit from aberrant mitosis without spindle checkpoint
Kishigami et al., Methods Mol Biol 2009 : In particular, we focus on a new, more efficient mouse cloning protocol using trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , which increases both in vitro and in vivo developmental rates from twofold to fivefold
Wang et al., Growth Factors 2009 : To investigate the functional involvement of HDACs in the signaling pathway of FGF2 and IL-1beta, we examined the effects of HDAC inhibition on activities of FGF2 or IL-1beta on gene expression of MMP-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 ( ADAMTS5 ), collagen type II, and aggrecan ... To investigate the functional involvement of HDACs in the signaling pathway of FGF2 and IL-1beta, we examined the effects of HDAC inhibition on activities of FGF2 or IL-1beta on gene expression of MMP-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 ( ADAMTS5 ), collagen type II, and aggrecan
Chabane et al., J Cell Biochem 2009 : We show here that inhibitors of histone deacetylase (HDAC) activity, trichostatin A (TSA), butyric acid ( BA ), and valproic acid ( BA ) prevented IL-1 induced mPGES-1 protein expression in human synovial fibroblasts
Kim et al., Exp Mol Med 2008 (Stomach Neoplasms) : We previously reported that trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , induced DLC-1 mRNA expression and accumulated acetylated histones H3 and H4 associated with the DLC-1 promoter in DLC-1 non expressing gastric cancer cells
Liu et al., J Physiol 2009 : The protein kinase PKD1 has recently been linked to slow fibre-type gene expression in fast skeletal muscle through phosphorylation of class II histone deacetylase (HDAC) molecules, resulting in nuclear efflux of HDAC and consequent activation of the transcription factor MEF2
Baltus et al., J Biol Chem 2009 : Herein we show that the mSin3A-HDAC complex positively regulates Nanog expression in ES cells through Sox2, a critical ES cell transcription factor and regulator of Nanog ... Herein we show that the mSin3A-HDAC complex positively regulates Nanog expression in ES cells through Sox2, a critical ES cell transcription factor and regulator of Nanog ... Our data demonstrate that the mSin3A-HDAC complex can positively regulate Nanog expression under proliferating conditions and that this activity is complementary to mSin3A mediated p53 dependent silencing of Nanog during differentiation ... Our data demonstrate that the mSin3A-HDAC complex can positively regulate Nanog expression under proliferating conditions and that this activity is complementary to mSin3A mediated p53 dependent silencing of Nanog during differentiation
Zhao et al., Cells Tissues Organs 2009 : We investigated the expression of a number of genes involved in embryonic development after treatment with trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , in the limbs of chicken embryos
Xiao et al., Mol Cancer Ther 2009 (Adenocarcinoma, Follicular...) : We have previously shown that Notch1 may function as a tumor suppressor and that histone deacetylase (HDAC) inhibitors can induce Notch1 expression in some endocrine cancers ... These results indicate that HDAC inhibitors activate Notch1 signaling in thyroid cancer cells and lead to the suppression of proliferation by cell cycle arrest
Nian et al., Environ Mol Mutagen 2009 (Neoplasms) : In mouse preclinical models, SFN inhibited HDAC activity and induced histone hyperacetylation coincident with tumor suppression
Niesen et al., Biol Pharm Bull 2009 (Carcinoma, Non-Small-Cell Lung...) : HDAC inhibitors that can be used to treat patients may augment the expression of tumor cell MHC class II , and the results suggest an opportunity to determine the immunological consequences of HDAC inhibitor treatment in tumor therapy
Yap et al., Anticancer Res 2009 (Ovarian Neoplasms) : Cells from insensitive ovarian cancer cells, SKOV3 and HEY, were cultured with and without the DNA methyltransferase (DNMT) inhibitor, 5-aza-2'-deoxycytidine ( AzaC ) and the histone deacetylase (HDAC) inhibitor , trichostatin (TSA)
Morita et al., J Neurosci Res 2009 : In addition, HDAC inhibitors enhanced serotonin stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha reduced neurosteroid production in the glioma cells
von Burstin et al., Gastroenterology 2009 (Lung Neoplasms...) : In line, mesenchymal pancreatic cancer specimens and primary cell lines from genetically engineered Kras ( G12D ) mice showed HDAC dependent down-regulation of E-cadherin and high metastatic potential
Sun et al., J Immunol 2009 : In this study we report that HDAC inhibition acetylates and activates STAT-3 , which regulates DCs by promoting the transcription of IDO ... These findings demonstrate a novel functional role for posttranslational modification of STAT-3 through acetylation and provide mechanistic insights into HDAC inhibition mediated immunoregulation by induction of IDO
Choi et al., J Immunol 2009 : Importantly, histone deacetylase (HDAC) inhibitors significantly enhanced IFN-gamma-inducible gene expression in trophoblast cells, but not fibroblasts ... We propose that HDAC mediated inhibition of IFN-gamma-inducible gene expression in mouse trophoblast cells may contribute to successful pregnancy by preventing activation of IFN-gamma responses that might otherwise facilitate the destruction of the placenta
Baumeister et al., Mol Cancer Ther 2009 : Our studies reveal that HDAC inhibitors specifically induce GRP78 , and the induction level is amplified by ER stress
Kim et al., Mol Cancer Res 2009 : Although histone deacetylase (HDAC) inhibitors are appreciated as a promising class of anticancer drugs, recent reports show that P-glycoprotein (P-gp) is induced by HDAC inhibitor treatment in cancer cells, resulting in multidrug resistance of cancer cells to other chemotherapeutic agents ... In this study, we investigated the molecular mechanism of HDAC inhibitor induction of P-gp expression ... Furthermore, specific down-regulation of HDAC1, but not HDAC2, by RNA silencing was enough to induce P-gp expression in HeLa cells, strongly supporting the essential role of HDAC1 in HDAC inhibitor induction of P-gp ... Furthermore, specific down-regulation of HDAC1, but not HDAC2, by RNA silencing was enough to induce P-gp expression in HeLa cells, strongly supporting the essential role of HDAC1 in HDAC inhibitor induction of P-gp
Kumamoto et al., Int J Cancer 2009 (Colonic Neoplasms...) : MMP13 expression was further induced by coexpression of ING2 with HDAC1 or with mSin3A, suggesting that the ING2-HDAC1-mSin3A complex members regulates expression of MMP13
Zhang et al., Hepatology research : the official journal of the Japan Society of Hepatology 2009 : Methods : Trichostatin A (TSA) , a potent HDAC-specific inhibitor , was administrated to mice with cecal ligation and puncture (CLP) induced sepsis
Choo et al., Bone 2009 : NFATc1 mediates HDAC dependent transcriptional repression of osteocalcin expression during osteoblast differentiation
Saito et al., Oncogene 2009 (Stomach Neoplasms) : Analyses of chromatin modification show that DNA demethylation and HDAC inhibition at Alu repeats activates silenced miR-512-5p by RNA polymerase II
Farhana et al., Mol Cancer Ther 2009 : SHP and Sin3A expression are essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis ... SHP and Sin3A expression are essential for adamantyl substituted retinoid related molecule mediated nuclear factor-kappaB activation, c-Fos/c-Jun expression, and cellular apoptosis ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression ... We examined the effect of loss of SHP and Sin3A expression in a number of cell types on 3-Cl-AHPC mediated growth inhibition and apoptosis induction, 3-Cl-AHPC mediated nuclear factor-kappaB (NF-kappaB) activation, and 3-Cl-AHPC mediated increase in c-Fos and c-Jun expression
Sangha et al., Curr Opin Oncol 2009 (Carcinoma, Non-Small-Cell Lung...) : Two treatment strategies, in development, seem particularly appealing for further study : insulin-like growth factor receptor ( IGF-1R ) and histone deacetylase (HDAC) inhibition ... Two treatment strategies, in development, seem particularly appealing for further study : insulin-like growth factor receptor ( IGF-1R ) and histone deacetylase (HDAC) inhibition
Dubois et al., Mol Biochem Parasitol 2009 : Trichostatin A (TSA) , valproic acid ( VPA ) and suberoylanilide hydroxamic acid ( SAHA ) inhibited global HDAC activity at all life-cycle stages
Norian et al., Journal of oncology 2009 : We found that HDAC inhibition in B-CLL cells led to increased TRAIL receptor expression, increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis ... We found that HDAC inhibition in B-CLL cells led to increased TRAIL receptor expression, increased caspase activation, decreased expression of antiapoptotic regulators such as Bcl-2, and ultimately, enhanced TRAIL induced apoptosis
Hong et al., FASEB J 2009 (Osteoarthritis) : When expressed in these cells, HDAC1 and HDAC2 repressed aggrecan and collagen 2 ( alpha1 ) expression but differed in their repression of collagen 9 ( alpha1 ), collagen 11 ( alpha1 ), dermatopontin, and cartilage oligomeric matrix protein ( COMP )
Zhou et al., Nucleic Acids Res 2009 : We also find that Lsh requires histone deacetylase (HDAC) activity to repress p16(INK4a) and treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Lsh ... We also find that Lsh requires histone deacetylase (HDAC) activity to repress p16(INK4a) and treatment with trichostatin A (TSA) is sufficient to block the repressor effect of Lsh
