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CXCL10 — IRF6

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Hua et al., Glia 2000 : Previous studies have demonstrated that in cultured rat astrocytes and microglia, stimulation with LPS or virus can induce the expression of IP-10 ... The results showed that in human microglia, IP-10 expression was induced equally potently by LPS , IFNbeta or IFNgamma
Perera et al., J Immunol 2001 : Therefore, the relative contribution of these proteins in the induction of cyclooxygenase 2 (COX-2), IL-12 p35, IL-12 p40, TNF-alpha, IFN-inducible protein (IP)-10 , and IFN consensus sequence binding protein ( ICSBP ) genes in response to LPS or the LPS-mimetic, Taxol, was examined using macrophages derived from mice deficient for these membrane associated proteins
Ohmori et al., J Leukoc Biol 2001 : LPS induced expression of an interferon ( IFN ) -inducible 10-kDa protein ( IP-10 ), IFN regulatory factor-1 (IRF-1), and inducible nitric oxide synthase (iNOS) mRNAs was severely impaired in macrophages prepared from Stat1-/- mice, whereas levels of tumor necrosis factor alpha and KC ( a C-X-C chemokine ) mRNA in LPS treated cell cultures were unaffected ... Activation of these STAT1 containing transcription factors was mediated by the intermediate induction of type I IFNs, since the LPS induced IP-10 , IRF-1, and iNOS mRNA expression was markedly reduced in macrophages from IFN-alpha/betaR-/- mice and blocked by cotreatment with antibodies against type I IFN
Zaks-Zilberman et al., Cytokine 2001 (Breast Neoplasms...) : In the human MDA-MB-231 breast cancer cell line, LPS also increased mRNA levels for both GM-CSF and IP-10 significantly, while, paclitaxel increased IP-10 mRNA levels with delayed kinetics and failed to induce GM-CSF mRNA
Gasper et al., Infect Immun 2002 : Consistent with these findings, Salmonella derived lipopolysaccharide (LPS) , but not S. aureus derived peptidoglycan, could induce expression of CXCL10 ... An antibody against toll-like receptor 4 (TLR4) could block the LPS induced CXCL10 production, demonstrating the functional expression of TLR4 by osteoblasts
Sharma et al., Immunol Lett 2004 : It is observed that rLcrV and rYopB inhibited the LPS induced expression of TNF-alpha, IFN-gamma, KC, IP-10 , and IL-12 in macrophages
Si et al., J Immunol 2004 (Acquired Immunodeficiency Syndrome) : Adenoviral transduction of super-repressor IkappaBalpha, dominant negative MKK6, and dominant negative Ras demonstrated that NF-kappaB and p38 MAPK were involved in LPS induced IFN-inducible protein 10/CXCL10 production ... Interestingly, although LPS induced IL-8/CXCL8 was dependent on NF-kappaB, the baseline or 15d-PGJ ( 2 ) -mediated IL-8/CXCL8 production was NF-kappaB independent
Sugiyama et al., Microbiol Immunol 2004 : 2-AP also reduced the expression of IFN-beta and IFN-inducible genes, such as IFN-gamma-inducible protein ( IP ) -10 and immune-responsive gene (IRG)-1, and the inducible type of NO synthase (iNOS) mRNA in response to LPS
Dürk et al., Int Immunol 2005 : Pharmacological studies with isotype-selective receptor agonists allowed us to show that 5-HTR(3) subtype up-regulates the LPS induced production of IL-1beta, IL-6 and IL-8/CXCL8 , while it was not involved in TNF-alpha and IL-12p40 secretion
Cassatella et al., Eur J Immunol 2005 : In this study, we show that modulation by IL-10 of LPS induced TNF-alpha, CXCL8/IL-8 and IL-1 receptor antagonist (IL-1ra) mRNA accumulation in neutrophils already expressing a functional IL-10R and antigenic SOCS-3 ( i.e. in `` 4-h cultured '' neutrophils ) occurs with kinetics that are similar to those observed in `` time 0 '' neutrophils, depends on de novo protein synthesis, but does not require SOCS-1, SOCS-3, heme oxygenase and Bcl-3 induction
Nagarajan et al., J Immunol 2005 (Chlamydia Infections) : During infections with Gram negative bacteria, the IP-10 response mediated through type I IFNs usually occurs as a result of TLR4 stimulation by bacterial LPS
Hasan et al., BMC immunology 2005 (Tuberculosis...) : BCG-, and LPS induced CXCL8 secretion was comparable between patients and controls
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : LPS did not induce RT4 cells to produce IP-10 and MDC
