◀ Back to RELA
NFKBIB — RELA
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
RELA
→
NFKBIB
(decreases, NFKBIB Activity)
Evidence: We have examined the question of robustness in inflammatory signalling systems, by overexpressing the relA component of NF-?B..[21,22]. A major element of the regulation of this transcription factor is its retention in the cytoplasm, and hence sequestration from the genes it controls, by inhibitors of the I-?B (inhibitory ?B) family.
-
FastForward regulation:
RELA
→
NFKBIB
(transcriptional regulation, unknown)
Schreiber et al., Proc Natl Acad Sci U S A 2006
Evidence: DNABINDING
-
KEGG NOD-like receptor signaling pathway:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG RIG-I-like receptor signaling pathway:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Cytosolic DNA-sensing pathway:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG T cell receptor signaling pathway:
NFKBIA/NFKBIB/NFKBIE
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG B cell receptor signaling pathway:
NFKBIA/NFKBIB/NFKBIE
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Neurotrophin signaling pathway:
NFKBIA/NFKBIB/NFKBIE
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Neurotrophin signaling pathway:
NFKBIA/NFKBIB/NFKBIE
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Adipocytokine signaling pathway:
NFKB1/RELA
→
NFKBIA/NFKBIB/NFKBIE
(protein-protein, dissociation)
-
KEGG Shigellosis:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Leishmaniasis:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Toxoplasmosis:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Measles:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Influenza A:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
KEGG Chemokine signaling pathway:
NFKBIA/NFKBIB
→
NFKB1/RELA
(protein-protein, dissociation)
-
NCI Pathway Database BCR signaling pathway:
I kappa B beta (NFKBIB)
→
NF-kappa-B/RelA complex (NFKB1-RELA)
(transcription, inhibits)
-
NCI Pathway Database BCR signaling pathway:
I kappa B beta (NFKBIB)
→
NF-kappa-B/RelA/I kappa B beta complex (NFKB1-RELA-NFKBIB)
(modification, collaborate)
-
NCI Pathway Database BCR signaling pathway:
IKK beta (IKBKB)
→
NF-kappa-B/RelA/I kappa B beta complex (NFKB1-RELA-NFKBIB)
(modification, activates)
-
NCI Pathway Database BCR signaling pathway:
NF-kappa-B/RelA/I kappa B beta complex (NFKB1-RELA-NFKBIB)
→
NF-kappa-B/RelA complex (NFKB1-RELA)
(modification, collaborate)
-
Reactome Reaction:
NFKBIB
→
RELA
(reaction)
Gil et al., Oncogene 2000, Häcker et al., Science's STKE : signal transduction knowledge environment 2006
-
Reactome Reaction:
NFKBIB
→
RELA
(indirect_complex)
-
WikiPathways RIG-I-like Receptor Signaling:
Complex of NFKBIA-NFKBIB
→
Complex of NFKB1-RELA
(mim-inhibition)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
NFKBIB
→
RELA
(activation)
-
WikiPathways Apoptosis:
NFKB1/RELA/NFKBIB/NFKBIE/NFKBIA
→
RELA/NFKB1
(activation)
-
WikiPathways Apoptosis:
NFKB1/RELA/NFKBIB/NFKBIE/NFKBIA
→
NFKBIA/NFKBIB/NFKBIE
(activation)
-
WikiPathways Chemokine signaling pathway:
NFKBIA/NFKBIB
→
NFKB1/RELA
(unknown)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
NFKBIB
—
RELA
Ganesh et al., Nature 2003, Simeonidis et al., Proc Natl Acad Sci U S A 1997*
-
IRef Bind Interaction:
NFKBIB
—
RELA
Suyang et al., Mol Cell Biol 1996*
-
IRef Bind_translation Interaction:
NFKBIB
—
RELA
(affinity chromatography technology)
Suyang et al., Mol Cell Biol 1996*
-
IRef Bind_translation Interaction:
NFKBIB
—
RELA
(coimmunoprecipitation)
Suyang et al., Mol Cell Biol 1996*
-
IRef Bind_translation Interaction:
NFKBIB
—
RELA