Tang et al., Acta Biochim Biophys Sin (Shanghai) 2009 : Here, we try to reveal how PRC2, PRC2 mediated repressive histone marker H3K27me3 , and active histone marker histone H4 acetylation ( acH4 ) regulate the CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... Here, we try to reveal how PRC2 , PRC2 mediated repressive histone marker H3K27me3, and active histone marker histone H4 acetylation ( acH4 ) regulate the CD11b transcription during alltrans retinoic acid ( ATRA ) -induced HL-60 leukemia cell differentiation ... These results suggested that the histone modification including PRC2 mediated repressive histone marker H3K27me3 and active histone marker acH4 may involve in CD11b transcription during HL-60 leukemia cells reprogramming to terminal differentiation
Feng et al., FEBS J 2009 (Lung Neoplasms) : We also show that histone deacetylase (HDAC) 3 and HDAC4 inhibited p16(INK4a) promoter activity in a dose dependent manner
Lee et al., Cancer prevention research (Philadelphia, Pa.) 2009 (Prostatic Neoplasms) : In an in vitro HDAC activity assay, the selenoamino acids, MSC and selenomethionine, had no effect at concentrations up to 2.5 mmol/L, whereas MSP and KMSB both inhibited HDAC activity
Zhang et al., J Biol Chem 2009 : Our results suggest that reduced expression of PRC2 component genes in cloned embryos results in defective modification of H3K27me3 to the differentiation related genes in pluripotent ICM cells
Ellison-Zelski et al., Mol Cell Biol 2009 : Reduction of Sin3A expression by RNA interference specifically inhibits estrogen induced repression of ESR1
Ma et al., Chin J Cancer 2009 (Neoplasm Invasiveness...) : HDAC suppresses the activation of PPARgamma through a series of molecular mechanisms
Song et al., Cardiovasc Res 2010 : In this study, we investigated the effect of trichostatin A (TSA) , a potent HDAC inhibitor , on the proliferation and migration of vascular smooth muscle cells ( VSMCs ), and we examined the role of reduced Trx1 levels in this effect
Pang et al., American journal of physiology. Renal physiology 2009 (Fibrosis...) : In this study, we investigated the effect of trichostatin A (TSA) , a specific histone deacetylase (HDAC) inhibitor , on the activation of renal interstitial fibroblasts in a rat renal interstitial fibroblast line ( NRK-49F ) and the development of renal fibrosis in a murine model of unilateral ureteral obstruction ( UUO )
Zhang et al., J Biol Chem 2009 : This is also the first report of HDAC regulation of PDGF-R alpha transcription
Davies et al., Cancer Lett 2010 (Breast Neoplasms) : Using HDAC activity assays, TRG inhibited HDAC activity in cells and in cell lysates, similar to that observed with TSA
Kee et al., J Mol Cell Cardiol 2009 (Cardiomegaly) : Recently, we reported that histone deacetylase (HDAC) inhibitors block cardiac hypertrophy and that activation of HDAC2 , one of the class I HDACs, is required for hypertrophy ... These results suggest that KLF4 , a novel anti-hypertrophic transcriptional regulator, mediates the HDAC inhibitor induced prevention of cardiac hypertrophy
Catalioto et al., Exp Cell Res 2009 : HDAC inhibitors induced a significant reduction of the expression of the transcription factor C/EBPalpha , an early marker of differentiation, and a diminution of fibronectin immunoreactivity was also observed
Chehl et al., HPB (Oxford) 2009 : Tq also increased p21 WAF1 expression, inhibited histone deacetylase (HDAC) activity, and induced histone hyperacetylation
Almeida et al., Neurotox Res 2010 : Both NGF and BDNF counteracted the increase in the levels of histone H3 and H4 acetylations and reduced histone deacetylase (HDAC) activity induced by 3-NP ... Both NGF and BDNF counteracted the increase in the levels of histone H3 and H4 acetylations and reduced histone deacetylase (HDAC) activity induced by 3-NP
Kamei et al., Journal of hepato-biliary-pancreatic sciences 2010 (Acute Disease...) : TREM-1 may act as an important mediator for inflammation and organ injury in SAP
Ho et al., J Nutr 2009 (Genomic Instability...) : We have previously found that sulforaphane (SFN) , a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells
Pilling et al., PloS one 2009 : In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163 , CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32 , CD163, CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163, CD172a, and CD206 on both macrophages and fibrocytes ... In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163, CD172a , and CD206 on both macrophages and fibrocytes
Kim et al., BMB Rep 2009 (Carcinoma, Hepatocellular...) : HDAC inhibitors markedly induced Egr-1 expression during the early period, after which expression levels decreased
Huang et al., Neurobiol Aging 2011 (Parkinson Disease) : Moreover, UCN directly inhibited the histone deacetylase (HDAC) activity and induced a robust increase in histone H3 acetylation levels
Krishnan et al., Oncogene 2010 (Colonic Neoplasms) : Further studies revealed modulation of claudin-1 mRNA stability by its 3'-UTR as the major mechanism underlying HDAC dependent claudin-1 expression
Seong et al., Hum Mol Genet 2010 (Disease Models, Animal...) : Supporting a direct stimulatory role, full-length recombinant huntingtin significantly increased the histone H3K27 tri-methylase activity of reconstituted PRC2 in vitro, and structure-function analysis demonstrated that the polyglutamine region augmented full-length huntingtin PRC2 stimulation, both in Hdh ( Q111 ) EBs and in vitro, with reconstituted PRC2
Cayo et al., American journal of translational research 2009 : We hypothesized that the HDAC inhibitor Sodium Butyrate ( NaB ) might activate Notch1 in pheochromocytoma resulting in altered tumor cell proliferation
Cao et al., Proc Natl Acad Sci U S A 2009 (Disease Models, Animal...) : We identified trichostatin A (TSA) , a pan-HDAC ( histone deacetylase ) inhibitor , as a compound that affected both body curvature and laterality
Enose-Akahata et al., PLoS Pathog 2009 (Paraparesis, Tropical Spastic) : High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease
Kakihana et al., J Thorac Oncol 2009 (Carcinoma, Non-Small-Cell Lung...) : In contrast to H460 and H661, H157 cells were resistant to E-cadherin up-regulation by HDAC inhibitors
Giommarelli et al., Cell Mol Life Sci 2010 : The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition
Sayan et al., Biochem Biophys Res Commun 2010 : In this study we tested the abilities of different HDAC inhibitors to induce TAp63 expression ... We discovered that two HDAC inhibitors belonging to the hydroxamate group, namely TSA and LBH589, are the most efficient inducers of TAp63 expression
Jung et al., Cell Mol Life Sci 2010 : Similarly, HDAC inhibitors induced cellular senescence through downregulation of PcGs and upregulation of JMJD3
Shen et al., Cell 2009 : In vitro JMJ inhibits PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically, JMJ is required for efficient binding of PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Li et al., Cancer Res 2010 (Colonic Neoplasms) : HDAC depletion relieved HDAC mediated transcriptional inhibition of the cyclin dependent kinase inhibitors p21WAF1 and p27KIP2, significantly increasing their expression and triggering cell cycle arrest in the G(2) phase of the cell cycle
Pasini et al., Nature 2010 : JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
Lee et al., Biochim Biophys Acta 2010 (Anoxia) : This repression was reversed by the HDAC inhibitor, trichostatin A (TSA) and HIF-1 inhibitor , YC-1
Shimizu et al., J Biol Chem 2010 : Thus, HDAC4 is a basal repressor of MMP-13 transcription, and PTH regulates HDAC4 to control MMP-13 promoter activity ... Thus, HDAC4 is a basal repressor of MMP-13 transcription, and PTH regulates HDAC4 to control MMP-13 promoter activity
Zhu et al., J Biol Chem 2010 : This study was undertaken to investigate the contribution of histone deacetylase (HDAC) to TNF-alpha expression in cardiomyocytes and the signaling mechanism of LPS induced HDAC activation ... Furthermore, our data reveal that LPS induced HDAC activity is mediated through reactive oxygen species from mitochondria and c-Src signaling
Rai et al., PloS one 2010 (Disease Models, Animal...) : Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich 's ataxia patients and in a mouse model
Li et al., Genes Dev 2010 : Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as Jarid2 knockdown reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access
Komorowsky et al., J Cell Mol Med 2009 : Therefore, we hypothesized that histone deacetylating enzymes (HDAC) , which modulate the accessibility of transcriptionally active promoter regions, might play a role in the regulation of CTGF gene expression ... Taken together, our data indicate that the effect of HDAC inhibitors on CTGF expression is largely cell dependent in non-tumour cells
Smith et al., Chem Biol 2010 : Loss of ING2 disrupts the in vivo binding of the Sin3 complex to the p21 promoter, an important target gene for cell growth inhibition by SAHA
Swingler et al., Biochem J 2010 : The present study demonstrates that MMP28 expression is induced by HDAC ( histone deacetylase ) inhibitors and that this effect is mediated through the GT-box ... Transient transfection assays have shown that the induction of MMP28 expression by the HDAC inhibitior TSA ( trichostatin A ) is mediated via Sp1 at the GT-box