Strengell et al., J Leukoc Biol 2006 : IL-21 pretreatment also dramatically reduced LPS stimulated production of tumor necrosis factor alpha, IL-12, CC chemokine ligand 5 (CCL5), and CXC chemokine ligand 10 (CXCL10) but not that of CXCL8
Wehrwein et al., Cardiovascular diabetology 2006 (Diabetes Mellitus, Type 1) : Monocytes were isolated from controls and T1D patients and the LPS stimulated increase of IL-6, CXCL8 , monocyte chemotactic protein 1 ( CCL2, MCP-1 ) and superoxide dismutase ( SOD 2 ), as well as the LPS mediated decrease of apolipoprotein E (Apo E) in primary human monocytes from controls and T1D patients was determined
De Plaen et al., Immunology 2006 : In conclusion, CXCL2 gene is expressed in enterocytes in response to both TNF and LPS
Herder et al., Int J Obes Relat Metab Disord 2007 : In cultures of human mature adipocytes and in vitro differentiated adipocytes, IP-10 expression under basal conditions and in the presence of IFNgamma, lipopolysaccharide (LPS) or interleukin (IL)-4 was characterized by reverse transcriptase-polymerase chain reaction, Luminex technology and immunofluorescence ... In in vitro differentiated adipocytes from s.c. and mammary depots and in mature s.c. adipocytes, IP-10 secretion was strongly upregulated by IFNgamma, whereas LPS or IL-4 did not affect IP-10 expression in s.c. mature adipocytes ... IP-10 expression could be significantly induced by IFNgamma, but not by LPS , which points to both similar reactivities and functional differences between adipocytes and innate immune cells
Carvalho et al., Inflammopharmacology 2006 (Disease Models, Animal...) : In vitro data revealed that U. guianensis impaired LPS induced nitric oxide and CXCL8 generation by murine peritoneal macrophages, as well as OVA induced interleukin-5 synthesis by previously sensitized spleen cells
Fan et al., Immunology 2007 : LPS induced production of KC and IL-1beta, SA-induced production of GM-CSF, KC and IP-10, and GBS induced production of IL-10, GM-CSF and IP-10 were unchanged in macrophages from Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Mariani et al., J Immunol 2007 : In addition, DC treatment with Bet.-APE significantly reduced LPS induced production of CXCL10/IP-10 , CCL5/RANTES ; induced CCL22/macrophage derived chemokine ; and did not significantly change release of CCL17/thymus and activation regulated chemokine
Hung et al., Pediatr Allergy Immunol 2007 : Ketotifen ( 5-50 microM ) significantly down-regulated lipopolysaccharide (LPS) induced MDC, MIG and IP-10 ( p < 0.05, each comparison ) in THP-1 cells and human primary monocytes in a dose dependent manner ... SB203580 [ p38-mitogen activated protein kinase ( MAPK ) inhibitor ] suppressed LPS induced MDC and IP-10 expression, and PD98059 ( ERK-MAPK inhibitor ) could only suppress LPS induced IP-10 , but not MDC expression
Tamassia et al., Eur J Immunol 2007 : Molecular mechanisms underlying the synergistic induction of CXCL10 by LPS and IFN-gamma in human neutrophils ... Finally, pharmacological inhibitors of NF-kappaB demonstrated its role in the induction of CXCL10 expression by LPS plus IFN-gamma in neutrophils, and by LPS or IFN-gamma in monocytes
Happel et al., Alcohol 2007 (Alcoholic Intoxication...) : IP-10 , MIG, and I-TAC in response to LPS were enhanced by exogenous interferon (IFN)-gamma, and these responses were blunted by exposure to ethanol
Zhai et al., Hepatology 2008 (Carcinoma, Hepatocellular...) : Consistent with these findings, our in vitro cell culture studies have shown that : ( 1 ) although hepatocytes alone failed to respond to lipopolysaccharide (LPS), when co-cultured with macrophages they did respond to LPS via macrophage derived IFN-beta ; ( 2 ) macrophages required type I IFN to sustain CXCL10 production in response to LPS
Pioli et al., J Immunol 2007 : In this study, we demonstrate that 17beta-estradiol ( E2 ) attenuates LPS induced expression of CXCL8 in human peripheral blood monocytes
Hung et al., Eur Respir J 2008 : In the present study, the effects of formoterol and salmeterol on lipopolysaccharide (LPS) induced expression of the Th2 related chemokine macrophage derived chemokine ( MDC ; CCL22 ) and the Th1 related chemokine interferon-gamma-inducible protein ( IP)-10 (CXCL10 ) were investigated in a monocytic cell line, THP-1, and in human primary monocytes
