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GSK3B — PI3

Text-mined interactions from Literome

Crowder et al., J Biol Chem 2000 : Stimulation with NGF resulted in PI 3-kinase dependent phosphorylation of GSK-3 beta and inhibition of its protein kinase activity, indicating that GSK-3 beta is targeted by PI 3-kinase/Akt in these neurons
Hetman et al., J Biol Chem 2002 : Interestingly, PI3K ( but not ERK1/2 ) induced the inhibitory phosphorylation of GSK3beta at Ser-9
Kanzaki et al., J Cell Biol 2004 : Furthermore, insulin induced GSK-3beta phosphorylation was mediated by both PI 3-kinase-PKB and the TC10-Par6-atypical PKC signaling pathways
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2005 : IGF-I dependent GSK-3 beta phosphorylation and the resulting GSK-3 beta inactivation were mediated by activation of a PI3-kinase dependent, phosphoinositide dependent kinase-1 ( PDK-1 ) -dependent, and Akt dependent mechanism
Kirshenboim et al., J Mol Neurosci 2004 : Lithium mediated phosphorylation of glycogen synthase kinase-3beta involves PI3 kinase dependent activation of protein kinase C-alpha
Beurel et al., Int J Oncol 2005 (Carcinoma, Hepatocellular) : Therefore, PI3K mediated GSK-3beta inhibition could be a mechanism by which cancer cells escape from chemotherapy induced apoptosis
Abbosh et al., Thyroid 2005 (Thyroid Neoplasms) : Activation of AKT by phosphatidylinositide-3 kinase (PI3K) , a RAS effector, results in GSK3beta phosphorylation and deactivation and subsequent beta-catenin upregulation in thyroid cancer
Almeida et al., J Biol Chem 2005 : Wnt3a induced phosphorylation of GSK-3beta and downstream activation of beta-catenin mediated transcription required ERK, PI3K , and Akt signaling
Fothergill et al., Virology 2006 (MAP Kinase Signaling System) : VLP induced PI3-kinase activity resulted in efficient downstream signaling to Akt and consequent phosphorylation of FKHR and GSK3beta
Peng et al., Zhonghua Xin Xue Guan Bing Za Zhi 2006 (Myocardial Reperfusion Injury) : Phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin prevented the increase of phospho-protein kinase B/Akt ( Ser473 ) and phospho-glycogen synthase kinase-3beta ( Ser9 ) induced by ischemic postconditioning, but only partly abolished the cardioprotection of ischemic postconditioning
Gowan et al., Assay Drug Dev Technol 2007 (Neoplasms, Experimental) : In this paper, optimization of the Meso Scale Discovery (MSD) ( Gaithersburg, MD ) platform to quantify changes in phospho-AKT and phospho-glycogen synthase kinase-3beta in response to a PI3-kinase inhibitor, LY294002, is described, initially in vitro and then within xenografted solid tumors
Nishihara et al., J Mol Cell Cardiol 2007 (Disease Models, Animal...) : A PKC inhibitor and a PI3 kinase inhibitor suppressed the IPC+EPO induced increase in the level of phospho-GSK-3beta-ANT complex
Duarte et al., Biochim Biophys Acta 2008 : Since phosphatidylinositol 3-kinase (PI-3K)/Akt mediated inhibition of GSK-3beta may stimulate protein synthesis and decrease apoptosis, we analysed mRNA and protein expression of `` candidate '' proteins involved in antioxidant defense, glucose metabolism and apoptosis
Nair et al., J Biol Chem 2008 : In contrast, inhibition of PI-3K blocked the phosphorylation of Akt and GSK-3beta ( activation ) and prevented the protection mediated by ropinirole
Kim et al., Cancer Lett 2008 (Breast Neoplasms...) : In addition, the basal activities of Akt and GSK-3beta were deregulated in MCF-7/ADR cells, and either the activation of PI3-kinase or the inhibition of GSK-3 restored the diminished transcription of VEGF
Mariappan et al., J Biol Chem 2008 (Diabetes Mellitus, Type 2...) : Incubation with selective kinase inhibitors showed that high glucose- and high insulin induced laminin beta1 synthesis and phosphorylation of GSK3beta were dependent on PI 3-kinase , Erk, and mTOR
Lee et al., Life Sci 2009 : We found that CAPE induces rapid and transient phosphorylation of glycogen synthase kinase (GSK)-3beta in a phosphoinositide 3-kinase (PI3K) dependent manner