(coimmunoprecipitation)
Ganesh et al., Nature 2003
-
IRef Bind_translation Interaction:
NFKBIB
—
RELA
(two hybrid)
Ganesh et al., Nature 2003, Simeonidis et al., Proc Natl Acad Sci U S A 1997*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(physical association, affinity chromatography technology)
Chu et al., Mol Cell Biol 1996*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(direct interaction, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(physical association, affinity chromatography technology)
Chen et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(direct interaction, pull down)
Chen et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(physical association, affinity chromatography technology)
Suyang et al., Mol Cell Biol 1996*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(direct interaction, pull down)
Suyang et al., Mol Cell Biol 1996*
-
IRef Biogrid Interaction:
NFKBIB
—
RELA
(physical association, affinity chromatography technology)
Pringle et al., Oncogene 2012*
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2):
TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I):
TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM TNF-alpha/NF-kappa B signaling complex 5:
TNF-alpha/NF-kappa B signaling complex 5 complex (CD3EAP-CHUK-CUL1-FBXW11-IKBKB-IKBKG-IQGAP2-KPNA2-LRPPRC-MCC-MTIF2-NFKB1-NFKB2-NFKBIB-PDCD2-POLR1A-POLR1B-POLR1D-POLR1E-POLR2H-POLR2L-RASAL2-REL-RELA-SKP1)
Bouwmeester et al., Nat Cell Biol 2004
-
MIPS CORUM IKB(beta)-RELA-cREL complex:
IKB(beta)-RELA-cREL complex complex (NFKBIB-REL-RELA)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of 26 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 18 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of REL-NFKBIB-REL-RELA-RELA-NFKBIB
(association, anti bait coimmunoprecipitation)
Whiteside et al., EMBO J 1997
-
IRef Corum Interaction:
Complex of 13 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Dip Interaction:
NFKBIB
—
RELA
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
RELA
—
NFKBIB
(in vivo)
Chen et al., J Biol Chem 2003*, Suyang et al., Mol Cell Biol 1996*
-
IRef Hprd Interaction:
RELA
—
NFKBIB
(in vitro)
Chen et al., J Biol Chem 2003*, Suyang et al., Mol Cell Biol 1996*
-
IRef Hprd Interaction:
Complex of 290 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 145 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 626 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
NFKBIB
—
RELA
(physical association, two hybrid array)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
NFKBIB
—
RELA
(physical association, two hybrid)
Yang et al., Oncogene 1999*
-
IRef Intact Interaction:
NFKBIB
—
RELA
(physical association, two hybrid)
Wang et al., Molecular systems biology 2011
-
IRef Intact Interaction:
NFKBIB
—
RELA
(physical association, anti bait coimmunoprecipitation)
Ganesh et al., Nature 2003
-
IRef Intact Interaction:
RELA
—
NFKBIB
(physical association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Intact Interaction:
Complex of COMMD1-RELA-NFKBIB-NFKBIA
(association, anti bait coimmunoprecipitation)
Ganesh et al., Nature 2003
-
IRef Ophid Interaction:
NFKBIB
—
RELA
(aggregation, confirmational text mining)
-
IRef Ophid Interaction:
NFKBIB
—
RELA
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
NFKBIB
—
RELA
(aggregation, confirmational text mining)
Bouwmeester et al., Nat Cell Biol 2004
Text-mined interactions from Literome
Algarté et al., J Virol 1999
(Respirovirus Infections) :
These experiments demonstrate a major role for IkappaBalpha in the regulation of
NF-kappaB induced IFN-beta gene activation and a minor
role for
