Gene interactions and pathways from curated databases and text-mining
CASP8: top 25 interacting genes (chr2:202122753-202152434)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only CASP8-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with CASP8, not among the Top 25
Other genes interacting with CASP8. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

AKT3 ▸ XIAP ▸ IL1B ▸ FASLG ▸ DIABLO ▸ MAPK3 ▸ IL1A ▸
BCL5 ▸ BCL6 ▸ BCL3 ▸ BCL9 ▸ EPHB2 ▸ MAPK1 ▸ IRF6 ▸
MAPK11 ▸ MAPK9 ▸ MAPK10 ▸ MAPK13 ▸ MAPK4 ▸ MAPK15 ▸ MAPK6 ▸
MAPK14 ▸ MAPK8 ▸ MAPK12 ▸ MAPK7 ▸ IFNG ▸ CASP3 ▸ APAF1 ▸
CAPN1 ▸ CAPN10 ▸ CAPN11 ▸ IL18 ▸ CAPN13 ▸ CAPN14 ▸ CAPN6 ▸
CAPN9 ▸ CAPN2 ▸ CAPN8 ▸ CAPN3 ▸ CAPN12 ▸ CAPN7 ▸ FADD ▸
CAPN15 ▸ CAPN5 ▸ STS ▸ ASIP ▸ DNTT ▸ MCL1 ▸ MMP9 ▸
MMP2 ▸ MMP12 ▸ MMP3 ▸ MMP14 ▸ MMP11 ▸ MMP1 ▸ MMP19 ▸
MMP13 ▸ MMP15 ▸ MMP17 ▸ MMP25 ▸ NLRP3 ▸ MMP24 ▸ MMP8 ▸
MMP7 ▸ CDKN1A ▸ MMP16 ▸ MMP20 ▸ MMP28 ▸ MMP27 ▸ MMP21 ▸
MMP10 ▸ MMP26 ▸ CASP9 ▸ JUN ▸ PDCD11 ▸ PDCD5 ▸ CASP12 ▸
RNF19A ▸ CFLAR ▸ PDCD7 ▸ PDCD2 ▸ PDCD6 ▸ PDCD10 ▸ PDCD4 ▸
PDCD1 ▸ CYCS ▸ NA ▸ CASP1 ▸ IGF1 ▸ ANXA5 ▸ CASP2 ▸
PCBD1 ▸ INS ▸ AHSA1 ▸ TGFB1 ▸ CASP6 ▸ HLA-DRB1 ▸ MPZ ▸
CASP7 ▸ PI3 ▸ NLRC4 ▸ EPO ▸ CASP10 ▸ CASP4 ▸ PIK3R1 ▸
CASP16 ▸ CASP5 ▸ PIK3CA ▸ CASP14 ▸ TNFRSF1A ▸ DDIT3 ▸ PRKCD ▸
DFFA ▸ TAT ▸ DISC2 ▸ DISC1 ▸ NOS2 ▸ PRDX2 ▸ MYLIP ▸
IL6 ▸ PCNA ▸ GSK3B ▸ CRK ▸ GRAP2 ▸ EGF ▸ IL4 ▸
CTSB ▸ BIRC2 ▸ SOD1 ▸ VEGFA ▸ CAST ▸ NOS1 ▸ IL8 ▸
EIF2AK2 ▸ IRF1 ▸ CTNNB1 ▸ DFFB ▸ PTGS2 ▸ NGF ▸ PAK2 ▸
BID ▸ LEP ▸ ROCK1 ▸ DNASE2 ▸ P2RX7 ▸ ALPI ▸ APP ▸
ABL1 ▸ DNASE1 ▸ HGF ▸ SOD2 ▸ BDNF ▸ CAT ▸ IL16 ▸