Tamassia et al., Int Immunol 2008 (Sepsis...) : Consistent with the presence of a fully functional IL-10R, modulation of LPS induced CXCL8 , CCL4, tumour necrosis factor-alpha and IL-1ra gene expression was also rapidly induced by IL-10 in septic, but not normal, neutrophils
Anand et al., J Immunol 2008 : In the present study, we determined the role of a nonreceptor proline-rich tyrosine kinase, Pyk2, in LPS induced IL-8 ( CXCL8 ) production in endothelial cells
Yu et al., Mol Cell Biochem 2008 : Although LPS- and PGN induced cytokine secretions were decreased greatly by MyD88 downregulation, IFN-gamma induced protein-10 ( IP10 ) and IFNbeta expression were enhanced by LPS irrespective of the downregulation of MyD88
Farkas et al., Scand J Immunol 2008 : LPS itself significantly augments CXCL-8 production and co-administration of MDP further increases cytokine secretion
Chung et al., Mol Cells 2009 : Microarray results showed that the induction of monocyte chemoattractant protein-1alpha ( MCP-1alpha ) and macrophage inflammatory protein-1alpha ( MIP-1alpha ), MIP-1beta, MIP-1gamma, regulated upon activation, normal T-cell expressed and secreted ( RANTES ), macrophage inflammatory protein-2 ( MIP-2 ), and interferon-gamma inducible protein 10 ( IP 10 ) by A. actinomycetemcomitans LPS was increased to 12.5, 1.53, 9.09, 17.3, 2.82, 16.1, and 18.1 folds at 18 h, respectively ... These results indicate that A. actinomycetemcomitans LPS stimulates the several chemokines expressions ( MIP-1alpha, MIP-1beta, MIP-1gamma, RANTES, MIP-2, and IP 10 ) in Raw 264.7 cells
Gouwy et al., J Leukoc Biol 2009 : Furthermore, LPS rapidly induced the expression of IL-8/CXCL8 but not of the CCL2 receptor CCR2 in monocytic cells
Cerciat et al., Glia 2010 : LPS induced an increase in the expression of IL-6 and IP-10 mRNA levels in astrocytes and an increase in IL-6 and IP-10 protein levels in the culture medium
Hoth et al., J Trauma 2009 (Contusions...) : Injury + LPS showed immune priming observed by lung injury histology and increased bronchoalveolar lavage neutrophilia, lung myeloperoxidase and serum IL-6, CXCL1 , and MIP-2 levels when compared with injury + vehicle or LPS alone
Yeh et al., Inflammation 2010 : Nonylphenol and 4-octylphenol were able to suppress LPS induced MDC and IP-10 expression
Kim et al., Immune network 2009 : As a result of these properties, we examined the effect of 15d-PGJ ( 2 ) on the LPS induced IL-8/CXCL8 mRNA expression in VSMCs from SHR ... A NAD ( P ) H oxidase inhibitor inhibited the upregulatory effect of 15d-PGJ ( 2 ) on LPS induced IL-8/CXCL8 mRNA expression in SHR VSMCs, and an increase in NAD ( P ) H oxidase activity was detected in SHR VSMCs treated with 15d-PGJ ( 2 ) /LPS ... Our results indicate that the upregulatory effect of 15d-PGJ ( 2 ) on LPS induced IL-8/CXCL8 expression in SHR VSMCs is mediated through the PPARgamma and ERK pathway, and may be related to NAD ( P ) H oxidase activity ... However, p38 inactivation may also play an important role in 15d-PGJ ( 2 ) /LPS induced IL-8/CXCL8 expression in SHR VSMCs
Sheldon et al., PloS one 2010 (Cattle Diseases...) : Endometrial epithelial or stromal cells from wild type but not Toll-like receptor 4 (TLR4) null mice secreted prostaglandin E ( 2 ) and chemokine ( C-X-C motif ) ligand 1 ( CXCL1 ) in response to LPS from EnPEC, highlighting the key role of LPS in PID
Cañas et al., Neuroscience 2010 (Encephalitis...) : However, it did not modify LPS induced IP-10 and SOCS-1 mRNA, proteins that participate in the JAK/STAT pathway
Nguyen et al., PloS one 2010 : In response to LPS , production of TNF-alpha, IP-10 and IL-12p70 reached adult levels between 6-9 months of life
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 potently suppressed LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and IRF3, indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Outtz et al., J Immunol 2010 (Inflammation) : Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10 , MCP-1, monokine induced by IFN-?, and TNF-a in macrophages in response to LPS/IFN-? ... Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10 , MCP-1, monokine induced by IFN-?, and TNF-a in macrophages in response to LPS/IFN-?