IkappaBbeta in the activation process
Kemler et al., Glia 1999
(Brain Neoplasms...) :
Role of IkappaBalpha and
IkappaBbeta in the biphasic nuclear translocation of
NF-kappaB in TNFalpha stimulated astrocytes and in neuroblastoma cells
Díaz-Guerra et al., J Immunol 1999
:
Treatment of cultured peritoneal macrophages with IFN-gamma resulted in tyrosine phosphorylation of IkappaBalpha and
IkappaBbeta ,
NF-kappaB activation , and expression of inducible NO synthase (iNOS)
Mortellaro et al., J Immunol 1999
:
PNU156804 inhibition of
NF-kappa B activation is
due to the inhibition of the degradation of I kappa B-alpha and
I kappa B-beta
Newton et al., J Biol Chem 1999
(Breast Neoplasms) :
Overexpression of IkappaBalpha but not
IkappaBbeta1 resulted in reduced constitutive DNA binding of
NF-kappaB in MDA-MB-231 cells ... Unexpectedly,
IkappaBbeta1 overexpression moderately
increased 12-O-tetradecanoylphorbol-13-acetate- and interleukin-1-inducible
NF-kappaB DNA binding
Hoshi et al., J Biol Chem 2000
:
Western blot analysis of I-kappaBalpha and
I-kappaBbeta ,
inhibitors of
NF-kappaB , indicated that I-kappaBalpha degradation, rather than I-kappaBbeta degradation, was important in NF-kappaB activation after the stimulation of TRAP and bFGF
Stasiolek et al., J Biol Chem 2000
(Astrocytoma...) :
These results suggest that
IkappaB-beta contributes to persistent
NFkappaB activation and NOS2 expression in glial cells, that IkappaB-beta is a stress protein inducible by hyperthermia or proteasome inhibitors, and that delayed addition of proteasome inhibitors can have stimulatory rather than inhibitory actions
Hajra et al., Proc Natl Acad Sci U S A 2000
(Arteriosclerosis) :
In control C57BL/6 mice, expression levels of p65, IkappaBalpha, and
IkappaBbeta were 5- to 18-fold higher in the HP region, yet
NF-kappaB was
activated in a minority of endothelial cells
Deng et al., J Biol Chem 2001
:
Based on these results, we conclude that 2-AAF up-regulates mdr1b through the generation of ROS, activation of IKK kinase, degradation of
I kappa B beta , and subsequent
activation of
NF-kappa B
Jaffray et al., J Gastrointest Surg 2000
(Acute Disease...) :
Elastase, carboxypeptidase A, and lipase induced degradation of
I kappa B-beta ( but not I kappa B-alpha ),
activation of
NF-kappa B , and production of TNF-alpha protein, whereas inhibition of I kappa B with pyrrolidine dithiocarbamate attenuated this response
Chakravortty et al., J Immunol 2001
:
SA
inhibited LPS induced
NF-kappaB activation by preventing loss of
IkappaB-alpha and -beta
Jiang et al., Oncogene 2001
(Adenocarcinoma...) :
To evaluate the role of the NF-kappaB signaling pathway in oncogenic transformation, we expressed
IkappaBbeta , a specific
inhibitor of
NF-kappaB , in two human lung adenocarcinoma cell lines, A549 and H441 ... Expression of
IkappaBbeta significantly
reduced NF-kappaB activation induced by cotransfection with p65/RelA or TNF-alpha and abrogated the basal NF-kappaB activity in A549 cells
Kuo et al., Oncogene 2002
(Carcinoma, Hepatocellular) :
2-AAF activates IkappaB kinase (IKK), resulting in degradation of
IkappaBbeta and
activation of
NF-kappaB
Mukhopadhyay et al., J Biol Chem 2002
:
The impaired
NF-kappaB activation in Bcr-Abl expressing cells was not
due to absence of the NF-kappaB proteins p65, p50, or p100 or of IkappaBalpha or
IkappaBbeta
Zingarelli et al., Shock 2002
(Shock, Septic) :
These events were preceded by degradation of inhibitors kappaBalpha ( IkappaBalpha ) and kappaBI (
IkappaBbeta ), and
activation of
nuclear factor-kappaB (NF-kappaB) in the lung
Budde et al., Mol Biol Cell 2002
:
We have found that