IFNB1 ▸ MAP3K1 ▸ APEH ▸ BCR ▸ IFI27 ▸ FOS ▸ MYC ▸
RIPK1 ▸ TCF4 ▸ CDK2 ▸ RAC1 ▸ MAP2K1 ▸ TCF21 ▸ TCF20 ▸
NOS3 ▸ NOD2 ▸ IL10 ▸ NFKBIA ▸ CTSD ▸ BMP1 ▸ TCF7 ▸
TLR2 ▸ TCF3 ▸ TCF19 ▸ TCF15 ▸ CA2 ▸ TCF12 ▸ TCF25 ▸
UPK3B ▸ IL2 ▸ TCF24 ▸ CSF2 ▸ HDAC2 ▸ HTRA2 ▸ NOX1 ▸
TCF23 ▸ TLR3 ▸ ADCYAP1 ▸ BIRC3 ▸ STAT1 ▸ ATP5O ▸ BIRC7 ▸
ARSK ▸ NLRP1 ▸ POLDIP2 ▸ AIM2 ▸ APOB ▸ MAGT1 ▸ FGF2 ▸
CDC73 ▸ CSF3 ▸ PRKDC ▸ TLR4 ▸ BAD ▸ LMNB1 ▸ HSPA5 ▸
GAL ▸ SOD3 ▸ HDAC1 ▸ CD8A ▸ NOX4 ▸ BMP4 ▸ ITIH4 ▸
PAF1 ▸ SMPD2 ▸ IL5 ▸ WDR61 ▸ SNAP25 ▸ KRT18 ▸ NOX3 ▸
AGTR1 ▸ LEO1 ▸ IL15 ▸ BMP7 ▸ MST1 ▸ IL33 ▸ IL11 ▸
RB1 ▸ CDK5 ▸ CTR9 ▸ RIPK2 ▸ IL3 ▸ PPP2R1A ▸ TLR7 ▸
BMP10 ▸ HMGB1 ▸ STAT3 ▸ PML ▸ CD79A ▸ PPP2R2B ▸ BMP3 ▸
GZMB ▸ NOX5 ▸ BMP2 ▸ BMP15 ▸ TLR5 ▸ HPR ▸ PDLIM7 ▸
CARD8 ▸ PPP2CA ▸ BMP6 ▸ HSPB1 ▸ ENDOG ▸ BMP5 ▸ NOD1 ▸
TRAF6 ▸ HTT ▸ TXN ▸ CREB1 ▸ WAS ▸ PTX4 ▸ PLCG1 ▸
GP5 ▸ GP9 ▸ RIPK3 ▸ TLR10 ▸ ICAM1 ▸ PGP ▸ TLR1 ▸
RBBP7 ▸ IL20 ▸ CSE ▸ CREB3 ▸ IL24 ▸ CDC6 ▸ IGF2 ▸
BIRC6 ▸ PRNP ▸ CCDC88A ▸ NPS ▸ GP2 ▸ JAK2 ▸ TLR8 ▸
LMNB2 ▸ ANXA1 ▸ GP6 ▸ PPARA ▸ CDH1 ▸ CREB5 ▸ TNFRSF1B ▸
LPA ▸ CD4 ▸ RAD51 ▸ GSN ▸ SYK ▸ CXCL9 ▸ MAP2K2 ▸
EGFR ▸ EIF2S1 ▸ BOC ▸ HIF1A ▸ IL21 ▸ APC ▸ MET ▸
PTX3 ▸ RBBP4 ▸ IL7 ▸ PLD1 ▸ GATA1 ▸ BRCA1 ▸ IKBKB ▸
SMARCB1 ▸ ARID1A ▸ MUC20 ▸ ACHE ▸ SMPD1 ▸ ABCC6 ▸ SYT1 ▸
MUC13 ▸ UCN ▸ MUC1 ▸ ACTL6A ▸ IL13 ▸ CDA ▸ IL25 ▸
MUC21 ▸ RAF1 ▸ SMARCE1 ▸ TLR6 ▸ IL31 ▸ SMARCA2 ▸ MSC ▸
SMARCC2 ▸ RRAS ▸ MUC16 ▸ IL27 ▸ TOP1 ▸ ANGPT2 ▸ IL32 ▸
SMARCC1 ▸ MUC8 ▸ MUC7 ▸ CARD9 ▸ FOXO3 ▸ MUC12 ▸ PPARG ▸
SMARCA4 ▸ TRAF1 ▸ CARD6 ▸ PAK1 ▸ IL9 ▸ MEFV ▸ KDR ▸