McCall et al., J Endocrinol 2010 (Insulin Resistance) : In addition, C10 inhibits palmitate induced IL6 and iNos up-regulation in both 3T3L1 adipocytes and RAW 264.7 macrophages, LPS induced NF-?B and IFN-ß activation in 3T3L1 cells, and LPS induced iNos, Ifn-ß, Il1ß, Cxcl10 , and Il6 expression in RAW 264.7 macrophages
Sheldon et al., PloS one 2010 : Stromal and epithelial cells isolated from the endometrium of WT but not Tlr4 ( -/- ) mice, secreted IL-6, CXCL1 , CCL20 and prostaglandin E ( 2 ) in response to LPS , in a concentration and time dependent manner
Tighe et al., Am J Respir Cell Mol Biol 2011 (Disease Models, Animal...) : Interestingly, ExMac stimulation with LPS resulted in complete suppression of CXCL10
Ban et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : Interestingly, among genes related to macrophage mediated immunity, LPS increased the expression of seven genes ( Adora2b, Fcgr2b, Cish, Cxcl10 , Clec4n, Il1a, and Il1b ) and decreased the expression of one gene ( Clec4a3 )
Huang et al., J Food Sci 2010 (Hypersensitivity...) : Our data demonstrated that kaempferol significantly inhibited the lipopolysaccharide (LPS) induced production of monocyte derived chemokine (MDC), interferon gamma induced protein 10 (IP-10) , and interleukin-8 (IL-8) in THP-1 cells
John et al., Exp Lung Res 2011 (Cystic Fibrosis) : In CFTR corrected cells, stimulation with LPS increased IP-10 secretion
Dhanushkodi et al., Viral Immunol 2011 : Although LPS did not induce release of IP-10 , it sharply inhibited ( p?=?0.004 ) SIN mediated IP-10 secretion
Tsai et al., J Investig Med 2011 (Inflammation...) : Imidapril and perindopril significantly downregulated lipopolysaccharide (LPS) induced TNF-a, I-309, and IP-10 in THP-1 cells and human primary monocytes ... Only extracellular signal regulated kinases and c-Jun N-terminal kinases (JNK) mitogen activated protein kinase inhibitors suppressed LPS induced IP-10 expression ... These data demonstrate that ACEI is effective in downregulating LPS induced TNF-a, I-309, and IP-10 , which play important roles in the pathogenesis of inflammation
Buenestado et al., Br J Pharmacol 2012 : Roflumilast and roflumilast N-oxide concentration-dependently reduced the LPS stimulated release of CCL2, CCL3, CCL4, CXCL10 and TNF-a from human lung macrophages, whereas that of CXCL1 or CXCL8 was not altered ... Roflumilast and roflumilast N-oxide reduced LPS induced release of CCL2, 3, 4, CXCL10 and TNF-a in human lung macrophages
Yamada et al., Journal of inflammation research 2008 : In TLR4 mutant mice, LPS induced upregulation of tumor necrosis factor-alpha ( TNF-a ), KC, and CXCL10 in plasma and BAL fluid was attenuate, which was not different after PGN
Kimura et al., Exp Eye Res 2012 : LPS induced the release of interleukin (IL)-6, IL-8, MCP-1, RANTES, IP-10 , eotaxin, and IL-12 from corneal fibroblasts
Takeda et al., Clin Exp Immunol 2012 : IFN-ß- or LPS induced CXCL10 production, expression of CXCL10 mRNA and phosphorylation of STAT1 were significantly reduced in the presence of the medium pretreated with CA beads compared with the control without the CA bead treatment
Diz-Chaves et al., Journal of neuroinflammation 2012 (Prenatal Exposure Delayed Effects) : LPS induced a significant increase in mRNA levels of IL-6, TNF-a and IP10 in the hippocampus of prenatally stressed mice but not of non stressed animals