Wei et al., J Neuroimmunol 2010 : The results suggest that inhibition of HDAC activity and BDNF-TrkB autocrine loop are involved in regulation of astrocytic BDNF transcription, whereas the mechanisms for elevated constitutive gene BDNF expression of LEW/N astrocytes remain to be investigated
Xia et al., Development 2010 (Polycystic Kidney Diseases) : Kidney-specific knockout of Mef2c, or genetrap-inactivation of a MEF2C transcriptional target, MIM, resulted in extensive renal tubule dilation and cysts, whereas Hdac5 heterozygosity or treatment with TSA , an HDAC inhibitor , reduced cyst formation in Pkd2 ( -/- ) mouse embryos
Hughes et al., Cancer Treat Res 2009 (Bone Neoplasms...) : Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a role for HDAC in regulating Notch pathway expression in osteosarcoma
Zhou et al., J Cell Physiol 2010 (Fibrosis...) : Corneal fibroblasts were treated with TGFbeta, a known profibrotic and anti-inflammatory factor in wound healing, in the absence or presence of trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor
Ford et al., Chest 2010 (Pulmonary Disease, Chronic Obstructive) : In an open-label study, low-dose theophylline when added to inhaled FP increased total HDAC activity in peripheral blood monocytes ninefold ( P < .01 ) compared with FP alone from the same patients with COPD
Nuutinen et al., Neurosci Lett 2010 (Alzheimer Disease) : We have observed earlier that histone deacetylase (HDAC) inhibitors can induce the expression of clusterin in several neuroblastoma and glioma cell lines ... Another clinically used HDAC inhibitor, the cancer drug, Vorinostat ( SAHA, suberoylanilide hydroxamic acid ), also robustly stimulated the expression of clusterin in human astrocytes
Zhou et al., Hepatobiliary Pancreat Dis Int 2010 (Acute Disease...) : We assessed the effects of the inhibitor of MCP-1 , Bindarit, on SAP and explored the mechanisms underlying SAP
Zhang et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : Luciferase assay demonstrated an activation of NF-kappaB by HDAC inhibition
Wang et al., Biochem Pharmacol 2010 : Here we demonstrate that ferritin H mRNA and protein are induced by histone deacetylase inhibitors ( HDAC inhibitors ), a promising class of anti-cancer drugs, in cultured human cancer cells
Liu et al., Cancer Cell 2010 (Leukemia, Myeloid) : Our results provide evidence that the mechanisms of Sp1/NFkappaB/HDAC/miR-29b dependent KIT overexpression contribute to leukemia growth and can be successfully targeted by pharmacological disruption of the Sp1/NFkappaB/HDAC complex or synthetic miR-29b treatment in KIT-driven AML
Adenuga et al., Arch Biochem Biophys 2010 : Furthermore, HDAC2 phosphorylation was required for HDAC2 interaction with transcription factors, co-repressor complex formation, CBP recruitment, acetylation on lysine residues and modulates transrepression activity
Dovey et al., Proc Natl Acad Sci U S A 2010 : Deletion of HDAC1, but not HDAC2 , causes a significant reduction in the HDAC activity of Sin3A , NuRD, and CoREST corepressor complexes ... Deletion of HDAC1, but not HDAC2 , causes a significant reduction in the HDAC activity of Sin3A, NuRD, and CoREST corepressor complexes
Jeon et al., Mol Cancer Ther 2010 (Neoplasm Invasiveness...) : In conclusion, the inhibition of HDAC successfully restored the expression of RECK under hypoxic conditions
Song et al., Pediatr Res 2010 : We hypothesized that absence of angiotensin (Ang) II in angiotensinogen (AGT)-deficient mice leads to defects in ureteric bud ( UB ) branching and that RAS genes are critically dependent on histone deacetylase (HDAC) activity
Liu et al., J Cell Biochem 2010 : Here, we found that an inhibitor of histone deacetylase (HDAC) , trichostatin A (TSA), can not repress LPS induced COX-2 but it increased the COX-2 level in RAW264.7 cells
Su et al., Oncogene 2010 (Sarcoma, Synovial) : In this study, we report a central role of the transcription factor , early growth response-1 (EGR1), in the regulation of HDAC inhibitor induced apoptotic cell death in synovial sarcoma ... Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor induced apoptosis in synovial sarcoma
Takizawa et al., Drug Metab Dispos 2010 : However, the effects of HDAC inhibitors on CYP2B induction are still not fully understood ... In this study, we investigated the effect of HDAC inhibitors on CAR mediated CYP2B induction ... HDAC inhibitors diminished the binding between CAR and HDAC1 and augmented the binding of steroid receptor coactivator-1 (SRC-1) to CAR ... These results provide novel insight into the mechanism by which HDAC inhibitors affect gene expression of CYP2B6
Yusuf et al., J Immunol 2010 : These data illustrate complexities of SAP dependent SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T ( FH ) cell and GC T ( FH ) cell differentiation
Alamdari et al., Am J Physiol Regul Integr Comp Physiol 2010 (Disease Models, Animal...) : Treatment of rats with dexamethasone increased expression of p300 and HAT activity, reduced expression of HDAC3 and -6, and inhibited HDAC activity
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : In this study, we found that tricostatin A (TSA) , an HDAC inhibitor , prevented transforming growth factor beta1 ( TGF-beta1 ) -induced apoptosis in cultured human renal proximal tubular epithelial cells ( RPTECs )
Lee et al., Mol Cell Biochem 2010 (Stomach Neoplasms) : TSA , a HDAC inhibitor , decreased HGF induced HADC-5 expression and also repressed uPA and MMP-9 expression
Lei et al., Int J Biochem Cell Biol 2010 : Three structurally unrelated HDAC inhibitors completely suppress transforming growth factor-beta1 ( TGF-beta1 ) -induced EMT in AML-12 murine hepatocytes and primary mouse hepatocytes
Cheng et al., J Cereb Blood Flow Metab 2011 (Brain Ischemia...) : Earlier studies show that SIK1 inhibits histone deacetylase (HDAC) activities by acting as a class IIa HDAC kinase ... The SIK1 siRNA also exacerbated OGD induced neuronal death in the presence of trichostatin A (TSA) , an HDAC inhibitor , and decreased histone H3 acetylation at 4 hours reoxygenation in TSA treated neurons
Tian et al., Ann N Y Acad Sci 2010 : Taken together, these findings suggest that inhibition of HDAC activity by TSA activates Bdnf transcription and a compensatory change in HDAC1 expression in neurons ... Taken together, these findings suggest that inhibition of HDAC activity by TSA activates Bdnf transcription and a compensatory change in HDAC1 expression in neurons
Verykokakis et al., Immunity 2010 : Here we showed that Id3 ( -/- ) CD8 ( + ) T cells had an innate-like phenotype and required SAP for their development
Shimizu et al., Leukemia 2010 (Lymphoma, B-Cell) : HDAC inhibitors, valproic acid ( VPA ) and romidepsin, increased CD20 expression at protein and mRNA levels in B-cell lymphoma cell lines with relatively low CD20 expression levels ... In mouse lymphoma models, HDAC inhibitors enhanced CD20 expression along with histone hyperacetylation in transplanted cells, and acted synergistically with rituximab to retard their growth
Pietrella et al., Infect Immun 2010 (Inflammation) : In particular Sap1, Sap2 , and Sap6 significantly induced interleukin-1ß (IL-1ß) , tumor necrosis factor alpha ( TNF-a ), and IL-6 production ... In particular Sap1, Sap2 , and Sap6 significantly induced interleukin-1ß (IL-1ß), tumor necrosis factor alpha ( TNF-a ), and IL-6 production
Negishi et al., PloS one 2010 : Levels of both Zfp277 and PcG proteins inversely correlated with those of reactive oxygen species ( ROS ) in senescing MEFs, but the treatment of Zfp277 ( -/- ) MEFs with an antioxidant restored the binding of PRC2 but not PRC1 to the Ink4a/Arf locus
Torres et al., Int J Oncol 2010 (Neuroblastoma) : In this study, we investigated the effect of trichostatin A or TSA ( an HDAC inhibitor ), and epoxomycin ( a proteasome inhibitor ) on MYCN and p53 expression in MYCN amplified neuroblastoma cells
Mulder et al., J Alzheimers Dis 2010 (Alzheimer Disease) : In conclusion, these data suggest that local production of SAP and CRP in the AD brain does not substantially contribute to the CSF levels
Feng et al., J Immunol 2010 : Using the HDAC inhibitor trichostatin A, we demonstrate that ISRE, IFNA , and IL6 promoters require HDAC activity for transactivation and transcription, whereas TNFa does not
Evankovich et al., J Biol Chem 2010 (Reperfusion Injury) : Levels of acetylated HMGB1 increased with a concomitant decrease in total nuclear HDAC activity, suggesting that suppression in HDAC activity contributes to the increase in acetylated HMGB1 release after oxidative stress in hepatocytes
Simboeck et al., J Biol Chem 2010 (MAP Kinase Signaling System) : Taken together we have revealed a cross-talk of reversible phosphorylation and acetylation signals that controls the activation of p21 by HDAC inhibitors and identify the phosphatase PP2A as chromatin associated transcriptional repressor in mammalian cells
Huang et al., Mol Pharmacol 2011 : This finding, together with the HDAC inhibitor induced up-regulation of KLF4 and E-cadherin , suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... This finding, together with the HDAC inhibitor induced up-regulation of KLF4 and E-cadherin , suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... This finding, together with the HDAC inhibitor induced up-regulation of KLF4 and E-cadherin, suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status ... Evidence indicates that this up-regulation of H3K4 methylation was attributable to the suppressive effect of these HDAC inhibitors on the expression of RBP2 and other JARID1 family histone demethylases, including PLU-1, SMCX, and LSD1, via the down-regulation of Sp1 expression