IL37 ▸ MUC17 ▸ IL19 ▸ IL26 ▸ SMARCD2 ▸ CCND1 ▸ MUC4 ▸
SMARCD1 ▸ MUC22 ▸ MDM2 ▸ ROCK2 ▸ MUC2 ▸ CDK8 ▸ MUC6 ▸
RENBP ▸ STX1A ▸ CCL2 ▸ HSPD1 ▸ CD79B ▸ IL22 ▸ MUC15 ▸
HMOX1 ▸ BECN1 ▸ CARD11 ▸ IRF3 ▸ LYN ▸ MUC19 ▸ IL34 ▸
TLR9 ▸ NPY6R ▸ VIM ▸ DST ▸ PLOD2 ▸ GRK5 ▸ MAP2K4 ▸
GRK7 ▸ PRKACB ▸ SP1 ▸ PRKACG ▸ CEP76 ▸ CCR7 ▸ SLCO6A1 ▸
PTBP1 ▸ CD40 ▸ GRB14 ▸ CEP170 ▸ MAP2K7 ▸ CEP95 ▸ PRKCG ▸
PRKAR1B ▸ NUP210 ▸ PXN ▸ PRKAR2A ▸ ALK ▸ MPST ▸ VIMP ▸
CARD17 ▸ CEP250 ▸ TCHP ▸ GRB2 ▸ PRKAR2B ▸ SETBP1 ▸ CARD16 ▸
IGF1R ▸ MAP2K6 ▸ PRKCA ▸ PEA15 ▸ CARD18 ▸ CARD14 ▸ TARDBP ▸
CEP41 ▸ NUP62 ▸ WNT1 ▸ CD47 ▸ CEP44 ▸ CEP72 ▸ SEC14L2 ▸
CDK4 ▸ CEP70 ▸ CEP192 ▸ CEP57 ▸ IKBKG ▸ PTK2 ▸ SKP1 ▸
HIST2H2BE ▸ PSEN1 ▸ MIF ▸ CEP120 ▸ GRB7 ▸ HIP1 ▸ CEP350 ▸
BIRC8 ▸ IRF4 ▸ CEP290 ▸ GUCY2D ▸ ME2 ▸ GRK6 ▸ GDNF ▸
CUL1 ▸ GRK4 ▸ PTHLH ▸ CEP135 ▸ EHMT1 ▸ PLD2 ▸ BIRC5 ▸
SETD2 ▸ FOXO1 ▸ E2F1 ▸ VCP ▸ RASA1 ▸ NPM1 ▸ TNFRSF10A ▸
HSP90AA1 ▸ ADIPOQ ▸ CEP128 ▸ PANX1 ▸ IRF2 ▸ DERL1 ▸ CEP85 ▸
ANGPT1 ▸ LYPLA1 ▸ ALB ▸ SLC17A5 ▸ SLC9A1 ▸ PIDD ▸ CEP19 ▸
HSF1 ▸ BACE1 ▸ CARD10 ▸ TRAF2 ▸ CEP78 ▸ NUP214 ▸ SOAT1 ▸
GRK1 ▸ CEP63 ▸ BCL2L12 ▸ ELAVL1 ▸ H2AFX ▸ IRF5 ▸ GRB10 ▸
DES ▸ TRAF3 ▸ NUP153 ▸ PSMD10 ▸ ATG5 ▸ CALM3 ▸ ARSA ▸
CEP112 ▸ HUNK ▸ CEP68 ▸ CEP97 ▸ CEP104 ▸ MEPE ▸ IL1RN ▸
CEP152 ▸ ARC ▸ CEP55 ▸ CEP89 ▸ VDAC1 ▸ PTEN ▸ LAT ▸
MAP2K5 ▸ MAP2K3 ▸ EPX ▸ CEP164 ▸ PRKAR1A ▸ NAB1 ▸ FHIT ▸
TNFSF12 ▸ TYR ▸ EIF4G3 ▸ MED14 ▸ NR0B1 ▸ TGM2 ▸ CXCL13 ▸
MT3 ▸ HCLS1 ▸ RAD21 ▸ MED8 ▸ CCR5 ▸ MLYCD ▸ FAF1 ▸
CCNH ▸ CALB1 ▸ PLK1 ▸ PDGFB ▸ CDK17 ▸ KLK3 ▸ MED1 ▸
CXCL17 ▸ MAP2 ▸ SUB1 ▸ ATM ▸ NUAK1 ▸ RARA ▸ TNFRSF10B ▸