IkappaBbeta expression is localized within the haploid spermatid stages of spermatogenesis and
follows the expression of nuclear
NF-kappaB
Lindgren et al., Biochem Biophys Res Commun 2003
:
Taken together, our data implicate distinct
roles for IkappaBalpha and
IkappaBbeta in regulating various
NF-kappaB activities
Chae et al., Immunopharmacol Immunotoxicol 2004
:
Here, we suggest that the degradations of IkappaB alpha and
IkappaB beta and the following
activation of
NF-kappaB are the targets of NAC and that NF-kappaB transcription factor is a pivotal clue to regulation of differentiation in TNFalpha exposed osteoblasts
Singh et al., Biochem Biophys Res Commun 2004
:
We also report the
involvement of IkappaB-alpha and
IkappaB-beta in the persistent activation of
NF-kappaB by L. donovani
Nasr et al., Oncogene 2005
(Leukemia-Lymphoma, Adult T-Cell...) :
PS-341 treatment of these cells stabilized IkappaBalpha,
IkappaBbeta , IkappaBvarepsilon, p21, p27 and p53 proteins and selectively
inhibited Rel-A DNA binding
NF-kappaB complexes ... PS-341 treatment of these cells stabilized IkappaBalpha,
IkappaBbeta , IkappaBvarepsilon, p21, p27 and p53 proteins and selectively
inhibited Rel-A DNA binding NF-kappaB complexes
Hertlein et al., Mol Cell Biol 2005
:
In contrast to the defined regulatory interplay between NF-kappaB and IkappaBalpha, much less is known regarding the
regulation of
IkappaBbeta by
NF-kappaB ... Here, we describe in detail the
regulation of
IkappaBbeta by
RelA/p65
Campa et al., Inflamm Res 2005
(Inflammation) :
Thus, poly I
induced an increase in
nuclear factor kappaB (NF-kappaB) transcriptional activity due to a long-term degradation of inhibitory NF-kappaB (IkappaB) beta while lipopolysaccharide (LPS) induced the degradation of both IkappaBalpha and
IkappaBbeta
Dias et al., J Nutr 2005
(Diabetes Mellitus, Experimental) :
Eight weeks later we measured TBARS and hydroperoxide initiated chemiluminescence ( QL ) in liver as markers of oxidative stress, and activities of the antioxidant enzymes catalase, superoxide dismutase ( SOD ), and glutathione peroxidase,
NF-kappaB activation by an electrophoretic mobility shift assay and expression of IkappaB kinases ( IKKalpha and IKKbeta ), the inhibitor IkappaB ( IkappaBalpha and
IkappaBbeta ), and iNOS by Western blot
Packham et al., Cell Death Differ 1997
:
NF-kappaB activation by both pathways was persistent and
due to the sequential degradation of IkappaB-alpha and
IkappaB-beta
Griffin et al., Biochem J 2006
:
Furthermore, in contrast with IkappaBalpha,
NF-kappaB activation did not
increase expression of endogenous
IkappaBbeta as assessed by analysis of mRNA and protein levels
Lentsch et al., Shock 2007
(Acute Disease...) :
In TK-/- mice, there was far less IkappaB-alpha and
IkappaB-beta protein and greater
activation of
NF-kappaB
Watanabe et al., Lab Invest 2007
(Hodgkin Disease) :
We also present the data that indicate the
involvement of
IkappaBbeta in
NF-kappaB induction by topoisomerase inhibitors ... The results also indicate that
IkappaBbeta is
involved in
NF-kappaB activation in H-RS cells and IkappaBbeta substitutes for IkappaBalpha in H-RS cells lacking wild-type IkappaBalpha
García-Román et al., Journal of carcinogenesis 2007
:
We propose that during liver regeneration, the transitory stimulation of the transcription factor response, assures blockade of NF-kappaB until recovery of the total mass of the liver and the persistent
NF-kappaB activation in early hepatocarcinogenesis may be
due to
IkappaB-beta and IkappaB-alpha degradation, mainly IkappaB-beta degradation, which contributes to gene transcription related to proliferation required for neoplastic progression