Wang et al., J Cereb Blood Flow Metab 2011 (Brain Edema...) : Our findings suggest that BBB protection by VPA involves HDAC inhibition mediated suppression of NF-?B activation, MMP-9 induction, and tight junction degradation ... Our findings suggest that BBB protection by VPA involves HDAC inhibition mediated suppression of NF-?B activation, MMP-9 induction, and tight junction degradation
Weems et al., J Biol Chem 2011 : In this paper, we have tested the hypothesis that differentiation dependent GLUT4 gene expression in 3T3-L1 adipocytes is dependent on the nuclear concentration of a class II histone deacetylase (HDAC) protein, HDAC5
Ferland et al., Neuroscience 2011 : In addition, since histone deacetylases ( HDACs ) contribute to the acetylation state of histones, we investigated the effects of two HDAC inhibitors, sodium butyrate, a class I and II global HDAC inhibitor, and sirtinol, a class III sirtuin inhibitor , on acetylation of histone 3 (H3) and H4
Aldana-Masangkay et al., J Biomed Biotechnol 2011 (Neoplasms) : Furthermore, HDAC6 is required for the activation of heat-shock factor 1 (HSF1), an activator of heat-shock protein encoding genes ( HSPs ) and CYLD , a cylindromatosis tumor suppressor gene ... Furthermore, HDAC6 is required for the activation of heat-shock factor 1 (HSF1) , an activator of heat-shock protein encoding genes ( HSPs ) and CYLD, a cylindromatosis tumor suppressor gene
LeBoeuf et al., Dev Cell 2010 : Mutant embryos display increased levels of acetylated p53 , which opposes p63 functions, and p53 is required for HDAC inhibitor mediated p21 expression in keratinocytes
Huang et al., Biochem Pharmacol 2011 (Carcinoma, Non-Small-Cell Lung) : In addition, MTX also increased E-cadherin expression through inhibition of histone deacetylase (HDAC) activity and downregulation of polycomb group protein enhancer of zeste homologue 2 (EZH2)
Kim et al., Int J Oncol 2011 (Neoplasms) : In addition, multidrug resistance protein 2 (MRP2) expression is selectively attenuated by HDAC inhibitors, especially SAHA and TSA, in KBV20C cells, whereas MDR1 and BCRP expressions are not affected
Liao et al., J Biol Chem 2011 (Breast Neoplasms) : PC4 functions are beyond TSA induced phosphatase release, PI3K mediated Sp1 phosphorylation, and HDAC1/2/mSin3A co-repressor release indicating its role as linker coactivator of Sp1 and the transcriptional machinery
Garlanda et al., Curr Pharm Des 2011 (Atherosclerosis...) : CRP and SAP are produced primarily in the liver in response to IL-6 , while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor ( TLR ) engagement
Findeisen et al., Arterioscler Thromb Vasc Biol 2011 (Disease Models, Animal...) : HDAC inhibition resulted in a transcriptional and posttranscriptional regulation of the cyclin dependent kinase inhibitors p21 ( Cip1 ) and p27 ( Kip ) ... Furthermore, HDAC inhibition repressed mitogen induced cyclin D1 mRNA expression and cyclin D1 promoter activity
Ramakrishna et al., J Biol Chem 2011 (Neoplasms) : SDS3 is a key component of the histone deacetylase (HDAC) dependent Sin3A co-repressor complex, serving to maintain its HDAC activity ... The deubiquitinating activity of USP17 on SDS3 negatively regulates SDS3 associated HDAC activity
Chen et al., Hepatology 2011 (Carcinoma, Hepatocellular...) : Our data indicate that HDAC inhibitors transcriptionally activated casein kinase ( CK ) 2a expression through increased association of acetylated histone H3 with the CK2a gene promoter
Jin et al., Journal of gynecologic oncology 2010 : Importantly, both HDAC inhibitors dose-dependently inhibited the expression of the antiapoptotic proteins Bcl-2 and x-linked inhibitor of apoptosis protein ( XIAP ) ... Importantly, both HDAC inhibitors dose-dependently inhibited the expression of the antiapoptotic proteins Bcl-2 and x-linked inhibitor of apoptosis protein ( XIAP )
Wang et al., PloS one 2011 (Adenocarcinoma...) : Several compounds in the categories of HSP90 inhibitor, HDAC inhibitor , PPAR agonist, PI3K inhibitor, passed our screening to be the leading candidates
Consalvi et al., Mol Med 2011 (Muscular Dystrophies...) : Studies performed in mouse models of Duchenne muscular dystrophy (DMD) indicate that dystrophin deficiency leads to deregulated HDAC activity, which perturbs downstream networks and can be restored directly, by HDAC blockade, or indirectly, by reexpression of dystrophin
Hnilicová et al., PloS one 2011 : In addition, HDAC inhibition reduced co-transcriptional association of the splicing regulator SRp40 with the target fibronectin exon
Mercado et al., Biochem Biophys Res Commun 2011 (Pulmonary Disease, Chronic Obstructive) : Although Nrf2 protein was clearly stabilized after hydrogen peroxide ( H ( 2 ) O ( 2 ) ) stimulation in a bronchial epithelial cell line ( BEAS2B ), Nrf2 stability was decreased and Nrf2 acetylation increased in the presence of an HDAC inhibitor, trichostatin A (TSA)
Shi et al., J Cell Physiol 2011 : We also observed that HDAC inhibitors enhanced the expression of Fgf4 and a subset of pluripotency genes in differentiated ESCs, but reduced their expression in undifferentiated and less differentiated ESCs
Park et al., Mol Cells 2011 : Nocodazole treatment induced G2/M arrest but co-treatment with TSA , an HDAC inhibitor , delayed cell cycle progression
Robert et al., Nature 2011 (Chromosomal Instability) : We also find that HDAC inhibition triggers Sae2 degradation by promoting autophagy that affects the DNA damage sensitivity of hda1 and rpd3 mutants
Clarke et al., Mol Nutr Food Res 2011 (Hyperplasia...) : The ability of SFN to inhibit histone deacetylase (HDAC) enzymes may be one mechanism by which it acts as a chemoprevention agent ... SFN treatment also selectively decreased HDAC activity, and Class I and II HDAC proteins, increased acetylated histone H3 at the promoter for P21, induced p21 expression and increased tubulin acetylation in prostate cancer cells ... In PrEC cells, SFN caused only a transient reduction in HDAC activity with no change in any other endpoints tested
Suzuki et al., J Biol Chem 2011 (Cell Transformation, Neoplastic...) : Furthermore, the inhibition of MEK or HDAC restored Cbp expression in human cancer cells harboring Cbp down-regulation through promoter hypomethylation
WEI et al., Nan Fang Yi Ke Da Xue Xue Bao 2011 : To investigate the mechanism of trichostatin A(TSA) , a histone deacetylase (HDAC) inhibitor , in inhibiting the activation of CD(4) ( + ) T cells in mice
Matsuzaki et al., Environ Health Prev Med 2003 : Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin dependent kinase inhibitor p21 ( WAF1/Cip1 ), a downstream target gene of p53, in a p53 independent manner ... Furthermore, we have recently shown that HDAC inhibitors activate Gadd45, another downstream target gene of p53, and p19(INK4d) , a gene functionally similar to p16(INK4a)
Matsuzaki et al., Environ Health Prev Med 2005 : We recently showed that histone deacetylase (HDAC) inhibitors, promising chemopreventive and chemotherapeutical agents, induce p15(INK4b) and p19(INK4d) gene expression and cause growth arrest, suggesting that both genes are important molecular targets for HDAC inhibitors ... We recently showed that histone deacetylase (HDAC) inhibitors, promising chemopreventive and chemotherapeutical agents, induce p15(INK4b) and p19(INK4d) gene expression and cause growth arrest, suggesting that both genes are important molecular targets for HDAC inhibitors
Tae et al., Nucleic Acids Res 2011 (Leukemia...) : Furthermore, inhibition of BRD7 expression reduces PRMT5 and PRC2 recruitment to ST7 and RBL2 promoters ; however, only ST7 becomes transcriptionally derepressed
Zeng et al., Cancer Res 2011 : We show that p53 is required for both HDAC and PcG to repress Arf expression ... We show that p53 is required for both HDAC and PcG to repress Arf expression
Pang et al., J Cell Biochem 2011 : Inhibition of HDAC activity with trichostatin A (TSA), blocked cell proliferation, decreased expression of Cyclin D1, a positive cell cycle regulator, and increased expression of p27 and p57, two negative cell cycle regulators
Schwalbe et al., J Biol Chem 1990 : Furthermore, SAP had little or no effect on the ability of C4BP to bind C4b
Fujisawa et al., Journal of translational medicine 2011 (Disease Models, Animal...) : In contrast, HDAC inhibition did not increase IL-13Ra2 in normal cell lines ... HDAC inhibitors dramatically sensitized cancer cells to immunotoxin in the cytotoxicity assay in vitro and increased IL-13Ra2 in the tumors subcutaneously implanted in the immunodeficient animals but not in normal mice tissues
Hu et al., Blood 2011 : HDAC inhibition using suberoylanilide hydroxamic acid or MS-275 significantly increased MCSFR and GMCSFR expression in leukemia cell lines that express PU.1 and mutated or translocated RUNX1
Xiong et al., Mol Carcinog 2012 (Colorectal Neoplasms) : The present study shows that trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , leads to the hyperacetylation of histones associated with the SOCS1 and SOCS3 promoters, but not the SHP1 promoter in CRC cells
Abdou et al., J Biol Chem 2011 : Thus, although mSin3A/HDAC1 interacted readily with LAP/LAP* in addition to LIP and that expression of LAP/LAP* was sufficient to recruit HDAC1 to the C/ebpa promoter, mutations in C/ebpß that abrogated HDAC1 association to LAP/LAP* in the absence of LIP provided no additional stimulation of differentiation or transcription beyond the deletion of LIP alone