PSMB9 ▸ C22orf29 ▸ EML2 ▸ RAD52 ▸ WNK1 ▸ PC ▸ FUT1 ▸
MTA1 ▸ APIP ▸ CDK18 ▸ PIN1 ▸ CDK16 ▸ EEF1A2 ▸ CDK7 ▸
TRAF7 ▸ GHSR ▸ CTSL ▸ XRCC6 ▸ FOXP3 ▸ CDK3 ▸ PRKAG1 ▸
NPPA ▸ MED15 ▸ SLPI ▸ THBS1 ▸ ACAD8 ▸ CCR3 ▸ MED7 ▸
CDK20 ▸ MTA2 ▸ WNT3A ▸ STSP1 ▸ SAA1 ▸ CDK15 ▸ KMT2A ▸
ADM ▸ SPP1 ▸ ODC1 ▸ S100A12 ▸ PRG4 ▸ PNPLA2 ▸ MED24 ▸
PRKAA2 ▸ PLD4 ▸ CAPNS1 ▸ VIP ▸ CDK10 ▸ TAC3 ▸ DAP3 ▸
IAPP ▸ IARS ▸ NANOG ▸ CA8 ▸ HTRA3 ▸ TNFRSF8 ▸ CDK6 ▸
HTRA4 ▸ MED6 ▸ RAB5A ▸ FAM168B ▸ SMAD3 ▸ PRG3 ▸ E2F3 ▸
BCAP31 ▸ ANXA6 ▸ CCR6 ▸ ANP32A ▸ CDK12 ▸ ETS2 ▸ MED23 ▸
RBL2 ▸ GPX3 ▸ PPT1 ▸ SHC1 ▸ NLRP7 ▸ NUP43 ▸ NLRC5 ▸
MED17 ▸ PMEL ▸ CDK9 ▸ HTRA1 ▸ VDAC3 ▸ DHCR24 ▸ AFP ▸
GLI1 ▸ ID3 ▸ CISH ▸ NAB2 ▸ TRA ▸ SIVA1 ▸ UCP2 ▸
CDK14 ▸ CCR1 ▸ CPOX ▸ BNIP3 ▸ JAK1 ▸ PAN3 ▸ PAEP ▸
STC1 ▸ SREBF2 ▸ CIB1 ▸ CENPK ▸ TET2 ▸ CALML3 ▸ ETS1 ▸
BAG3 ▸ IFNA2 ▸ MED4 ▸ GYS1 ▸ RAC2 ▸ EDNRA ▸ ACSM3 ▸
SDS ▸ ACIN1 ▸ TFAP2A ▸ XAF1 ▸ TET3 ▸ CDC42 ▸ STX2 ▸
NACA ▸ DAPK2 ▸ EMP3 ▸ KLKB1 ▸ RAD17 ▸ MED25 ▸ IRS1 ▸
MED26 ▸ CCR4 ▸ ING1 ▸ RAD1 ▸ CCR9 ▸ LRP1 ▸ IFIH1 ▸
BLM ▸ CCR2 ▸ AIP ▸ PTCH1 ▸ ATG3 ▸ MED13 ▸ ATF2 ▸
JAK3 ▸ MT4 ▸ MED12 ▸ MED21 ▸ QRICH1 ▸ RUNX3 ▸ RAD18 ▸
SMAD7 ▸ IDO1 ▸ HRK ▸ CD2 ▸ PRKAG2 ▸ NANOS2 ▸ MST1R ▸
ZGLP1 ▸ GPI ▸ QRICH2 ▸ GPX1 ▸ IRF8 ▸ MTOR ▸ APOBEC3D ▸
HDAC6 ▸ GRP ▸ TSC22D3 ▸ CDCA5 ▸ APEX1 ▸ CPA1 ▸ GYS2 ▸
GJA1 ▸ E2F2 ▸ SREBF1 ▸ TET1 ▸ KLF4 ▸ MICE ▸ SERPINA1 ▸
GSTT1 ▸ PAN2 ▸ LRRC59 ▸ PPP1R3A ▸ DAXX ▸ IRF7 ▸ NAIP ▸
PARG ▸ PSENEN ▸ MTA3 ▸ HRD ▸ APOE ▸ TGFB3 ▸ CCK ▸
EIF4G2 ▸ NTN1 ▸ CYR61 ▸ ERVK-6 ▸ CFL1 ▸ DYRK1A ▸ ABCD1 ▸
HDAC4 ▸ NTF4 ▸ ATF5 ▸ PRKAB2 ▸ IFI44 ▸ CTRL ▸ GNA11 ▸
LGALS1 ▸ TIMP3 ▸ DIDO1 ▸ SMAD4 ▸ CTNND1 ▸ PRG2 ▸ CTNNBL1 ▸