Shi et al., Am J Physiol Gastrointest Liver Physiol 2009
(Colitis...) :
The translocation of
NF-kappaB was
inhibited by blocking the degradation of
IkappaBbeta
Morais et al., Nephrol Dial Transplant 2010
(Carcinoma, Renal Cell...) :
PDTC significantly decreased RCC growth and the expression of
NF-kappaB subunits ( p50, p52, c-Rel and RelB ), upstream IKK-beta and IKK-gamma, but did not
induce any changes in the expression of IkappaB-alpha and
IkappaB-beta
Beg et al., Genes Dev 1995
:
Our results indicate that
I kappa b beta , but not I kappa B alpha, is
required for the signal dependent activation of
NF-kappa B in fibroblasts
Good et al., J Virol 1996
:
Persistent activation of
NF-kappa B/Rel by human T-cell leukemia virus type 1 tax
involves degradation of
I kappa B beta
Suyang et al., Mol Cell Biol 1996
:
Role of unphosphorylated, newly synthesized
I kappa B beta in persistent activation of
NF-kappa B
Harhaj et al., Mol Cell Biol 1996
:
Interestingly, activation of these NF-kappaB/Rel complexes by the CD28 signal is associated with the rapid degradation of both IkappaBalpha and
IkappaBbeta , two major cytoplasmic
inhibitors of
NF-kappaB/Rel
Hauf et al., Proc Natl Acad Sci U S A 1997
(Leukemia P388...) :
Listeria monocytogenes infection of P388D1 macrophages results in a biphasic
NF-kappaB ( RelA/p50 )
activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and
IkappaBbeta degradation ... We suggest that products of the enzymatic activity of phospholipases directly interfere with host cell signal transduction pathways, thus leading to persistent
NF-kappaB activation via persistent
IkappaBbeta degradation
Cheshire et al., Mol Cell Biol 1997
:
Synergistic
activation of
NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo
I kappaBbeta degradation
Chen et al., Mol Pharmacol 1997
:
Transfection with a plasmid containing cDNA encoding mouse
IkappaBbeta , an
inhibitor of
NF-kappaB , resulted in increased toxicity by menadione
Miyamoto et al., Mol Cell Biol 1998
:
We observed that
IkappaB beta , another
NF-kappaB inhibitor , is also complexed with c-Rel but slowly degraded by a proteasome dependent process in WEHI231 cells
Attar et al., Mol Cell Biol 1998
:
These results show that in nonstimulated T cells,
IkappaB beta can not efficiently displace IkappaB alpha bound to RelA containing complexes and that persistent
NF-kappaB activity is
required for proper T-cell responses in vivo
Hehner et al., J Biol Chem 1998
:
Sesquiterpene lactones specifically
inhibit activation of
NF-kappa B by preventing the degradation of I kappa B-alpha and
I kappa B-beta
Krappmann et al., Immunobiology 1997
:
Regulation of
NF-kappa B activity by I kappa B alpha and
I kappa B beta stability
Bitko et al., J Virol 1998
:
Persistent activation of
RelA by respiratory syncytial virus
involves protein kinase C, underphosphorylated
IkappaBbeta , and sequestration of protein phosphatase 2A by the viral phosphoprotein
Coscoy et al., Virology 1998
(Cell Transformation, Neoplastic...) :
Therefore, Tax induced cell transformation in mice correlates with the degradation of IkappaB alpha and
IkappaB beta and with the constitutive
activation of
NF-kappaB
Zen et al., Exp Cell Res 1998
:
Lipopolysaccharide induced
NF-kappaB activation in human endothelial cells
involves degradation of IkappaBalpha but not
IkappaBbeta
O'Connell et al., J Biol Chem 1998
:
Phosphorylation of the IkappaB cytoplasmic inhibitors, IkappaBalpha,
IkappaBbeta , and IkappaBepsilon, by these kinases
triggers proteolytic degradation and the release of
NF-kappaB/Rel proteins into the nucleus