Ramsey et al., Cancer Res 2011 (Carcinoma, Squamous Cell) : Repression of proapoptotic Bcl-2 family member genes including p53 upregulated modulator of apoptosis ( PUMA ) by p63/HDAC is required for survival of SCC cells
Schmitges et al., Mol Cell 2011 : In addition to H3K4me3, PRC2 is inhibited by H3K36me2/3 ( i.e., both H3K36me2 and H3K36me3 )
Zhou et al., Blood 2011 (Leukemia, Myeloid, Acute) : We show that disruption of PRC2 , either by DZNep treatment or EZH2 knockdown, reactivates TXNIP, inhibits thioredoxin activity, and increases reactive oxygen species ( ROS ), leading to apoptosis
Chen et al., J Cell Biochem 2011 : HDAC inhibition increases the up-regulation of GATA4 , MEF2C, Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ... HDAC inhibition increases the up-regulation of GATA4, MEF2C , Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ... HDAC inhibition increases the up-regulation of GATA4, MEF2C , Nkx2.5, cardiac actin, and a-SMA mRNA and protein levels that were abrogated by MG132 ... Notably, HDAC inhibitors led to noticeable HDAC4 degradation, which was effectively prevented by MG132
Barnhart et al., J Cell Biol 2011 : Furthermore, HJURP recruitment to endogenous centromeres required the Mis18 complex
Burba et al., PloS one 2011 : Our results show that HDAC blockade leads to phenotype changes in CD34 ( + ) cells with enhanced self renewal and cardioprotection
Sakharkar et al., Alcohol Clin Exp Res 2012 : Here, we investigated the involvement of amygdaloid histone deacetylases (HDAC) induced epigenetic changes in rapid ethanol tolerance (RET)
Zijlstra et al., Eur Respir J 2012 (Asthma) : Furthermore, IL-17A reduced HDAC activity, and overexpression of HDAC2 reversed IL-17A induced GC insensitivity
Pufahl et al., J Cell Mol Med 2012 : 5-LO promoter activity and mRNA expression were up-regulated by the class I HDAC inhibitors apicidin and MS-275 but not by class II inhibitors
Hsu et al., Biochim Biophys Acta 2011 : In the present study, we explored the actions of trichostatin A (TSA) , a potent HDAC inhibitor , on lipopolysaccharide (LPS) induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells ( HUVECs )
Wang et al., Development 2011 : Skor2 overexpression suppresses BMP signaling in an HDAC dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression ... Skor2 overexpression suppresses BMP signaling in an HDAC dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression ... Skor2 overexpression suppresses BMP signaling in an HDAC dependent manner and stimulates Shh promoter activity, suggesting that Skor2 represses BMP signaling to activate Shh expression
Yang et al., Cell Transplant 2012 : This study was to investigate the effect of trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , on cardiac differentiation of bone marrow mesenchymal stem cells ( MSCs ) in vitro
Koon et al., Am J Pathol 2011 (Colitis) : Because histone deacetylase (HDAC) modulates transcription of several genes involved in inflammation, we investigated participation of HDAC in SP-induced CCN1 expression in human colonic epithelial NCM460 cells overexpressing NK-1R ( NCM460-NK-1R ) and in primary colonocytes ... HDAC overexpression activated basal and SP-induced CCN1 promoter activity ... Thus, SP-mediated CCN1 expression in the inflamed human and mouse colon involves increased HDAC activity
Wang et al., Nucleic Acids Res 2012 : We found that trichostatin A (TSA) , an inhibitor of HDAC ( histone deacetylase ), induces p16(INK4A) expression in an HBP1 dependent manner
Holmes et al., Virology 2011 (HIV Infections) : We discovered that Foxp3 inhibited cellular HDAC activity in T cells, and mutations in the forkhead domain that ablate Foxp3 function also abolished its ability to inhibit HDAC
Zhang et al., Nat Med 2011 (Chronic Disease...) : In wild-type but not Gad2 knockout mice, HDAC inhibitors strongly increased GAD65 activity, restored GABA synaptic function and relieved sensitized pain behavior
Zhang et al., Oncogene 2012 (Lymphoma, Non-Hodgkin) : Here, we investigated mechanisms of miR-15a/16-1 transcriptional repression and its epigenetic regulation by c-Myc and histone deacetylase (HDAC) in MCL
Zhang et al., J Biol Chem 2011 : We show that CDYL dramatically enhances the methyltransferase activity of PRC2 toward oligonucleosome substrates in vitro ... CDYL is required for chromatin targeting and maximal enzymatic activity of PRC2 at their common target sites
Tseng et al., PloS one 2011 : Inhibition of HDAC function resulted in aberrant expression of Notch1 and BMP2 , two genes known to be required for tail regeneration ... Inhibition of HDAC function resulted in aberrant expression of Notch1 and BMP2, two genes known to be required for tail regeneration
Alam et al., J Biol Chem 2011 (Inflammation) : Importantly, HDAC3 was essential for the constitutive transcription of PI3K and IRF3 , which might be responsible for the basal level of galectin-9 expression ... Importantly, HDAC3 was essential for the constitutive transcription of PI3K and IRF3, which might be responsible for the basal level of galectin-9 expression
McCormack et al., Leukemia 2012 (Leukemia, Myeloid, Acute) : Our results suggest the concomitant targeting of MDM2-p53 and HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML ... Our results suggest the concomitant targeting of MDM2-p53 and HDAC inhibition , may be an effective therapeutic strategy for the treatment of AML
Koseki et al., Int J Neuropsychopharmacol 2012 (Psychomotor Agitation) : It also prevented the PCP induced decrease of acetylated Lys9 in histone H3-positive cells and increase of the histone deacetylase (HDAC)5 level in the prefrontal cortex
Sampath et al., Blood 2012 (Leukemia, Lymphocytic, Chronic, B-Cell) : HDAC inhibition triggered the accumulation of the transcriptionally activating chromatin modification H3K4me2 and restored the expression of miR-15a , miR-16, and miR-29b in approximately 35 % of samples
Mulder et al., Exp Neurol 2012 (Alzheimer Disease) : Further, SAP-C1q increased SCARB1 expression in control astrocytes when combined with Aßoligo
Erlich et al., Br J Cancer 2012 (Carcinoma, Squamous Cell...) : Importantly, we observed intratumoural HDAC inhibition and PI3K inhibition as assessed by histone H3 acetylation status and phospho-AKT staining, respectively
Mannava et al., Blood 2012 (Multiple Myeloma) : Instead, KLF9 levels correlated with bortezomib dependent inhibition of histone deacetylases (HDAC) and were increased by the HDAC inhibitor LBH589 ( panobinostat )
Calfa et al., Hippocampus 2012 : HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons
Neri et al., Mol Cell Biol 2012 : Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells
Cho et al., Clin Exp Allergy 2012 (Nasal Polyps) : The aim of this study was to study the effect of trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , on transforming growth factor ( TGF ) -ß1 induced myofibroblast differentiation and ECM accumulation in nasal polyp derived fibroblasts ( NPDFs )
Li et al., Int Immunopharmacol 2012 : This study aimed to examine the molecular mechanism of the inflammatory responses caused by cigarette smoke extract (CSE) and the effects of erythromycin ( EM ) on CSE induced HDAC protein expression in human macrophages in vitro
Li et al., Cancer Lett 2012 (Bone Neoplasms...) : Pharmacologic inhibitor of HDAC , trichostatin A (TSA) promoted p53-p300 interaction and recruitment of p53 Lys-382 to promoter regions of its target genes p21 and Puma, consequently inducing apoptosis and stabilizing the acetylation of p53 at Lys-382 together with the upregulation of p21 and Puma, which were impaired in EFTs cells after the knockdown of p53 expression
Bajbouj et al., J Neurooncol 2012 (Glioblastoma) : As expected, TSA promoted the accumulation of total acetylated histones H3 and H4 and a decrease in endogenous HDAC activity
Zhang et al., J Pharmacol Exp Ther 2012 (Myocardial Infarction...) : In addition, infarcted mice received a daily intraperitoneal injection of TSA ( 0.1 mg/kg ), a selective HDAC inhibitor
Vrba et al., Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011 : HDAC inhibitors sodium butyrate and sodium valproate do not affect human ncor1 and ncor2 gene expression in HL-60 cells ... HDAC inhibitors sodium butyrate and sodium valproate do not affect human ncor1 and ncor2 gene expression in HL-60 cells ... Both HDAC inhibitors caused a significant increase in NCF2 mRNA levels without affecting NCOR1 or NCOR2 mRNA levels
Vilas-Zornoza et al., Leukemia 2012 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Here, we analyzed the therapeutic effect of LBH589 , a class I-II HDAC inhibitor , in acute lymphoblastic leukemia ( ALL )
Lee et al., Proc Natl Acad Sci U S A 2012 : The OSS induced HDAC signaling and EC responses are mediated by phosphatidylinositol 3-kinase/Akt
Kerr et al., Cell Death Differ 2012 : Furthermore, we found that the histone deacetylase (HDAC) inhibitor Vorinostat ( SAHA ) enhances the acetylation of Ku70, thereby disrupting the FLIP/Ku70 complex and triggering FLIP polyubiquitination and degradation by the proteasome
Lee et al., J Physiol 2012 : In addition, HDAC6 inhibition blocked the up-regulation of SGK in animals exposed to acute stress
Yi et al., Chemotherapy 2012 (Carcinoma...) : DNMT inhibitors and HDAC inhibitors regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo ... DNMT inhibitors and HDAC inhibitors regulate E-cadherin and Bcl-2 expression in endometrial carcinoma in vitro and in vivo