TMED7 ▸ ADH5 ▸ GNRH1 ▸ SEPT4 ▸ RHO ▸ MAP3K7 ▸ CDK1 ▸
CFTR ▸ PLD3 ▸ NTF3 ▸ RANBP2 ▸ PGF ▸ CCNC ▸ TAC4 ▸
PRKAA1 ▸ IRF9 ▸ SRC ▸ TRAF5 ▸ CSF1 ▸ DLG1 ▸ SERPINB9 ▸
PLD6 ▸ HMGCR ▸ CHUK ▸ TRAF4 ▸ EIF4G1 ▸ PLD5 ▸ EMP2 ▸
RIPK4 ▸ RAC3 ▸ ITCH ▸ PRKAB1 ▸ ANG ▸ CCR10 ▸ VDAC2 ▸
PTPN11 ▸ TAC1 ▸ CRYAB ▸ SATB1 ▸ SERPINF1 ▸ DNAJC5 ▸ CCR8 ▸
CCL19 ▸ CDK19 ▸ CD8B ▸ CDK13 ▸ SERP2 ▸ COP ▸ HIPK2 ▸
IGFBP3 ▸ CALR ▸ NLRP5 ▸ EMP1 ▸ RAD50 ▸ MME ▸ NCL ▸
KRR1 ▸ CUL3 ▸ HNRNPH2 ▸ UBB ▸ COL5A2 ▸ ATG4D ▸ COL4A4 ▸
CRADD ▸ YES1 ▸ PLEC ▸ COL6A1 ▸ ITGB1 ▸ CDK11B ▸ PLA2G4B ▸
TUBA1C ▸ COL4A1 ▸ UBC ▸ RNF34 ▸ TNFSF14 ▸ MAP3K14 ▸ UBR5 ▸
CASP8AP2 ▸ UBE2D1 ▸ EDA2R ▸ MAP1LC3A ▸ FIS1 ▸ SQSTM1 ▸ EP300 ▸
CD247 ▸ COL4A6 ▸ IL1R1 ▸ RPS27 ▸ TOPORS ▸ SPARC ▸ ITGB3 ▸
ITGA2 ▸ TNFRSF25 ▸ SORBS1 ▸ TUBA1A ▸ IL1R2 ▸ TUBB ▸ COL11A2 ▸
LY96 ▸ USP54 ▸ EZR ▸ RNF135 ▸ HIST1H4A ▸ PTPN13 ▸ BFAR ▸
IFT57 ▸ CLIP3 ▸ ARHGDIA ▸ PICALM ▸ CD3E ▸ COL5A1 ▸ IRS4 ▸
SYF2 ▸ ATN1 ▸ CLTC ▸ DEDD2 ▸ ATAD3A ▸ PDIA6 ▸ MAP4K4 ▸
STK24 ▸ DDX28 ▸ TFCP2 ▸ OTUD7B ▸ PARK7 ▸ COL4A3 ▸ PRKCI ▸
CDK11A ▸ CD3D ▸ NEFH ▸ NR1H4 ▸ TRIM25 ▸ AR ▸ KARS ▸
COL4A5 ▸ COPS6 ▸ MALT1 ▸ MSN ▸ COL6A3 ▸ COL3A1 ▸ ACTG2 ▸
RPS27L ▸ ITGAV ▸ COL1A2 ▸ COL7A1 ▸ NUCB2 ▸ EIF3S10 ▸ RAB10 ▸
COL2A1 ▸ NUCB1 ▸ GRIA1 ▸ IQGAP1 ▸ PLIN4 ▸ COL1A1 ▸ TNFAIP3 ▸
PARK2 ▸ TRIM28 ▸ USP2 ▸ RALGDS ▸ PYCARD ▸ PCYT1A ▸ CD14 ▸
MAPT ▸ PIDD1 ▸ PTPN6 ▸ EIF4A1 ▸ RALBP1 ▸ COL11A1 ▸ PIAS1 ▸
MAP1LC3B ▸ COL6A2 ▸ CHD3 ▸ KHDRBS1 ▸ BNIP3L ▸ DNAJC7 ▸ TICAM2 ▸
UBE2L3 ▸ CD3G ▸ MYO9A ▸ ACTA2 ▸ NOL3 ▸
Data information
Please see the Gene Interactions Track Manual.