Wendlandt et al., Innate Immun 2012 : When miR-200b or miR-200c mimics were transfected into the differentiated monocytic THP-1 cell line, the abundance of MyD88 transcripts, as well as LPS induced expression of the pro-inflammatory molecules IL-6, CXCL9 and TNF-a were diminished
Roos et al., Biochem Biophys Res Commun 2012 (Pneumonia) : We hypothesized that C/EBPß in the lung epithelium contributes to lipopolysaccharide (LPS) induced airway neutrophilia and expression of neutrophil chemoattractant chemokine ( C-X-C ) motif ligand ( CXCL)1, as well as the suppressive effects of long acting ß ( 2 ) -agonists ( LABAs ) and glucocorticoids (GCs)
Schreiber et al., J Antibiot (Tokyo) 2012 : Compounds ( 1 ) and ( 2 ) inhibited lipopolysaccharide (LPS)/interferon-? ( IFN-? ) -induced CXCL10 promoter activity in transiently transfected MM6 cells in a dose dependent manner with IC ( 50 ) values of 39-41?µM and also reduced LPS/IFN-? induced CXCL10 protein synthesis and excretion
Philippe et al., Ann Rheum Dis 2013 (Arthritis, Rheumatoid) : Transfection of miR-20a mimics decreases IL-6 and CXCL10 release by RA FLS and IL-1ß and TNF-a by activated THP-1 cells but only in response to LPS
Li et al., PloS one 2012 (Sepsis) : Especially, Y enhanced the inhibitory effect of Ber on LPS induced IP-10 mRNA expression
Park et al., Life Sci 2013 (Inflammation) : PEITC suppressed the activation of IRF3 and the expression of IP-10 induced by lipopolysaccharide (LPS) or polyinosinic-polycytidylic acid ( poly [ I:C ] )
Plumb et al., PloS one 2013 : 17-BMP suppression of LPS induced TNFa, IL-6 and CXCL8 was measured by ELISA and GR phosphorylation was measured by immunohistochemistry and Western blot
Tebo et al., Cell Immunol 1994 : The OA- and LPS stimulated increases in IP-10 and TNF alpha mRNA were mediated through increases in the transcriptional activity of the genes as measured by nuclear run-on analysis
Manthey et al., Infect Immun 1993 : Herein, we examined the ability of these structures to regulate murine macrophage tumor necrosis factor (TNF) secretion and LPS-inducible gene expression ( tumor necrosis factor alpha [TNF-alpha ], interleukin-1 beta [IL-1 beta ], IP-10 , type 2 TNF receptor [TNFR-2 ], D3, and D8 genes ) ... Under these conditions, LPS induced expression of IP-10 , D3, and D8 was suppressed regardless of the LPS concentration used ( concentrations tested up to 50 micrograms/ml ), while expression of TNF-alpha mRNA was enhanced about fourfold
Gómez-Chiarri et al., Am J Pathol 1993 : LPS induced transient IP-10 mRNA expression that peaked at 8 hours ; TNF-alpha mRNA was also increased
Ohmori et al., J Biol Chem 1993 : These results indicate that the 230 nucleotides upstream from the transcription start site are important for transcriptional control of the IP-10 gene in response to IFN gamma and LPS
Tebo et al., Blood 1998 : First, LPS induced IP-10 mRNA expression was blocked in cells cotreated with cycloheximide ... Finally, the IL-10 mediated suppression of LPS stimulated IP-10 production could be rescued by cotreatment with IFNbeta
Cheng et al., J Interferon Cytokine Res 1998 : Transcription of the IP-10 gene requires interferon ( IFN ) -stimulated response element ( ISRE ) and kappaB sites to be induced by lipopolysaccharide (LPS) , IFN-gamma, virus, and poly ( I:C )