Shimizu-Hirota et al., Genes Dev 2012 : In turn, MT1-MMP dependent PI3Kd activation regulates the immunoregulatory Mi-2/NuRD nucleosome remodeling complex that is responsible for controlling macrophage immune response ... In turn, MT1-MMP dependent PI3Kd activation regulates the immunoregulatory Mi-2/NuRD nucleosome remodeling complex that is responsible for controlling macrophage immune response
Yan et al., Oncogene 2013 : Here we found that histone deacetylase (HDAC) inhibitors suppress both wild-type and mutant p53 transcription in time- and dose dependent manners
Li et al., Epigenetics 2012 (Colonic Neoplasms...) : However, histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate ( NaBt ) significantly increased Wnt5a mRNA expression in SW620
Dang et al., Gastroenterology research and practice 2012 : Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction ( IBD ) , which significantly increases the disease severity and risk of mortality
Alamdari et al., Metabolism 2013 (Muscular Atrophy) : In recent studies, inhibition of p300/HAT expression and activity and stimulation of SIRT1 dependent HDAC activity reduced glucocorticoid induced catabolic response in skeletal muscle, providing further evidence that hyperacetylation plays a role in muscle wasting
Buurman et al., Gastroenterology 2012 (Carcinoma, Hepatocellular...) : In cell lines, inhibition of HDAC significantly increased levels of hsa-miR-449a ... In cell lines, inhibition of HDAC significantly increased levels of hsa-miR-449a
Shi et al., Biochem J 2012 : We demonstrated that the transcriptional repression of Foxk1 is dependent on the Sin3-Sds3 repression complex, and knockdown of Sds3 results in cell-cycle arrest
Vogelauer et al., J Biol Chem 2012 : In contrast, free CoA , like unconjugated butyrate, inhibits HDAC activity in vitro
Vitoriano-Souza et al., PloS one 2012 : With regard to cytokines, the SAP led to production of interleukin (IL)-2 , IL-6, and IL-4 ... With regard to cytokines, the SAP led to production of interleukin (IL)-2, IL-6, and IL-4 ... With regard to cytokines, the SAP led to production of interleukin (IL)-2, IL-6 , and IL-4
Gu et al., Anticancer Drugs 2012 (Neuroblastoma) : Our studies showed that inhibition of HDAC decreased NB proliferation, and induced caspase activity and G1 growth arrest
Zhang et al., Neuroscience 2012 (Disease Models, Animal) : These results demonstrate that VPA appears to protect RGCs from ONC by inhibiting neuronal apoptosis possibly via the activation of BDNF-TrkB signaling and HDAC inhibition ... These results demonstrate that VPA appears to protect RGCs from ONC by inhibiting neuronal apoptosis possibly via the activation of BDNF-TrkB signaling and HDAC inhibition
Lu et al., Toxicol Mech Methods 2012 (Carbon Tetrachloride Poisoning...) : The results suggested that oxidative stress in CCl ( 4 ) -exposed mice induce the expression of HDAC2 , while inhibition of HDAC result in exacerbated liver injury
Gammoh et al., Autophagy 2012 (Neoplasms) : In this study, we show that HDAC inhibition triggers autophagy by suppressing MTOR and activating the autophagic kinase ULK1
Yang et al., Cancer Biol Ther 2012 (Glioblastoma) : In addition, siRNA silencing of Sin3B induced an increase in the expression of c-Myc and Sin3A, which contributed to increased expression of Mad4 ... The association of c-IAP1 with Sin3B or Mad4 suggested that Sin3B might interfere with the binding of c-IAP1 to Mad4 ; however, overexpression of Sin3B did not affect the interaction between Mad4 and c-IAP1 ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2 , c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2, c-IAP2 and ASK1 , known targets of c-IAP1 E3 ligase activity ... Exogenous expression of Sin3B also inhibited c-IAP1 mediated degradation of Mad1, TRAF2, c-IAP2 and ASK1, known targets of c-IAP1 E3 ligase activity
He et al., PLoS Genet 2012 : One possible role of PRC2 mediated H3K27me3 in the leaf-to-callus transition might relate to elimination of leaf features by silencing leaf-regulatory genes, as most leaf-preferentially expressed regulatory genes could not be silenced in the leaf explants of clf swn
Hsing et al., American journal of physiology. Renal physiology 2012 (Acute Kidney Injury) : In vitro, the effects of DEX or trichostatin A ( TSA , an HDAC inhibitor ) on TNF-a, monocyte chemotactic protein ( MCP-1 ), BMP-7, and HDAC mRNA expression in LPS stimulated rat renal tubular epithelial NRK52E cells, was determined using real-time PCR
Nagathihalli et al., Mol Cancer Ther 2012 (Carcinoma, Non-Small-Cell Lung...) : Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC mediated downregulation of E-cadherin
Backues et al., Autophagy 2012 : The Ume6-Sin3-Rpd3 complex regulates ATG8 transcription to control autophagosome size
Debeb et al., Stem Cells 2012 (Breast Neoplasms...) : Moreover, while HDAC inhibitors upregulated ß-catenin expression and significantly increased WNT reporter activity, a TCF4 dominant negative construct abolished HDAC-inhibitor induced expansion of CSCs
Huang et al., Stem Cells 2012 : UCN directly inhibited the histone deacetylase (HDAC) activity and induced a robust increase in histone H3 acetylation levels
Jensen et al., Mol Immunol 2013 (Calcium Signaling...) : A NKG2D dependent cytolytic assay and staining with a recombinant NKG2D-Fc fusion protein showed that calcium chelation impaired the functional ability of NKG2D-ligands induced by HDAC-inhibitor treatment ... The HDAC-inhibitor induced cell surface expression of ULBP2 , but not MICA/B, was sensitive to treatment calmidazolium and trifluoperazine, two agents known to block calcium signaling ... The HDAC-inhibitor induced cell surface expression of ULBP2, but not MICA/B , was sensitive to treatment calmidazolium and trifluoperazine, two agents known to block calcium signaling ... However, binding of galectin-1 to cell surface glycoproteins was not critical for constitutive or HDAC-inhibitor induced MICA/B and ULBP2 cell surface expression ... However, binding of galectin-1 to cell surface glycoproteins was not critical for constitutive or HDAC-inhibitor induced MICA/B and ULBP2 cell surface expression
Otsuji et al., PloS one 2012 : Histone H3 acetylation was induced chemically by treating primitive hESC/hiPSC-CMs with Trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , resulting in an immediate increase in global cardiac gene expression
Zhang et al., Asian Pac J Cancer Prev 2012 (Lung Neoplasms) : In this study, we investigated the effect of trichostatin A (TSA) , one such HDAC inhibitor , in combination with docetaxel ( TXT ), a cytotoxic chemotherapy agent or erlotinib, a novel molecular target therapy drug, on lung cancer A549 cells
Shi et al., J Dermatol Sci 2012 (Dermatitis, Allergic Contact) : Trichostatin A (TSA) , a potent HDAC inhibitor , has anti-tumor and anti-inflammatory effects
Ivanova et al., Arch Toxicol 2013 (Leukemia, Promyelocytic, Acute...) : We identified a chiral VPA derivative, ( S ) -2-pentyl-4-pentynoic acid, previously characterized as HDAC inhibitor that induced massive programmed cell death in a strongly enantioselective manner in U937 histiocytic lymphoma cells and NB4 acute promyelocytic leukemia cells
Schmidt et al., Diabetes Technol Ther 2012 (Diabetes Mellitus, Type 1) : Conclusions : This study documents persisting beneficial effects of SAP on HbA1c , treatment satisfaction, magnitude of diabetes related problems, and fear of hypoglycemia 36 months after therapy start
Saito et al., Osteoarthritis Cartilage 2013 (MAP Kinase Signaling System) : HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2 , ADAMTS-5, and MMP-3 at both the mRNA and protein levels within 1h ... HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2, ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ... HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2, ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ... HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2, ADAMTS-5, and MMP-3 at both the mRNA and protein levels within 1h ... The CTS induced expression of RUNX-2 and ADAMTS-5 was suppressed by HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes ... The CTS induced expression of RUNX-2 and ADAMTS-5 was suppressed by HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes
Duan et al., Prostate 2013 (Prostatic Neoplasms) : While androgen suppresses EZH2 in CRPC cells, in LNCaP cells, physiological concentrations of androgen stimulate expression of PRC2 genes ( EZH2, SUZ12, and EED ), which is mediated by androgen induced ANCCA and involves E2F and histone H3K4me3 methylase MLL1 complex
Zhang et al., Cancer Cell 2012 (Lymphoma, B-Cell) : We investigated the transcriptional and epigenetic repression of miR-29 by MYC, HDAC3 , and EZH2 in mantle cell lymphoma and other MYC associated lymphomas
Soriano et al., J Neurochem 2013 : We found that, while HDAC5 and HDAC4 mutants lacking their N-terminal phosphorylation sites ( HDAC4 ( MUT ), HDAC5 ( MUT ) ) are constitutively nuclear, co-expression with SMRT renders them exportable by signals that trigger SMRT export, such as synaptic activity, HDAC inhibition , and Brain Derived Neurotrophic Factor (BDNF) signaling
Ballaré et al., Nature structural & molecular biology 2012 : These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells ... These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells
Han et al., Radiation oncology (London, England) 2012 (Carcinoma, Non-Small-Cell Lung...) : X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin , upregulate Axin expression and induce apoptosis of lung cancer cells
Hidalgo et al., Cell stem cell 2012 : Epigenomic and gene expression changes induced by Ezh1 deletion in senesced HSCs demonstrated that Ezh1 mediated PRC2 activity catalyzes monomethylation and dimethylation of H3K27
Tang et al., Journal of the American Heart Association 2012 : However, inhibition of HDAC activity did not suppress Notch activation of the HRT target genes ... Although CBF-1 mediated Notch signaling was increased by HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated Notch signaling was increased by HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated Notch signaling is not suppressed by HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 ) ... Although CBF-1 mediated Notch signaling is not suppressed by HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )
Madapura et al., Cell cycle (Georgetown, Tex.) 2012 : Modifying p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was sufficient to upregulate SAP expression, indicating that SAP is a target of p53 in T cells
Mims et al., Leukemia 2013 (Leukemia, Myeloid, Acute) : Thus, HDAC inhibition may increase miR-29b expression
Shah et al., Dev Dyn 2013 : These effects of VPA were mimicked by Trichostatin A (TSA) , a well established pan-HDAC inhibitor , but not by valpromide, which is structurally similar to VPA but does not inhibit HDACs
Wessels et al., Immunobiology 2013 : The effects of histone deacetylase (HDAC)-inhibition by trichostatin A (TSA) on IL-1ß and TNFa expression and their promoter structures were measured in promyeloid HL-60 cells
Shi et al., Biochem Biophys Res Commun 2013 : Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes ... Here we provide the first evidence that hypoxia and HDAC inhibitors selectively and synergistically stimulate expression of miR-126 in cardiac myocytes ... MiR-126 expression was increased 1.7-fold ( p < 0.05 ) after 1h of hypoxic exposure and this was further enhanced to 3.0-fold ( p < 0.01 ) by simultaneously blocking HDAC with the pan-HDAC inhibitor Tricostatin A (TSA)
Iordache et al., International journal of molecular sciences 2012 : RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin, CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin, CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin , CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin , CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin, CD133, CXCR4 and Tie-2 ... RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin, CD133 , CXCR4 and Tie-2 ... Furthermore, flow cytometry analysis illustrated that HDAC inhibitors selectively reduce the expression of VEGFR(2), CD117, VE-cadherin , and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that HDAC inhibitors selectively reduce the expression of VEGFR(2), CD117, VE-cadherin, and ICAM-1 , whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that HDAC inhibitors selectively reduce the expression of VEGFR(2) , CD117, VE-cadherin, and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells ... Furthermore, flow cytometry analysis illustrated that HDAC inhibitors selectively reduce the expression of VEGFR(2), CD117 , VE-cadherin, and ICAM-1, whereas the expression of CD34 and CD45 remained unchanged, demonstrating that HDAC is involved in endothelial differentiation of progenitor cells
Li et al., Blood 2013 (Leukemia, Myeloid, Acute) : Suppression of miR-193a expands the oncogenic activity of the fusion protein AML-ETO, because miR-193a represses the expression of multiple target genes, such as AML1/ETO, DNMT3a, HDAC3 , KIT, CCND1, and MDM2 directly, and increases PTEN indirectly
Zhou et al., Leukemia 2013 (Leukemia, Myeloid, Acute) : HDAC inhibition by SNDX-275 ( Entinostat ) restores expression of silenced leukemia associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML ... We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL , in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB , and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1 ... We here report that inhibition of histone deacetylase (HDAC) using the specific class I HDAC inhibitor SNDX-275 restored the expression of Nur77/Nor1 and induced expression of activator protein 1 transcription factors c-Jun and JunB, and of death receptor TRAIL, in AML cells and in CD34 ( + ) /38 ( - ) AML LSCs. Importantly, SNDX-275 induced extensive apoptosis in AML cells, which could be suppressed by silencing nur77 and nor1
Cai et al., Mol Cell 2013 : Ectopically expressed PHF1 induced Tudor dependent stabilization of PRC2 complexes on bulk chromatin and mediated spreading of PRC2 and H3K27me3 into H3K36me3 containing chromatin regions
Chan et al., Stem Cells 2013 : Depletion of PRDM14 reduces PRC2 binding at these loci and the concomitant reduction of H3K27me3 modification ... In addition, we show that PRDM14 recruits PRC2 to repress a key mesenchymal gene ZEB1 , which enhances mesenchymal-to-epithelial transition in the initiation event of iPSC reprogramming
Bellucci et al., PloS one 2013 (Breast Neoplasms) : Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z
Vasilatos et al., Carcinogenesis 2013 (Breast Neoplasms) : Taken together, these results provide novel mechanistic insight into the breast cancer subtype dependent role of LSD1 in mediating HDAC activity and therapeutic efficacy of HDAC inhibitor
Liu et al., Acta Neurobiol Exp (Wars) 2012 : Inhibition of HDAC by trichostatin A (TSA) blocked the proliferation, increased neuronal differentiation and decreased astrocyte differentiation of the NPCs ... These findings collectively demonstrate that in the situation of not affecting survival and migration, HDAC inhibition may induce more neuronal differentiation
Lee et al., Circ Res 2013 (Disease Models, Animal...) : HDAC inhibition promoted MR acetylation, leading to decreased transcriptional activity of MR. Knockdown or inhibition of HDAC3 resulted in reduced expression of MR target genes induced by mineralocorticoids
Ye et al., J Cell Sci 2013 : HDAC5-deficient mice have reduced cardiac PTB protein abundance, and HDAC inhibition in myocytes causes a reduction in endogenous expression of cellular FLICE-like inhibitory protein ( cFLIP ) and caspase dependent cleavage of PTB
Chen et al., Carcinogenesis 2013 (Bone Marrow Neoplasms...) : Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin ... Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin
Fragola et al., PLoS Genet 2013 : These results indicate that PRC2 mediated H3K27 trimethylation is required on a highly selective core of Polycomb targets whose repression enables TF-dependent cell reprogramming
Sachweh et al., Cell death & disease 2013 : Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression
Brett et al., Current treatment options in oncology 2013 : Similarly, cell cycle inhibitors targeting cyclin dependent kinases as well as HDAC inhibitors have shown promise in early studies
Giudice et al., PloS one 2013 (Carcinoma, Squamous Cell...) : Paradoxically, inhibition of HDAC also induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of BMI-1 , an oncogene associated with tumor aggressiveness, and expression of the vimentin mesenchymal marker ... Paradoxically, inhibition of HDAC also induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of BMI-1, an oncogene associated with tumor aggressiveness, and expression of the vimentin mesenchymal marker ... Paradoxically, inhibition of HDAC also induced epithelial-mesenchymal transition (EMT) in HNSCC cells, accumulation of BMI-1, an oncogene associated with tumor aggressiveness, and expression of the vimentin mesenchymal marker
Lewis et al., Science 2013 (Brain Neoplasms...) : We find that H3K27M inhibits the enzymatic activity of the Polycomb repressive complex 2 through interaction with the EZH2 subunit
Khan et al., FEBS Lett 2013 : HDAC inhibitors prevent the induction of the immediate-early gene FOSL1 , but do not alter the nucleosome response ... HDAC inhibitors prevent FOSL1 gene induction and the association of HDAC1, 2 and 3 with the gene body ... HDAC inhibitors prevent FOSL1 gene induction and the association of HDAC1 , 2 and 3 with the gene body
Fernández-Alvarez et al., Oncogenesis 2012 : We also examined the acetylation status of the COX-2 promoter and the effects of histone deacetylase (HDAC) inhibitors on COX-2 expression
Sato et al., PloS one 2013 : Trichostatin A (TSA) , an HDAC inhibitor , enhanced lipopolysaccharide (LPS) induced production of IL-6 in OP9 preadipocytes but not the mature adipocytes
Valdora et al., International journal of molecular sciences 2013 : On the other hand, the treatment of MB cells with Trichostatin A (TSA) , a potent inhibitor of histone deacetylases (HDAC) , was able to restore both DKK3 mRNA and protein
Liu et al., Journal of inflammation (London, England) 2013 : In addition, HDAC inhibitors significantly inhibited poly ( I:C ) -induced IL-6 production in both of the epithelial cells
Xu et al., Frontiers in pharmacology 2013 : The effects of HDAC inhibition on connexin43 (Cx43) expression and functional GJ assembly were examined in primary cultured neonatal mouse ventricular myocytes
Yang et al., Zhongguo Zhong Xi Yi Jie He Za Zhi 2013 (Disease Models, Animal...) : To observe the effects of Qingyi Granule ( QYG ) on the changes of total protein expressions in the pancreatic tissue of rats with severe acute pancreatitis (SAP) induced by sodium taurocholate (STC)
Lin et al., Inflammation 1990 : Purified mouse interferon-beta (IFN-beta) , but not IFN-alpha, also induced SAP production
Lodrini et al., Nucleic Acids Res 2013 (Neuroblastoma) : In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183
Huang et al., Cell death & disease 2013 (Disease Models, Animal...) : Fibroblasts from patients with IPF likewise exhibited decreased histone acetylation and increased H3K9Me3 at the Fas promoter and increased their expression of Fas in the presence of an HDAC inhibitor
Scuto et al., Cell death & disease 2013 (Lymphoma) : SIRT1 activation enhances HDAC inhibition mediated upregulation of GADD45G by repressing the binding of NF-?B/STAT3 complex to its promoter in malignant lymphoid cells
Yen et al., Cancer Gene Ther 2013 : IDO shRNA induced tumor infiltrating CD8? and CD4? T cells, whereas OSU-HDAC42 treatment induced tumor infiltrating CD4? T cells
Cho et al., Immune network 2013 : Both IL-4 and HDAC inhibitors suppressed COX-2 expression in dose dependent manners
Zhou et al., PloS one 2013 : C. parvum infection suppressed transcription of the mir-424-503 gene in a NF-kB- and HDAC dependent manner
Gao et al., J Immunol 2013 : In this study, we investigated the role of histone deacetylase (HDAC) activity in TRIM22 induction by IFN-? and its underlying mechanism ... We found that the HDAC activity, especially that conferred by HDAC6, was required for IFN-? induced TRIM22 transcription
Aldiri et al., Development 2013 (Wnt Signaling Pathway) : We also show that Wnt/ß-catenin signaling acting through the receptor Frizzled 5, but independent of Sox2, regulates expression of key PRC2 subunits in the developing retina
Liu et al., Toxicol Lett 2013 (Adenocarcinoma...) : Trichostatin A (TSA) , a classical HDAC inhibitor , has been demonstrated to induce cell cycle arrest, promote cell apoptosis, and inhibit metastasis
Derkacheva et al., EMBO J 2013 : While p55 is not essential for the in vitro enzymatic activity of PRC2 , plant MSI1 was required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower ... While p55 is not essential for the in vitro enzymatic activity of PRC2, plant MSI1 was required for the functions of the EMBRYONIC FLOWER and the VERNALIZATION PRC2 complexes including trimethylation of histone H3 Lys27 ( H3K27 ) at the target chromatin, as well as gene repression and establishment of competence to flower
Gopal et al., Cancer Genet 2013 (Stomach Neoplasms) : Our reporter assays and gene reactivation studies using 5-aza-2'-deoxycytidine, a DNA demethylating agent, and trichostatin A (TSA) , a histone deacetylase (HDAC) inhibitor , demonstrated that epigenetic mechanisms are involved in the down-regulation of SOSTC1 expression
Shakespear et al., J Biol Chem 2013 (Inflammation) : A novel class IIa-selective HDAC inhibitor reduced recombinant human HDAC7 enzyme activity as well as TLR induced production of inflammatory mediators in thioglycollate elicited peritoneal macrophages ... A hypoxia-inducible factor (HIF) 1 binding site in this promoter was required for HDAC dependent TLR-inducible promoter activity and for Hdac7- and HIF-1a mediated trans-activation
Nogee et al., Am J Perinatol 1988 (Hyaline Membrane Disease...) : SAP-35 expression is enhanced by 3'-5'-cyclic adenosine monophosphate and epidermal growth factor during perinatal differentiation of type II epithelial cells
Siripont et al., Cell Immunol 1988 : Binding of SAP to M phi required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6 ... Binding of SAP to M phi required Ca2+ or Mg2+ and was inhibited at a pH less than or equal to 5.6
Ozkan et al., J Trauma 1987 : Reversal of SAP induced immunosuppression and SAP detection by a monoclonal antibody
Sarlo et al., Cell Immunol 1985 : The mouse macrophage line P388D1, also could bind SAP and display enhanced IL-1 production in response to SAP
Korewicki et al., Cor Vasa 1985 (Coronary Disease...) : The effects of intravenous nitroglycerin ( NTG ), trimetaphan ( TMP ), and phentolamine (PTL) on pulmonary artery diastolic pressure ( PADP ), systemic arterial pressure (SAP) , cardiac index ( CI ) and systemic vascular resistance ( SVR ) in patients ( 12 in each treated group ) with chronic ischaemic heart failure are analyzed
Sipe et al., Ann N Y Acad Sci 1982 (Acute Disease...) : Unlike SAA synthesis, BCG-preinfection fails to synergistically augment the LPS induced SAP response
Bugni et al., Am Heart J 1980 (Arterial Occlusive Diseases...) : The effect of mean systemic arterial pressure (SAP) on myocardial O2 consumption ( MVO2 ) coronary blood flow (CBF) and the reduction of left ventricular ( LV ) reserve capacity resulting from coronary artery occlusion was studied in 25 open-chest pentobarbital anesthetized dogs with fixed cardiac output and controlled heart rate ( HR ) and SAP
Büscher et al., Mol Cell Biol 1995 : Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and TCF/SAP ... Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and TCF/SAP
Nawaz et al., Mol Gen Genet 1994 : The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator ... SIN3 positively regulates the transcriptional activities of GAL4 and the HAP1 activator ... SIN3 positively regulates the transcriptional activities of GAL4 and the HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for SIN3 mediated regulation of hPR, GAL4, and the HAP1 activator ... Deletion analysis of the SIN3 PAH motifs shows that the PAH3 motif is essential for SIN3 mediated regulation of hPR, GAL4 , and the HAP1 activator
García de Frutos et al., J Immunol 1994 : Even though C4BP, C4 ( H2O ), and SAP form a multimolecular complex in fluid phase, SAP was found to inhibit binding of C4BP to immobilized C4 ( H2O ) ... Heparin, which is known to inhibit the interaction between SAP and C4BP, was also found to counteract the inhibitory effect of SAP on C4BP binding to C4 ( H2O )
Ku et al., Cytokine 1993 (Carcinoma, Hepatocellular...) : By contrast, gene expression of the major APR of the mouse, serum amyloid P-component (SAP) , a structural homologue of CRP, increased in response to either IL-1 or IL-6 under the same conditions ... By contrast, gene expression of the major APR of the mouse, serum amyloid P-component (SAP) , a structural homologue of CRP, increased in response to either IL-1 or IL-6 under the same conditions
Husøy et al., Carcinogenesis 1993 (Cell Transformation, Neoplastic) : The effects of 12-O-tetradecanoylphorbol-13-acetate ( TPA ), 12-deoxyphorbol-13-phenylacetate ( DOPP ), 12-deoxyphorbol-13-phenylacetate-20-acetate ( DOPP A ), sapintoxin D (SAP D) and sapintoxin A (SAP A) on the decrease in [ 125I ] epidermal growth factor (EGF) binding ( indicating protein kinase C activation ), suppression of gap junctional intercellular communication ( GJIC ) and induction of morphological cell transformation (MCT) in Syrian hamster embryo (SHE) cells were investigated
Tsai et al., J Biol Chem 1993 : Binding of ARF1 and -3, but not ARF5, was enhanced by SAP ... Binding of ARF1 and -3, but not ARF5 , was enhanced by SAP ... B36, an inactive derivative of BFA, did not inhibit SAP dependent binding of ARF1 and -3
Molewijk et al., Psychopharmacologia 1995 : The 5-HT2C/1B receptor agonist m-CPP , the inverse BZD receptor agonists FG 7142 and DMCM, and the alpha 2-adrenoceptor antagonist yohimbine, to all of which putative anxiogenic effects have been ascribed, had no effect on SAP directed towards the prod
Rao et al., Oncogene 1996 (Cell Transformation, Neoplastic...) : This constant expression profile, coupled with the observation that over-expression of mSin3A does not augment the anti-Myc activity of Mxi1-SR in the rat embryo fibroblast ( REF ) transformation assay, suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function ... This constant expression profile, coupled with the observation that over-expression of mSin3A does not augment the anti-Myc activity of Mxi1-SR in the rat embryo fibroblast ( REF ) transformation assay, suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function
Zahedi et al., J Biol Chem 1996 : Binding of SAP to type IV collagen was inhibited by both SAP and C-reactive protein (CRP)
Zahedi et al., J Biol Chem 1997 : Competition binding assays indicate that the binding of SAP to laminin is inhibited by both SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine ... Competition binding assays indicate that the binding of SAP to laminin is inhibited by both SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine
Whitmarsh et al., Mol Cell Biol 1997 : In contrast, SAP-1 is activated by ERK and p38 MAP kinases but not by JNK
Jin et al., Mol Cell Biol 1998 : Incubation of human colon carcinoma SW620 cells in 100-ng/ml trichostatin A (TSA) , a specific HDAC inhibitor , increased the steady-state level of MDR1 mRNA 20-fold
de Haas et al., J Immunol 1998 : In search for the LPS binding site of SAP, we found that pep27-39 , a 13-mer peptide consisting of amino acids 27-39 of SAP, competitively inhibited the binding of LPS to SAP ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that SAP could not prevent binding of LPS to soluble CD14 , in contrast to pep27-39 ... Performing gel filtration of FITC labeled ReLPS incubated with soluble CD14, we showed that SAP could not prevent binding of LPS to soluble CD14, in contrast to pep27-39
Liedtke et al., Oncogene 1998 (Cell Transformation, Neoplastic) : Regulation of Bcr-Abl induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase ... Regulation of Bcr-Abl induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase